Hydrothermal tank unit and system for producing diclofenac sodium sustained-release tablets

Abstract

This utility model provides a hydrothermal tank device and a system for producing diclofenac sodium sustained-release tablets, relating to the field of pharmaceutical equipment technology. The hydrothermal tank device includes a tank body with a first liquid inlet and a liquid outlet, which are connected by a liquid circulation pipe for circulating the liquid in the tank. The device also includes a gas supply pipe connected to the liquid circulation pipe, with the connection point between the gas supply pipe and the liquid circulation pipe located near the liquid outlet. A first sealing element is installed downstream to block the connection between the liquid outlet and the liquid circulation pipe. By providing the first sealing element, and because the gas supply pipe is connected to the circulation pipe, when compressed gas is introduced into the gas supply pipe, the gas can flow along the circulation pipe and exert pressure on the residual liquid therein, especially effectively removing residual liquid that is difficult to drain from the lower part of the pipe. This purging operation avoids long-term liquid stagnation and effectively prevents the growth of microorganisms in the liquid circulation pipe.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment technology, and in particular to a hot liquid tank device and a system for producing diclofenac sodium sustained-release tablets. Background Technology

[0002] In the production of diclofenac sodium sustained-release tablets, it is necessary to dissolve the materials cetyl alcohol and octadecyl alcohol by heating hot water to 70°C and using a water bath circulation method. The hot liquid tank is the core component of the heating system used to store, heat and stably provide circulating hot water, and provide a constant heat source for the granulation process.

[0003] Water in the hydrothermal tank is discharged from the outlet and transported to the inlet through the circulation pipeline, where it re-enters the hydrothermal tank to complete one cycle. Because there are high and low levels in the circulation pipeline, the remaining water in the low-level pipeline cannot be completely discharged after the cycle is completed. The long-term residual water will become a breeding ground for microorganisms, affecting the safety assessment of the equipment. Utility Model Content

[0004] The technical problem to be solved by this utility model is to overcome the defects in the prior art where, due to the existence of high and low level areas in the circulation pipeline, the residual water in the low level pipeline cannot be completely discharged after circulation ends, and the long-term residual water will become a breeding ground for microorganisms, affecting the safety assessment of the equipment. The present invention provides a hot liquid tank device and a system for producing diclofenac sodium sustained-release tablets.

[0005] The present invention solves the above-mentioned technical problems through the following technical solution:

[0006] This utility model provides a hydrothermal tank device, which includes a tank body, a first liquid inlet and a liquid outlet, and the first liquid inlet and the liquid outlet are connected by a liquid circulation pipe. The liquid circulation pipe is used to circulate the liquid in the tank body. The hydrothermal tank device also includes a gas supply pipe, which is connected to the liquid circulation pipe, and the connection between the gas supply pipe and the liquid circulation pipe is close to the liquid outlet.

[0007] A first sealing element is also provided downstream of the liquid outlet, which is used to block the connection between the liquid outlet and the liquid circulation pipeline.

[0008] In this solution, the first sealing element installed downstream of the liquid outlet blocks its connection with the liquid circulation pipeline. At the same time, since the gas supply pipeline is connected to this section of the circulation pipeline, when compressed gas is introduced into the gas supply pipeline, the gas can flow along the circulation pipeline and exert a pushing pressure on the residual liquid therein. In particular, it can completely discharge the residual liquid in the low-level area of ​​the circulation pipeline that is not easy to drain naturally. This purging operation avoids long-term liquid retention, thereby effectively preventing the growth of microorganisms in the liquid circulation pipeline.

[0009] Optionally, the hydrothermal tank assembly further includes a tee pipe;

[0010] The first port of the three-way pipe is connected to the liquid outlet, the second port of the three-way pipe is connected to the liquid circulation pipe, and the third port of the three-way pipe is connected to the gas transmission pipe.

[0011] The first sealing element is installed at the connection between the three-way pipe and the liquid outlet.

