An ultrasonic hemolysis device and blood gas analyzer

Abstract

The utility model discloses an ultrasonic wave hemolysis device and blood gas analyzer, ultrasonic wave hemolysis device includes: ultrasonic transducer, one end of ultrasonic transducer is connected with a amplitude lever, and the amplitude lever is connected with an oscillation pipeline, and the oscillation pipeline is connected with blood sample delivery pipeline, and the output of blood sample delivery pipeline is connected with a colorimetric mechanism. Compared with prior art, the ultrasonic transducer and amplitude lever part in the ultrasonic wave hemolysis device provided by the application are arranged in the flow path in front of the colorimetric mechanism, the ultrasonic part is not directly abutted on the side wall of the colorimetric mechanism, when the blood sample is treated by ultrasonic vibration, the problem that the surface of the colorimetric mechanism is scratched and damaged is avoided, at the same time, since the ultrasonic part is arranged in interval with the colorimetric mechanism, the problem that the pollution in the inner wall of the colorimetric part is mixed in the new blood sample to be measured and the detection result is inaccurate is also prevented, the detection precision is significantly improved, and the ultrasonic wave hemolysis device provided by the application also has the advantages of simple structure, good ultrasonic effect and convenient operation.

Description

Technical Field

[0001] This utility model belongs to the field of medical device technology, and relates to a hemolysis device and a blood analyzer, specifically an ultrasonic hemolysis device and a blood gas analyzer. Background Technology

[0002] In modern medical research, blood analysis has received increasing attention, and the analysis of blood components using spectroscopy is one of the key directions of blood research. Total hemoglobin (tHB), oxyhemoglobin (O2Hb), reduced hemoglobin, reduced hemoglobin (FHHb), methemoglobin (MetHb), carboxyhemoglobin (COHb), and oxygen saturation (sO2) in human blood are all important indicators in blood gas analysis and have significant clinical analytical value. Due to limitations in the composition of blood itself, it is difficult to obtain ideal spectral analysis results by directly irradiating blood with a light source. Currently, analytical instruments for detecting these parameters mostly employ the following steps: first, the blood cells are disrupted, and then the sample is analyzed using spectrophotometry. Disruption methods can generally be divided into ultrasonic disruption and reagent-based hemolysis. Among these, ultrasonic disruption has received significant attention due to its advantages such as high efficiency and good disruption effect.

[0003] Currently, various ultrasonic hemolysis devices are available on the market and have played an important role in medical and scientific research activities. However, existing ultrasonic hemolysis devices have the following technical problems: To improve ultrasonic efficiency, in existing blood gas testing equipment, the ultrasonic device is installed in close contact with the cuvette. When blood is drawn into the cavity of the cuvette, the ultrasonic device activates ultrasound, breaking down red blood cells in the blood through cavitation, mechanical, and thermal effects. However, because the ultrasonic device is in close contact with the cuvette, the high-frequency vibration of the ultrasonic device can easily scratch the surface of the cuvette, thereby reducing the light transmittance of the colorimetric area and causing distorted test results. In addition, when there is contamination inside the cuvette, the ultrasonic vibration can also cause the blood sample to be tested to mix with the residual contaminant, resulting in inaccurate test results.

[0004] In view of this, it is necessary to further improve the existing ultrasonic hemolysis device. Utility Model Content

[0005] Therefore, the technical problem to be solved by this utility model is that traditional ultrasonic hemolysis devices are prone to scratching the surface of cuvettes and mixing residual contaminants with the blood sample to be tested, resulting in distorted test results. Thus, an ultrasonic hemolysis device and blood gas analyzer with high detection accuracy are proposed.

[0006] To solve the above-mentioned technical problems, the technical solution of this utility model is as follows:

[0007] The first aspect of this utility model provides an ultrasonic hemolysis device, which includes: an ultrasonic transducer, one end of which is connected to an amplitude transformer, the amplitude transformer is connected to an oscillation tube, the oscillation tube is connected to a blood sample delivery tube, and the output end of the blood sample delivery tube is connected to a colorimetric mechanism.

