Microbial fermentation device based on partition temperature control

Abstract

The utility model discloses a kind of microbial fermentation devices based on partition temperature control, it is related to fermentation device technical field.The utility model discloses a fermentation tank, inner bag is equipped in fermentation tank, temperature regulating chamber is formed between fermentation tank inner side wall and inner bag outer side wall, temperature regulating chamber is divided into multiple temperature control zones along vertical direction;Several heat exchange pipelines are equipped in temperature regulating chamber, at least one heat exchange pipeline is set corresponding to each temperature control zone, each heat exchange pipeline is wound on inner bag outer side wall in corresponding temperature control zone;Wherein, heat exchange pipeline is used to input heat exchange medium, heat exchange medium occurs thermal bridge reaction with inner bag through heat exchange pipeline and changes the temperature of temperature control zone.The utility model is adopted, and it is separated into independent temperature control unit in fermentation tank, the bottom, middle, top of fermentation tank can be independently temperature regulated, prevent that the local temperature change of fermentation tank too large leads to microbial overheating inactivation, especially suitable for the microbial fermentation process needing stage temperature or local temperature control.

Description

Technical Field

[0001] This utility model relates to the field of fermentation device technology, and more specifically, to a microbial fermentation device based on zoned temperature control. Background Technology

[0002] Microbial fermentation is generally carried out in fermenters, which are industrial devices used for microbial fermentation. The main body of a fermenter is typically a cylindrical structure made of stainless steel, and it usually contains a stirring paddle for agitating the fermentation material. Existing microbial fermenters use a single temperature control method, often employing a single jacketed heating / cooling system, which cannot independently regulate the temperature of different areas within the tank (such as the bottom, middle, and top). For example, in the fermentation of filamentous fungi, the heat generated by mycelial metabolism is concentrated in the middle of the tank, but traditional equipment can only cool the entire tank, resulting in energy waste and delayed temperature control. Therefore, traditional single-zone temperature control systems cannot quickly remove the metabolic heat from the mycelium, leading to sudden temperature rises in certain areas and easily causing microbial overheating and inactivation. Utility Model Content

[0003] The purpose of this invention is to provide a microbial fermentation device based on zoned temperature control. By dividing the interior of the fermenter into independent temperature control units, the bottom, middle and top of the fermenter can be independently regulated, preventing excessive local temperature changes in the fermenter from causing microbial overheating and inactivation. It is particularly suitable for microbial fermentation processes that require staged temperature changes or local temperature control.

[0004] The technical solution adopted in this utility model is as follows:

[0005] This application provides a microbial fermentation device based on zoned temperature control, including a fermenter, an inner liner inside the fermenter, a temperature-regulating chamber formed between the inner wall of the fermenter and the outer wall of the inner liner, and the temperature-regulating chamber is divided into multiple temperature-control zones along the vertical direction.

[0006] The temperature control chamber is provided with a plurality of heat exchange pipes, which are arranged vertically at intervals within the temperature control chamber. Each temperature control zone is provided with at least one heat exchange pipe. Each heat exchange pipe is wound around the outer wall of the inner liner within the corresponding temperature control zone, and both ends of the heat exchange pipe pass through the side wall of the fermenter and extend outward. The heat exchange pipe is used to input the heat exchange medium, which undergoes a thermal bridge reaction with the inner liner through the heat exchange pipe and changes the temperature of the temperature control zone.

[0007] Furthermore, in some embodiments of this utility model, a heat-conducting layer is provided between the heat exchange pipe and the outer wall of the inner liner. The heat-conducting layer is disposed on the outer wall of the inner liner and is used to transfer heat between the heat exchange pipe and the inner liner.

[0008] Furthermore, in some embodiments of this utility model, the inner wall of the inner liner is provided with a plurality of temperature sensors, which are evenly spaced along the vertical direction; it also includes a control terminal, and the temperature sensors are electrically connected to the control terminal.