[0012] In this design, a three-way pipe is used to connect the liquid outlet, the liquid circulation pipe, and the gas transmission pipe. The first sealing element is installed at the connection between the three-way pipe and the liquid outlet. During normal circulation, the first sealing element remains open, and the liquid flows smoothly into the circulation pipe through the liquid outlet and the three-way pipe, ensuring the continuity of circulation. When purging is required, the first sealing element is closed to block the connection between the liquid outlet and the circulation pipe. The gas transmission pipe is then directly connected to the circulation pipe through the three-way pipe. At this time, compressed gas is introduced into the gas transmission pipe. The gas can flow along the circulation pipe and exert pressure on the residual liquid, especially the liquid in the low-level area that is difficult to discharge, to completely discharge it. This effectively avoids the problem of microbial growth caused by long-term liquid stagnation. At the same time, the integrated design of the three-way structure simplifies the pipeline connection and improves the compactness and ease of operation of the device.

[0013] Optionally, a second sealing element is provided at the connection between the tee pipe and the gas transmission pipe, the second sealing element being used to block the connection between the gas transmission pipe and the tee pipe.

[0014] In this solution, by installing a second sealing element at the connection between the tee pipe and the gas transmission pipe to block or open the connection between the two, the gas transmission pipe and the liquid circulation pipe are controlled. During normal liquid circulation, the second sealing element remains closed to prevent gas in the gas transmission pipe from accidentally entering the circulation pipe. When it is necessary to inject compressed gas into the circulation pipe using the gas transmission pipe, the second sealing element can be opened to allow gas to enter the circulation path only through the tee pipe.

[0015] Optionally, the liquid circulation pipeline is also connected to a drain pipeline, which is located near the first liquid inlet of the liquid circulation pipeline;

[0016] The hydrothermal tank device further includes a third sealing element and a drain valve. The third sealing element is installed on the pipeline between the first inlet and the inlet of the drain pipe, and the drain valve is installed on the drain pipe.

[0017] In this design, a drain pipe is installed near the first inlet on the liquid circulation pipeline, which can quickly discharge residual liquid in the circulation pipeline when it needs to be emptied or maintained. The third sealing element is installed on the pipeline between the first inlet and the inlet of the drain pipe, which can prevent the liquid in the liquid circulation pipeline from re-entering the tank when the pipeline is cleaned, ensuring that the residual liquid in the liquid circulation pipeline will not enter the tank and cause pollution to the inside of the tank. The drain valve can flexibly adjust the draining process by switching it on and off.

[0018] Optionally, the hydrothermal tank assembly further includes a flow control valve, which is disposed on the gas pipeline.

[0019] In this solution, a flow control valve is installed on the gas pipeline to precisely control the flow rate of gas within the pipeline. Under pipeline cleanliness conditions, the flow control valve can adjust the gas flow rate and pressure as needed, ensuring that compressed gas effectively pushes residual liquid out, while preventing the risk of pipeline overpressure due to excessive gas injection.

[0020] Optionally, the hot liquid tank device further includes a three-way valve, the three ports of which are respectively connected to the liquid outlet, the gas pipeline and the liquid circulation pipeline.

[0021] In this design, a three-way valve is used to connect the liquid outlet, gas pipeline and liquid circulation pipeline. The multi-path switching function of a single valve body realizes efficient and coordinated control of the system fluid. At the same time, the three-way valve reduces the number of components and connection nodes, thus reducing the risk of leakage.

[0022] Optionally, the tank body is further provided with a second liquid inlet, which is used to replenish liquid into the tank body;

[0023] And / or, the tank body is further provided with a through hole, and a float is installed in the through hole, the float being used to detect the liquid level in the tank body.

[0024] Optionally, the hot liquid tank device further includes a circulation pump for driving the flow of liquid in the liquid circulation pipe.

[0025] This invention also provides a system for producing diclofenac sodium sustained-release tablets, the system comprising the hydrothermal tank apparatus as described above.

[0026] Optionally, the system further includes a dissolving device for dissolving hexadecyl alcohol and octadecyl alcohol, the dissolving device including a dissolving tank, and the liquid circulation pipe disposed on the outer periphery of the dissolving tank.

