A kit for detecting changes in liver fibrosis stage

Abstract

The utility model relates to medical detection technical field, concretely is a kit for detecting liver fibrosis level change, including support box, reagent grading injection mechanism and temperature control mechanism, the four corners at support box bottom are fixedly connected with antiskid foot pad, reagent grading injection mechanism and temperature control mechanism fixedly connect in the inside of support box, in the utility model, through the setting of vibration piece, sharp needle head and reagent clamping plate, vibration piece produces vibration when working, makes serum sample and reagent in reaction box fully mix, accelerates the reaction speed, improves the accuracy of detection result, sharp needle head cooperates electric telescopic column and reagent fixed assembly, can accurate control reagent fixed assembly's lift height, ensure that reagent bottle can accurately aim at sharp needle head, realize accurate, automatic injection of reagent, greatly improve the detection efficiency, avoid the detection failure because of missing the time of adding due to human, reagent clamping plate can adjust, can adapt to different specifications reagent bottle, enhance the versatility of reagent box.

Description

Technical Field

[0001] This invention relates to the field of medical testing technology, and in particular to a reagent kit for detecting changes in the grade of liver fibrosis. Background Technology

[0002] Hepatic fibrosis (HF) is a reversible pathophysiological phenomenon characterized by the formation of abnormally large amounts of scar tissue within the liver as it attempts to repair and replace damaged cells. Patients with HF often have no specific clinical symptoms. However, if it progresses to cirrhosis, symptoms such as indigestion, loss of appetite, and jaundice may occur, and it can even lead to serious consequences such as massive ascites, portal hypertension, upper gastrointestinal bleeding, and liver failure.

[0003] When using the existing technical solution, a class of initiators, auxiliary chromogenic agents, and labeled antibody reagents that can bind to CHI3L1 need to be added to the reaction box at regular intervals. Multiple batches of reagent bottles need to be prepared and placed next to each reaction box. This involves a large amount of work, and the addition of reagents requires time marking, which can easily lead to missing the addition time, resulting in inaccurate test results or interruption of the test process, seriously affecting the efficiency and accuracy of the test.

[0004] To address the above problems, this invention provides a kit for detecting changes in the grade of liver fibrosis. Utility Model Content

[0005] The purpose of this invention is to solve the problems of cumbersome detection procedures, inaccurate test results due to human factors, and low detection efficiency in the existing technology, and to propose a reagent kit for detecting changes in the level of liver fibrosis.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a reagent kit for detecting changes in the level of liver fibrosis, comprising a support box, a reagent graded injection mechanism, and a temperature control mechanism. Anti-slip pads are fixedly connected to the four corners of the bottom of the support box. The reagent graded injection mechanism and the temperature control mechanism are fixedly connected inside the support box. The reagent graded injection mechanism includes a reaction box fixedly connected inside the support box.

[0007] The reagent graded injection mechanism includes a vibrating plate and a sharp needle, with the vibrating plate fixedly connected to the inside of the reaction chamber.

[0008] A connecting plate is fixedly connected to the bottom of the sharp needle. The sharp needle is arranged at four equal intervals at the top of the connecting plate. A sliding slot is opened inside the reaction box. A support frame is slidably connected inside the sliding slot. The support frame is slidably connected to the inside of the reaction box through the sliding slot. An electric telescopic column is fixedly connected at four equal intervals at the bottom of the support frame. A reagent fixing assembly is fixedly connected to the bottom of the electric telescopic column.

[0009] Furthermore, the reagent fixing assembly includes a reagent fixing ring fixedly connected to the bottom of the electric telescopic column. Adjusters are threadedly connected to both sides of the reagent fixing ring. A bearing is rotatably connected to the far end of the adjuster. A reagent clamping plate is fixedly connected to the outer surface of the bearing. The bearing is fitted into the outer surface of the reagent clamping plate. The adjuster and the reagent clamping plate are symmetrically arranged inside the reagent fixing ring.

