一种阿瑞匹坦中间体低温反应装置
By using cooling pipes and insulation layers to maintain temperature uniformity in the aprepitant intermediate low-temperature reaction device, and utilizing the convection circulation of inner and outer spiral blades to achieve thorough mixing of materials, the problems of temperature fluctuation and uneven mixing in traditional devices are solved, thereby improving reaction efficiency and product quality.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SUZHOU QIAOBEIDI PHARMACEUTICAL TECHNOLOGY CO LTD
- Filing Date
- 2025-08-14
- Publication Date
- 2026-07-17
AI Technical Summary
Traditional reaction equipment is inadequate in maintaining a low-temperature environment and material mixing efficiency, resulting in temperature fluctuations and uneven mixing, which affects the product quality of aprepitant intermediates.
A low-temperature reaction device for aprepitant intermediate was designed. Cooling pipes and insulation layers between the inner and outer barrels are used to maintain temperature uniformity. The material is fully mixed by the convection circulation of inner and outer spiral blades, and sealing is used to prevent external interference and ensure reaction stability.
This achieves uniform temperature distribution within the reaction chamber, avoids localized overheating or overcooling, improves reaction efficiency and product quality, and extends the service life of the device.
Smart Images
Figure CN224507112U_ABST
Abstract
Claims
1. A low temperature reaction apparatus for an intermediate of aprepitant, characterized by: include: The barrel (1) with an opening at the top and the lid (2) are covered and installed at the opening at the top of the barrel (1). The barrel (1) includes an inner barrel (11) and an outer barrel (12). The inner barrel (11) is located inside the outer barrel (12). The inner barrel (11) is provided with a reaction chamber (110). A cooling pipe (3) is provided between the inner barrel (11) and the outer barrel (12). The cooling pipe (3) is used to ensure that the reaction chamber (110) is always at a preset temperature. A set of feeding ports (4) are provided on the cover (2), and each feeding port (4) is connected to the reaction chamber (110); The stirring assembly (5) includes: a rotating shaft (51) and an inner spiral blade (52). The rotating shaft (51) is rotatably disposed in the reaction chamber (110). The inner spiral blade (52) is mounted on the rotating shaft (51) and extends axially along the rotating shaft (51). An outer spiral blade (53) is provided on the outside of the inner spiral blade (52). The outer spiral blade (53) extends axially along the rotating shaft (51). The spiral direction of the outer spiral blade (53) is opposite to that of the inner spiral blade (52).
2. The low temperature reaction apparatus for an intermediate of aprepitant according to claim 1, characterized by: On the outer side wall of the inner barrel (11), the cooling pipe (3) is spirally arranged along the axial direction of the inner barrel (11); on the outer side of the bottom wall of the inner barrel (11), the cooling pipe (3) is spirally arranged from the inside to the outside along the center of the bottom wall of the inner barrel (11).
3. The low temperature reaction apparatus for an intermediate of aprepitant according to claim 2, characterized by: A heat insulation layer (6) is provided between the inner barrel (11) and the outer barrel (12), and the heat insulation layer (6) is covered on the outside of the cooling pipe (3).
4. The low temperature reaction apparatus for an intermediate of aprepitant according to claim 1, wherein: The stirring assembly (5) further includes: a driving device (54) and a pair of mounting seats (55). The driving device (54) is mounted on the cover (2). The driving end of the driving device (54) is connected to the rotating shaft (51). The pair of mounting seats (55) are located in the reaction chamber (110). The rotating shaft (51) passes through the pair of mounting seats (55). The pair of mounting seats (55) includes: a lower seat (551) and an upper seat (552). The lower seat (551) is located at the bottom of the inner barrel (11). A set of support rods (56) is provided on the outside of the upper seat (552). The set of support rods (56) are spaced apart circumferentially along the rotating shaft (51). The support rods (56) extend axially to the side wall of the inner barrel (11).
5. The low temperature reaction apparatus for an intermediate of aprepitant according to claim 4, characterized by: A bearing (57) is provided between the rotating shaft (51) and each mounting base (55). The bearing (57) is mounted on the mounting base (55) and sleeved on the rotating shaft (51).
6. The low temperature reaction apparatus for an intermediate of aprepitant according to claim 1, wherein: A sealing element (7) is provided between the barrel body (1) and the cover body (2), and the sealing element (7) extends along the circumference of the barrel body (1).
7. The low temperature reaction apparatus for an intermediate of aprepitant according to claim 1, characterized by: A set of mounting ears (8) is provided on the outer side wall of the barrel (1), and the set of mounting ears (8) is evenly spaced along the circumference of the barrel (1).