[0027] In this scheme, the liquid circulation pipeline of the hot liquid tank device forms a heat exchange with the dissolving tank, stably maintaining the dissolving temperature in the dissolving tank and promoting the uniform dissolution of materials in the dissolving tank.

[0028] The positive and progressive effects of this utility model are as follows:

[0029] By blocking the connection between the liquid outlet and the liquid circulation pipeline by the first sealing element installed downstream of the outlet, and because the gas supply pipeline is connected to this section of the circulation pipeline, when compressed gas is introduced into the gas supply pipeline, the gas can flow along the circulation pipeline and exert pushing pressure on the residual liquid therein, especially able to completely discharge the residual liquid in the low-level area of ​​the circulation pipeline that is not easy to drain naturally; this purging operation avoids long-term liquid retention, thereby effectively preventing the growth of microorganisms in the liquid circulation pipeline. Attached Figure Description

[0030] Figure 1 A schematic diagram illustrating the connection and positional relationships between various structures of a hydrothermal tank device according to an embodiment of this utility model. Figure 1 ;

[0031] Figure 2 A schematic diagram illustrating the connection and positional relationships between various structures of a hydrothermal tank device according to an embodiment of this utility model. Figure 2 ;

[0032] Figure 3 This is a top view of a hydrothermal tank device according to an embodiment of the present invention.

[0033] Tank 1

[0034] First liquid inlet 11

[0035] Liquid outlet 12

[0036] Second liquid inlet 13

[0037] Through hole 14

[0038] Liquid circulation pipeline 2

[0039] Gas pipeline 3

[0040] First sealing element 4

[0041] 5-way pipe

[0042] Second sealing element 6

[0043] Drain pipe 7

[0044] Drain valve 71

[0045] Third sealing element 8

[0046] Flow control valve 9

[0047] Circulation pump 10 Detailed Implementation

[0048] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0049] It should be noted that if the embodiments of this utility model involve directional indicators (such as up, down, left, right, front, back, etc.), the directional indicators are only used to explain the relative positional relationship and movement of the components in a specific posture. If the specific posture changes, the directional indicators will also change accordingly.

[0050] Furthermore, if the embodiments of this utility model involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of indicated technical features. Therefore, features defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. If the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this utility model.

[0051] Example 1

[0052] Please see Figures 1 to 3 This utility model provides a hydrothermal tank device. Figure 1 A schematic diagram illustrating the connection and positional relationships between various structures of a hydrothermal tank device according to an embodiment of this utility model. Figure 1 , Figure 2 A schematic diagram illustrating the connection and positional relationships between various structures of a hydrothermal tank device according to an embodiment of this utility model. Figure 2 , Figure 3 This is a top view of a hydrothermal tank device according to an embodiment of the present invention, as shown in the figure. Figures 1 to 3As shown, the hot liquid tank device includes a tank body 1, which has a first liquid inlet 11 and a liquid outlet 12. The first liquid inlet 11 and the liquid outlet 12 are connected by a liquid circulation pipe 2, which is used to circulate the liquid in the tank body 1. The hot liquid tank device also includes a gas transmission pipe 3, which is connected to the liquid circulation pipe 2, and the connection between the gas transmission pipe 3 and the liquid circulation pipe 2 is close to the liquid outlet 12. A first sealing member 4 is also provided downstream of the liquid outlet 12, which is used to block the connection between the liquid outlet 12 and the liquid circulation pipe 2.

[0053] By blocking the connection between the liquid outlet 12 and the liquid circulation pipe 2 by the first sealing element 4 located downstream of the liquid outlet 12, and since the gas supply pipe 3 is connected to this section of the circulation pipe, when compressed gas is introduced into the gas supply pipe 3, the gas can flow along the circulation pipe and exert a pushing pressure on the residual liquid therein, especially able to completely discharge the residual liquid in the low-level area of ​​the circulation pipe that is not easy to drain naturally; this purging operation avoids long-term liquid retention, thereby effectively preventing the growth of microorganisms in the liquid circulation pipe 2.