[0008] Preferably, a through groove is formed on the side of the amplitude transformer away from the ultrasonic transducer, and the oscillation pipeline passes through and is connected to the through groove.

[0009] Preferably, the end of the amplitude transformer away from the ultrasonic transducer is detachably connected to a tightening screw, and when the tightening screw is connected to the amplitude transformer, the end of the tightening screw abuts against the oscillation pipeline.

[0010] Preferably, the amplitude rod is fitted with a mounting flange.

[0011] Preferably, a liquid sensor is connected to the inlet end of the blood sample delivery pipeline.

[0012] Preferably, the blood sample delivery pipeline includes a first blood sample delivery pipeline and a second blood sample delivery pipeline sleeved at both ends of the oscillating pipeline.

[0013] Preferably, both the first and second blood sample delivery lines are flexible transparent lines; the oscillation line is a steel pipe.

[0014] Preferably, the first blood sample delivery line is also connected to a sample injection mechanism, which is connected to a cleaning fluid driving mechanism; the second blood sample delivery line is connected to a blood sample driving mechanism.

[0015] Preferably, the ultrasonic transducer is connected to the amplitude transformer via a locking screw; the ultrasonic transducer is also connected to an ultrasonic control unit.

[0016] A second aspect of this invention provides a blood gas analyzer, which includes the aforementioned ultrasonic hemolysis device.

[0017] The above-mentioned technical solution of this utility model has the following advantages compared with the prior art:

[0018] The ultrasonic hemolysis device provided by this utility model includes: an ultrasonic transducer, an amplitude transformer connected to one end of the ultrasonic transducer, an oscillation tube connected to the amplitude transformer, a blood sample delivery tube connected to the oscillation tube, and an output end of the blood sample delivery tube connected to a colorimetric mechanism. Compared with the prior art, the ultrasonic transducer and amplitude transformer components in the ultrasonic hemolysis device provided by this application are arranged in the flow path in front of the colorimetric mechanism. The ultrasonic components do not directly abut against the side wall of the colorimetric mechanism. When the blood sample is processed by ultrasonic vibration, the problem of scratching and damaging the surface of the colorimetric mechanism is avoided. At the same time, since the ultrasonic components and the colorimetric mechanism are spaced apart, it also prevents the contamination on the inner wall of the colorimetric component from falling off due to ultrasonic vibration and mixing with the new blood sample to be tested, thus preventing inaccurate test results. This significantly improves the detection accuracy. The ultrasonic hemolysis device provided by this application also has the advantages of simple structure, good ultrasonic effect, and convenient operation. Attached Figure Description

[0019] To make the content of this utility model easier to understand, the present utility model will be further described in detail below with reference to specific embodiments and accompanying drawings.

[0020] Figure 1 This is a schematic diagram of the ultrasonic hemolysis device provided in this embodiment of the present invention;

[0021] Figure 2 This is a partial structural schematic diagram of the ultrasonic hemolysis device provided in this embodiment of the present invention;

[0022] Figure 3 This is a schematic diagram of the internal structure of the blood gas analyzer provided in this embodiment of the utility model.

[0023] The reference numerals in the figure are as follows: 1-Ultrasonic transducer; 2-Amplitude bar; 3-Oscillating tubing; 4-Colorimetric mechanism; 5-Tightening screw; 6-Mounting flange; 7-Liquid sensor; 8-First blood sample delivery tubing; 9-Second blood sample delivery tubing; 10-Sample injection mechanism; 11-Washing solution driving mechanism; 12-Blood sample driving mechanism; 13-Locking screw; 14-Reagent pack. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0025] In the description of this utility model, it should be understood that the terms "upper" and "lower" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship that is commonly placed when the product of this utility model is in use, or the orientation or positional relationship that is commonly understood by those skilled in the art. They are only used to facilitate the description of this utility model and to simplify the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0026] The terms "first" and "second" in this utility model are merely used for distinction in description and have no special meaning.

