Microfluidic disc-based point-of-care blood type analyzer
By integrating microfluidic discs and temperature control components, the instantaneous blood typing analyzer solves the problems of large size and cumbersome operation of existing blood typing analyzers, realizing portable and simple automated blood typing analysis with clear and reliable results and easy data management.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- JIANGSU ZEA BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-07-28
- Publication Date
- 2026-07-14
AI Technical Summary
Existing small blood typing analyzers are bulky, inconvenient to carry, and cumbersome to operate, requiring manual transfer of card strips multiple times for experiments and result recording.
The system employs a microfluidic disc-based point-of-care blood typing analyzer that integrates centrifugation, incubation, and optical detection functions. It utilizes microfluidic disc rotation and temperature control components for automated detection, and combines an industrial camera and barcode scanner to achieve automated operation.
It enables portable and convenient blood type analysis, with intuitive and stable results, reliable and clear data, and the ability to save experimental results locally for easy computer management. The temperature control component ensures reaction stability.
Smart Images
Figure CN224500644U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to a blood typing analyzer, specifically a real-time blood typing analyzer based on a microfluidic disc. Background Technology
[0002] With the rapid development of transfusion science and technology, the demand for personalized transfusion therapy in clinical practice has increased significantly, and the risks of transfusion have also grown. Therefore, blood typing analyzers play a crucial role in the development of the medical industry. Blood typing analyzers primarily use agglutination tests, which utilize the agglutination reaction between red blood cells and blood group antigens and antibodies in a liquid medium to determine blood type. Traditional small blood typing analyzers are mostly cassette-type analyzers, containing separate functional areas such as centrifuge chambers, incubation chambers, and imaging positions. These instruments are relatively large, inconvenient to move and carry, and require multiple manual transfers of the cassettes for testing and result recording, resulting in a cumbersome operating procedure. Therefore, smaller, more portable, and easier-to-operate blood typing analyzers have become a new market demand.
[0003] The information disclosed in this background section is intended only to enhance the understanding of the overall background of this utility model and should not be construed as an admission or in any way implying that the information constitutes prior art known to those skilled in the art. Utility Model Content
[0004] Purpose of this utility model: The technical problem to be solved by this utility model is to address the shortcomings of the existing technology by providing a real-time blood typing analyzer based on a microfluidic disc, which enables real-time detection with a single loading of the microfluidic disc, eliminating the need for multiple manual transfers.
[0005] To address the aforementioned technical problems, this utility model discloses a point-of-care blood typing analyzer based on a microfluidic disk, which includes:
[0006] chassis;
[0007] Disk centrifuge module used to support and drive the rotation of microfluidic disks;
[0008] An in-and-out pushing device connects the housing to the disc centrifugal module. The disc centrifugal module moves relative to the housing under the drive of the in-and-out pushing device and has a disc loading / unloading position and a disc detection position.
[0009] The system includes a detection module and a rotation positioning module, which are respectively installed in the housing. When the disc centrifugation module moves to the disc detection position, the disc centrifugation module is located below the detection module, and the two are formed to create a disc reaction chamber between them. The rotation positioning module can be disengaged from the disc centrifugation module to control the rotation angle of the microfluidic disc.
[0010] Specifically, the disc centrifuge module includes:
[0011] The centrifuge module platform is slidably mounted on the housing;
[0012] A rotating body holder for supporting the microfluidic disk is rotatably mounted above the centrifuge module platform;
[0013] A centrifugal motor is installed below the centrifugal module platform; the top end of the centrifugal motor's shaft passes through the centrifugal module platform and connects to the rotating body fixing seat;
[0014] And a driven wheel for releasable engagement with the rotary positioning module, the driven wheel being coaxially fixedly connected to the shaft of the centrifugal motor.
[0015] Specifically, the rotation positioning module includes:
[0016] The positioning motor is fixedly installed inside the housing.
[0017] And the drive wheel, which is connected to the rotating shaft of the positioning motor;
[0018] When the disc centrifugation module moves to the disc detection position, the driving wheel is connected to the driven wheel of the disc centrifugation module, thereby enabling the rotation positioning module to engage with the disc centrifugation module.
