HPLC column packer pressure control device

Abstract

This utility model discloses a pressure control device for an HPLC column packer, including a column packer body and a robotic arm. The robotic arm is externally mounted on the column packer body, and its power output end has a quick-change interface. A PLC control box is located on one side of the column packer body, and a homogenizing tank is located on the other side. A pressure relief valve is located at the top of the column packer body, and a support frame is located at the top of the column packer body on the side of the pressure relief valve. Pressure gauges are symmetrically arranged at the top of the column packer body on the side of the support frame, and a placement sleeve is located inside the support frame. This utility model not only provides shock-absorbing support for the camera to prevent camera shaking, facilitates horizontal adjustment of the camera angle and flexible assembly and disassembly of the contour clamp, and facilitates precise programmed control of the column packing pressure, but also improves the accuracy of column packing.

Description

Technical Field

[0001] This utility model relates to the field of pressure control device technology, specifically a pressure control device for an HPLC column packing machine. Background Technology

[0002] Chromatography is a separation and analysis method, with separation being the core. Therefore, the chromatographic column, which performs the separation function, is the heart of the chromatographic system. The requirements for chromatographic columns include high column efficiency, good selectivity, and fast analysis speed. Commercially available particulate packing materials for HPLC, such as porous silica gel and silica-based bonded phases, alumina, organic polymer microspheres (including ion exchange resins), and porous carbon, require a column packer for column packing. Traditional HPLC column packers rely on manual valve adjustment for pressure control, which has the following structural defects: strong operational dependence: pressure adjustment is entirely done manually by observing the pressure gauge and manually rotating the valve; different operators have significantly different techniques (e.g., rotation speed, force), leading to uneven packing density; low pressure control accuracy; and the process is not reproducible, resulting in significant batch-to-batch column performance differences. Although some existing column packers have added electronic pressure sensors and electric valves, they still suffer from high costs and the need for manual preset of fixed pressure points. Furthermore, they do not address the structural innovation requirement of visually recognizing pressure gauge values ​​combined with a robotic arm for valve adjustment. To improve this situation, a pressure control device for an HPLC column packer is proposed.

[0003] As disclosed in authorization announcement number CN220276349U, a high-performance liquid chromatography (HPLC) column packing machine includes a housing with an air inlet, a liquid inlet, and a high-pressure liquid outlet. An oil-water filter and a pneumatic pump are housed inside the housing. A media regulating valve, a driving pressure gauge, a working pressure gauge, and a gas pressure regulating valve are all fixed to the front panel of the housing. The air inlet connects to the oil-water filter and then to the inlet of the driving gas regulating valve. The gas pressure regulating valve has multiple interfaces; one interface is connected to the driving pressure gauge via a pipeline, and another interface is connected to the air inlet of the pneumatic pump via a pipeline. The high-pressure liquid outlet of the pneumatic pump is connected to the high-pressure liquid outlet via the working pressure gauge. The liquid inlet of the pneumatic pump is connected to the media regulating valve, allowing switching between two displacement liquid media.

[0004] Although it achieves the use of high-pressure pneumatic boosting principle, it has the characteristics of high safety, high pressure, good pressure resistance, long pressure holding, portability, simple structure, good stability, and easy loading and disassembly of chromatographic columns;

[0005] However, it did not solve the problem that the existing pressure control device is not conducive to providing shock absorption support for the camera to prevent camera shaking, is not conducive to horizontal adjustment of the camera angle and flexible assembly and disassembly of the contour clamp, and affects the accuracy of column packing. Utility Model Content

[0006] The purpose of this invention is to provide a pressure control device for an HPLC column packer, in order to solve the problems mentioned in the background art, such as the inconvenience of the pressure control device in providing shock-absorbing support for the camera to prevent camera shaking, the difficulty in horizontally adjusting the camera angle and flexibly disassembling and assembling the contour clamp, which affects the accuracy of column packing.

