用于模拟胫骨横向骨搬运生物力学环境的细胞拉伸装置
By employing a mechanical transmission design combining a manual knob and a precision threaded pair, along with the deformation of an elastic culture dish, an ultra-low-speed stretching of 1 mm/day for the cell stretching device was achieved. This solves the problem that existing devices cannot accurately simulate the biomechanical environment of transverse bone transport in the tibia, providing a realistic biomechanical environment simulation and supporting in vitro research on the TTT treatment mechanism.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIV
- Filing Date
- 2025-08-14
- Publication Date
- 2026-07-17
AI Technical Summary
Existing cell stretching devices cannot accurately simulate the ultra-low-speed stretching mode of 1 mm/day, nor can they truly simulate the biomechanical environment of transverse bone transport in the tibia, thus limiting in vitro research on the TTT treatment mechanism and the development of related medical devices.
Employing a mechanical transmission design with a manual knob and precision threaded pair, it achieves precise displacement from micrometer to sub-millimeter level through manual fine-tuning and precise screw connection between the screw and moving parts. Combined with the uniform deformation of the elastic culture vessel, it simulates an ultra-low-speed stretch of 1 mm/day, precisely matching the bone transport rate in TTT clinical settings.
It achieves precise micro-stress stimulation of cells, accurately simulates the clinical biomechanical environment of TTT, overcomes the defect of excessive speed of electric drive devices, and provides a real biomechanical environment simulation for in vitro research.
Smart Images
Figure CN224513511U_ABST
Abstract
Claims
1. A cell stretching device for simulating a tibial transverse bone transport biomechanical environment, characterized by, include: Mounting substrate; A movable component, which is slidably disposed on the mounting base along a first direction, and the movable component has a threaded hole; A flexible culture dish, wherein a first end of the flexible culture dish is connected to the mounting base, and a second end of the flexible culture dish is connected to the moving component, and the flexible culture dish is used to hold cells; A knob; and a screw connected to the knob, the screw passing through the mounting base and screwed into the threaded hole to drive the moving part to slide.
2. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 1, wherein, The mounting base is provided with a first positioning mark; The knob is provided with a first scale mark, which is used to indicate the rotation angle or gear of the knob. When the knob is rotated, any scale line of the first scale mark can be aligned with the first positioning mark.
3. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 2, wherein, The mounting base is provided with a second scale mark, which is arranged along the first direction. The second scale mark is used to indicate the linear displacement of the moving part. The moving part is provided with a second positioning mark, which can be aligned with any scale line of the second scale mark when the moving part moves.
4. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 1, wherein, The mounting base has an inner cavity, and the moving part and the elastic culture vessel are both disposed within the inner cavity. The knob is located outside the mounting base. The mounting base is provided with a first transparent observation section, which is used for a microscope to observe the cells on the elastic culture vessel from outside the mounting base.
5. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 4, wherein, The flexible culture vessel is a structure made of transparent material; The mounting base is also provided with a second transparent section, which is located at the upper and lower ends of the mounting base along with the first transparent observation section. The second transparent section is used for the microscope to observe the cells on the elastic culture dish from outside the mounting base.
6. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 5, wherein, The mounting base includes: The bottom cover is provided with the second transparent portion and the bottom cover also has a mounting groove; A mounting bracket, wherein the mounting bracket is disposed on the mounting groove, and the mounting bracket is connected to the first end of the flexible culture dish; and The top cover has the first transparent observation section and is placed on the bottom cover. The top cover, the mounting bracket, and the bottom cover form the inner cavity.
7. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 6, wherein, The mounting bracket includes: Support base, which is connected to the bottom cover; A guide rail is provided on the support base; A sliding component is slidably disposed on the guide rail along the first direction; the moving component is connected to the sliding component; The first end of the elastic culture vessel is connected to the support base or the guide rail.
8. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 7, wherein, The mounting bracket also includes: A positioning component, which is connected to the support base or the guide rail, has two first slots, which are spaced apart along a second direction, which is perpendicular to the first direction. The moving component has two second slots, which are spaced apart along the second direction; The first end of the elastic culture vessel is provided with two first clamping parts, each of which is clamped in a corresponding first clamping groove; the second end of the elastic culture vessel is provided with two second clamping parts, each of which is clamped in a corresponding second clamping groove.
9. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 6, wherein, At least the bottom cover and the top cover are made of transparent material.
10. The cell stretching device for simulating a tibial transverse cutnove bone biomechanical environment of claim 1, wherein, The cell stretching device for simulating a tibial transverse bone transport biomechanical environment further comprises: A bearing is arranged on the mounting base, and the screw rod penetrates the inner ring of the bearing and is in interference fit with the inner ring of the bearing, so that the inner ring of the bearing can rotate with the screw rod.