[0019] Specifically, the drive wheel is configured to rotate in place. The disc centrifugation module, driven by the infeed / outfeed pushing device, also has a disc centrifugation position located below the detection module. When the disc centrifugation module is in the disc centrifugation position, the rotation positioning module disengages from the disc centrifugation module, and the disc centrifugation module can drive the microfluidic disc it carries to rotate and centrifuge.
[0020] Specifically, the infeed / outfeed pushing device is an electric push rod, the motor of which is mounted on the housing, and the push rod is connected to the disc centrifuge module via an adapter 126. The extension and retraction of the push rod causes the disc centrifuge module to move relative to the housing between the disc loading / unloading position and the disc detection position.
[0021] Furthermore, the instant blood typing analyzer also includes a heating assembly, an air inlet, an air outlet, and a fan. The heating assembly includes a first heating aluminum substrate and a second heating aluminum substrate. The first heating aluminum substrate is disposed at the top of the disc reaction chamber and connected to the detection module, while the second heating aluminum substrate is disposed at the bottom of the disc reaction chamber and connected to the disc centrifugation module. The first and second heating aluminum substrates are configured to jointly heat the air inside the disc reaction chamber. The air inlet is located in the detection module, and the air outlet is located in the housing. One end of the disc reaction chamber is connected to the outside of the disc reaction chamber through the air inlet, and the other end of the disc reaction chamber is connected to the outside of the disc reaction chamber through the air outlet. The fan is located in the air outlet.
[0022] Specifically, the detection module is an optical detection module, comprising:
[0023] A detection module platform is installed in the housing; the detection module platform is configured to form the disk reaction chamber with the disk centrifugation module when the disk is in the disk detection position.
[0024] An industrial camera, fixed to the detection module platform and configured to capture images of the reaction chamber in the microfluidic disk carried by the disk centrifugation module at the disk detection position.
[0025] Furthermore, the instant blood typing analyzer also includes a background light source, which is installed on the disc centrifugation module; when the disc centrifugation module is in the disc detection position, the background light source can provide backlight for the industrial camera.
[0026] Furthermore, the instant blood typing analyzer also includes a barcode scanner, which is mounted on the detection module platform and configured to scan the QR code on the microfluidic disc carried by the disc centrifugation module at the disc detection position.
[0027] Furthermore, the instant blood typing analyzer also includes a power supply, which is located on the side of the housing away from the disc centrifugation module. The infeed / outfeed pushing device, the disc centrifugation module, the detection module, and the rotation positioning module are all electrically connected to the power supply.
[0028] Beneficial effects:
[0029] 1. The microfluidic disc-based point-of-care blood typing analyzer of this invention integrates centrifugation, incubation and optical detection in the same area, without the need for manual assistance during the process; after the integration of functions, the analyzer is small in size and light in weight, and can be compatible with discs of the same shape but different detection methods, and has standardized and convenient operation.
[0030] 2. This utility model uses an industrial camera to photograph and save the results of the reaction chamber separately. The difference between positive and negative results in the reaction chamber is large, so the results are intuitive, stable, reliable, clear and easy to save.
[0031] 3. By storing experimental results locally, this utility model enables the biochemical analyzer to have the feature of data management via computer.
[0032] 4. The temperature control component of this utility model uses a first heating aluminum substrate and a second heating aluminum substrate to heat the air in the disk reaction chamber; by drawing air out through a fan, the outside air flows into the disk reaction chamber from the air inlet, flows over the surface of the microfluidic disk, and then flows out from the air outlet, which can quickly reduce the temperature of the reaction chamber to room temperature without affecting the subsequent replacement of the disk without a temperature bath for experiments. Attached Figure Description
[0033] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments, and the advantages of the present invention in the above and / or other aspects will become clearer.
[0034] Figure 1 This is a three-dimensional assembly view of a microfluidic disc-based real-time blood typing analyzer provided for an embodiment of the present invention, with the disc centrifugation module in the disc loading / unloading position.
[0035] Figure 2 for Figure 1 The diagram shown is an isometric view of the instant blood typing analyzer after the disc centrifugation module and the detection module have been removed.