[0007] To achieve the above objectives, this utility model provides the following technical solution: a pressure control device for an HPLC column packer, comprising a column packer body and a robotic arm. The robotic arm is externally mounted on the column packer body, and a quick-change interface is provided at the power output end of the robotic arm. A PLC control box is located on one side of the column packer body, and a homogenizing tank is located on the other side of the column packer body. A pressure relief valve is located at the top of the column packer body, and a support frame is located at the top of the column packer body on one side of the pressure relief valve. Pressure gauges are symmetrically arranged at the top of the column packer body on one side of the support frame. A placement sleeve is located inside the support frame. Multiple sets of equally spaced inner connecting buckles are provided on the outer wall of the placement sleeve, and multiple sets of equally spaced outer connecting buckles are provided on the inner wall of the support frame. Steel wire ropes are provided at both the upper and lower ends of the outer connecting buckles, and the steel wire ropes extend to the surface of the inner connecting buckles and connect with them. A placement rod is located inside the placement sleeve.

[0008] Preferably, a balance plate is provided at the top of the placement rod, and a movable shaft is provided at the bottom of the balance plate, and the balance plate is movably connected to the placement rod through the movable shaft.

[0009] Preferably, an electric push rod is provided on the side wall of the placement rod, and the electric push rod is movably connected to the placement rod.

[0010] Preferably, the output end of the electric push rod is provided with a push arm, and the end of the push arm near the balance plate is provided with a hinge shaft, and the push arm is movably connected to the balance plate through the hinge shaft.

[0011] Preferably, cameras are symmetrically arranged at the top of the balance plate, and level instruments are arranged on the side walls of the balance plate.

[0012] Preferably, the quick-change interface has a connecting rod inside, and a contour clamp is provided at the end of the connecting rod away from the quick-change interface.

[0013] Preferably, the outer wall of the connecting rod is provided with an external thread, the inner wall of the quick-change interface is provided with an internal thread, and the external thread and the internal thread are threadedly connected.

[0014] Preferably, torque sensors are symmetrically arranged on the inner wall of the contouring fixture, and the torque sensors are fixedly connected to the contouring fixture.

[0015] Compared with the prior art, the beneficial effects of this utility model are: the pressure control device not only provides shock-absorbing support for the camera to prevent camera shaking, but also facilitates the horizontal adjustment of the camera angle and the flexible assembly and disassembly of the contour clamp, and facilitates the programmed and precise control of the column packing pressure, but also improves the accuracy of column packing.

[0016] (1) Insert the placement rod into the inside of the placement sleeve. The placement rod and the placement sleeve are interference fit. Install the camera on the top of the balance plate. The electric push rod drives the push arm to move. The push arm drives the balance plate to rotate around the movable axis through the hinge shaft. The balance plate drives the camera to rotate to adjust the camera angle. By observing the level, the camera is adjusted to a horizontal position so that the camera is aligned with the pressure gauge. The device will generate vibration during operation. In order to avoid the camera from shifting due to vibration, if vibration occurs, the vibration is transmitted to the inside of the placement sleeve through the placement rod. The placement sleeve drives the inner connecting buckle to move and the inner connecting buckle pulls the steel wire rope. Under the limiting cooperation of the outer connecting buckle, the outer connecting buckle provides a reverse pull to the steel wire rope to offset the shaking of this part, thereby achieving the effect of shock absorption and preventing the lens from shaking. It provides shock absorption support for the camera and prevents the camera from shaking during monitoring, which causes data deviation. It also facilitates the horizontal adjustment of the camera angle.

[0017] (2) The PLC control box controls the robotic arm to move the connecting rod and the contouring fixture to the position of the pressure relief valve. The PLC control box calculates the required rotation angle of the valve according to the target value and opens the pressure relief valve through the contouring fixture. The torque sensor in the contouring fixture monitors the rotation resistance in real time. When the limit is exceeded, the action stops and an alarm is triggered. After the target pressure is reached, the PLC control box controls the robotic arm to lock the valve position and maintain it for the set time. The chromatographic pressure in the homogenizer is then pumped into the chromatographic column. After that, the pressure relief valve is closed. If the model of the pressure relief valve is different and the contouring fixture needs to be replaced, the connecting rod is rotated to remove the connecting rod from the quick-change interface. Then, a new contouring fixture is installed and reinstalled. This achieves flexible disassembly and assembly of the contouring fixture and improves the convenience of disassembly and assembly. Attached Figure Description

