Heating device and water for injection production system

Abstract

The utility model provides a kind of heating device and water for injection production system.The heating device includes kettle body, along by inside to outside direction, the kettle body includes inner shell, intermediate shell, heat preservation layer and outer shell in proper order, there is gap between the inner shell and intermediate shell, the gap between the intermediate shell and the inner shell is used to fill heat conducting medium, the heating device further includes electric heater for heating the heat conducting medium.The present application adjusts the structure of kettle body in prior art from double layer to three layers, adjusts the heating mode of water for injection from direct heating to indirect heating, avoids the technical problem that electric heating device in prior art can directly contact water for injection in water tank, its material itself can cause pollution to water for injection, dead angle (such as corner) of water tank forms water flow blind area, these pollutants can deposit and adhere with microorganism such as bacteria, affect the water quality of water for injection.

Description

Technical Field

[0001] This utility model relates to the field of water for injection production technology, and in particular to a heating device and a water for injection production system. Background Technology

[0002] Water for injection is used as a solvent in the preparation of injection solutions and sterile rinsing agents, or as the final rinsing water for packaging materials that come into direct contact with sterile drugs, such as bottles and rubber stoppers, in the production of sterile water injections and powder injections. It is widely used in the preparation of various drugs.

[0003] The production process of water for injection requires maintaining a constant temperature environment. Related technologies typically employ a double-tube sheet heat exchanger to heat the total return water using industrial steam, ensuring the water for injection is kept in a state of temperature above 70°C during circulation. To maintain this temperature-controlled circulation, a gas-fired boiler needs to be operated at night. However, this production method results in a waste of gas resources.

[0004] In related technologies, an electric heating device is added to the water tank to heat the water for injection overnight, so as to keep the water for injection circulating at a temperature above 70°C. However, the electric heating device comes into direct contact with the water for injection in the water tank, and its material itself can contaminate the water for injection. Dead corners of the water tank (such as corners) form blind spots for water flow, and these contaminants can accumulate and adhere with bacteria and other microorganisms, affecting the water quality for injection. Utility Model Content

[0005] This invention provides a heating device and a water for injection production system to solve the technical problems of the above-mentioned electric heating device directly contacting the water for injection in the water tank, the material itself causing pollution to the water for injection, and dead corners (such as corners) of the water tank forming blind spots for water flow, where these pollutants will deposit and adhere with bacteria and other microorganisms, affecting the water quality of the water for injection.

[0006] To achieve the above objectives, the technical solution of this utility model is as follows:

[0007] Firstly, this utility model provides a heating device, which includes a vessel body. Along the direction from the inside to the outside, the vessel body sequentially includes an inner shell, an intermediate shell, a heat insulation layer, and an outer shell. A gap is left between the inner shell and the intermediate shell. The gap between the intermediate shell and the inner shell is used to fill a heat-conducting medium. The heating device also includes an electric heater for heating the heat-conducting medium.

[0008] In this invention, by adding an intermediate shell and leaving a gap between the intermediate shell and the inner shell, a heat-conducting medium (such as heat-conducting oil) can be filled in the gap. An electric heater then heats the heat-conducting medium, causing heat exchange between it and the water for injection located within the vessel, thereby indirectly heating the water for injection. In other words, this application, by adjusting the vessel structure from two layers to three layers in the prior art and changing the heating method of the water for injection from direct heating to indirect heating, avoids the technical problems of existing electric heating devices directly contacting the water for injection in the tank, causing contamination of the water for injection by the heating device itself, and dead zones in the tank (such as corners) where contaminants accumulate and adhere with bacteria and other microorganisms, affecting the water quality of the water for injection.

[0009] In one embodiment of the present invention, the top of the vessel is provided with a water return port, and the water return port is connected to a spray element via a pipe. The spray element is located at the top of the vessel body.

[0010] In this invention, by adding a spray element located at the top of the vessel body, the inner wall and corners of the vessel body can be rinsed by the spray element, preventing the deposition of microbial film, avoiding the formation of water flow blind zones (i.e., "dead water zones"), reducing the risk of the formation of bacteria and other microorganisms, and preventing the growth of bacteria and other microorganisms in static water environments. Furthermore, when the temperature of the water for injection exceeds 80°C, the spray element can also evenly distribute hot water, improving the sterilization effect.

[0011] In one embodiment of this utility model, the spraying element is a spray ball.

