A sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets

Abstract

This invention provides a sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets, belonging to the technical field of sampling devices for dissolution rate determination. It includes a syringe tube with a piston embedded inside. A push-pull rod is fixedly mounted on the left side of the piston. A through-tube extends through the right end of the syringe tube, and a needle is fitted onto the through-tube. A drain hole is provided on the side of the through-tube. In this invention, the needle is inserted into the dissolution cup, and the push-pull rod is pulled to extract the dissolution solution. The one-way inlet component inside the through-tube opens, allowing the dissolution solution to enter the syringe tube. When it is necessary to drain the dissolution solution from the syringe tube for dissolution rate testing, the needle is pulled out without blocking the drain hole. This push-pull rod, through the piston, forces the sampled dissolution solution from the syringe tube through the drain hole, filtered through a microporous membrane, and discharged. The dissolution solution is then tested. Sampling and filtration are achieved simultaneously, making the operation simple and convenient.

Description

Technical Field

[0001] This utility model relates to the technical field of sampling devices for dissolution testing, and in particular to a sampling device for dissolution testing of moxifloxacin hydrochloride tablets. Background Technology

[0002] Dissolution testing of moxifloxacin hydrochloride tablets is typically performed using a dissolution apparatus, usually employing the paddle method (USP). <711> ChP0931), with a rotation speed of 50 rpm, a dissolution medium of pH 1.2 hydrochloric acid solution or pH 4.5 acetate buffer, and a temperature controlled at 37℃±0.5℃, to dissolve moxifloxacin hydrochloride tablets. The dissolved liquid needs to be sampled using a sampling device to extract the dissolution sample from the dissolution cup for testing. The sampling time points for dissolution samples are usually 5 / 15 / 30 / 45 minutes, etc.

[0003] In the process of extracting dissolution samples, a syringe is usually used to extract the dissolution solution from the dissolution cup for sampling. To ensure the accuracy of the dissolution determination, the extracted sample needs to be filtered after sampling to remove insoluble particles. Existing sampling devices cannot filter the dissolution solution and other equipment is required for filtration, which is inconvenient. Therefore, a sampling device for the dissolution determination of moxifloxacin hydrochloride tablets is designed to solve the above problems. Utility Model Content

[0004] The purpose of this invention is to solve the problems existing in the above-mentioned background technology, and to propose a sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets.

[0005] The technical problem to be solved by this utility model is to provide a sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets, thereby solving the problems of existing sampling devices for determining the dissolution rate of moxifloxacin hydrochloride tablets.

[0006] To solve the above-mentioned technical problems, this utility model provides the following technical solution:

[0007] A sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets includes a syringe tube, a push-pull rod, a piston, a through tube, and a needle. The piston is embedded in the syringe tube, and the push-pull rod is fixedly mounted on the left side surface of the piston. The through tube extends through the right end of the syringe tube, and a needle is sleeved on the through tube. A drain hole is provided on the side of the through tube, and a microporous filter membrane is installed in the drain hole via an assembly. A one-way liquid inlet assembly is installed in the through tube.

[0008] Preferably, the piston is airtightly connected to the inner surface of the syringe tube.

[0009] Preferably, when the needle is sleeved on the through tube, the connection between the needle and the through tube can block the drain hole, and the drain hole is located on the left side of the one-way liquid inlet assembly.

[0010] Preferably, the pore size of the microporous filter membrane is 0.45 μm.

[0011] Preferably, the one-way liquid inlet assembly includes a fixing ring, an annular groove, an elastic rubber sheet, and a sealing rubber plate. The fixing ring is fixedly disposed on the right side of the inner surface of the through pipe. An annular groove is formed on the left side surface of the fixing ring. An elastic rubber sheet is fixed above the fixing ring, and a sealing rubber plate is fixedly disposed on the elastic rubber sheet.

[0012] Preferably, the sealing rubber plate matches the annular groove, and the diameter of the sealing rubber plate is larger than the diameter of the central through hole of the fixing ring.

[0013] Preferably, when the elastic rubber sheet does not deform, the sealing rubber plate is embedded in the annular groove to seal the central through hole of the fixing ring.