[0009] Furthermore, in some embodiments of this utility model, the inner liner is provided with a plurality of temperature regulating tubes at intervals, the temperature regulating tubes are provided with temperature regulating sleeves, and the sidewalls of the temperature regulating sleeves are provided with a plurality of electric heating elements at intervals along their circumference, the electric heating elements abutting against the inner sidewalls of the temperature regulating tubes.

[0010] Furthermore, in some embodiments of this utility model, the sidewall of the temperature regulating sleeve is provided with a plurality of semiconductor cooling chips spaced apart along its circumference, the semiconductor cooling chips are arranged crosswise with the electric heating chips, and the cooling end of the semiconductor cooling chip abuts against the inner sidewall of the temperature regulating tube.

[0011] Furthermore, in some embodiments of this utility model, the temperature regulating sleeve is slidably disposed inside the temperature regulating tube along the extension direction of the temperature regulating tube, and also includes a connecting wire. One end of the connecting wire slides through the fermenter and is electrically connected to the semiconductor refrigeration chip and the electric heating chip, and the other end of the connecting wire is used to connect to an external control terminal.

[0012] Furthermore, in some embodiments of this utility model, the top and bottom of the temperature regulating sleeve are provided with heat dissipation fans, and the heat dissipation fans are electrically connected to the connecting wires.

[0013] Furthermore, in some embodiments of this utility model, the fermenter is provided with heat dissipation holes at both the top and bottom, and the heat dissipation holes are connected to the temperature control pipe.

[0014] Compared with the prior art, the embodiments of this utility model have at least the following advantages or beneficial effects:

[0015] 1. This application divides the interior of the fermenter into independent temperature control units by setting up three independent heat exchange pipes, which can independently adjust the temperature of the bottom, middle and top of the fermenter, preventing excessive local temperature changes in the fermenter from causing microbial overheating and inactivation. It is particularly suitable for microbial fermentation processes that require staged temperature changes or local temperature control.

[0016] 2. This application incorporates a temperature control tube, an electric heating element, and a semiconductor cooling element. When the fermentation broth needs to be heated, the electric heating element is energized and generates heat. The heat generated by the electric heating element is then transferred to the fermentation broth through the temperature control tube, facilitating heating of the central portion of the fermentation broth. When the fermentation broth needs to be cooled, the semiconductor cooling element is energized. The semiconductor cooling element absorbs the heat from the temperature control tube and moves the heat from the cooling end to the heating end. In this way, the semiconductor cooling element can cool the central portion of the fermentation broth. Combined with the heat exchange pipes on the outside of the fermentation broth, this improves the temperature control efficiency of the fermentation broth. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 A schematic diagram of the structure of a microbial fermentation device based on zoned temperature control provided in an embodiment of this utility model;

[0019] Figure 2 A partial cross-sectional view of a fermenter provided for an embodiment of this utility model;

[0020] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0021] Figure 4 A transverse sectional view showing the positions of the temperature regulating tube and temperature regulating sleeve provided in an embodiment of this utility model.

[0022] Icons: 1-Fermentation tank; 2-Inner liner; 3-Temperature control chamber; 4-Heat exchange pipe; 5-Heat conduction layer; 6-Temperature sensor; 7-Temperature control tube; 8-Temperature control sleeve; 9-Electric heating element; 10-Semiconductor cooling chip; 11-Connecting wire; 12-Heat dissipation fan; 13-Heat dissipation hole. Detailed Implementation

[0023] The embodiments of this application will now be described in detail with reference to the accompanying drawings.

[0024] Example 1

[0025] Please refer to Figures 1-4This embodiment provides a microbial fermentation device based on zoned temperature control, including a fermentation tank 1, an inner liner 2 inside the fermentation tank 1, the inner liner 2 being used to place microorganisms and carry out microbial fermentation, a temperature regulating chamber 3 being formed between the inner side wall of the fermentation tank 1 and the outer side wall of the inner liner 2, and the temperature regulating chamber 3 being divided into multiple temperature control zones along the vertical direction.