[0036] Figure 3 for Figure 2 The structure shown is a front view.
[0037] Figure 4 for Figure 1 The image shows an isometric view of the disc centrifugation module in a point-of-care blood typing analyzer.
[0038] Figure 5 for Figure 4 The image shows the bottom isometric view of the disc centrifuge module.
[0039] Figure 6 for Figure 1 The image shows an isometric view of the disc centrifugation module in the point-of-care blood typing analyzer, with a microfluidic disc loaded.
[0040] Figure 7 for Figure 1 The image shows an isometric view of the detection module in a point-of-care blood typing analyzer.
[0041] Figure 8 for Figure 7The image shows the bottom isometric view of the detection module.
[0042] Figure 9 for Figure 1 The diagram shown is an isometric view of the instant blood typing analyzer after the detection module has been removed.
[0043] Figure 10 for Figure 1 The image shows a right-side view of the real-time blood typing analyzer with the disc centrifugation module in the disc detection position.
[0044] The reference numerals in the attached figures are as follows: 100, Instantaneous blood typing analyzer; 111, Housing; 112, Power supply; 120, Disc centrifuge module; 121, Centrifuge module platform; 122, Rotating body fixing seat; 123, Centrifuge motor; 124, Driven wheel; 126, Adapter; 130, Infeed / Outfeed pushing device; 140, Detection module; 141, Detection module platform; 142, Industrial camera; 150, Rotary positioning module; 151, Positioning motor; 152, Drive wheel; 1711, First heating aluminum substrate; 1712, Second heating aluminum substrate; 172, Air inlet; 173, Air outlet channel; 174, Fan; 180, Background light source; 190, Barcode scanner head; 200, Microfluidic disc; 210, Reaction chamber. Detailed Implementation
[0045] Example 1
[0046] like Figures 1 to 10 As shown, the microfluidic disc-based instantaneous blood typing analyzer 100 of this embodiment includes: a housing 111; a disc centrifugation module 120 for carrying and rotating the microfluidic disc 200; an infeed / outfeed pushing device 130 connecting the housing 111 and the disc centrifugation module 120, the disc centrifugation module 120 moving relative to the housing 111 under the drive of the infeed / outfeed pushing device 130 to have a disc loading / unloading position and a disc detection position; and a detection module 140 and a rotation positioning module 150, the detection module 140 and the rotation positioning module 150 respectively mounted on the housing 111; when the disc centrifugation module 120 moves to the disc detection position, the disc centrifugation module 120 is located below the detection module 140 and the two are formed to form a disc reaction chamber therebetween, the rotation positioning module 150 can be disengaged from the disc centrifugation module 120 to control the rotation angle of the microfluidic disc 200. When the disc centrifuge module 120 moves to the disc loading and unloading position, the disc centrifuge module 120 is located outside the detection module 140, so that the microfluidic disc 200 above the disc centrifuge module 120 is sent out to the outside of the biochemical analyzer.
[0047] Specifically, such as Figure 4 , Figure 5 and Figure 6As shown, the disc centrifuge module 120 includes a centrifuge module platform 121, a rotating body mounting base 122 for supporting the microfluidic disc 200, a centrifuge motor 123, and a driven wheel 124 for detachable engagement with the rotation positioning module 150. The centrifuge module platform 121 is slidably mounted on the housing 111 via a slide rail assembly 125. The rotating body mounting base 122 is rotatably mounted above the centrifuge module platform 121. The centrifuge motor 123 is mounted below the centrifuge module platform 121. The top end of the rotating shaft of the centrifuge motor 123 passes through the centrifuge module platform 121 and connects to the rotating body mounting base 122. The driven wheel 124 is coaxially and fixedly connected to the rotating shaft of the centrifuge motor 123.
[0048] More specifically, a connecting device for a rotating body for medical testing, as disclosed in Chinese Utility Model Patent No. CN222510960U, is provided between the rotating body holder 122 and the microfluidic disk 200. The microfluidic disk 200 corresponds to the rotating body in the Utility Model Patent, and the rotating body holder 122 corresponds to the rotating body holder in the Utility Model Patent.