[0014] Preferably, the mounting assembly includes an external threaded ring fixed to the outside of the microporous filter membrane, and the microporous filter membrane is fixed to the bottom of the central through hole of the external threaded ring. An internal hexagonal groove is provided above the internal through hole of the external threaded ring, and an internal thread matching the external threaded ring is provided in the drain hole. A blocking ring is fixedly provided at the bottom of the inner side of the drain hole.

[0015] Preferably, the bottom of the external threaded ring is fully embedded in the drain hole when it contacts the blocking ring.

[0016] Preferably, the syringe tube is made of transparent plastic, and the outer surface of the syringe tube is engraved with milliliter markings.

[0017] Compared with the prior art, this utility model has at least the following beneficial effects:

[0018] In the above scheme, by setting up a drain hole, a microporous filter membrane, and a one-way liquid inlet component, when sampling the dissolution solution in the dissolution cup of the dissolution apparatus, the needle is sleeved on the through tube, and the connection between the needle and the through tube seals the drain hole. The needle is inserted into the dissolution cup, and the push-pull rod is pulled to draw out the dissolution solution. The one-way liquid inlet component in the through tube is opened, and the dissolution solution enters the syringe tube. When it is necessary to discharge the dissolution solution in the syringe tube for dissolution degree testing, the needle is pulled out. The needle will not block the drain hole. The push-pull rod is pushed, and the push-pull rod, through the piston, discharges the sampled dissolution solution in the syringe tube through the drain hole and after filtration through the microporous filter membrane. The dissolution solution is then tested. The sampling and filtration effects are achieved simultaneously. The operation is simple and convenient.

[0019] In the above scheme, by setting up a one-way liquid inlet component, when the liquid is drawn, the piston moves to the left along the syringe tube, the air pressure in the syringe tube decreases, and under the action of air pressure, the elastic rubber sheet deforms, so that the sealing rubber plate rotates along the elastic rubber sheet. The sealing rubber plate releases the seal on the central through hole on the fixing ring, so as to achieve the effect of drawing out the dissolution liquid. When the drawn liquid is discharged, under the action of the elastic force of the elastic rubber sheet, the sealing rubber plate is embedded in the annular groove to seal the central through hole on the fixing ring, preventing the sampled dissolution liquid from being discharged from the through tube, thus achieving the effect of one-way liquid inlet.

[0020] In the above solution, by setting up an installation component, when it is necessary to replace the microporous filter membrane, simply insert a hex wrench into the internal hexagonal groove, rotate the external threaded ring, remove the external threaded ring from the drain hole on the through tube, and then thread the new microporous filter membrane and the external threaded ring into the drain hole to replace the microporous filter membrane. The operation is simple and convenient. Attached Figure Description

[0021] The accompanying drawings, which are incorporated herein and form part of the specification, illustrate embodiments of the present disclosure and, together with the specification, further serve to explain the principles of the present disclosure and enable those skilled in the art to implement and use the present disclosure.

[0022] Figure 1 This is a three-dimensional schematic diagram of the overall structure of this utility model;

[0023] Figure 2 This is a schematic cross-sectional view of the overall structure of this utility model;

[0024] Figure 3 This utility model Figure 1 Enlarged structural diagram at point A in the middle;

[0025] Figure 4 This is a three-dimensional structural diagram of the through-tube and microporous filter membrane in this utility model;

[0026] Figure 5 This utility model Figure 4 Enlarged structural diagram at point B.

[0027] [Figure Labels]

[0028] 1. Syringe tube; 101. Milliliter scale; 2. Push-pull rod; 3. Piston; 4. Through tube; 401. Drain hole; 402. Blocking ring; 5. Needle; 6. Microporous filter membrane; 601. External threaded ring; 602. Internal hexagonal groove; 7. Retaining ring; 701. Annular groove; 702. Elastic rubber sheet; 703. Sealing rubber plate.

[0029] As shown in the figure, specific structures and devices are marked in the figure to clearly illustrate the structure of the embodiment of this utility model. However, this is only for illustrative purposes and is not intended to limit this utility model to this specific structure, device and environment. Those skilled in the art can adjust or modify these devices and environments according to specific needs. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0031] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0032] like Figure 1 , Figure 2 and Figure 3 As shown, an embodiment of this utility model provides a sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets, including a syringe tube 1, a push-pull rod 2, a piston 3, a through tube 4, and a needle 5. The piston 3 is embedded in the syringe tube 1, and the push-pull rod 2 is fixedly installed on the left side surface of the piston 3. The through tube 4 is installed through the right end of the syringe tube 1, and the needle 5 is sleeved on the through tube 4. A drain hole 401 is opened on the side of the through tube 4, and a microporous filter membrane 6 is installed in the drain hole 401 through an installation assembly. A one-way liquid inlet assembly is installed in the through tube 4.