[0018] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0019] Figure 2 This is a three-dimensional structural diagram of the column loading machine body of this utility model;

[0020] Figure 3 This is a three-dimensional structural diagram of the quick-change interface and connecting rod of this utility model;

[0021] Figure 4 This is a three-dimensional perspective structural diagram of the support frame of this utility model;

[0022] Figure 5 This is a rear view structural diagram of the balance plate of this utility model;

[0023] Figure 6 This is a schematic diagram of the electrical connection structure of this utility model.

[0024] In the diagram: 1. Column loading machine body; 2. Pressure relief valve; 3. PLC control box; 4. Pressure gauge; 5. Homogenizing tank; 6. Camera; 7. Robotic arm; 8. Quick-change interface; 9. Support frame; 10. Placement sleeve; 11. Placement rod; 12. Internal thread; 13. External thread; 14. Connecting rod; 15. Torque sensor; 16. Internal connecting buckle; 17. Steel wire rope; 18. External connecting buckle; 19. Electric push rod; 20. Push arm; 21. Hinge shaft; 22. Movable shaft; 23. Balance plate; 24. Level; 25. Contouring clamp. Detailed Implementation

[0025] To further illustrate the technical means and effects adopted by this utility model in order to achieve the intended utility model purpose, the following detailed description of the specific implementation methods, structure, features and effects of this utility model is provided in conjunction with the accompanying drawings and preferred embodiments.

[0026] Please see Figure 1-6 An embodiment of this utility model provides a pressure control device for an HPLC column packer, comprising a column packer body 1 and a robotic arm 7. The robotic arm 7 is provided on the outside of the column packer body 1, and a quick-change interface 8 is provided at the power output end of the robotic arm 7. A PLC control box 3 is provided on one side of the column packer body 1, and a homogenizing tank 5 is provided on the other side of the column packer body 1. A pressure relief valve 2 is provided at the top of the column packer body 1. A support frame 9 is provided at the top of the column packer body 1 on one side of the pressure relief valve 2. Pressure gauges 4 are symmetrically provided at the top of the column packer body 1 on one side of the support frame 9. A placement sleeve 10 is provided inside the support frame 9. Multiple sets of internal connecting buckles 16 with equal spacing are provided on the outer wall of the placement sleeve 10. Multiple sets of external connecting buckles 18 with equal spacing are provided on the inner wall of the support frame 9. Steel wire ropes 17 are provided at both the upper and lower ends of the external connecting buckles 18, and the steel wire ropes 17 extend to the surface of the internal connecting buckles 16 and connect with the internal connecting buckles 16. A placement rod 11 is provided inside the placement sleeve 10.

[0027] A balance plate 23 is provided at the top of the placement rod 11, and a movable shaft 22 is provided at the bottom of the balance plate 23. The balance plate 23 is movably connected to the placement rod 11 through the movable shaft 22.

[0028] An electric push rod 19 is provided on the side wall of the placement rod 11. The electric push rod 19 plays the role of power drive and is movably connected to the placement rod 11. A push arm 20 is provided at the output end of the electric push rod 19. A hinge shaft 21 is provided at the end of the push arm 20 near the balance plate 23, and the push arm 20 is movably connected to the balance plate 23 through the hinge shaft 21.

[0029] A camera 6 is symmetrically arranged at the top of the balance plate 23, and a level 24 is arranged on the side wall of the balance plate 23.