[0049] More specifically, the slide rail assembly 125 includes a fixed rail and a movable rail that can slide relative to the fixed rail, wherein the movable rail is fixedly mounted on the bottom of the centrifugal module platform 121 and the fixed rail is mounted on the housing 111.
[0050] Specifically, such as Figure 9 As shown, the rotary positioning module 150 includes a positioning motor 151 and a drive wheel 152. The positioning motor 151 is fixedly installed inside the housing 111, and the drive wheel 152 is connected to the rotating shaft of the positioning motor 151 via a transmission connection. Figure 10 As shown, when the disc centrifugal module 120 moves to the disc detection position, the driving wheel 152 and the driven wheel 124 of the disc centrifugal module 120 are connected by a transmission, realizing the engagement of the rotation positioning module 150 with the disc centrifugal module 120. Preferably, the outer periphery of the driving wheel 152 is covered with a rubber layer. When the disc centrifugal module 120 moves to the disc detection position, the driven wheel 124 of the disc centrifugal module 120 presses against the rubber layer on the outer periphery of the driving wheel 152, thereby engaging with the driving wheel 152 and achieving a stable transmission connection.
[0051] In this embodiment, the position of the drive wheel 152 is relatively fixed and can only rotate in its original position. Therefore, the disc centrifugation module 120, driven by the infeed / outfeed push device 130, also has a disc centrifugation position located below the detection module 140. When the disc centrifugation module 120 is in the disc centrifugation position, the rotation positioning module 150 is disengaged from the disc centrifugation module 120, and the disc centrifugation module 120 can drive the microfluidic disc 200 it carries to rotate and centrifuge at high speed.
[0052] Specifically, such as Figure 2 and Figure 9As shown, the infeed / outfeed pushing device 130 is an electric push rod. The motor of the electric push rod is mounted on the housing 111, and the push rod is connected to the disc centrifuge module 120 via an adapter 126. The extension and retraction movement of the push rod drives the disc centrifuge module 120 to move relative to the housing 111 between the disc loading / unloading position and the disc detection position. More specifically, see... Figure 9 The push rod of the electric push rod is connected to the bottom of the centrifugal module platform 121 of the disc centrifugal module 120 via the adapter 126.
[0053] Furthermore, the instant blood typing analyzer 100 also includes a temperature control component configured to control the temperature of the microfluidic disc 200 carried on the disc centrifugation module 120 located at the disc detection position, providing an incubation environment for the microfluidic disc 200.
[0054] Specifically, such as Figure 1 , Figure 2 and Figure 3 As shown, the temperature control component includes a heating component, an air inlet 172, an air outlet 173, and a fan 174. The heating component is used to heat the air in the disk reaction chamber. The air inlet 172 is located on the detection module platform 141 of the detection module 140, and the air outlet 173 is located on the housing 111. One end of the disk reaction chamber is connected to the outside of the disk reaction chamber through the air inlet 172, and the other end of the disk reaction chamber is connected to the outside of the disk reaction chamber through the air outlet 173. The fan 174 is located in the air outlet 173.
[0055] In this embodiment, the temperature of the disk reaction chamber is adjusted by controlling the air volume through the fan 174, so that the microfluidic disk 200 can react at a suitable temperature and ensure the stability of the reaction.
[0056] Preferably, such as Figure 1 As shown, the air inlet 172 and the detection module platform 141 are located on the same side of the device.
[0057] More specifically, such as Figure 4 and Figure 8 As shown, the heating assembly includes a first heating aluminum substrate 1711 and a second heating aluminum substrate 1712. The first heating aluminum substrate 1711 is disposed at the top of the disk reaction chamber and connected to the detection module 140. The second heating aluminum substrate 1712 is disposed at the bottom of the disk reaction chamber and connected to the disk centrifugation module 120. The first heating aluminum substrate 1711 and the second heating aluminum substrate 1712 are configured to jointly heat the air inside the disk reaction chamber.
