一种用于凝胶制剂湿热灭菌的工具盒
By designing a toolbox for moist heat sterilization of gel formulations, using long-rod screws and nuts to tighten the syringe stopper, combined with a spring and guide tube structure, the problem of stopper damage caused by gel expansion or pressure difference is solved, ensuring the integrity of the sterile barrier during the sterilization process.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- ZHEJIANG TIANYAN BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-04-03
- Publication Date
- 2026-07-17
AI Technical Summary
During the moist heat sterilization process of gel formulations, the expansion of the gel inside the syringe or the pressure difference between the inside and outside of the stopper may cause the stopper to be ejected, damaging the sterile barrier and resulting in product spoilage.
A toolbox for moist heat sterilization of gel preparations was designed, including a box body and a cover. The syringe stopper is pressed into the bottle mouth by the cooperation of a long rod screw and nut, and the rigid contact is reduced by the use of a spring and guide tube structure to prevent damage to the stopper.
This effectively prevents the rubber stopper from being ejected, avoids product spoilage, and ensures the integrity of the aseptic barrier during the sterilization process.
Smart Images
Figure CN224505929U_ABST
Abstract
Claims
1. A kit for moist heat sterilization of a gel formulation comprising a box body (1) and a lid (2), characterized in that: The cover (2) is fitted onto the top of the box (1). The bottom of the box (1) near both sides is provided with a first through hole (11), and the top of the cover (2) near both sides is provided with a second through hole (21). A long rod screw (3) is inserted and movably connected in the second through hole (21). The bottom of the long rod screw (3) is inserted into the first through hole (11), and a nut (31) is fitted and threaded onto one end of the long rod screw (3) extending into the first through hole (11). A protective tube (5) is fixedly connected to the inner bottom wall of the box body (1) near the first through hole (11). The first through hole (11) is located inside the protective tube (5). The long rod screw (3) passes through the protective tube (5). A spring (41) is fixedly connected to the inner top wall of the cover body (2) near both sides. A pressing plate (4) is fixedly connected to the bottom of the spring (41). The cover (2) is also fixedly connected to the inner top wall near the second through hole (21) and the second through hole (21) is located inside the guide tube (42). The long rod screw (3) is inserted into the inner hole of the guide tube (42). The pressing plate (4) has sliding holes (421) at both ends. The pressing plate (4) is sleeved on the outer surface of the guide tube (42) through the sliding holes (421) and is slidably connected to the guide tube (42). The spring (41) is sleeved on the outer surface of the guide tube (42). The bottom of the guide tube (42) is fixedly connected to a boss (422).
2. A kit for moist heat sterilization of a gel formulation according to claim 1, wherein The bottom of the box body (1) is provided with several flow holes (12), and the flow holes (12) are arranged in a rectangular array.
3. A kit for moist heat sterilization of a gel formulation according to claim 1, wherein The cover (2) has several circumferentially distributed observation holes (22) on its circumferential side, with the top and bottom of the observation holes (22) close to the top and bottom of the cover (2), respectively.
4. A kit for moist heat sterilization of a gel formulation according to claim 1, wherein The bottom sides of the box (1) are fixedly connected with support columns (6), and the height of the support columns (6) is greater than the length of the long rod screw (3) extending out of the first through hole (11).
5. A kit for moist heat sterilization of a gel formulation according to claim 1, wherein The inner diameter of the protective tube (5) is larger than the diameter of the long rod screw (3).
6. A kit for moist heat sterilization of a gel formulation according to claim 1, wherein Two springs (41) are provided, and the size of the pressing plate (4) is adapted to the size of the cover (2).
7. A kit for moist heat sterilization of a gel formulation according to claim 1, wherein The boss (422) is used to prevent the pressing plate (4) from separating from the guide tube (42).