[0026] The temperature-regulating chamber 3 is provided with a plurality of heat exchange pipes 4, which are arranged vertically at intervals in the temperature-regulating chamber 3. At least one heat exchange pipe 4 is provided for each temperature control zone. Each heat exchange pipe 4 is wound around the outer wall of the inner liner 2 in the corresponding temperature control zone, and both ends of the heat exchange pipe 4 pass through the side wall of the fermenter 1 and extend outward. The heat exchange pipe 4 is used to input the heat exchange medium, which reacts with the inner liner 2 through the heat exchange pipe 4 to change the temperature of the temperature control zone.

[0027] In this embodiment, three temperature control zones and three heat exchange pipes 4 are used, with their installation positions corresponding to the bottom, middle, and top of the fermenter 1, respectively. The heat exchange pipes 4 in this embodiment can be made of metal pipes with good thermal conductivity, and the inner liner 2 can also be made of metal with good thermal conductivity.

[0028] In the specific implementation process, microorganisms are placed inside the inner liner 2 of the fermentation tank 1 for fermentation. The selected microorganisms can be filamentous fungi or other microorganisms that require phased temperature changes or local temperature control. The three heat exchange pipes 4 can be connected to external heat exchangers respectively. When the temperature inside the inner liner 2 rises during fermentation, if the local temperature rises rapidly, such as the temperature in the middle of the fermentation tank 1, the heat exchanger can deliver a cooler refrigerant into the middle heat exchange pipe 4 for heat exchange, which can quickly cool the middle part of the inner liner 2. At the same time, the heat exchanger can deliver a slightly warmer refrigerant into the top and bottom heat exchange pipes 4 for heat exchange, which can cool the top and bottom parts of the inner liner 2. Compared with cooling in the middle, the cooling speed at the top and bottom is slower, and the required heat exchanger power is lower. Therefore, the microbial fermentation device provided in this application can independently regulate the temperature of the bottom, middle and top of the fermentation tank 1 by dividing the interior of the fermentation tank 1 into independent temperature control units, which prevents excessive local temperature changes in the fermentation tank 1 from causing microbial overheating and inactivation. It is particularly suitable for microbial fermentation processes that require staged temperature changes or local temperature control.

[0029] Exemplary, such as Figures 2-3As shown, in some embodiments, a heat-conducting layer 5 is provided between the heat exchange pipe 4 and the outer wall of the inner liner 2. The heat-conducting layer 5 is disposed on the outer wall of the inner liner 2 and is used to transfer heat between the heat exchange pipe 4 and the inner liner 2. In this embodiment, the heat-conducting layer 5 can be made of copper wire, which is bent in a serpentine shape to form a mesh structure and attached to the outer wall of the inner liner 2. In this way, heat is transferred between the heat exchange pipe 4 and the inner liner 2 through the heat-conducting layer 5, which facilitates the improvement of heat exchange efficiency.

[0030] Exemplary, such as Figures 2-3 As shown, in some embodiments, the inner wall of the inner liner 2 is provided with multiple temperature sensors 6, which are evenly spaced along the vertical direction; a control terminal is also included, and the temperature sensors 6 are electrically connected to the control terminal. In this embodiment, the control terminal can be a computer. After the temperature sensors 6 are evenly spaced along the vertical direction, the temperature information of the fermentation liquid at various heights within the inner liner 2 can be collected by each temperature sensor 6 and transmitted to the computer. Operators can also view the temperature information of the fermentation liquid at different heights during fermentation in real time via the computer, facilitating the adjustment of the heat exchanger power corresponding to the heat exchange pipes 4 at the bottom, middle, and top, making operation simple and convenient.

[0031] Example 2

[0032] When the temperature is controlled by setting three layers of heat exchange pipes 4 on the outer wall of the inner liner 2, the temperature can only be adjusted on the outer side of the fermentation liquid. The temperature changes quickly on the outer side of the fermentation liquid, but the temperature changes slowly on the part of the fermentation liquid near the middle because it is far away from the heat exchange pipes 4, resulting in poor temperature control efficiency.

