A fully automated mass spectrometer

Abstract

The application belongs to the technical field of mass spectrometers, and relates to a full-automatic mass spectrometer, which comprises a chip module, a mass spectrometer module, a first adjusting module and a transfer module. The chip module is provided with a chip seat for placing a chip. The mass spectrometer module is provided with an opening for taking out and placing the chip. The first adjusting module is arranged on the chip module and used for adjusting the chip module so that the chip is located on the same straight line as the opening. The transfer module is arranged on the chip module or the mass spectrometer module and used for transporting the chip into the mass spectrometer module and taking the chip out of the mass spectrometer module. The technical scheme provided by the application can realize automatic feeding and discharging, keep the position consistent every time, facilitate the adjustment of the position of the chip module, and further improve the accuracy and efficiency of feeding and discharging.

Description

Technical Field

[0001] This application relates to the field of mass spectrometry technology, and more specifically, to a fully automated mass spectrometer. Background Technology

[0002] Matrix-assisted laser desorption / desorption / time-of-flight mass spectrometry (MALDI-TOF) is a widely used biomolecular mass spectrometer. It works by mixing the sample to be analyzed with a matrix to form a co-crystal. When a laser irradiates the co-crystal, the matrix absorbs the laser energy and then transfers the energy to the sample, causing desorption and ionization. The particles generated by sample ionization are accelerated under the influence of an electric field and eventually reach the time-of-flight mass spectrometer detector. Different substances arrive at the detector at different times, allowing for precise calculation of ion molecular weights based on their arrival times. However, current technologies require manual placement of the chip into the mass spectrometer, which is inefficient. While some existing technologies employ mechanical methods for chip transfer, these methods suffer from low reliability and are difficult to adjust.

[0003] Therefore, existing technology cannot meet the needs. Utility Model Content

[0004] The technical problem to be solved by the embodiments of this application is that the prior art has low efficiency in manually placing the chip into the mass spectrometer and low mechanical reliability and difficulty in debugging when using mechanical methods to transfer the chip.

[0005] To address the aforementioned technical problems, this application provides a fully automated mass spectrometer, employing the following technical solution:

[0006] A fully automated mass spectrometer, comprising:

[0007] A chip module, wherein the chip module is provided with a chip socket for placing chips;

[0008] A mass spectrometer module is disposed on one side of the chip module, and the mass spectrometer module is provided with an opening for removing and inserting the chip;

[0009] A first adjustment module is disposed on the chip module and is used to adjust the chip module so that the chip and the opening are on the same straight line;

[0010] A transfer module, disposed on the chip module or mass spectrometer module, is used to transport the chip into and out of the mass spectrometer module.

[0011] Furthermore, the fully automated mass spectrometer also includes a base plate, on which the chip module and the mass spectrometer module are mounted. The chip module includes a support frame. The first adjustment module includes a connector mounted on one of the base plate and the support frame, and a connecting groove mounted on the other. The first adjustment module adjusts the direction of movement of the chip module to a first direction, and the length direction of the connecting groove is parallel to the first direction.

[0012] Furthermore, the chip module also includes a chip holder, on which the chip is disposed. The support frame and the chip holder are movably connected. The first adjustment module also includes a first motor, a first transmission component, and a second transmission component. The first transmission component and the second transmission component are respectively disposed on the first motor and the chip holder. The first transmission component and the second transmission component are connected in transmission. The first motor drives the first transmission component and the second transmission component, thereby driving the chip holder to move along the first direction.

[0013] Furthermore, the transfer module includes a gripper assembly, a second adjustment assembly, and a third adjustment assembly. The second adjustment assembly is used to drive the gripper assembly to move along a second direction, and the third adjustment assembly is used to drive the gripper assembly to move along a third direction. The second direction is parallel to the straight line where the chip and the opening are located.

[0014] Furthermore, the gripper assembly includes a drive member, a moving member, and at least two grippers. The moving member is disposed on the output shaft of the drive member and between the two grippers. The drive member is used to drive the moving member to move, so that the grippers clamp or release the chip.