[0054] Specifically, a first sealing element 4 is provided downstream of the liquid outlet 12. During liquid circulation, the first sealing element 4 downstream of the liquid outlet 12 is opened, and the liquid outlet 12 is connected to the liquid circulation pipeline 2. The liquid in the tank 1 can re-enter the first liquid inlet 11 of the tank 1 through the liquid circulation pipeline 2. After the liquid circulation is completed, under pipeline cleaning conditions, the first sealing element 4 is closed, blocking the connection between the liquid outlet 12 and the liquid circulation pipeline 2. At this time, compressed gas is introduced into the gas supply pipeline 3. The compressed gas enters the liquid circulation pipeline 2 and purges the residual liquid in the pipeline, so that the residual liquid at the lower level of the liquid circulation pipeline 2 is discharged, preventing the growth of microorganisms in the pipeline.

[0055] In this embodiment, the hot liquid tank device also includes a three-way pipe 5; the first interface of the three-way pipe 5 is connected to the liquid outlet 12, the second interface of the three-way pipe 5 is connected to the liquid circulation pipe 2, and the third interface of the three-way pipe 5 is connected to the gas transmission pipe 3; the first sealing member 4 is installed at the connection between the three-way pipe 5 and the liquid outlet 12.

[0056] By setting up a three-way pipe 5 to connect the liquid outlet 12, the liquid circulation pipe 2, and the gas transmission pipe 3 respectively, and installing the first sealing member 4 at the connection between the three-way pipe 5 and the liquid outlet 12, during normal circulation, that is, under liquid circulation conditions, the first sealing member 4 remains open, and the liquid flows smoothly into the circulation pipe through the liquid outlet 12 and the three-way pipe 5, ensuring the continuity of circulation; when purging is required, that is, under pipe cleaning conditions, the first sealing member 4 is closed to block the connection between the liquid outlet 12 and the circulation pipe, and the gas transmission pipe 3 is directly connected to the circulation pipe through the three-way pipe 5. At this time, compressed gas is introduced into the gas transmission pipe 3, and the gas can flow along the circulation pipe and form a pushing pressure on the residual liquid, especially the liquid in the low-level area that is not easy to be discharged, so as to completely discharge it, thereby effectively avoiding the problem of microbial growth caused by long-term liquid stagnation. At the same time, the integrated design of the three-way structure simplifies the pipeline connection and improves the compactness and ease of operation of the device.

[0057] In this embodiment, a second sealing element 6 is provided at the connection between the three-way pipe 5 and the gas transmission pipe 3. The second sealing element 6 is used to block the connection between the gas transmission pipe 3 and the three-way pipe 5.

[0058] By blocking or opening the connection between the two by the second sealing element 6 installed at the connection between the three-way pipe 5 and the gas transmission pipe 3, the gas transmission in the gas transmission pipe 3 and the liquid circulation pipe 2 can be controlled. During normal liquid circulation, the second sealing element 6 remains closed to prevent gas in the gas transmission pipe 3 from accidentally entering the circulation pipe. When it is necessary to inject compressed gas into the circulation pipe using the gas transmission pipe 3, the second sealing element 6 can be opened so that the gas enters the circulation path only through the three-way pipe 5.

[0059] Specifically, the second sealing element 6 is located at the connection between the three-way pipe 5 and the gas transmission pipe 3. The first sealing element 4 and the second sealing element 6 work together. Under liquid circulation conditions, the first sealing element 4 is opened and the second sealing element 6 is closed, blocking the connection between the three-way pipe 5 and the gas transmission pipe 3. This allows the liquid outlet 12 to connect with the liquid circulation pipe 2, while blocking the connection between the gas transmission pipe 3 and the liquid circulation pipe 2, ensuring normal liquid circulation within the tank 1. Under pipeline cleaning conditions, the first sealing element 4 is closed, blocking the connection between the liquid outlet 12 and the liquid circulation pipe 2. The second sealing element 6 is opened, connecting the gas transmission pipe 3 and the liquid circulation pipe 2. Gas introduced into the gas transmission pipe 3 enters the liquid circulation pipe 2 to purge the liquid inside.