[0033] Please refer to Figures 1-4 Based on Embodiment 1, this embodiment features a plurality of temperature-regulating tubes 7 spaced apart within the inner liner 2. Each temperature-regulating tube 7 contains a temperature-regulating sleeve 8, and the sidewall of the temperature-regulating sleeve 8 is spaced apart with a plurality of electric heating elements 9. These electric heating elements 9 abut against the inner sidewall of the temperature-regulating tube 7. The temperature-regulating tubes 7 in this embodiment can be made of copper, which has good thermal conductivity. Preferably, four temperature-regulating tubes 7 are arranged spaced apart along the circumference of the inner liner 2, and all four temperature-regulating tubes 7 are inserted into the fermentation liquid. By using the temperature-regulating tubes 7 and the electric heating elements 9, when it is necessary to raise the temperature of the fermentation liquid, the electric heating elements 9 can be energized and heated. The heat generated by the electric heating elements 9 can then be transferred to the fermentation liquid through the temperature-regulating tubes 7, facilitating heating of the central portion of the fermentation liquid. Combined with the heating from the heat exchange pipe 4 on the outer side of the fermentation liquid, this improves the temperature regulation efficiency of the fermentation liquid.

[0034] Exemplary, such as Figures 1-4As shown, in some embodiments, the sidewall of the temperature-regulating sleeve 8 is provided with a plurality of semiconductor cooling chips 10 spaced apart circumferentially. The semiconductor cooling chips 10 are arranged intersectingly with the electric heating elements 9, and the cooling end of the semiconductor cooling chip 10 abuts against the inner sidewall of the temperature-regulating tube 7. When the semiconductor cooling chip 10 is energized, its cooling end can absorb heat for cooling, and its heating end can discharge heat for heating. Thus, by setting the semiconductor cooling chip 10, when it is necessary to cool the fermentation liquid, the semiconductor cooling chip 10 can be energized, and the semiconductor cooling chip 10 absorbs the heat from the temperature-regulating tube 7 and moves the heat from the cooling end to the heating end. In this way, the semiconductor cooling chip 10 can cool the part of the fermentation liquid near the middle, and in conjunction with the heat exchange pipe 4 on the outside of the fermentation liquid, the temperature regulation efficiency of the fermentation liquid can be improved. In this embodiment, the semiconductor cooling chip 10 and the electric heating element 9 are arranged intersectingly, so the electric heating element 9 can be selected for heating alone, or the semiconductor cooling chip 10 can be selected for cooling alone, which is convenient to operate.

[0035] Exemplary, such as Figures 1-4 As shown, in some embodiments, the temperature-regulating sleeve 8 is slidably disposed within the temperature-regulating tube 7 along its extension direction. It also includes a connecting wire 11, one end of which slides through the fermenter 1 and is electrically connected to the semiconductor refrigeration chip 10 and the electric heating element 9. The other end of the connecting wire 11 is used to connect to an external control terminal. In this embodiment, the control terminal is a computer, used for starting and stopping the semiconductor refrigeration chip 10 and the electric heating element 9. The connecting wire 11 connects the semiconductor refrigeration chip 10 and the electric heating element 9, facilitating power supply. Since the outer wall of the inner liner 2 is divided into three different positions—bottom, middle, and top—for individual control, by sliding the temperature-regulating sleeve 8 along the extension direction of the temperature-regulating tube 7, the operator can pull the entire temperature-regulating sleeve 8 within the temperature-regulating tube 7 using the connecting wire 11. This allows adjustment of the placement height of the semiconductor refrigeration chip 10 and the electric heating element 9, enabling flexible temperature control of the bottom, middle, and top positions in the fermentation liquid.

[0036] Exemplary, such as Figures 2-3 As shown, in some embodiments, the temperature-regulating sleeve 8 is equipped with a cooling fan 12 at both the top and bottom, and the cooling fan 12 is electrically connected to the connecting wire 11. The fermenter 1 is equipped with heat dissipation holes 13 at both the top and bottom, and the heat dissipation holes 13 are connected to the temperature-regulating pipe 7. In this embodiment, the cooling fan 12 is electrically connected to the connecting wire 11 and controlled by a control terminal. When the thermoelectric cooler 10 is started for cooling, the cooling fan 12 can be started simultaneously. The cooling fan 12 dissipates the heat generated by the thermoelectric cooler 10 through the heat dissipation holes 13 to the temperature-regulating pipe 7, preventing heat from accumulating in the temperature-regulating pipe 7 and affecting the cooling effect of the thermoelectric cooler 10.