[0015] Furthermore, the movable component is provided with a movable component, which is slidably connected to the gripper via the movable component. The gripper is provided with a clearance groove and an abutment portion, and a return spring is connected between the two grippers. When the movable component abuts against the abutment portion, the movable component opens the gripper to release the chip. When the movable component moves into the clearance groove, the gripper is reset by the return spring to clamp the chip.

[0016] Furthermore, a target cover is provided on the opening, and the target cover is provided with a slot for the gripper to clamp.

[0017] Furthermore, the mass spectrometer module is also provided with a base for placing the target cover, and the base and the opening are located on the same straight line.

[0018] Furthermore, the third adjustment component includes a second motor, a first fixing member, and a second fixing member. The gripper assembly and the second motor are fixedly mounted on the first fixing member. The second output shaft of the second motor is fixedly mounted on the second fixing member. The second motor drives the second output shaft to rotate so that the first fixing member and the second fixing member move closer to each other and further away from each other.

[0019] Furthermore, the second adjustment component includes a third motor, a first slide rail, and a bracket. The first slide rail is slidably mounted on the bracket. The gripper assembly and the second motor are fixedly mounted on the first slide rail via the first fixing member. The third motor is fixedly mounted on the bracket. The third output shaft of the third motor is fixedly mounted on the second fixing member. The third motor drives the third output shaft to rotate, so that the second fixing member and the third motor move closer to each other and further away from each other.

[0020] Compared with the prior art, the embodiments of this application have the following advantages: This application transfers the chip through the transfer module, which is highly efficient and can realize automated loading and unloading, maintaining the same position for each loading and unloading. In addition, this application adjusts the chip module through the first adjustment module so that the chip and the opening are on the same straight line, which is beneficial for the loading and unloading of the transfer module, facilitates the adjustment of the position of the chip module, and further improves the accuracy and efficiency of loading and unloading. Attached Figure Description

[0021] To more clearly illustrate the solution of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the structure of the fully automated mass spectrometer according to an embodiment of this application;

[0023] Figure 2 This is a partial exploded view of the fully automated mass spectrometer according to an embodiment of this application;

[0024] Figure 3 This is a schematic diagram of the chip module structure according to an embodiment of this application;

[0025] Figure 4 This is a front view of the transfer module according to an embodiment of this application;

[0026] Figure 5 This is a partial exploded view of the transfer module according to an embodiment of this application;

[0027] Figure 6This is a schematic diagram of the structure of the third adjustment component according to an embodiment of this application;

[0028] Figure 7 This is an exploded view of the gripper assembly according to an embodiment of this application;

[0029] Figure 8 This is a cross-sectional view of the gripper assembly in the chip-released state according to an embodiment of this application;

[0030] Figure 9 This is a cross-sectional view of the gripper assembly in the chip clamping state according to an embodiment of this application;

[0031] Figure 10 This is a cross-sectional view of the gripper assembly in the state of clamping the target cover according to an embodiment of this application.

[0032] Reference numerals: 100, chip module; 200, mass spectrometer module; 300, transfer module; 400, gripper assembly; 500, second adjustment assembly; 600, third adjustment assembly; 1, chip; 11, opening; 12, base plate; 13, target cover; 14, base; 15, foot pad; 2, support frame; 21, chip holder; 10, connector; 30, connecting groove; 3, first motor; 31, first transmission component; 32, second transmission component; 5. Driving component; 51. Moving component; 52. Gripper; 521. Clearance groove; 522. Abutment part; 53. Movable component; 54. Return spring; 6. Second motor; 61. First fixing component; 62. Second fixing component; 63. Second output shaft; 64. Second guide rail; 65. Second slider; 66. First travel limit switch; 7. Third motor; 8. First slide rail; 81. Bracket; 82. Second travel limit switch; 83. First slider. Detailed Implementation

[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs; the terminology used herein in the specification of the application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application; the terms "comprising" and "having," and any variations thereof, in the specification, claims, and foregoing drawings of this application are intended to cover non-exclusive inclusion. The terms "first," "second," etc., in the specification, claims, or foregoing drawings of this application are used to distinguish different objects, not to describe a particular order.