[0027] Example

[0028] This embodiment provides an ultrasonic hemolysis device. Please refer to [link / reference]. Figures 1-2 The ultrasonic hemolysis device includes an ultrasonic transducer 1, which converts the input electrical power into mechanical power (ultrasound) and then transmits it. One end of the ultrasonic transducer 1 is connected to an amplitude transformer 2, which amplifies the displacement or velocity of the mechanically vibrating particles and concentrates the ultrasonic energy over a small area (i.e., energy focusing). The side of the amplitude transformer 2 away from the ultrasonic transducer 1 is connected to an oscillation tube 3, which is connected to a blood sample delivery tube. The output end of the blood sample delivery tube is connected to a colorimetric mechanism 4.

[0029] The ultrasonic hemolysis device provided in this embodiment transmits ultrasonic waves generated by the ultrasonic transducer 1 to the oscillation tube 3 via the amplitude transformer 2. The blood sample to be tested is transported to the oscillation tube 3 via the blood sample delivery tube. Under the action of the ultrasonic waves, cavitation, mechanical vibration, and thermal effects are generated, causing the red blood cells in the blood to continuously break down and release various hemoglobins. The blood sample after ultrasonic hemolysis is transported to the colorimetric unit 4 via the blood sample delivery tube for subsequent testing. The colorimetric unit 4 is a cuvette used to hold the blood sample to be tested. In the ultrasonic hemolysis device provided in this embodiment, the ultrasonic transducer 1, amplitude transformer 2, oscillation tube 3, and other ultrasonic components are arranged in the flow path in front of the colorimetric unit 4, spaced apart from the colorimetric unit 4 and not directly attached to the side wall of the colorimetric unit 4. This avoids scratching or damaging the surface of the colorimetric unit 4 and ensures the light transmittance of the colorimetric unit 4. Meanwhile, since the ultrasonic components are not attached to the colorimetric mechanism 4, the problem of residual contaminants on the inner wall of the colorimetric mechanism 4 being shaken off and mixed with the blood sample during ultrasonic hemolysis is avoided, thus preventing the test results from being distorted. Therefore, the ultrasonic hemolysis device provided in this embodiment significantly improves the detection accuracy. Moreover, the ultrasonic hemolysis device has a simple structure, better ultrasonic effect, more convenient operation, and better practicality.

[0030] This embodiment also provides a blood gas analyzer, such as Figure 3As shown, the blood gas analyzer includes the aforementioned ultrasonic hemolysis device, and the blood sample after being broken down by the ultrasonic hemolysis device can be analyzed and tested by the blood gas analyzer.

[0031] To securely connect the oscillating conduit 3 to the amplitude transformer 2, a through groove is formed on the side of the amplitude transformer 2 away from the ultrasonic transducer 1. In this embodiment, the oscillating conduit 3 is a hollow cylindrical steel pipe, the cross-sectional shape of the through groove is circular, and the inner diameter of the through groove is slightly larger than the outer diameter of the oscillating conduit 3. This allows the oscillating conduit 3 to smoothly pass through and connect to or separate from the amplitude transformer 2, making the assembly and disassembly of the ultrasonic hemolysis device more convenient. Specifically, the axial direction of the through groove, i.e., the axial direction of the oscillating conduit 3, is perpendicular to the axial direction of the amplitude transformer 2 and the ultrasonic transducer 1, i.e., as shown below. Figure 1 As shown, the length direction of the oscillation tube 3 is perpendicular to the length direction of the amplitude transformer 2. By using a steel pipe as the oscillation tube 3, it is not easily damaged under long-term ultrasonic oscillation, thus extending the service life of the ultrasonic hemolysis device.

[0032] To prevent the oscillation tube 3 from shaking or falling off relative to the amplitude transformer 2 during ultrasonic hemolysis, a tightening screw 5 is detachably connected to the end of the amplitude transformer 2 away from the ultrasonic transducer 1. After the oscillation tube 3 is inserted into the through groove of the amplitude transformer 2, the tightening screw 5 ensures that the oscillation tube 3 is tightly pressed against the inner wall of the through groove, preventing the oscillation tube 3 from loosening. Figure 1 As shown, to improve the stability of the connection, there are 3 tightening screws 5. The 3 tightening screws 5 are connected to the amplitude rod 2 at intervals through threaded holes opened at the end of the amplitude rod 2.