[0012] In this invention, by setting the spray element as a spray ball, the coverage area of ​​the spraying zone can be increased, further reducing the risk of the formation of bacteria and other microorganisms, and further preventing the growth of bacteria and other microorganisms in a static water environment.

[0013] In one embodiment of the present invention, the top of the vessel is provided with a pressure manhole and a breather valve.

[0014] In this invention, by adding a pressure manhole and a breather valve to the top of the vessel, the valve can be automatically opened or closed when the pressure inside the vessel changes (such as temperature fluctuations), allowing air to enter and exit, but preventing microorganisms, particulate matter, impurities, etc. in the air from entering the vessel and preventing contamination of the water for injection.

[0015] In one embodiment of the present invention, a rupture disc is provided at the top of the vessel body.

[0016] In this invention, by adding a rupture disc to the top of the vessel, damage to the vessel under overpressure or vacuum conditions can be avoided, while ensuring the sterility and safety of the environment inside the vessel.

[0017] In one embodiment of the present invention, the vessel body is provided with a drain port for discharging the heat-conducting medium.

[0018] In one embodiment of this utility model, a safety valve is provided on the upper part of the vessel body.

[0019] In this invention, by adding a safety valve to the upper part of the vessel, it is possible to prevent the internal pressure of the heat transfer medium layer from becoming too high due to the steam generated during the heating process, which could damage the vessel.

[0020] In one embodiment of this utility model, the insulation layer is a polyurethane insulation layer.

[0021] In one embodiment of this utility model, the thickness of the insulation layer is 45-55mm.

[0022] Secondly, this utility model also provides a water for injection production system, which includes the heating device described above.

[0023] In one embodiment of the present invention, the water for injection production system further includes a circulation pipe and a heat exchanger. The circulation pipe is connected to the heating device, and the heat exchanger is arranged around the outside of the circulation pipe. The heat exchanger is connected to a steam inlet pipe. Attached Figure Description

[0024] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with this application and, together with the description, serve to explain the principles of this application. It is obvious that the drawings described below are merely some embodiments of this application, and those skilled in the art can obtain other drawings based on these drawings without any inventive effort.

[0025] In the attached diagram:

[0026] Figure 1 This is a schematic diagram of the structure of a heating device provided in an embodiment of the present invention;

[0027] Figure 2 This is a schematic diagram of the structure of a water for injection production system provided in one embodiment of the present invention.

[0028] The attached figures are labeled as follows:

[0029] 1-Heating device, 1101-Inner shell, 1102-Intermediate shell, 1103-Insulation layer, 1104-Outer shell, 1105-Return water inlet, 1106-Breath valve, 1107-Rupture disc, 1108-Spray element, 1109-Safety valve, 1110-Drain outlet, 1111-Inlet, 1112-Exhaust valve, 1113-High level valve, 1114-Low level valve, 1115-Water supply inlet, 1116-Temperature sensor, 1117-Steam sterilization port, 1118-Outlet, 1119-Pressure manhole, PI-Pressure gauge, T-Temperature transmitter, AIT-Conductivity transmitter, FT-Flow sensor, TE-Local thermometer;

[0030] 2-Circulation pipe;

[0031] 3-Heat exchanger;

[0032] 4-Steam inlet pipe;

[0033] 5-Condensate inlet pipe.

[0034] 6-Drainage ditch;

[0035] 7-Condensate outlet pipe. Detailed Implementation

[0036] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0037] It should be noted that all directional indicators (such as up, down, left, right, front, back, inside, outside, top, bottom, etc.) in this utility model embodiment are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.

[0038] In this utility model, unless otherwise explicitly specified and limited, the terms "connection" and "fixation" should be interpreted broadly. For example, "fixation" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0039] Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed by this utility model.

[0040] In related technologies, an electric heating device is added to the water tank to heat the water for injection overnight, so as to keep the water for injection circulating at a temperature above 70°C. After analyzing the related technologies, the inventors found that the electric heating device directly contacts the water for injection in the water tank, and its material itself can contaminate the water for injection. Dead corners of the water tank (such as corners) form blind spots for water flow, and these contaminants can accumulate and adhere with bacteria and other microorganisms, affecting the water quality for injection.