[0060] In this embodiment, a drain pipe 7 is also connected to the liquid circulation pipe 2. The drain pipe 7 is located near the first inlet 11 of the liquid circulation pipe 2 and is used to drain the liquid in the liquid circulation pipe 2. The hot liquid tank device also includes a third sealing member 8 and a drain valve 71. The third sealing member 8 is installed on the pipeline between the first inlet 11 and the inlet of the drain pipe 7, and the drain valve 71 is installed on the drain pipe 7.

[0061] The drain pipe 7, located near the first inlet 11 on the liquid circulation pipe 2, can quickly discharge residual liquid in the circulation pipe when it needs to be emptied or maintained. The third sealing element 8 is installed on the pipeline between the first inlet 11 and the inlet of the drain pipe 7. When cleaning the pipeline, it can prevent the liquid in the liquid circulation pipe 2 from re-entering the tank 1, ensuring that the residual liquid in the liquid circulation pipe 2 will not enter the tank 1 and cause pollution to the inside of the tank 1. The drain valve 71 can flexibly adjust the draining process by switching it on and off.

[0062] In this embodiment, the hot liquid tank device also includes a flow control valve 9, which is installed on the gas pipeline 3.

[0063] A flow control valve 9 is installed on the gas transmission pipeline 3 to precisely control the flow rate of gas within the pipeline 3. Under pipeline cleaning conditions, the flow control valve 9 can adjust the gas flow rate and pressure as needed to ensure that the compressed gas effectively pushes the residual liquid out, while preventing the risk of pipeline overpressure due to excessive gas injection.

[0064] Combination Figure 2 and Figure 3 Continuing the explanation, in this embodiment, the tank 1 is also provided with a second liquid inlet 13. The second liquid inlet 13 is used to replenish liquid into the tank 1. Specifically, in the process of producing diclofenac sodium sustained-release tablets, the liquid in the tank 1 needs to be heated to 70°C, and the materials cetyl alcohol and octadecyl alcohol in the dissolution tank need to be dissolved using a water circulation method. After being dissolved into a liquid state, the liquid in the tank 1 needs to circulate and exchange heat to reduce the temperature in the dissolution tank to 50°C before feeding and granulation. However, it takes a long time for the liquid in the tank 1 to cool down from 70°C to 50°C by itself through circulation, which affects the production efficiency of the product. Therefore, by providing a second liquid inlet 13 to the tank 1, cold water can be added to the inside of the tank 1, allowing the liquid inside the tank 1 to cool down quickly and improving production efficiency.

[0065] Specifically, the tank body 1 is also provided with a through hole 14, and a float is installed in the through hole 14. The float is used to detect the liquid level in the tank body 1.

[0066] In this embodiment, the hot liquid tank device also includes a circulation pump 10, which is located downstream of the liquid outlet 12 and is used to drive the liquid flow in the liquid circulation pipeline 2.

[0067] Example 2

[0068] In this embodiment, the other structures of the hydrothermal tank device are the same as in Embodiment 1, except that the outlet 12 of the tank body 1, the gas pipeline 3 and the liquid circulation pipeline 2 are connected through the three ports of the three-way valve.

[0069] The design employs a three-way valve to connect the liquid outlet 12, the gas delivery pipeline 3, and the liquid circulation pipeline 2. This multi-path switching function of a single valve body enables efficient and coordinated control of the system fluids. In liquid circulation mode, the three-way valve connects the liquid outlet 12 to the liquid circulation pipeline 2, while blocking the gas delivery pipeline 3. In pipeline clean mode, the three-way valve switches paths, blocking the connection between the liquid outlet 12 and the liquid circulation pipeline 2 and connecting the gas delivery pipeline 3 to the liquid circulation pipeline 2. Compressed gas can be directly injected into the liquid circulation pipeline 2 through the three-way valve, pushing out any residual liquid at the lower level of the liquid circulation pipeline 2. The use of a three-way valve reduces the number of components and connection points, lowering the risk of leakage.