[0033] In this embodiment, the piston 3 is airtightly connected to the inner surface of the syringe tube 1, which facilitates the extraction and discharge of the dissolution liquid by the syringe tube 1 during the process of the push-pull rod 2 driving the piston 3 to move.

[0034] In this embodiment, when the needle 5 is sleeved on the through tube 4, the sleeve joint between the needle 5 and the through tube 4 can block the drain hole 401 to prevent gas from entering from the drain hole 401, which facilitates the needle 5 to extract the dissolution solution of moxifloxacin hydrochloride tablets, and the drain hole 401 is located on the left side of the one-way liquid inlet assembly.

[0035] In this embodiment, the microporous filter membrane 6 has a pore size of 0.45 μm, which achieves the effect of filtering insoluble particles in the dissolution solution.

[0036] By incorporating a drain hole 401, a microporous filter membrane 6, and a one-way inlet assembly, when sampling the dissolution solution from the dissolution cup of the dissolution apparatus, the needle 5 is fitted onto the through tube 4, with the connection between the needle 5 and the through tube 4 sealing the drain hole 401. The needle 5 is then inserted into the dissolution cup, and the push-pull rod 2 is pulled to extract the dissolution solution. The one-way inlet assembly inside the through tube 4 opens, allowing the dissolution solution to enter the syringe tube 1. When it is necessary to discharge the dissolution solution from the syringe tube 1 for dissolution testing, the needle 5 is pulled out, preventing it from sealing the drain hole 401. The push-pull rod 2 is then pushed, and the piston forces the sampled dissolution solution from the syringe tube 1 through the drain hole 401 and filtered through the microporous filter membrane 6 before being discharged. This allows for the testing of the dissolution solution, achieving filtration simultaneously with sampling. The operation is simple and convenient.

[0037] like Figure 3 Shown:

[0038] In this embodiment, the one-way liquid inlet assembly includes a fixing ring 7, an annular groove 701, an elastic rubber sheet 702, and a sealing rubber plate 703. The fixing ring 7 is fixedly disposed on the right side of the inner surface of the through pipe 4. An annular groove 701 is opened on the left side surface of the fixing ring 7. An elastic rubber sheet 702 is fixed above the fixing ring 7, and a sealing rubber plate 703 is fixedly disposed on the elastic rubber sheet 702.

[0039] In this embodiment, the sealing rubber plate 703 is matched with the annular groove 701, and the diameter of the sealing rubber plate 703 is larger than the diameter of the central through hole of the fixing ring 7, so that the sealing rubber plate 703 can seal the central through hole of the fixing ring 7.

[0040] In this embodiment, when the elastic rubber sheet 702 does not deform, the sealing rubber plate 703 is embedded in the annular groove 701 to seal the central through hole of the fixing ring 7, thereby preventing the leaching liquid from being discharged from the through pipe 4.

[0041] By incorporating a one-way liquid inlet assembly, when liquid is drawn, the piston 3 moves to the left along the syringe tube 1, reducing the air pressure inside the syringe tube 1. Under the action of the air pressure, the elastic rubber sheet 702 deforms, causing the sealing rubber plate 703 to rotate along the elastic rubber sheet 702. The sealing rubber plate 703 releases the blockage of the central through hole on the fixing ring 7, achieving the effect of drawing out the dissolution liquid. When the drawn liquid is discharged, under the action of the elastic force of the elastic rubber sheet 702, the sealing rubber plate 703 is embedded in the annular groove 701 to block the central through hole on the fixing ring 7, preventing the sampled dissolution liquid from being discharged from the through tube 4, thus achieving the effect of one-way liquid inlet.

[0042] like Figure 4 Shown:

[0043] In this embodiment, the mounting assembly includes an external threaded ring 601 fixed to the outside of the microporous filter membrane 6, and the microporous filter membrane 6 is fixed to the bottom of the central through hole of the external threaded ring 601. An internal hexagonal groove 602 is provided above the internal through hole of the external threaded ring 601. An internal thread matching the external threaded ring 601 is provided in the drain hole 401. A blocking ring 402 is fixedly provided at the bottom inner side of the drain hole 401.