[0010] Furthermore, connecting columns are fixedly connected to both ends of the bottom of the support frame, and a support plate is fixedly connected to the bottom of the connecting columns. Sliding through holes are provided on both sides of the support plate at four equal intervals.

[0011] Furthermore, a handle is fixedly connected to the top of the support frame, and the support frame and the reagent fixing assembly are symmetrically arranged inside the reaction box.

[0012] Furthermore, the temperature control mechanism includes a cooler fixedly connected inside the support box, the cooler being symmetrically arranged inside the support box, and the temperature control mechanism including connecting frames threadedly connected to both sides of the support box.

[0013] Furthermore, a servo motor is fixedly connected inside the connecting frame, and a cooling fan is fixedly connected to the output end of the servo motor. The servo motor and the cooling fan are symmetrically arranged inside the connecting frame.

[0014] Furthermore, dustproof and ventilated mesh plates are fixedly connected to both sides of the connecting frame, and limiting components are threadedly connected to both sides of the connecting frame. The connecting frame is threadedly connected to both sides of the support box through the limiting components.

[0015] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0016] 1. In this invention, the vibrating plate, sharp needle, and reagent clamping plate create a vibration that promotes thorough mixing of the serum sample and reagents within the reaction chamber, accelerating the reaction speed and improving the accuracy of the test results. The sharp needle, in conjunction with the electric telescopic column and reagent fixing assembly, allows for precise control of the height of the reagent fixing assembly, ensuring that the reagent bottle is accurately aligned with the sharp needle. This enables precise and automatic reagent injection, eliminating the need for manual addition of reagents one by one, significantly improving testing efficiency and preventing errors caused by missed addition times. The reagent clamping plate is adjustable to accommodate reagent bottles of different sizes, enhancing the versatility of the reagent kit.

[0017] 2. In this utility model, through the setting of a cooler, a cooling fan, and a dustproof and ventilated mesh plate, the cooler maintains a low-temperature environment in the reaction chamber, reduces the temperature around the reaction chamber, maintains the activity of serum samples and reagents, ensures the accuracy of test results, protects the activity of serum and reagents, accelerates air circulation, dissipates the heat generated by the cooler, improves cooling efficiency, and prevents heat accumulation from damaging the internal components of the reagent kit, thereby improving cooling efficiency. The dustproof and ventilated mesh plate blocks dust, ensures normal operation of the equipment, extends the service life of the reagent kit, and provides a stable and reliable environment for the detection process. Attached Figure Description

[0018] Figure 1 A three-dimensional structural schematic diagram of a reagent kit for detecting changes in the grade of liver fibrosis is provided for this utility model;

[0019] Figure 2 A schematic diagram of the sharp needle in a reagent kit for detecting changes in the grade of liver fibrosis is provided for this utility model;

[0020] Figure 3 This invention proposes a reagent kit for detecting changes in the grade of liver fibrosis. Figure 2 Enlarged view of point A;

[0021] Figure 4 This invention provides a schematic diagram of the structure of a dustproof and breathable mesh plate in a reagent kit for detecting changes in the grade of liver fibrosis.

[0022] Figure 5 This invention provides a schematic diagram of the reagent fixation ring in a reagent kit for detecting changes in the grade of liver fibrosis.

[0023] Figure 6 This invention proposes a reagent kit for detecting changes in the grade of liver fibrosis. Figure 5 Enlarged diagram of point B.