[0034] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0035] To enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings.

[0036] The samples used in matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF-MS) need to be ionized, which requires a spotting device, also known as a pretreatment device for nucleic acid mass spectrometers. Usually, a separate spotting device is used, where the sample is spotted onto a silicon chip target and then manually placed into the mass spectrometer port before entering the mass spectrometer chamber for ionization analysis. The problem with this is that it requires manual intervention and is not efficient or automated.

[0037] Another common approach in existing technology is to use an integrated unit that automatically spots and transfers samples before they enter the mass spectrometer chamber for analysis. However, because the sample pretreatment unit and the mass spectrometer are fixed together, initial instrument setup is very cumbersome. Since the sample pretreatment unit and the mass spectrometer are separate modules, they require separate packaging for transport. Upon arrival at the user's location, assembly and adjustment are necessary, not only in height but also in the X and Y directions, which is quite inconvenient. Furthermore, the modular design requires space for assembly and adjustment, resulting in a very large integrated unit that occupies significant laboratory space. This also increases the distance required for the transfer module (300mm), leading to a higher probability of malfunction and deformation, and significantly reducing the instrument's accuracy and reliability. Moreover, any change in instrument location necessitates complete re-calibration, which is extremely inconvenient.

[0038] This application provides a fully automated mass spectrometer. Please refer to [link / reference]. Figures 1-10 As shown, the fully automated mass spectrometer includes:

[0039] Chip module 100, wherein chip 1 is disposed on chip module 100;

[0040] A mass spectrometer module 200 is disposed on one side of the chip module 100, and the mass spectrometer module 200 is provided with an opening 11 for removing and inserting the chip 1;

[0041] A first adjustment module is disposed on the chip module 100 and is used to adjust the chip module 100 so that the chip 1 and the opening 11 are on the same straight line.

[0042] A transfer module 300 is disposed on the chip module 100 or the mass spectrometer module 200, for transporting the chip 1 into the mass spectrometer module 200 and removing it from the mass spectrometer module 200.

[0043] This application uses the transfer module 300 to transfer the chip 1, which is more efficient than manual methods, enabling automated loading and unloading and maintaining consistent positions for each loading and unloading. In addition, this application uses the first adjustment module to adjust the chip module 100 so that the chip 1 and the opening 11 are on the same straight line, which is beneficial for the loading and unloading of the transfer module 300, and facilitates the adjustment of the position of the chip module 100, further improving the accuracy and efficiency of loading and unloading.

[0044] Furthermore, the statement that the chip 1 and the opening 11 are on the same straight line means that the center line of the chip 1 and the center line of the opening 11 are on the same straight line, that is, on the axis of the first direction X.

[0045] As attached Figure 1 To be continued Figure 2 As shown, in one embodiment, the fully automated mass spectrometer further includes a base plate 12. The chip module 100 and the mass spectrometer module 200 are disposed on the base plate 12. The chip module 100 includes a support frame 2. The first adjustment module includes a connector 10 disposed on one of the base plate 12 and the support frame 2, and a connecting groove 30 disposed on the other. The direction in which the first adjustment module adjusts the movement of the chip module 100 is defined as a first direction X. The length direction of the connecting groove 30 is parallel to the first direction X. By setting the connecting groove 30, the chip module 100 can be moved along the first direction X during installation, so that the connector 10 is placed at different positions in the connecting groove 30. The adjusted chip module 100 is fixed on the base plate 12 by the connector 10, which is beneficial for the splicing and debugging of the fully automated mass spectrometer. The chip 1 and the opening 11 are located on the same straight line, which facilitates the transfer module 300 to grasp and transfer the chip 1, reducing the occupied volume and deformation, and reducing the probability of mass spectrometer failure.

[0046] Furthermore, a foot pad 15 is provided below the base plate 12. The foot pad 15 can support the fully automatic mass spectrometer and also adjust the height to ensure that the base plate 12 is level. The connecting groove 30 is provided on the support frame 2, and the connecting member 10 is provided on the base plate 12. The connecting member 10 can be a bolt, connecting column, positioning pin, etc.

