A magnetic bead reagent mixing device for use on an incubation facility

Abstract

The utility model relates to in-vitro diagnosis equipment technical field, concretely relates to a kind of magnetic bead reagent mixing device for incubation mechanism, the incubation mechanism includes mounting bracket, incubation tray rotationally arranged on mounting bracket, incubation motor being arranged on mounting bracket and being transmission connection with incubation tray, the incubation rack being arranged at the lower end of incubation tray, and reaction cup is placed on the incubation rack, the mixing device includes mixing motor being arranged on mounting bracket and being located inside incubation tray, eccentric shaft being arranged on the output end of mixing motor, mixing bearing being arranged on eccentric shaft, mixing rocker arm being arranged on mounting bracket and being sleeved on mixing bearing one end, mixing clamping groove being arranged on the other end of mixing rocker arm;The reaction cup bottom part corresponds with mixing clamping groove and is passed in from mixing clamping groove.The utility model is simple and effective in structure, low in cost, small in oscillation amplitude, low in noise, and good in mixing effect.

Description

Technical Field

[0001] This utility model relates to the field of in vitro diagnostic equipment technology, specifically to a magnetic bead reagent mixing device for use in an incubation mechanism. Background Technology

[0002] With its ever-expanding market, the automated fluorescence immunoassay analyzer, an in vitro diagnostic device based on fluorescent labeling technology, is a highly sensitive detection instrument widely used in clinical diagnosis, biomedical research, drug development, and environmental monitoring. Its core technology utilizes the specific binding of fluorescent substances to antibodies or antigens, combined with an optical detection system, to achieve quantitative analysis of biomolecules. In recent years, with breakthroughs in biotechnology and increasing demands for automation, this equipment has gradually evolved towards higher precision, higher throughput, and greater portability.

[0003] In the process of testing and analysis using this equipment, reagent mixing is an essential step. Existing technologies for magnetic bead reagent mixing mechanisms, in order to improve mixing efficiency and achieve automation, often employ mechanical vibration mixing, rotational mixing, magnetically driven mixing, or ultrasonic mixing. However, these methods are complex in structure, expensive, and noisy, causing considerable inconvenience to staff. Utility Model Content

[0004] To solve the above problems, this utility model provides a magnetic bead reagent mixing device for incubation mechanisms, which has a simple and effective structure, low cost, small vibration amplitude, low noise, and good mixing effect.

[0005] The technical solution adopted by this utility model is to provide a magnetic bead reagent mixing device for an incubation mechanism. The incubation mechanism includes a mounting frame, an incubation tray rotatably mounted on the mounting frame, an incubation motor mounted on the mounting frame and connected to the incubation tray, a stacking frame arranged in a ring array at the lower end of the incubation tray, and reaction cups stacked between the stacking frames. The incubation tray has a ring structure. The mixing device includes a mixing motor mounted on the mounting frame and located inside the incubation tray, an eccentric shaft mounted on the output end of the mixing motor, a mixing bearing mounted on the eccentric shaft, a mixing rocker arm mounted on the mounting frame and fitted at one end to the mixing bearing, and a mixing slot mounted at the other end of the mixing rocker arm. The output end of the mixing motor is vertically downward and fixed to the eccentric shaft. The mixing bearing is mounted on the eccentric shaft. The inner end of the mixing rocker arm is provided with a sleeve hole and fitted onto the mixing bearing. The bottom of the reaction cup corresponds to the mixing slot and passes through the mixing slot.

[0006] The sleeve hole has a long slot structure.

[0007] It also includes a fixing hole on the mounting bracket, a stepped hole on the mixing rocker arm, and a limiting bolt in the fixing hole and the stepped hole, wherein the stepped hole is a long slot hole structure.

[0008] It also includes a heating film mounted on the mounting bracket and corresponding to the bottom of the reaction vessel, the heating film being located below the mixing rocker arm.

[0009] The beneficial effects of this invention are that it provides a magnetic bead reagent mixing device for use in incubation mechanisms of in vitro diagnostic equipment. A mixing motor drives an eccentric shaft to rotate, which in turn causes a mixing bearing to move eccentrically. The mixing rocker arm, driven by the eccentric movement of the mixing bearing, oscillates, causing the reaction cup within the mixing slot to oscillate, thus achieving mixing of the magnetic beads and reagents within the reaction cup. This design is simple and effective, low in cost, has a small oscillation amplitude, low noise, and good mixing effect. Attached Figure Description

[0010] Figure 1 This is a top view of the structure of this utility model;

[0011] Figure 2 This is a schematic diagram of the structure of this utility model from below;

[0012] Figure 3 This is a schematic diagram of the structure of the novel mixing rocker arm.