[0058] Specifically, such as Figure 7 and Figure 8As shown, the detection module 140 is an optical detection module, including a detection module platform 141 and an industrial camera 142. The detection module platform 141 is mounted on the housing 111 and is configured to form the aforementioned disk reaction chamber with the disk centrifuge module 120 when it is in the disk detection position. The industrial camera 142 is fixed to the detection module platform 141 and its fixed position is configured to capture images of the reaction chamber 210 in the microfluidic disk 200 carried by the disk centrifuge module 120 when it is in the disk detection position. More specifically, as shown... Figure 8 As shown, the first heated aluminum substrate 1711 is mounted on the detection module platform 141.
[0059] In this embodiment, under the control of the rotation positioning module 150, the reaction chamber 210 in the microfluidic disk 200 rotates sequentially to be directly below the industrial camera 142, where the industrial camera 142 takes pictures, analyzes them, and saves the recorded data.
[0060] Furthermore, such as Figure 5 As shown, the instant blood typing analyzer 100 also includes a background light source 180, which is mounted on the disc centrifugation module 120. When the disc centrifugation module 120 is in the disc detection position, the background light source 180 can provide backlight for the industrial camera 142.
[0061] During the photo-taking process, the background light source 180 provides backlighting for the industrial camera 142 to take photos, improving the clarity of the photos and thus improving the detection efficiency.
[0062] Furthermore, such as Figure 1 and Figure 7 As shown, the instant blood typing analyzer 100 also includes a barcode scanner 190. The barcode scanner 190 is installed in the detection module 140 and its installation position is configured to scan the QR code on the microfluidic disc 200 carried by the disc centrifugation module 120 at the disc detection position, thereby achieving the function of data classification, making data storage easier and facilitating computer retrieval and unified management.
[0063] Specifically, such as Figure 1 and Figure 7 As shown, the barcode scanner 190 is mounted on the detection module platform 141 of the detection module 140.
[0064] Furthermore, such as Figure 1 and Figure 2 As shown, the instant blood typing analyzer 100 also includes a power supply 112, which is located on the side of the housing 111 away from the disc centrifugation module 120. The inlet / outlet push device 130, the disc centrifugation module 120, the detection module 140 and the rotation positioning module 150 are electrically connected to the power supply 112.
[0065] The following describes how the instant blood typing analyzer 100 of this invention is used in the blood typing analysis process, as shown in this embodiment.
[0066] like Figure 1 As shown, the control device 130 moves the disc centrifuge module 120 toward the outside of the biochemical analyzer to the disc loading / unloading position. The operator places the microfluidic disc 200 loaded with the sample to be analyzed on the rotating body fixing seat 122 of the disc centrifuge module 120.
[0067] The control device 130 further moves the disc centrifugation module 120 towards the interior of the biochemical analyzer to the disc centrifugation position inside the analyzer (not shown in the figure). At the disc centrifugation position, the disc centrifugation module 120 and the rotation positioning module 150 are still disengaged. The centrifugation motor 123 of the disc centrifugation module 120 is started. The centrifugation motor 123 drives the rotating body fixing seat 122 to rotate at low speed for several revolutions and then stops. The purpose of this step is to stably fix the microfluidic disc 200 onto the rotating body fixing seat 122. Thus, the microfluidic disc 200 is loaded into the disc centrifugation module 120.
[0068] like Figure 10 As shown, the control device 130 further drives the disc centrifugation module 120 towards the interior of the biochemical analyzer to the disc detection position. At this time, the driving wheel 152 of the rotary positioning module 150 and the driven wheel 124 of the disc centrifugation module 120 engage to form a transmission connection, realizing the engagement of the rotary positioning module 150 and the disc centrifugation module 120. After engagement, the positioning motor 151 of the rotary positioning module 150 starts, and the positioning motor 151 drives the centrifugation motor 123 to rotate the microfluidic disc 200, moving the QR code on the microfluidic disc 200 under the barcode scanner 190. After scanning, the barcode scanner 190 identifies the type of the microfluidic disc 200 and records the information of the microfluidic disc 200.