[0047] As attached Figure 1 To be continued Figure 3 As shown, in one embodiment, the chip module 100 further includes a chip holder 21, on which the chip 1 is disposed. The support frame 2 is movably connected to the chip holder 21. The first adjustment module further includes a first motor 3, a first transmission component 31, and a second transmission component 32. The first transmission component 31 and the second transmission component 32 are respectively disposed on the first motor 3 and the chip holder 21, and are connected in a transmission manner. The first motor 3 drives the first transmission component 31 and the second transmission component 32, thereby driving the chip holder 21 to move along the first direction X. The position of the chip module 100 can be further adjusted, and the first motor 3, the first transmission component 31, and the second transmission component 32 can be used to move the chip holder 21 along the first direction X, thereby realizing functions such as spotting and placing chips.

[0048] Furthermore, the first motor 3 is a through-type lead screw stepper motor, the first transmission component 31 is fixed on the chip holder 21, and the second transmission component 32 is configured as the lead screw on the first motor 3. The first motor 3 drives the second transmission component 32 to rotate, so that the second transmission component 32 drives the chip holder 21 to move back and forth on the support frame 2 along the first direction X through the first transmission component 31.

[0049] Furthermore, in existing technologies, the pretreatment and mass spectrometer are manufactured separately and then spliced ​​together. To facilitate rapid setup and debugging for customers, this application uses a single base plate 12 to house the mass spectrometer module 200 and the chip module 100. The mass spectrometer module 200 is fixed to the base plate 12 by four positioning blocks, keeping it stationary, while the chip module 100 can move back and forth. The entire integrated machine is 712mm long, which is a significant reduction in size compared to traditional nucleic acid mass spectrometer integrated machines.

[0050] As attached Figure 1 To be continued Figure 2 and attached Figure 4 To be continued Figure 10As shown, in one embodiment, the transfer module 300 includes a gripper assembly 400, a second adjustment assembly 500, and a third adjustment assembly 600. The second adjustment assembly 500 is used to drive the gripper assembly 400 to move along a second direction Y, and the third adjustment assembly 600 is used to drive the gripper assembly 400 to move along a third direction Z. The second direction Y is parallel to the straight line where the chip 1 and the opening 11 are located. The gripper assembly 400 can move in the second direction Y via the second adjustment assembly 500, so that the gripper assembly 400 can grip the chip 1 on the chip module 100 located on one side of the mass spectrometer module 200 and transfer it to the mass spectrometer module 200. At the same time, when the gripper assembly 400 moves above the opening 11, the gripper assembly 400 can move along the third direction Z via the third adjustment assembly 600, thereby placing the chip 1 from the opening 11 into the mass spectrometer module 200, or taking out the processed chip 1 from the mass spectrometer module 200. The structure is simple, the transfer is convenient, no manual intervention is required, and the fully automated sample spotting, target entry and exit are achieved. It also maintains the same position for each loading and unloading, improving efficiency and yield.

[0051] Furthermore, the first direction X, the second direction Y, and the third direction Z are arranged perpendicularly to each other, meaning that the first direction X, the second direction Y, and the third direction Z correspond to the X, Y, and Z axes in a Cartesian coordinate system, respectively. When viewed directly from the fully automated mass spectrometer, the first direction X is the front-back direction, the second direction Y is the left-right direction, and the third direction Z is the up-down direction.

[0052] As attached Figure 7 To be continued Figure 10 As shown, in one embodiment, the gripper assembly 400 includes a drive member 5, a movable member 51, and at least two grippers 52. The movable member 51 is disposed on the output shaft of the drive member 5 and between the two grippers 52. The drive member 5 drives the movable member 51 to move, causing the grippers 52 to clamp or release the chip 1. By retracting the movable member 51 to open the grippers 52, the front ends of the grippers 52 are positioned on both sides of the chip 1. Then, by extending the movable member 51 forward, the grippers 52 return to their original position after losing the support of the movable member 51, thereby clamping the chip 1. The structure is simple, the clamping method is stable and efficient, and it effectively prevents the chip 1 from falling and being damaged during transportation.