[0044] In this embodiment, when the bottom of the external threaded ring 601 contacts the blocking ring 402, it is completely embedded in the drain hole 401, and the external threaded ring 601 will not affect the needle 5 being sleeved on the through tube 4.

[0045] With the installation components in place, when the microporous filter membrane 6 needs to be replaced, simply insert a hex wrench into the internal hexagonal groove 602, rotate the external threaded ring 601, remove the external threaded ring 601 from the drain hole 401 on the through tube 4, and then thread the new microporous filter membrane 6 and the external threaded ring 601 into the drain hole 401 to replace the microporous filter membrane 6. The operation is simple and convenient.

[0046] In this embodiment, the syringe tube 1 is made of transparent plastic, and the outer surface of the syringe tube 1 is engraved with milliliter scale 101, which makes it convenient to observe the amount of dissolution solution drawn out of the syringe tube 1 through the milliliter scale 101, and facilitates the detection of dissolution.

[0047] This utility model encompasses any substitutions, modifications, equivalent methods, and solutions made within the spirit and scope of this utility model. To provide the public with a thorough understanding of this utility model, specific details are described in detail in the following preferred embodiments; however, those skilled in the art will fully understand this utility model even without these detailed descriptions. Furthermore, to avoid unnecessary confusion regarding the essence of this utility model, well-known methods, processes, procedures, components, and circuits are not described in detail.

[0048] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. A sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets, characterized in that, The syringe includes a syringe tube (1), a push-pull rod (2), a piston (3), a through tube (4), and a needle (5). The piston (3) is embedded in the syringe tube (1). The push-pull rod (2) is fixedly installed on the left side surface of the piston (3). The through tube (4) is installed through the right end of the syringe tube (1). The needle (5) is sleeved on the through tube (4). A drain hole (401) is opened on the side of the through tube (4). A microporous filter membrane (6) is installed in the drain hole (401) through an installation component. A one-way liquid inlet component is installed in the through tube (4).

2. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 1, characterized in that: The piston (3) is airtightly connected to the inner surface of the syringe tube (1).

3. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 2, characterized in that: When the needle (5) is sleeved on the through tube (4), the sleeve of the needle (5) and the through tube (4) can block the drain hole (401), and the drain hole (401) is located on the left side of the one-way liquid inlet assembly.

4. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 3, characterized in that: The microporous filter membrane (6) has a pore size of 0.45 μm.

5. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 4, characterized in that: The one-way liquid inlet assembly includes a fixing ring (7), an annular groove (701), an elastic rubber sheet (702), and a sealing rubber plate (703). The fixing ring (7) is fixedly disposed on the right side of the inner surface of the through pipe (4). An annular groove (701) is opened on the left side surface of the fixing ring (7). An elastic rubber sheet (702) is fixed above the fixing ring (7). A sealing rubber plate (703) is fixedly disposed on the elastic rubber sheet (702).

6. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 5, characterized in that: The sealing rubber plate (703) is matched with the annular groove (701), and the diameter of the sealing rubber plate (703) is larger than the diameter of the central through hole of the fixing ring (7).

7. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 6, characterized in that: When the elastic rubber sheet (702) does not deform, the sealing rubber plate (703) is embedded in the annular groove (701) to seal the central through hole of the fixing ring (7).

8. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 1, characterized in that: The mounting assembly includes an external threaded ring (601) fixed to the outside of the microporous filter membrane (6), and the microporous filter membrane (6) is fixed to the bottom of the central through hole of the external threaded ring (601). An internal hexagonal groove (602) is provided above the internal through hole of the external threaded ring (601). An internal thread matching the external threaded ring (601) is provided in the drain hole (401). A blocking ring (402) is fixedly provided at the bottom of the inner side of the drain hole (401).

9. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 8, characterized in that: When the bottom of the external threaded ring (601) contacts the blocking ring (402), it is completely embedded in the drain hole (401).

10. The sampling device for determining the dissolution rate of moxifloxacin hydrochloride tablets according to claim 1, characterized in that: The syringe tube (1) is made of transparent plastic, and the outer surface of the syringe tube (1) is engraved with milliliter scale (101).

Images