[0037] In this specification, the terms "one embodiment," "another embodiment," "embodiment," etc., refer to specific features, structures, or characteristics described in connection with that embodiment, which are included in at least one embodiment described in the general description of this application. The appearance of the same term in multiple places in the specification does not necessarily refer to the same embodiment. Furthermore, when a specific feature, structure, or characteristic is described in connection with any embodiment, the intention is to suggest that implementing such a feature, structure, or characteristic in conjunction with other embodiments also falls within the scope of this utility model.

[0038] Although the present invention has been described herein with reference to several illustrative embodiments, it should be understood that many other modifications and implementations can be devised by those skilled in the art, which will fall within the scope and spirit of the principles disclosed herein. More specifically, various variations and modifications can be made to the components and / or layout of the subject matter combination within the scope of the disclosure, drawings, and claims. Besides variations and modifications to the components and / or layout, other uses will be apparent to those skilled in the art.

Claims

1. A microbial fermentation device based on zoned temperature control, characterized in that: The fermenter includes an inner liner, and a temperature-regulating chamber is formed between the inner wall of the fermenter and the outer wall of the inner liner. The temperature-regulating chamber is divided into multiple temperature-controlled zones along the vertical direction. The temperature control chamber is provided with a plurality of heat exchange pipes, which are arranged vertically at intervals within the temperature control chamber. At least one heat exchange pipe is provided for each temperature control zone. Each heat exchange pipe is wound around the outer wall of the inner liner within the corresponding temperature control zone, and both ends of the heat exchange pipe pass through the side wall of the fermenter and extend outward. The heat exchange pipe is used to input the heat exchange medium, which undergoes a thermal bridge reaction with the inner liner through the heat exchange pipe and changes the temperature of the temperature control zone.

2. The microbial fermentation device based on zoned temperature control according to claim 1, characterized in that: A heat-conducting layer is provided between the heat exchange pipe and the outer wall of the inner liner. The heat-conducting layer is located on the outer wall of the inner liner and is used to transfer heat between the heat exchange pipe and the inner liner.

3. The microbial fermentation device based on zoned temperature control according to claim 1, characterized in that: The inner wall of the liner is provided with multiple temperature sensors, which are evenly spaced along the vertical direction; it also includes a control terminal, and the temperature sensors are electrically connected to the control terminal.

4. The microbial fermentation device based on zoned temperature control according to claim 1, characterized in that: The inner liner is provided with multiple temperature regulating tubes at intervals, and a temperature regulating sleeve is provided inside the temperature regulating tube. Multiple electric heating elements are provided at intervals along the side wall of the temperature regulating sleeve, and the electric heating elements abut against the inner side wall of the temperature regulating tube.

5. A microbial fermentation device based on zoned temperature control according to claim 4, characterized in that: The sidewall of the temperature-regulating sleeve is provided with a plurality of semiconductor cooling chips spaced apart along its circumference. The semiconductor cooling chips are arranged intersectingly with the electric heating chips, and the cooling end of the semiconductor cooling chip abuts against the inner sidewall of the temperature-regulating tube.

6. A microbial fermentation device based on zoned temperature control according to claim 5, characterized in that: The temperature regulating sleeve is slidably disposed inside the temperature regulating tube along the extension direction of the temperature regulating tube, and also includes a connecting wire. One end of the connecting wire slides through the fermenter and is electrically connected to the semiconductor refrigeration chip and the electric heating chip. The other end of the connecting wire is used to connect to an external control terminal.

7. A microbial fermentation device based on zoned temperature control according to claim 6, characterized in that: The temperature regulating sleeve is equipped with cooling fans at both the top and bottom, and the cooling fans are electrically connected to the connecting wires.

8. A microbial fermentation device based on zoned temperature control according to claim 7, characterized in that: The fermenter is provided with heat dissipation holes at the top and bottom, and the heat dissipation holes are connected to the temperature control pipe.

Images