[0053] As attached Figure 7 To be continued Figure 10As shown, in one embodiment, the movable member 51 is provided with a movable member 53, and the movable member 51 is slidably connected to the gripper 52 through the movable member 53. The gripper 52 is provided with a relief groove 521 and an abutment portion 522, and a return spring 54 is also connected between the two grippers 52; as shown in the attached figure. Figure 8 As shown, when the movable member 53 abuts against the abutting part 522, the moving member 51 opens the gripper 52 to release the chip 1; as shown in the attached diagram. Figure 9 As shown, when the movable part 53 moves into the clearance groove 521, the gripper 52 is reset by the return spring 54 to clamp the chip 1. The movable part 51 is slidably connected to the gripper 52 through the movable part 53, which reduces friction during movement and prevents jamming. The addition of the return spring 54 enhances the clamping force of the gripper 52 on the chip 1, making the clamping method stable and efficient, and further preventing the chip 1 from falling and being damaged during transportation.

[0054] As attached Figure 1 To be continued Figure 2 and attached Figure 10 As shown, in one embodiment, a target cover 13 is further provided on the opening 11, and the target cover 13 is provided with a slot 131 for the gripper 52 to clamp. The target cover 13 closes the opening 11 when the fully automated mass spectrometer is working to prevent external interference from ionization analysis performed on the chip 1.

[0055] As attached Figure 1 To be continued Figure 2 As shown, in one embodiment, the mass spectrometer module 200 is further provided with a base 14 for placing the target cover 13, and the base 14 and the opening 11 are located on the same straight line. This allows the gripper assembly 400 of the transfer module 300 to first transfer the target cover 13 from the opening 11 to the base 14, then transfer the chip 1 from the chip module 100 to the mass spectrometer module 200, and finally transfer the target cover 13 located on the base 14 to the opening 11, sealing the opening 11. This facilitates loading and unloading by the transfer module 300, resulting in a simple structure, convenient transport, and enabling the fully automated mass spectrometer to achieve automated loading and unloading while maintaining consistent loading and unloading positions, thus improving efficiency and yield.

[0056] Furthermore, the fact that the seat 14 and the opening 11 are on the same straight line means that the center line of the seat 14 and the center line of the opening 11 are on the same straight line, that is, on the axis of the first direction X.

[0057] As attached Figure 4 To be continued Figure 6As shown, in one embodiment, the third adjustment component 600 includes a second motor 6, a first fixing member 61, and a second fixing member 62. The gripper assembly 400 and the second motor 6 are fixedly mounted on the first fixing member 61, and the second output shaft 63 of the second motor 6 is fixedly mounted on the second fixing member 62. The second motor 6 drives the second output shaft 63 to rotate, causing the first fixing member 61 and the second fixing member 62 to move closer to and further away from each other. The second motor 6 allows the gripper assembly 400 to move in the Z-direction, thereby placing the chip 1 from the opening 11 into the mass spectrometer module 200 or removing the analyzed chip 1 from the mass spectrometer module 200. The structure is simple, and the transport is convenient, enabling the fully automatic mass spectrometer to achieve automated loading and unloading, maintaining consistent loading and unloading positions each time, thus improving efficiency and yield.

[0058] Furthermore, the second motor 6 is a through-type lead screw stepper motor, and the second output shaft 63 is configured as the lead screw on the first motor 3. The second motor 6 drives the second output shaft 63 to rotate. Since one end of the second output shaft 63 is fixedly connected to the second fixing member 62, the second motor 6 drives the first fixing member 61 to climb or descend, that is, drives the gripper assembly 400 to move back and forth along the third direction Z.

[0059] Furthermore, the third adjustment component 600 includes a second guide rail 64 disposed on the second fixing member 62 and a second slider 65 disposed on the first fixing member 61. The second slider 65 is slidably disposed on the second guide rail 64, which facilitates the second motor 6 to drive the first fixing member 61 to climb or descend.

[0060] Furthermore, the third adjustment component 600 also includes a first travel limit switch 66 disposed on the second fixing member 62. When the first fixing member 61 moves along the third direction Z and touches the first travel limit switch 66, it reaches the zero position of the Z axis.