[0069] After identifying the type of the microfluidic disc 200, the instantaneous blood typing analyzer controls the infeed / outfeed pusher 130 to further move the disc centrifugation module 120 to the disc centrifugation position. If the microfluidic disc 200 requires a warming bath, such as... Figure 4 and Figure 8As shown, the first heating aluminum substrate 1711 and the second heating aluminum substrate 1712 together heat the air in the disk reaction chamber, causing the microfluidic disk 200 to heat up. Simultaneously, the airflow is controlled by the fan 174 to regulate the temperature of the disk reaction chamber, ensuring the microfluidic disk 200 can react at a suitable temperature and guaranteeing reaction stability. Once the temperature is suitable, the centrifugal motor 123 of the disk centrifuge module 120 is started. The microfluidic disk 200 rotates at high speed under the drive of the centrifugal motor 123, causing the reagents in the microfluidic disk 200 and the sample to be analyzed to be centrifuged into the reaction chamber 210 within the microfluidic disk 200 for homogenization. After the homogenization reaction is complete, the first heating aluminum substrate 1711 and the second heating aluminum substrate 1712 stop heating, and the centrifugal motor 123 of the disk centrifuge module 120 stops and remains stationary for a period of time. During the resting process, the fan 174 draws external air through the air inlet 172 and sends it to the microfluidic disk 200 to dissipate heat from the microfluidic disk 200.
[0070] After the settling period, the control device 130 further moves the disc centrifugation module 120 to the disc detection position, causing the rotation positioning module 150 to engage with the disc centrifugation module 120. The positioning motor 151 in the rotation positioning module 150 starts, causing the reaction chamber 210 in the microfluidic disc 200 to rotate sequentially to directly below the industrial camera 142. The industrial camera 142 then takes and analyzes the images, saving the recorded data. During the image capture process, the background light source 180 provides backlighting for the industrial camera 142, improving image clarity and thus increasing detection efficiency.
[0071] After the test is completed, the control device 130 drives the disk centrifugal module 120 to move to the disk unloading position. The operator can then remove the used microfluidic disk 200 and proceed to the next round of experiments.
[0072] Each experiment is independent, and the experimental items can be determined by directly changing the microfluidic disk, without the need to manually set the program.
[0073] Example 2
[0074] Unlike Embodiment 1, in this embodiment, the driving wheel 152 of the rotary positioning module 150 can be configured to rise and fall to separate from the driven wheel 124. This allows the disc centrifugation module 120, located at the disc detection position, to be decoupled from the rotary positioning module 150 without needing to move, thereby driving the microfluidic disc 200 it carries to rotate at high speed. In other words, the device in this embodiment may not have a disc centrifugation position. The other parts of the biochemical analyzer in this embodiment are the same as in Embodiment 1, and therefore will not be described again.
[0075] This invention provides a concept and method for a point-of-care blood typing analyzer based on a microfluidic disc. Many methods and approaches exist for implementing this technical solution; the above description is merely a preferred embodiment. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of this invention, and these improvements and modifications should also be considered within the scope of protection of this invention. All components not explicitly stated in this embodiment can be implemented using existing technology.
Claims
1. A point-of-care blood typing analyzer based on a microfluidic disc, characterized in that, include: Casing (111); Disk centrifuge module (120) for carrying and driving the microfluidic disk (200) to rotate. An in-and-out pushing device (130) connects the housing (111) and the disc centrifugal module (120). The disc centrifugal module (120) moves relative to the housing (111) under the drive of the in-and-out pushing device (130) and has a disc loading / unloading position and a disc detection position. The microfluidic disk (200) is equipped with a detection module (140) and a rotation positioning module (150), which are respectively installed on the housing (111). When the disk centrifugation module (120) moves to the disk detection position, the disk centrifugation module (120) is located below the detection module (140) and the two are formed to form a disk reaction chamber between them. The rotation positioning module (150) can be disengaged from the disk centrifugation module (120) to control the rotation angle of the microfluidic disk (200).
2. The real-time blood typing analyzer based on microfluidic discs according to claim 1, characterized in that, The disc centrifuge module (120) includes: Centrifuge module platform (121) is slidably disposed on the housing (111); A rotating body holder (122) for supporting the microfluidic disk (200) is rotatably disposed above the centrifuge module platform (121); A centrifugal motor (123) is installed below the centrifugal module platform (121); the top end of the rotating shaft of the centrifugal motor (123) passes through the centrifugal module platform (121) and is connected to the rotating body fixing seat (122); And a driven wheel (124) for releasable engagement with the rotary positioning module (150), the driven wheel (124) being coaxially fixedly connected to the shaft of the centrifugal motor (123).