[0013] Figure 4 yes Figure 3 Enlarged view of A in the middle;

[0014] Figure 5 yes Figure 3 Enlarged view of B in the middle;

[0015] Figure 6 This is a schematic diagram of the structure of the mounting frame and reaction cup of this utility model;

[0016] Figure 7 This is a schematic diagram of the structure connecting the incubation tray and the incubation motor.

[0017] In the attached diagram, 1 is the mounting frame, 2 is the incubation tray, 3 is the incubation motor, 4 is the stacking frame, 5 is the reaction cup, 6 is the mixing motor, 7 is the eccentric shaft, 8 is the mixing bearing, 9 is the mixing rocker arm, 10 is the mixing slot, 11 is the sleeve hole, 12 is the stepped hole, 13 is the limit bolt, and 14 is the heating diaphragm. Detailed Implementation

[0018] like Figure 1-7As shown, this utility model provides a magnetic bead reagent mixing device for an incubation mechanism. The incubation mechanism includes a mounting frame 1, an incubation disk 2 rotatably mounted on the mounting frame 1, an incubation motor 3 mounted on the mounting frame 1 and pulsatorically connected to the incubation disk 2, a stacking frame 4 arranged in a ring array at the lower end of the incubation disk 2, and reaction cups 5 stacked between the stacking frames 4. The incubation disk 2 has a ring structure. The mixing device includes a mixing motor 6 mounted on the mounting frame 1 and located inside the incubation disk 2, and a mixing... The mixing motor 6 has an eccentric shaft 7 at its output end, a mixing bearing 8 mounted on the eccentric shaft 7, a mixing rocker arm 9 mounted on the mounting bracket 1 with one end fitted onto the mixing bearing 8, and a mixing slot 10 at the other end of the mixing rocker arm 9. The output end of the mixing motor 6 is vertically downward and fixed to the eccentric shaft 7. The mixing bearing 8 is mounted on the eccentric shaft 7. The inner end of the mixing rocker arm 9 is provided with a sleeve hole 11 and fitted onto the mixing bearing 8. The bottom of the reaction cup 5 corresponds to the mixing slot 10 and passes through the mixing slot 10.

[0019] This design is for an incubation mechanism in an in vitro diagnostic device. The incubation mechanism mainly consists of a mounting frame 1, an incubation tray 2, an incubation motor 3, and a support frame 4. The incubation motor 3 drives the incubation tray 2 to rotate on the mounting frame 1. The reaction cup 5 is conveyed to the support frame 4 via a conveying mechanism and rotates in a circular motion with the incubation tray 2. The reaction cup 5 has a conical structure. The incubation motor 3 and the incubation tray 2 are connected by a gear installed at the output end of the incubation motor 2 and teeth designed on the inner or outer circumference of the corresponding gear on the incubation tray 2. The two mesh to form a transmission. On the other side of the incubation tray 2, a rotational limiting wheel is provided. The limiting wheel has an annular groove on its outer circumference. The gear at the shaft end of the incubation motor 2 forms a rotational limiting connection with the incubation tray 2. (See attached diagram.) Figure 7 The structure of scaffolding 4 can be referenced in the appendix. Figure 6 Furthermore, the above structure has already been patented, and you can refer to the application document with application number 2025204096825 entitled "Reaction Cup Transfer Device", so it will not be described in detail again.

[0020] The mixing motor 6 is a stepper motor, fixed on the mounting bracket 1 and located at the center of the incubation tray 2. The shaft end of the mixing motor 6 passes through the mounting bracket 1 and points vertically downward. An eccentric shaft 7 is fixed to the shaft end of the mixing motor 6, and a mixing bearing 8 is fitted and fixed on the eccentric shaft 7. The inner end of the mixing rocker arm 9 is limited on the mounting bracket 1 but not fixedly connected. The inner end of the mixing rocker arm 9 is fitted onto the mixing bearing 8 through the sleeve hole 11. The mixing groove 10 on the outer end of the mixing rocker arm 9 corresponds to the reaction cup 5. When reaction cup 5 undergoes circular motion, its bottom passes through the mixing slot 10. When the bottom of reaction cup 5 is within the mixing slot 10, the mixing motor 6 drives the eccentric shaft 7 to rotate, causing the mixing bearing 8 to move eccentrically. The mixing rocker arm 9, driven by the eccentric movement of the mixing bearing 8, wobbles. The mixing rocker arm 9 pushes the bottom of reaction cup 5 through the mixing slot 10, causing the reaction cup 5 to wobble, thereby achieving mixing of the magnetic beads and reagents within the reaction cup 5. This design is simple in structure, driven uniformly by the mixing motor 6, and is simple, effective, low-cost, with small oscillation amplitude, low noise, and good mixing effect.