[0024] Legend:

[0025] 1. Support box; 2. Reagent grading injection mechanism; 21. Reaction box; 22. Vibrating plate; 23. Sharp needle; 24. Connecting plate; 25. Sliding slot; 26. Support frame; 27. Electric telescopic column; 28. Reagent fixing assembly; 281. Reagent fixing ring; 282. Regulator; 283. Bearing; 284. Reagent clamping plate; 29. ​​Connecting column; 210. Support plate; 211. Sliding through hole; 212. Handle; 3. Temperature control mechanism; 31. Refrigerator; 32. Connecting frame; 33. Servo motor; 34. Cooling fan; 35. Dustproof and ventilated mesh plate; 36. Limiting component; 4. Anti-slip pad. Detailed Implementation

[0026] Please see Figure 1-6 This utility model provides a technical solution: a reagent kit for detecting changes in the level of liver fibrosis, including a support box 1, a reagent graded injection mechanism 2 and a temperature control mechanism 3. Anti-slip pads 4 are fixedly connected to the four corners of the bottom of the support box 1. The reagent graded injection mechanism 2 and the temperature control mechanism 3 are fixedly connected inside the support box 1. The reagent graded injection mechanism 2 includes a reaction box 21 fixedly connected inside the support box 1.

[0027] The specific setup and function of its reagent grading injection mechanism 2 and temperature control mechanism 3 will be explained below.

[0028] In this embodiment: the reagent graded injection mechanism 2 includes a vibrating plate 22 and a sharp needle 23, with the vibrating plate 22 fixedly connected to the inside of the reaction box 21.

[0029] A connecting plate 24 is fixedly connected to the bottom of the sharp needle 23. The sharp needle 23 is arranged at four equal intervals at the top of the connecting plate 24. A sliding groove 25 is opened inside the reaction box 21. A support frame 26 is slidably connected inside the sliding groove 25. The support frame 26 is slidably connected to the inside of the reaction box 21 through the sliding groove 25. An electric telescopic column 27 is fixedly connected at four equal intervals at the bottom of the support frame 26. A reagent fixing assembly 28 is fixedly connected to the bottom of the electric telescopic column 27.

[0030] The effects achieved by the above components are as follows: through the vibration function of the vibrating plate 22, the reasonable distribution of the sharp needles 23, and the coordinated operation of the support frame 26, the electric telescopic column 27 and the reagent fixing component 28, the precise and automatic injection of reagents and the efficient mixing reaction of serum and reagents are realized, effectively avoiding the impact of human operation errors on the test results and significantly improving the efficiency and accuracy of the test.

[0031] Specifically, the reagent fixing assembly 28 includes a reagent fixing ring 281 fixedly connected to the bottom of the electric telescopic column 27. Adjusters 282 are threadedly connected to both sides of the reagent fixing ring 281. A bearing 283 is rotatably connected to the far end of the adjuster 282. A reagent clamping plate 284 is fixedly connected to the outer surface of the bearing 283. The bearing 283 is fitted into the outer surface of the reagent clamping plate 284. The adjuster 282 and the reagent clamping plate 284 are symmetrically arranged inside the reagent fixing ring 281.

[0032] The effect achieved by the above components is as follows: by rotating the adjuster 282, the reagent clamping plate 284 can be pushed to rotate along the bearing 283, thereby adjusting the distance between the two reagent clamping plates 284, firmly clamping reagent bottles of different diameters, enhancing the compatibility of the reagent kit with various reagent bottles, and reliably fixing both standard and special specification reagent bottles, ensuring the smooth progress of the testing process.

[0033] Specifically, the bottom of the support frame 26 is fixedly connected to the two ends of the connecting column 29, and the bottom of the connecting column 29 is fixedly connected to the support plate 210. The support plate 210 has sliding through holes 211 at four equal intervals on both sides.

[0034] The effects achieved by the above components are as follows: the connecting column 29 and the support plate 210 enhance the structural stability of the support frame 26, making it more stable during movement and less prone to shaking or displacement. The sliding through hole 211 can be used to insert components such as fixing rods, further restricting the direction of movement of the support frame 26 and preventing it from shaking randomly in the reaction box 21, thus ensuring the accuracy and stability of the reagent fixing assembly 28 during the movement and injection of reagents.

[0035] Specifically, a handle 212 is fixedly connected to the top of the support frame 26, and the support frame 26 and the reagent fixing assembly 28 are symmetrically arranged inside the reaction box 21.