[0030] Insert the placement rod 11 into the placement sleeve 10. The placement rod 11 and the placement sleeve 10 are interference-fitted. Mount the camera 6 on the top of the balance plate 23. Turn on the electric push rod 19, which drives the push arm 20 to move. The push arm 20 drives the balance plate 23 to rotate around the movable shaft 22 via the hinge shaft 21. The balance plate 23 drives the camera 6 to rotate, thereby adjusting the angle of the camera 6. By observing the level 24, the camera 6 is adjusted to a horizontal position so that the camera 6 is aligned with the pressure gauge 4. This device will generate vibration during operation. To avoid the vibration from damaging the camera... If a deviation occurs and vibration occurs, the vibration is transmitted to the inside of the placement sleeve 10 through the placement rod 11. The placement sleeve 10 drives the inner connecting buckle 16 to move, and the inner connecting buckle 16 pulls the steel wire rope 17. Under the limiting cooperation of the outer connecting buckle 18, the outer connecting buckle 18 provides a reverse pull to the steel wire rope 17, thereby canceling out the shaking of this part, thus achieving the effect of shock absorption, avoiding lens shaking, providing shock absorption support for the camera, avoiding camera shaking during monitoring and causing data deviation, and facilitating horizontal adjustment of the camera angle;

[0031] The quick-change interface 8 has a connecting rod 14 inside, and a contour clamp 25 is provided at the end of the connecting rod 14 away from the quick-change interface 8.

[0032] The outer wall of the connecting rod 14 is provided with an external thread 13, the inner wall of the quick-change interface 8 is provided with an internal thread 12, and the external thread 13 and the internal thread 12 are threadedly connected. The inner wall of the contour clamp 25 is symmetrically provided with torque sensors 15, and the torque sensors 15 are fixedly connected to the contour clamp 25.

[0033] The device is controlled by a PLC control box 3. Its workflow is as follows: the chromatographic column is placed at the bottom of the homogenizing tank 5; the camera 6 monitors the pressure data on the pressure gauge 4 in real time and transmits the monitored pressure data to the PLC control box 3; the PLC control box 3 calculates the current pressure value; the PLC control box 3 then controls the robotic arm 7 to move the connecting rod 14 and the contour clamp 25 to the position of the pressure relief valve 2; the PLC control box 3 calculates the required rotation angle of the valve based on the target value and opens the pressure relief valve 2 through the contour clamp 25; the torque sensor 1 inside the contour clamp 25... 5. Real-time monitoring of rotational resistance; if the limit is exceeded, the action stops and an alarm is triggered. After reaching the target pressure, the PLC control box 3 controls the robotic arm 7 to lock the valve position and maintain it for the set time, pressing the chromatographic pressure in the homogenizer 5 into the chromatographic column. Then, the pressure relief valve 2 is closed. If the pressure relief valve 2 is of a different model and the contour clamp 25 needs to be replaced, rotate the connecting rod 14. Under the threaded connection of the external thread 13 and the internal thread 12, the connecting rod 14 is removed from the quick-change interface 8. Then, a new contour clamp 25 is replaced and reinstalled. This achieves flexible disassembly and assembly of the contour clamp, improving the convenience of disassembly and assembly.

[0034] Working principle: Insert the placement rod 11 into the placement sleeve 10. The placement rod 11 and the placement sleeve 10 are interference-fitted. Mount the camera 6 on the top of the balance plate 23. Turn on the electric push rod 19, which drives the push arm 20 to move. The push arm 20 drives the balance plate 23 to rotate around the movable shaft 22 via the hinge shaft 21. The balance plate 23 drives the camera 6 to rotate, thereby adjusting the angle of the camera 6. By observing the level 24, the camera 6 is adjusted to a horizontal position, so that the camera 6 is aligned with the pressure gauge 4. This device... Vibration occurs during operation. To prevent camera 6 from shifting due to vibration, if vibration occurs, it is transmitted through the placement rod 11 to the inside of the placement sleeve 10. The placement sleeve 10 then moves the inner connecting buckle 16, which pulls the steel wire rope 17. Under the limiting action of the outer connecting buckle 18, the outer connecting buckle 18 provides a reverse pull to the steel wire rope 17, thereby counteracting the shaking and achieving shock absorption to prevent lens shake. This device is controlled by the PLC control box 3. The workflow is as follows: The chromatographic column is placed at the bottom of the homogenizing tank 5. The camera 6 monitors the pressure data on the pressure gauge 4 in real time and transmits the monitored pressure data to the PLC control box 3. The PLC control box 3 calculates the current pressure value and controls the robotic arm 7 to move the connecting rod 14 and the contour clamp 25 to the position of the pressure relief valve 2. The PLC control box 3 calculates the required rotation angle of the valve based on the target value and opens the pressure relief valve 2 through the contour clamp 25. The torque within the contour clamp 25... Sensor 15 monitors the rotational resistance in real time. When the resistance exceeds the limit, it stops and alarms. After reaching the target pressure, PLC control box 3 controls robotic arm 7 to lock the valve position and maintain it for the set time. The chromatographic pressure in homogenizer 5 is then pumped into the chromatographic column. After that, the pressure relief valve 2 is closed. If the pressure relief valve 2 is a different model and the contour clamp 25 needs to be replaced, rotate connecting rod 14. Under the threaded connection of external thread 13 and internal thread 12, disconnect connecting rod 14 from quick-change interface 8. Then replace with a new contour clamp 25 and reinstall it.