[0021] like Figure 4 As shown, the sleeve hole 11 is a long slot hole structure.

[0022] The inner end of the mixing rocker arm 9 is fitted onto the mixing bearing 8 through the sleeve hole 11. It is not fixed, and the mixing bearing 8 can rotate within the sleeve hole 11. The sleeve hole 11 is designed as a long slot structure, and its length direction is opposite to the length direction of the mixing rocker arm 9. For example, if the length direction of the mixing rocker arm 9 is left and right, then the length direction of the sleeve hole 11 is front and back. This design allows the mixing bearing 8 to move eccentrically, causing the mixing rocker arm 9 to swing along the overhang direction, which is the input and output direction of the reaction cup 5 on the stacking frame 4, without causing damage to the reaction cup 5.

[0023] like Figure 4 As shown, it also includes a fixing hole on the mounting bracket 1, a stepped hole 12 on the mixing rocker arm 9, and a limiting bolt 13 in the fixing hole and the stepped hole 12. The stepped hole 12 is a long slot hole structure.

[0024] The fixing hole, the stepped hole 12, and the limiting bolt 13 form a limiting connection between the mixing rocker arm 9 and the mounting frame 1. The limiting bolt 13 passes through the fixing hole from the lower end of the stepped hole 12 upwards. The fixing hole is a threaded hole. The limiting bolt 13 is not tightened, so that there is a gap between the mixing rocker arm 9 and the mounting frame 1. Since the stepped hole 12 is a long slot hole, the length is opposite to the overhang direction of the mixing rocker arm 9, which allows the mixing rocker arm 9 to reciprocate in the overhang direction. The structure is simple, the connection is stable, and it does not hinder the movement of the mixing rocker arm 9.

[0025] like Figure 2As shown, it also includes a heating film 14 disposed on the mounting frame 1 and corresponding to the bottom of the reaction cup 5, the heating film 14 being located below the mixing rocker arm 9.

[0026] The heating membrane 14 can heat the magnetic beads and reagents in the reaction vessel 5 to ensure that the reagents are at a suitable temperature when mixed.

Claims

1. A magnetic bead reagent mixing device for an incubation mechanism, the incubation mechanism comprising a mounting frame (1), an incubation tray (2) rotatably mounted on the mounting frame (1), an incubation motor (3) mounted on the mounting frame (1) and pulsatorically connected to the incubation tray (2), a stacking rack (4) arranged in a ring array at the lower end of the incubation tray (2), and reaction cups (5) stacked between the stacking racks (4), wherein the incubation tray (2) has a ring structure, characterized in that: The mixing device includes a mixing motor (6) mounted on the mounting frame (1) and located inside the incubation tray (2), an eccentric shaft (7) mounted on the output end of the mixing motor (6), a mixing bearing (8) mounted on the eccentric shaft (7), a mixing rocker arm (9) mounted on the mounting frame (1) and fitted at one end onto the mixing bearing (8), and a mixing slot (10) mounted at the other end of the mixing rocker arm (9). The output end of the mixing motor (6) is vertically downward and fixed to the eccentric shaft (7). The mixing bearing (8) is installed on the eccentric shaft (7). The inner end of the mixing rocker arm (9) is provided with a sleeve hole (11) and is fitted onto the mixing bearing (8). The bottom of the reaction cup (5) corresponds to the mixing slot (10) and passes through the mixing slot (10).

2. The magnetic bead reagent mixing device for an incubation mechanism according to claim 1, characterized in that: The sleeve hole (11) is a long slot hole structure.

3. The magnetic bead reagent mixing device for an incubation mechanism according to claim 1, characterized in that: It also includes a fixing hole on the mounting bracket (1), a step hole (12) on the mixing rocker arm (9), and a limiting bolt (13) in the fixing hole and the step hole (12), wherein the step hole (12) is a long slot hole structure.

4. The magnetic bead reagent mixing device for an incubation mechanism according to claim 1, characterized in that: It also includes a heating film (14) disposed on the mounting bracket (1) and corresponding to the bottom of the reaction cup (5), the heating film (14) being located below the mixing rocker arm (9).

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