[0036] The effects achieved by the above components are as follows: the symmetrical structure makes the support frame 26 more evenly stressed when moving and carrying reagent bottles, ensuring the stability of the entire reagent fractionation injection mechanism 2, avoiding situations such as the support frame 26 tilting or reagent bottles falling due to uneven stress, facilitating the operation and maintenance of the reagent kit, and improving work efficiency.

[0037] Specifically, the temperature control mechanism 3 includes a cooler 31 fixedly connected inside the support box 1. The cooler 31 is symmetrically arranged inside the support box 1. The temperature control mechanism 3 includes a connecting frame 32 threadedly connected to both sides of the support box 1.

[0038] The effects achieved by the above components are as follows: the connecting frame 32 is used to install and fix components such as the servo motor 33 and the cooling fan 34, and at the same time, it serves to connect the support box 1 with the external heat dissipation device, so that the entire temperature control system forms a complete heat dissipation circulation structure. The cooler 31 and the connecting frame 32 together construct a stable temperature control environment, ensuring that the samples and reagents in the reaction box 21 are always in a suitable low temperature state, providing a reliable environmental guarantee for the detection work and improving the reliability of the detection results.

[0039] Specifically, a servo motor 33 is fixedly connected inside the connecting frame 32, and a cooling fan 34 is fixedly connected to the output end of the servo motor 33. The servo motor 33 and the cooling fan 34 are symmetrically arranged inside the connecting frame 32.

[0040] The effects achieved by the above components are as follows: the servo motor 33 drives the cooling fan 34 to rotate at high speed, accelerating air circulation and quickly expelling the heat generated by the cooler 31 during operation from the support box 1, preventing heat from accumulating inside the support box 1 and affecting the cooling effect and the normal operation of other components inside the reagent kit. At the same time, the symmetrically arranged servo motor 33 and cooling fan 34 can make the airflow more uniform, improve the heat dissipation efficiency, effectively assist the cooler 31 in heat dissipation, ensure that the cooler 31 works continuously and stably, maintain the low temperature environment around the reaction box 21, extend the service life of each component inside the reagent kit, and ensure that the detection work can be operated stably for a long time.

[0041] Specifically, dustproof and ventilation mesh plates 35 are fixedly connected to both sides of the connecting frame 32, and limiting members 36 are threadedly connected to both sides of the connecting frame 32. The connecting frame 32 is threadedly connected to both sides of the support box 1 through the limiting members 36.

[0042] The effects achieved by the above components are as follows: by adjusting the limiting component 36, the connecting frame 32 can be easily installed or disassembled, which facilitates the maintenance, upkeep and replacement of components such as the servo motor 33 and the cooling fan 34 inside the connecting frame 32. The dustproof and ventilated mesh plate 35 ensures the cleanliness of the inside of the equipment and extends the service life of the equipment. The limiting component 36 facilitates the maintenance and upkeep of the equipment, making the maintenance of the temperature control mechanism 3 more convenient and efficient, and ensuring the long-term stable operation of the temperature control mechanism 3.

[0043] Working principle: When detecting changes in liver fibrosis level, serum samples are first added to reaction box 21. According to the reagent bottle specifications, the spacing of reagent clamping plates 284 in reagent fixing assembly 28 is adjusted by rotating adjuster 282. Reagent bottles containing different reagents such as a class I initiator, CHI3L1 labeled antibody reagent, auxiliary chromogenic agent, etc. are fixed on reagent fixing ring 281. Then, the support frame 26 is slid into the appropriate position in reaction box 21 along sliding groove 25 by handle 212.

[0044] The lifting program of the electric telescopic column 27 is set so that it raises the reagent bottle to the sharp needle 23 according to the preset time of the detection process. The sharp needle 23 punctures the rubber stopper of the reagent bottle, and the reagent is injected into the reaction box 21 under the pressure inside the bottle. At the same time, the vibrating plate 22 is activated to promote the serum sample and the injected reagent to mix and react fully.