[0035] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to a preferred embodiment, it is not intended to limit the present utility model. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present utility model. Any indirect modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present utility model without departing from the scope of the present utility model shall still fall within the scope of the present utility model.

Claims

1. A pressure control device for an HPLC column packer, comprising a column packer body (1) and a robotic arm (7), characterized in that: A robotic arm (7) is provided on the outside of the column loading machine body (1). The power output end of the robotic arm (7) is provided with a quick-change interface (8). A PLC control box (3) is provided on one side of the column loading machine body (1). A homogenizing tank (5) is provided on the other side of the column loading machine body (1). A pressure relief valve (2) is provided at the top of the column loading machine body (1). A support frame (9) is provided at the top of the column loading machine body (1) on one side of the pressure relief valve (2). Symmetrically arranged on the top of the column loading machine body (1) on one side of the support frame (9) are... The pressure gauge (4) has a placement sleeve (10) inside the support frame (9). The outer wall of the placement sleeve (10) has multiple sets of equally spaced inner connecting buckles (16). The inner wall of the support frame (9) has multiple sets of equally spaced outer connecting buckles (18). The upper and lower ends of the outer connecting buckles (18) are provided with wire ropes (17), and the wire ropes (17) extend to the surface of the inner connecting buckles (16) and are connected to the inner connecting buckles (16). The placement sleeve (10) has a placement rod (11) inside.

2. The HPLC column packing machine pressure control device according to claim 1, characterized in that: The top of the placement rod (11) is provided with a balance plate (23), and the bottom of the balance plate (23) is provided with a movable shaft (22). The balance plate (23) is movably connected to the placement rod (11) through the movable shaft (22).

3. The HPLC column packing machine pressure control device according to claim 1, characterized in that: An electric push rod (19) is provided on the side wall of the placement rod (11), and the electric push rod (19) is movably connected to the placement rod (11).

4. The HPLC column packing machine pressure control device according to claim 3, characterized in that: The output end of the electric push rod (19) is provided with a push arm (20), and the end of the push arm (20) near the balance plate (23) is provided with a hinge shaft (21), and the push arm (20) is movably connected to the balance plate (23) through the hinge shaft (21).

5. The HPLC column packing machine pressure control device according to claim 2, characterized in that: A camera (6) is symmetrically arranged at the top of the balance plate (23), and a level (24) is arranged on the side wall of the balance plate (23).

6. The pressure control device for an HPLC column packer according to claim 1, characterized in that: The quick-change interface (8) is provided with a connecting rod (14) inside, and a contour clamp (25) is provided at the end of the connecting rod (14) away from the quick-change interface (8).

7. The HPLC column packing machine pressure control device according to claim 6, characterized in that: The outer wall of the connecting rod (14) is provided with an external thread (13), and the inner wall of the quick-change interface (8) is provided with an internal thread (12), and the external thread (13) and the internal thread (12) are threadedly connected.

8. The HPLC column packing machine pressure control device according to claim 6, characterized in that: Torque sensors (15) are symmetrically arranged on the inner wall of the contour jig (25), and the torque sensors (15) are fixedly connected to the contour jig (25).

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