一种外泌体分离用振荡装置
By using modular design and positioning components, the problems of low efficiency and easy damage to test tubes in existing exosome oscillation devices have been solved, achieving an efficient and safe exosome separation process.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- DOLAIMI BIOTECHNOLOGY (WUHAN) CO LTD
- Filing Date
- 2025-07-31
- Publication Date
- 2026-07-17
AI Technical Summary
Existing exosome oscillation devices are inefficient when processing large batches of samples, and the test tubes are easily damaged during oscillation, affecting experimental results.
A vibration device for exosome separation was designed. It adopts a modular design, with a tray that can be detachably connected to the test tube container and positioning components, so as to achieve rapid fixation and stable vibration of the test tube and avoid damage to the test tube.
It improves the efficiency of high-throughput experiments, reduces sample transfer preparation time, enhances equipment reusability and test tube safety, and ensures the accuracy of experimental results.
Smart Images
Figure CN224506883U_ABST
Abstract
Claims
1. An oscillation device for exosome separation, characterized by, include: The outer shell (1) is provided with a tray (2) inside the outer shell (1). The tray (2) can move vertically along the inside of the outer shell (1). The outer shell (1) and the tray (2) are connected together by an oscillation component (6) for driving the tray (2) to achieve vertical oscillation. The test tube container (3) is detachably connected to the upper part of the tray (2). It has several sets of placement holes (4) for placing exosome test tubes and is equipped with a positioning component (7) to fix the exosome test tubes in the placement holes (4). The outer shell (1) has open operation ports (5) on both sides. The test tube container (3) can be taken out from the outer shell (1) by means of the operation ports (5). End caps (8) for sealing the inside of the outer casing (1) are detachably attached to the top of the outer casing (1).
2. The oscillation device for exosome separation according to claim 1, characterized in that, The positioning component (7) includes a movable cavity (71) opened on the side of the placement hole (4), the movable cavity (71) is connected to the placement hole (4), a rotatable shaft (72) is provided in the movable cavity (71), a stop rod (73) is sleeved on the shaft (72), and the clamping end of the stop rod (73) can extend through the movable cavity (71) into the placement hole (4); it also includes a pressing bolt (74) threaded to the top of the test tube container (3), the bottom of the pressing bolt (74) abuts against the pressing end of the stop rod (73), when the pressing bolt (74) moves down to press the pressing end of the stop rod (73), the clamping end of the stop rod (73) extends into the placement hole (4) to press and fix the exosome test tube between the placement hole (4) and the clamping end of the stop rod (73).
3. The oscillation device for exosome separation according to claim 2, characterized in that, The clamping end of the abutment (73) is connected to an arc-shaped pressure head (75), the inner wall of which is a flexible structure and abuts against the exosome test tube.
4. The oscillation device for exosome separation according to claim 2, characterized in that, The pressing ends of the pressing bolt (74) and the abutment rod (73) are respectively connected to the first magnetic absorbing piece.
5. The oscillation device for exosome separation according to claim 1, wherein The oscillation assembly (6) includes a connecting plate (61) fixed inside the outer shell (1), two sets of fixed cylinders (62) are fixedly connected above the connecting plate (61), and a first spring (63) is connected between the inside of the two fixed cylinders (62) and the support plate (2). A guide cylinder (64) is connected between the two fixed cylinders (62). A drive motor (65) is provided below the connecting plate (61). The output shaft of the drive motor (65) is connected to two cams. A drive rod is hinged between the two cams. A push cylinder (66) is hinged at the other end of the drive rod. The push cylinder (66) is pushed by the drive rod to move vertically inside the guide cylinder (64). The top of the push cylinder (66) abuts against the bottom wall of the support plate (2) and pushes the support plate (2) to achieve vertical oscillation inside the outer shell (1).
6. The oscillation device for exosome separation according to claim 5, wherein The bottom of the pallet (2) is fixed with a limiting cylinder (67), which is placed inside the guide cylinder (64) and moves vertically along the guide cylinder (64).
7. The oscillation device for exosome separation according to claim 6, wherein The bottom of the tray (2) is connected to a limiting rod and a limiting plate (68), and a limiting ring (69) is fixedly connected above the push cylinder (66). A second spring (610) is provided between the limiting ring (69) and the limiting plate (68).
8. The oscillation device for exosome separation according to claim 7, characterized in that, The top of the limiting ring (69) and / or the bottom wall of the push plate are provided with flexible anti-collision pads (611).
9. The oscillation device for exosome separation according to claim 1, wherein The top of the tray (2) and the bottom of the test tube container (3) are both provided with a second magnetic chuck (9). The two side walls of the test tube container (3) are fixedly connected with handles (10). The handles (10) can be placed in the operating port (5) and moved vertically. With the help of the handles (10), the test tube container (3) can be separated from the outer shell (1).
10. The oscillation device for exosome separation according to claim 1, wherein The outer shell (1) has guide grooves (11) on both sides, and guide blocks (12) are connected to both sides of the support plate (2). The guide blocks (12) can slide along the guide grooves (11).