3. The real-time blood typing analyzer based on microfluidic discs according to claim 1, characterized in that, The rotation positioning module (150) includes: The positioning motor (151) is fixedly installed inside the housing (111); And the drive wheel (152) is connected to the shaft of the positioning motor (151) via a drive transmission; When the disc centrifugal module (120) moves to the disc detection position, the driving wheel (152) is connected to the driven wheel (124) of the disc centrifugal module (120) to realize the engagement of the rotary positioning module (150) with the disc centrifugal module (120).
4. The real-time blood typing analyzer based on microfluidic discs according to claim 3, characterized in that, The drive wheel (152) is configured to rotate in place; the disc centrifugation module (120) also has a disc centrifugation position located below the detection module (140) under the drive of the inlet and outlet push device (130). When the disc centrifugation module (120) is located at the disc centrifugation position, the rotation positioning module (150) and the disc centrifugation module (120) are in a disengaged state, and the disc centrifugation module (120) can drive the microfluidic disc (200) it carries to rotate and centrifuge.
5. The real-time blood typing analyzer based on microfluidic discs according to claim 1, characterized in that, The infeed / outfeed pushing device (130) is an electric push rod. The motor of the electric push rod is installed on the housing (111). The push rod of the electric push rod is connected to the disc centrifugal module (120) through the adapter (126). The extension and retraction movement of the push rod of the electric push rod drives the disc centrifugal module (120) to move relative to the housing (111) between the disc loading / unloading position and the disc detection position.
6. The real-time blood typing analyzer based on microfluidic discs according to claim 1, characterized in that, It also includes a heating assembly, an air inlet (172), an air outlet (173), and a fan (174). The heating assembly includes a first heating aluminum substrate (1711) and a second heating aluminum substrate (1712). The first heating aluminum substrate (1711) is disposed at the top of the disk reaction chamber and connected to the detection module (140). The second heating aluminum substrate (1712) is disposed at the bottom of the disk reaction chamber and connected to the disk centrifugation module (120). The first heating aluminum substrate (1711) and the second heating aluminum substrate (1712) are connected together. The hot aluminum substrate (1712) is configured to heat the air in the disk reaction chamber together; the air inlet (172) is opened in the detection module (140), the air outlet channel (173) is opened in the housing (111), one end of the disk reaction chamber is connected to the outside of the disk reaction chamber through the air inlet (172), and the other end of the disk reaction chamber is connected to the outside of the disk reaction chamber through the air outlet channel (173); the fan (174) is arranged in the air outlet channel (173).
7. The real-time blood typing analyzer based on a microfluidic disc as described in claim 1, characterized in that, The detection module (140) is an optical detection module, comprising: A detection module platform (141) is installed on the housing (111); the detection module platform (141) is configured to form the disk reaction chamber with the disk centrifugation module (120) when it is in the disk detection position; An industrial camera (142) is fixed to the detection module platform (141) and its fixed position is configured to capture images of the reaction chamber (210) in the microfluidic disk (200) carried by the disk centrifugation module (120) at the disk detection position.
8. The real-time blood typing analyzer based on a microfluidic disc according to claim 7, characterized in that, It also includes a background light source (180), which is installed on the disk centrifugation module (120); when the disk centrifugation module (120) is in the disk detection position, the background light source (180) can provide backlight for the industrial camera (142).
9. The real-time blood typing analyzer based on a microfluidic disc according to claim 7, characterized in that, It also includes a barcode scanner (190), which is mounted on the detection module platform (141) and the mounting position is configured to scan the QR code on the microfluidic disk (200) carried by the disk centrifugation module (120) at the disk detection position.
10. The real-time blood typing analyzer based on a microfluidic disc according to claim 1, characterized in that, It also includes a power supply (112), which is located on the side of the housing (111) away from the disc centrifuge module (120). The inlet / outlet pushing device (130), the disc centrifuge module (120), the detection module (140) and the rotation positioning module (150) are electrically connected to the power supply (112).