[0041] Based on the above problems, one embodiment of the present invention provides a heating device 1, which includes a vessel body. Along the direction from the inside to the outside, the vessel body includes an inner shell 1101, an intermediate shell 1102, a heat insulation layer 1103, and an outer shell 1104 in sequence. A gap is left between the inner shell 1101 and the intermediate shell 1102. The gap between the intermediate shell 1102 and the inner shell 1101 is used to fill the heat-conducting medium. The heating device also includes an electric heater 12 for heating the heat-conducting medium. The thickness of the heat insulation layer 1103 is 45-55mm, and the heat insulation layer 1103 is a polyurethane heat insulation layer.

[0042] The top of the vessel is provided with a water return port 1105 and a rupture disc 1107. The water return port 1105 is connected to a spray element 1108 via a pipe. The spray element 1108 is located at the top of the vessel and is a spray ball.

[0043] A safety valve 1109 is installed at the top of the vessel body;

[0044] The vessel body is equipped with a drain port 1110 for discharging the heat transfer medium.

[0045] Another embodiment of this utility model provides a water for injection production system, which includes a heating device 1, a circulation pipe 2 and a heat exchanger 3 as described above. The circulation pipe 2 is connected to the heating device 1, and the heat exchanger 3 is arranged around the outside of the circulation pipe 1. The heat exchanger 3 is connected to a steam inlet pipe 4.

[0046] In the following description, numerous details are explored to provide a more thorough explanation of embodiments of the present invention. However, it will be apparent to those skilled in the art that embodiments of the present invention may be practiced without these specific details. In other embodiments, well-known structures and devices are shown in the form of drawings rather than in detail to avoid obscuring embodiments of the present invention.

[0047] Please see Figure 1 , Figure 1 This is a schematic diagram of the structure of a heating device provided in an embodiment of the present invention, as shown below. Figure 1 As shown, the heating device is used to replace industrial steam to heat water for injection at night, so as to keep the water for injection at a temperature above 70°C in a heat preservation cycle.

[0048] Please continue reading. Figure 1 The heating device 1 includes a vessel body, which, from the inside out, comprises an inner shell 1101, an intermediate shell 1102, a heat insulation layer 1103, and an outer shell 1104. A gap exists between the inner shell 1101 and the intermediate shell 1102, and this gap is used to fill a heat-conducting medium. The inner shell 1101, intermediate shell 1102, and outer shell 1104 are all made of stainless steel. The heat insulation layer 1103 has a thickness of 45-55 mm and is a polyurethane insulation layer. Examples of heat-conducting media include heat-conducting oil. The top of the vessel body has a return water inlet 1105 and a water inlet 1111. The top of the vessel body also has a breather valve 1106 and a pressure manhole 1119. A rupture disc 1107 is located at the breather valve 1106. The upper part of the vessel body is equipped with a safety valve 1109, an exhaust valve 1112, and a high-level valve 1113. The lower part of the vessel body is equipped with a low-level valve 1114, a water inlet 1115, a drain outlet 1110 for discharging heat transfer medium, a steam sterilization outlet 1117, and a water outlet 1118 for discharging water for injection. A temperature sensor 1116 is installed at the steam sterilization outlet 1117. The return water inlet 1105 is connected to a spray element 1108 via a pipe. The spray element 1108 is located at the top of the vessel body. The spray element 1108 is a spray ball, which can be a rotating spray ball or a fixed spray ball, etc. Rotating spray balls and fixed spray balls are existing technologies and will not be described in detail here.

[0049] In this invention, by adding a spray element 1108 located inside the vessel, the inner wall and corners of the vessel can be rinsed, preventing the deposition of microbial films, avoiding the formation of water flow blind zones (i.e., "dead water zones"), reducing the risk of bacterial and other microbial formation, and preventing the growth of bacteria and other microorganisms in static water environments. Furthermore, when the temperature of the water for injection exceeds 80°C, the spray element 1108 can evenly distribute hot water, improving the sterilization effect. In this invention, by setting the spray element 1108 as a spray ball, the coverage area of ​​the spray zone can be increased, further reducing the risk of bacterial and other microbial formation and further preventing the growth of bacteria and other microorganisms in static water environments. In this invention, by adding a pressure manhole 1111 and a breather valve 1106 to the top of the vessel, the valve can automatically open or close when the pressure inside the vessel changes (such as temperature fluctuations), allowing air to enter and exit while blocking microorganisms, particulate matter, impurities, etc., from entering the vessel, preventing contamination of the water for injection. In this invention, by adding a rupture disc 1107 to the top of the vessel, damage to the vessel under overpressure or vacuum conditions can be prevented, while ensuring the sterility and safety of the internal environment of the vessel. In this invention, by adding a safety valve 1109 to the upper part of the vessel, damage to the vessel can be prevented from caused by excessive internal pressure due to steam generated during heating of the heat transfer medium layer.