[0045] Throughout the testing process, the cooler 31 continuously cools the environment, reducing the temperature around the reaction chamber 21. The servo motor 33 drives the cooling fan 34 to expel the heat generated by the cooler 31. The dustproof and ventilated mesh 35 prevents dust from entering, ensuring that the reaction chamber 21 is always kept in a suitable low-temperature and clean environment, thus protecting the activity of serum samples and reagents. After the reaction is completed, the sample in the reaction chamber 21 is taken out and sent to a medical chromatograph for analysis and compared with the liver fibrosis grade table to obtain the patient's liver fibrosis grade.

Claims

1. A reagent kit for detecting changes in liver fibrosis grade, comprising a support box (1), a reagent graded injection mechanism (2), and a temperature control mechanism (3), characterized in that: Anti-slip pads (4) are fixedly connected to the four corners of the bottom of the support box (1). The reagent graded injection mechanism (2) and the temperature control mechanism (3) are fixedly connected to the inside of the support box (1). The reagent graded injection mechanism (2) includes a reaction box (21) fixedly connected to the inside of the support box (1). The reagent graded injection mechanism (2) includes a vibrating plate (22) and a sharp needle (23), wherein the vibrating plate (22) is fixedly connected to the inside of the reaction box (21); The bottom of the sharp needle (23) is fixedly connected to a connecting plate (24). The sharp needle (23) is arranged at a four-part interval on the top of the connecting plate (24). The reaction box (21) has a sliding groove (25) inside. A support frame (26) is slidably connected inside the sliding groove (25). The support frame (26) is slidably connected to the inside of the reaction box (21) through the sliding groove (25). The bottom of the support frame (26) is fixedly connected to an electric telescopic column (27) at a four-part interval. The bottom of the electric telescopic column (27) is fixedly connected to a reagent fixing assembly (28).

2. The kit for detecting changes in liver fibrosis grade according to claim 1, characterized in that: The reagent fixing assembly (28) includes a reagent fixing ring (281) fixedly connected to the bottom of the electric telescopic column (27). Adjusters (282) are threadedly connected to both sides of the reagent fixing ring (281). A bearing (283) is rotatably connected to the far end of the adjuster (282). A reagent clamping plate (284) is fixedly connected to the outer surface of the bearing (283). The bearing (283) is fitted into the outer surface of the reagent clamping plate (284). The adjuster (282) and the reagent clamping plate (284) are symmetrically arranged inside the reagent fixing ring (281).

3. The kit for detecting changes in liver fibrosis grade according to claim 1, characterized in that: The bottom ends of the support frame (26) are fixedly connected to connecting columns (29), and the bottom of the connecting columns (29) is fixedly connected to a support plate (210). The support plate (210) has sliding through holes (211) at four equal intervals on both sides.

4. The kit for detecting changes in liver fibrosis grade according to claim 3, characterized in that: The top of the support frame (26) is fixedly connected to a handle (212), and the support frame (26) and the reagent fixing assembly (28) are symmetrically arranged inside the reaction box (21).

5. The kit for detecting changes in liver fibrosis grade according to claim 1, characterized in that: The temperature control mechanism (3) includes a cooler (31) fixedly connected inside the support box (1). The cooler (31) is symmetrically arranged inside the support box (1). The temperature control mechanism (3) includes a connecting frame (32) threadedly connected to both sides of the support box (1).

6. The kit for detecting changes in liver fibrosis grade according to claim 5, characterized in that: A servo motor (33) is fixedly connected inside the connecting frame (32), and a cooling fan (34) is fixedly connected to the output end of the servo motor (33). The servo motor (33) and the cooling fan (34) are symmetrically arranged inside the connecting frame (32).

7. The kit for detecting changes in liver fibrosis grade according to claim 6, characterized in that: The connecting frame (32) is fixedly connected to the two sides of the dustproof and ventilation mesh plate (35), and the two sides of the connecting frame (32) are threadedly connected to the limiting member (36). The connecting frame (32) is threadedly connected to the two sides of the support box (1) through the limiting member (36).

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