[0061] As attached Figure 4 To be continued Figure 6As shown, in one embodiment, the second adjustment component 500 includes a third motor 7, a first slide rail 8, and a bracket 81. The first slide rail 8 is slidably disposed on the bracket 81. The gripper assembly 400 and the second motor 6 are fixedly disposed on the first slide rail 8 via the first fixing member 61. The third motor 7 is fixedly disposed on the bracket 81. The third output shaft 71 of the third motor 7 is fixedly disposed on the second fixing member 62. The third motor 7 drives the third output shaft 71 to rotate, so that the second fixing member 62 and the third motor 7 move closer and further away from each other. The third motor 7 enables the gripper assembly 400 to move in the second direction Y, thereby allowing the gripper assembly 400 to transfer the target cover 13 from the opening 11 to the base 14, transfer the chip 1 from the chip module 100 to the mass spectrometer module 200, and transfer the target cover 13 located on the base 14 to the opening 11 and seal the opening 11. The structure is simple and the transfer is convenient, enabling the fully automatic mass spectrometer to achieve automated loading and unloading, and maintain the same position for each loading and unloading, thereby improving efficiency and yield.

[0062] Furthermore, the bracket 81 is also provided with a first slider 83, the first slide rail 8 and the first slider 83 are slidably connected, the third motor 7 is a through-type lead screw stepper motor, the third output shaft 71 is configured as the lead screw on the first motor 3, the third motor 7 drives the third output shaft 71 to rotate, since one end of the third output shaft 71 is fixedly connected to the second fixing member 62, the third motor 7 drives the second fixing member 62 and the first slide rail 8 to move left or right on the first slider 83, that is, drives the gripper assembly 400 to move back and forth along the second direction Y.

[0063] Furthermore, the second adjustment component 500 also includes a second travel limit switch 82 disposed on the first slide rail 8. When the first slide rail 8 moves along the third direction Z and the right end of the first slide rail 8 touches the second travel limit switch 82, it reaches the zero position of the Y axis.

[0064] Working principle: First, the sample is applied to the slot of chip 1 using a sample application device; second, the gripper assembly 400 of the transfer module 300 first picks up the target cover 13 from the opening 11, moves it along the second direction Y and places it on the base 14, then moves it along the second direction Y to above the chip 1, then moves it along the third direction Z to the chip 1 and clamps it, then moves it along the third direction Z and then along the second direction Y, thereby moving the chip 1 to the opening 11. Above 1, the chip 1 can be moved along the third direction Z to place it into the mass spectrometer module 200. Finally, the target cover 13 on the base 14 is clamped and transferred to the opening 11 to seal the opening 11. Then, the mass spectrometer module 200 is started. At this time, the space inside the mass spectrometer module 200 is evacuated by the pre-pump. The chip 1 is moved into the mass spectrometer cavity through the mass spectrometer's transfer module for laser ionization analysis. After the analysis is completed, the target removal process is reversed, and the next cycle is repeated.

[0065] Obviously, the embodiments described above are only some embodiments of this application, not all embodiments. The accompanying drawings show preferred embodiments of this application, but do not limit the patent scope of this application. This application can be implemented in many different forms; rather, the purpose of providing these embodiments is to provide a more thorough and comprehensive understanding of the disclosure of this application. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing specific embodiments, or make equivalent substitutions for some of the technical features. Any equivalent structures made using the content of this application's specification and drawings, directly or indirectly applied to other related technical fields, are similarly within the scope of patent protection of this application.

Claims

1. A fully automated mass spectrometer, characterized in that, include: A chip module (100) is provided with a chip holder for placing a chip (1); A mass spectrometer module (200) is disposed on one side of the chip module (100), and the mass spectrometer module (200) is provided with an opening (11) for taking out and putting in the chip (1); The first adjustment module is disposed on the chip module (100) and is used to adjust the chip module (100) so that the chip (1) and the opening (11) are on the same straight line; A transfer module (300) is disposed on the chip module (100) or the mass spectrometer module (200) for transporting the chip (1) into the mass spectrometer module (200) and removing it from the mass spectrometer module (200).