[0033] An external mounting flange 6 is fitted onto the amplitude transformer 2. The amplitude transformer, which is connected to the ultrasonic transducer 1 and the oscillation pipeline 3, can be fixedly installed in the blood gas analyzer through the mounting flange 6.

[0034] To monitor in real time whether blood sample enters the blood sample delivery pipeline and to activate the ultrasonic transducer when blood sample enters, a liquid sensor 7 is connected to the inlet end of the blood sample delivery pipeline, and an ultrasonic control unit is connected to the ultrasonic transducer 1 to control the ultrasonic transducer 1 to start or stop working. In this embodiment, the liquid sensor 7 is a photoelectric sensor; the ultrasonic control unit is an ultrasonic control board, preferably model GT-P9003V4. When the blood sample to be tested enters the blood sample delivery pipeline and flows through the liquid sensor 7, the liquid sample entry signal is transmitted from the liquid sensor 7 to the ultrasonic control unit, providing a start signal to the ultrasonic control unit. The ultrasonic control unit controls the ultrasonic transducer 1 to activate the ultrasonic transducer, and the blood sample is delivered from the blood sample delivery pipeline to the oscillating pipeline 3. The ultrasonic waves generated by the ultrasonic transducer 1 are transmitted to the oscillating pipeline 3, thereby performing ultrasonic hemolysis on the blood sample in the oscillating pipeline 3, causing the red blood cells in the blood to break down continuously and release various hemoglobins. After ultrasonic hemolysis, the blood sample flows out from the outlet end of the oscillating pipeline 3 and is delivered to the colorimetric unit 4 through the blood sample delivery pipeline for subsequent testing.

[0035] Please see Figures 2-3 In the ultrasonic hemolysis device provided in this embodiment, the blood sample delivery pipeline includes a first blood sample delivery pipeline 8 and a second blood sample delivery pipeline 9 sleeved at both ends of the oscillating pipeline 3. In this embodiment, one end of the first blood sample delivery pipeline 8 is connected to the blood sample inlet end and the other end is sleeved to the oscillating pipeline 3. The liquid sensor is connected to the first blood sample delivery pipeline 8. One end of the second blood sample delivery pipeline 9 is sleeved to the end of the oscillating pipeline 3 away from the first blood sample delivery pipeline 8 and the other end is connected to the colorimetric mechanism 4. During ultrasonic disruption, the blood sample flows into the oscillating pipeline 3 from the first blood sample delivery pipeline 8 and is delivered to the oscillating pipeline 3. After ultrasonic disruption, the blood sample flows into the second blood sample delivery pipeline 9 from the oscillating pipeline 3 and is delivered to the colorimetric mechanism via the second blood sample delivery pipeline 9. The first blood sample delivery line 8 and the second blood sample delivery line 9 are both flexible transparent lines. In this embodiment, transparent medical silicone rubber tubing (such as transparent PVC tubing) can be used. By using the above materials, the first blood sample delivery line 8 and the second blood sample delivery line 9 can be tightly connected to both ends of the oscillating line 3, with good sealing performance, preventing blood sample leakage during delivery and ultrasonic crushing. At the same time, the delivery status of blood samples in the blood sample delivery line can be observed in real time.

[0036] The ultrasonic hemolysis device provided in this embodiment also has the technical effect of automatically cleaning the tubing. To ensure smooth input and output of blood samples, specifically in this embodiment: a sample inlet 10 is connected to the end of the first blood sample delivery tubing 8 away from the oscillating tubing 3; the sample inlet 10 is connected to a cleaning fluid driving mechanism 11; a second blood sample delivery tubing 9 is connected to a blood sample driving mechanism 12. In this embodiment, both the cleaning fluid driving mechanism 11 and the blood sample driving mechanism 12 are peristaltic pumps. The sample inlet 10 has an inlet for adding blood samples and an interface for connecting to the cleaning fluid driving mechanism 11. The cleaning fluid is stored in a reagent pack 14, and the cleaning fluid driving mechanism 11 is connected to both the reagent pack and the interface of the sample inlet 10 via tubing.