[0070] Example 3

[0071] This embodiment also provides a system for producing diclofenac sodium sustained-release tablets, the system including the hydrothermal tank device as described in Embodiment 1 or Embodiment 2 above.

[0072] The system also includes a dissolving device for dissolving hexadecyl alcohol and octadecyl alcohol, which includes a dissolving tank and a liquid circulation pipe 2 disposed on the outer periphery of the dissolving tank.

[0073] The liquid circulation pipe 2 of the hydrothermal tank device exchanges heat with the dissolution pool, stabilizing the dissolution temperature in the dissolution pool and promoting the uniform dissolution of hexadecyl alcohol and octadecyl alcohol. At the same time, the sealing components of the hydrothermal tank device and the purging of the liquid circulation pipe 2 by introducing compressed gas into the gas delivery pipe 3 can prevent liquid residue and microbial growth in the liquid circulation pipe 2, ensuring the cleanliness of the entire system and meeting the strict hygiene requirements of pharmaceutical production.

[0074] The various embodiments in this specification are described in a progressive manner. Similar or identical parts between embodiments can be referred to mutually. Each embodiment focuses on describing the differences from other embodiments. In particular, the device embodiments are basically similar to the method embodiments, so the description is relatively simple; relevant parts can be referred to the descriptions of the method embodiments.

[0075] The above description is only a preferred embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A hot liquid tank device comprising a tank body having a first liquid inlet and a liquid outlet, the first liquid inlet and the liquid outlet being in communication by a liquid circulation conduit for circulating liquid in the tank body, characterized in that, The hot liquid tank device also includes a gas supply pipeline, which is connected to the liquid circulation pipeline, and the connection between the gas supply pipeline and the liquid circulation pipeline is close to the liquid outlet. A first sealing element is also provided downstream of the liquid outlet, which is used to block the connection between the liquid outlet and the liquid circulation pipeline.

2. The thermal fluid tank arrangement of claim 1, wherein, The hydrothermal tank assembly also includes a three-way pipe; The first port of the three-way pipe is connected to the liquid outlet, the second port of the three-way pipe is connected to the liquid circulation pipe, and the third port of the three-way pipe is connected to the gas transmission pipe. The first sealing element is installed at the connection between the three-way pipe and the liquid outlet.

3. The thermal fluid tank arrangement of claim 2, wherein, A second sealing element is also provided at the connection point between the tee pipe and the gas transmission pipe. The second sealing element is used to block the connection between the gas transmission pipe and the tee pipe.

4. The thermal fluid tank apparatus of claim 1, wherein, The liquid circulation pipeline is also connected to a drain pipeline, which is located near the first liquid inlet of the liquid circulation pipeline. The hydrothermal tank device further includes a third sealing element and a drain valve. The third sealing element is installed on the pipeline between the first inlet and the inlet of the drain pipe, and the drain valve is installed on the drain pipe.

5. The thermal fluid tank arrangement of claim 1, wherein, The hydrothermal tank device also includes a flow control valve, which is installed on the gas pipeline.

6. The thermal fluid tank arrangement of claim 1, wherein, The hydrothermal tank device also includes a three-way valve, the three ports of which are respectively connected to the liquid outlet, the gas pipeline and the liquid circulation pipeline.

7. The thermal fluid tank apparatus of claim 1, wherein, The tank body is also provided with a second liquid inlet, which is used to replenish liquid into the tank body; And / or, the tank body is further provided with a through hole, and a float is installed in the through hole, the float being used to detect the liquid level in the tank body.

8. The thermal fluid tank apparatus of claim 1, wherein, The hydrothermal tank assembly also includes a circulation pump for driving the flow of liquid in the liquid circulation pipeline.

9. A system for producing diclofenac sodium sustained-release tablets, characterized in that, The system includes a hydrothermal tank apparatus as described in any one of claims 1-8.

10. The system of claim 9, wherein, The system also includes a dissolving device for dissolving hexadecyl alcohol and octadecyl alcohol, the dissolving device comprising a dissolving tank, and the liquid circulation pipe disposed on the outer periphery of the dissolving tank.

Images