2. The fully automated mass spectrometer according to claim 1, characterized in that, The fully automated mass spectrometer also includes a base plate (12), the chip module (100) and the mass spectrometer module (200) are disposed on the base plate (12), the chip module (100) includes a support frame (2), the first adjustment module includes a connector (10) disposed on one of the base plate (12) and the support frame (2) and a connecting groove (30) disposed on the other, the first adjustment module adjusts the direction of movement of the chip module (100) to a first direction, and the length direction of the connecting groove (30) is parallel to the first direction.

3. The fully automated mass spectrometer according to claim 2, characterized in that, The chip module (100) further includes a chip holder (21), the chip (1) is disposed on the chip holder (21), the support frame (2) and the chip holder (21) are movably connected, the first adjustment module further includes a first motor (3), a first transmission component (31) and a second transmission component (32), the first transmission component (31) and the second transmission component (32) are respectively disposed on the first motor (3) and the chip holder (21), the first transmission component (31) and the second transmission component (32) are connected in transmission, the first motor (3) drives the first transmission component (31) and the second transmission component (32), thereby driving the chip holder (21) to move along the first direction.

4. The fully automated mass spectrometer according to any one of claims 1-3, characterized in that, The transfer module (300) includes a gripper assembly (400), a second adjustment assembly (500), and a third adjustment assembly (600). The second adjustment assembly (500) is used to drive the gripper assembly (400) to move along a second direction, and the third adjustment assembly (600) is used to drive the gripper assembly (400) to move along a third direction. The second direction is parallel to the straight line where the chip (1) and the opening (11) are located.

5. The fully automated mass spectrometer according to claim 4, characterized in that, The gripper assembly (400) includes a drive member (5), a moving member (51), and at least two grippers (52). The moving member (51) is disposed on the output shaft of the drive member (5) and is disposed between the two grippers (52). The drive member (5) is used to drive the moving member (51) to move, so that the grippers (52) clamp or release the chip (1).

6. The fully automated mass spectrometer according to claim 5, characterized in that, The movable member (51) is provided with a movable member (53), which is slidably connected to the gripper (52) through the movable member (53). The gripper (52) is provided with a relief groove (521) and an abutment part (522). A return spring (54) is also connected between the two grippers (52). When the movable member (53) abuts against the abutment part (522), the movable member (51) opens the gripper (52) to release the chip (1). When the movable member (53) moves into the relief groove (521), the gripper (52) is reset by the return spring (54) to clamp the chip (1).

7. The fully automated mass spectrometer according to claim 5, characterized in that, The opening (11) is also provided with a target cover (13), and the target cover (13) is provided with a slot (131) for the gripper (52) to clamp.

8. The fully automated mass spectrometer according to claim 7, characterized in that, The mass spectrometer module (200) is also provided with a base (14) for placing the target cover (13), and the base (14) and the opening (11) are located on the same straight line.

9. The fully automated mass spectrometer according to claim 4, characterized in that, The third adjustment component (600) includes a second motor (6), a first fixing member (61), and a second fixing member (62). The gripper assembly (400) and the second motor (6) are fixedly mounted on the first fixing member (61). The second output shaft (63) of the second motor (6) is fixedly mounted on the second fixing member (62). The second motor (6) drives the second output shaft (63) to rotate so that the first fixing member (61) and the second fixing member (62) move closer to each other and further away from each other.

10. The fully automated mass spectrometer according to claim 9, characterized in that, The second adjustment assembly (500) includes a third motor (7), a first slide rail (8), and a bracket (81). The first slide rail (8) is slidably mounted on the bracket (81). The gripper assembly (400) and the second motor (6) are fixedly mounted on the first slide rail (8) via the first fixing member (61). The third motor (7) is fixedly mounted on the bracket (81). The third output shaft (71) of the third motor (7) is fixedly mounted on the second fixing member (62). The third motor (7) drives the third output shaft (71) to rotate so that the second fixing member (62) and the third motor (7) move closer to each other and further away from each other.

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