[0037] The working process of the ultrasonic hemolysis device provided in this embodiment is as follows: When it is necessary to perform ultrasonic disruption on the blood sample, the blood sample is dripped into the sample injection mechanism 10. Under the action of the blood sample driving mechanism 12, the blood sample passes through the liquid sensor 7. At this time, the ultrasonic transducer 1 is activated, and the blood sample is input through the first blood sample delivery pipeline 8 and delivered to the oscillation pipeline 3. The blood sample is ultrasonically disrupted under the ultrasonic action of the ultrasonic transducer 1. The blood sample after disruption and hemolysis is delivered from the oscillation pipeline 3 to the colorimetric mechanism 4 through the second blood sample delivery pipeline 9 for subsequent testing.

[0038] When the tubing needs cleaning, the cleaning fluid drive mechanism 11 is activated to transfer the cleaning fluid from the reagent pack 14 to the sample injection mechanism 10 via the tubing. Then, the blood sample drive mechanism 12 is activated, causing the cleaning fluid to enter the first blood sample delivery tubing 8 from the sample injection mechanism 10 and sequentially pass through the oscillating tubing 3 and the second blood sample delivery tubing 9 to achieve the effect of cleaning the entire tubing. In this embodiment, preferably, the ultrasonic transducer 1 is turned on during tubing cleaning, so that the cleaning effect can be further improved through the cavitation and vibration of ultrasound.

[0039] Furthermore, to securely connect the ultrasonic transducer 1 and the amplitude transformer 2 and improve the robustness of the ultrasonic hemolysis device, the ultrasonic transducer 1 and the amplitude transformer 2 are connected by a locking screw 13, such as... Figure 1 As shown, the locking screw 13 passes through the ultrasonic transducer 1 and connects to the amplitude transformer 2.

[0040] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the protection scope of this invention.

Claims

1. An ultrasonic hemolysis device, characterized in that, include: An ultrasonic transducer, one end of which is connected to an amplitude transformer, the amplitude transformer is connected to an oscillation tube, the oscillation tube is connected to a blood sample delivery tube, and the output end of the blood sample delivery tube is connected to a colorimetric mechanism.

2. The ultrasonic hemolysis device according to claim 1, characterized in that, A through groove is formed on the side of the amplitude transformer away from the ultrasonic transducer, and the oscillation pipeline passes through and is connected to the through groove.

3. The ultrasonic hemolysis device according to claim 2, characterized in that, The end of the amplitude transformer away from the ultrasonic transducer is detachably connected to a tightening screw. When the tightening screw is connected to the amplitude transformer, the end of the tightening screw abuts against the oscillation pipeline.

4. The ultrasonic hemolysis device according to any one of claims 1-3, characterized in that, The amplitude transformer is externally fitted with a mounting flange.

5. The ultrasonic hemolysis device according to claim 4, characterized in that, A liquid sensor is connected to the inlet end of the blood sample delivery pipeline.

6. The ultrasonic hemolysis device according to claim 5, characterized in that, The blood sample delivery pipeline includes a first blood sample delivery pipeline and a second blood sample delivery pipeline sleeved at both ends of the oscillating pipeline.

7. The ultrasonic hemolysis device according to claim 6, characterized in that, Both the first and second blood sample delivery lines are flexible transparent lines; the oscillation line is a steel pipe.

8. The ultrasonic hemolysis device according to claim 7, characterized in that, The first blood sample delivery line is also connected to a sample injection mechanism, which is connected to a cleaning fluid driving mechanism; the second blood sample delivery line is connected to a blood sample driving mechanism.

9. The ultrasonic hemolysis device according to claim 8, characterized in that, The ultrasonic transducer is connected to the amplitude transformer via a locking screw; the ultrasonic transducer is also connected to an ultrasonic control unit.

10. A blood gas analyzer, characterized in that, Includes the ultrasonic hemolysis device as described in any one of claims 1-9.

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