[0050] Please see Figure 1 The heating device also includes an electric heater 12, which is used to heat the heat-conducting medium so that heat exchange occurs between the heated heat-conducting medium and the water for injection located in the vessel, thereby indirectly heating the water for injection. The electric heater 12 is connected to a power source (not shown). The electric heater 12 uses a flange-type heating tube, which is existing technology and will not be described in detail here.

[0051] In this invention, by setting the electric heater 12 to use a flange-type electric heating tube, the heating efficiency can be improved, the heat energy conversion rate can be increased, and the heating temperature can be precisely controlled.

[0052] The principle of this utility model is as follows: by adding an intermediate shell 1102 and leaving a gap between the intermediate shell 1102 and the inner shell 1101, a heat-conducting medium (such as heat-conducting oil) can be filled in the gap between the intermediate shell 1102 and the inner shell 1101. The heat-conducting medium is heated by an electric heater 12, so that heat exchange occurs between the heat-conducting medium and the water for injection located in the vessel body, thereby indirectly heating the water for injection. In other words, this application adjusts the structure of the vessel body in the prior art from two layers to three layers and changes the heating method of the water for injection from direct heating to indirect heating. This avoids the technical problem that in the prior art, the electric heating device directly contacts the water for injection in the water tank, and its material itself will cause pollution to the water for injection. The dead corners of the water tank (such as corners) form water flow blind zones, and these pollutants will deposit and adhere with bacteria and other microorganisms, affecting the water quality of the water for injection.

[0053] Please see Figure 2 , Figure 2 This is a schematic diagram of the structure of a water for injection production system provided in an embodiment of the present invention. The water for injection production system includes a heating device 1, a circulation pipe 2, and a heat exchanger 3 as described above.

[0054] Please continue reading. Figure 2 The circulation pipe 2 serves as the pipeline for the circulation process of water for injection. The circulation pipe 2 is connected to the heating device 1. The heat exchanger 3 is wound around the outside of the circulation pipe 2. The heat exchanger 3 has a heat exchange inlet and a heat exchange outlet. The heat exchange inlet is connected to the condensate outlet pipe 7. The heat exchange outlet is connected to the return water inlet 1105, steam inlet pipe 4, and condensate inlet pipe 5 of the heating device 1. The drain outlet 1110 is connected to the drain pipe, and a drain ditch 6 is provided below the drain pipe. The heat exchanger 3 adopts a double tube sheet heat exchanger, which is existing technology and will not be described in detail here.

[0055] The above embodiments are merely illustrative of the principles and effects of this utility model and are not intended to limit the scope of this utility model. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of this utility model. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in this utility model should still be covered by the claims of this utility model.

Claims

1. A heating device, the heating device comprising a vessel body, characterized in that, Along the direction from the inside out, the vessel body sequentially includes an inner shell, an intermediate shell, a heat insulation layer, and an outer shell. A gap is left between the inner shell and the intermediate shell. The gap between the intermediate shell and the inner shell is used to fill the heat-conducting medium. The heating device also includes an electric heater for heating the heat-conducting medium.

2. The heating device as described in claim 1, characterized in that, The top of the vessel is provided with a water return port, which is connected to a spray element via a pipe. The spray element is located at the top of the vessel.

3. The heating device as described in claim 2, characterized in that, The spray element is a spray ball.

4. The heating device as described in claim 1, characterized in that, The top of the vessel is equipped with a rupture disc.

5. The heating device as described in claim 1, characterized in that, The vessel body is provided with a drain port for discharging the heat-conducting medium.

6. The heating device as described in claim 1, characterized in that, A safety valve is provided on the upper part of the vessel.

7. The heating device as described in claim 1, characterized in that, The insulation layer is a polyurethane insulation layer.

8. The heating device as claimed in claim 1, characterized in that, The thickness of the insulation layer is 45-55mm.

9. A water-for-injection production system, characterized in that, The water for injection production system includes a heating device as described in any one of claims 1-8.

10. The water-for-injection production system as described in claim 9, characterized in that, The water for injection production system also includes a circulation pipe and a heat exchanger. The circulation pipe is connected to the heating device, and the heat exchanger is arranged around the outside of the circulation pipe. The heat exchanger is connected to a steam inlet pipe.

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