A cryogenic tube holder
By designing the isolation cylinder and limiting block structure of the cryopreservation tube clamp, the risk of contamination of cryopreservation tubes in liquid nitrogen tanks was solved, achieving higher cryopreservation safety and usage flexibility.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- BIOLOGIX TECH CO LTD
- Filing Date
- 2025-08-21
- Publication Date
- 2026-07-21
AI Technical Summary
When existing cryopreservation tubes are used in liquid nitrogen tanks, they are easily contaminated by contaminating components, resulting in a high risk of biological sample contamination. Furthermore, existing technologies are insufficient to effectively reduce the risk of contamination spread.
Design a cryopreservation tube clamp, including a clamp body and an isolation cylinder sleeved on its outside. Through the cooperation of the limiting block and the bending part, the cryopreservation tube is isolated from the contaminated parts inside the liquid nitrogen tank, and the stability and flexibility are improved by the cooperation of the buckle and the locking hole.
It effectively reduces the risk of contamination of cryopreservation tubes, limits the spread of contamination, improves the safety and flexibility of cryopreservation, and enhances the stability and reliability of the isolation cylinder and tube clamp body.
Smart Images
Figure CN224522212U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of cryopreservation tube clamp technology, and specifically to a cryopreservation tube clamp. Background Technology
[0002] Cryopreservation tubes are laboratory consumables used to hold biological samples.
[0003] Cryotube clamps are clamps used to hold multiple cryotubes. See also Figure 1 , Figure 2 and Figure 3 The cryopreservation tube clamp includes a tube clamp body 1. The tube clamp body 1 has multiple clamping positions 11 and multiple unloading holes 12 in the vertical direction. The clamping positions 11 correspond one-to-one with the unloading holes 12. The clamping positions 11 are used to clamp the cryopreservation tube 2. When it is necessary to remove the cryopreservation tube 2, the staff can push the cryopreservation tube 2 out of the unloading hole 12 and forcefully push it out of the clamping position 11.
[0004] Liquid nitrogen tanks are ultra-low temperature storage devices used for cryopreserving biological samples.
[0005] When bulk cryopreservation of biological samples is required, firstly, multiple cryovials containing the biological samples are clamped into the holding positions of the cryovial clamps; then, the multiple cryovial clamps are placed into the lifting cylinder of the liquid nitrogen tank. Using cryovial clamps facilitates the placement and retrieval of cryovials into the lifting cylinder of the liquid nitrogen tank.
[0006] When the inner walls of liquid nitrogen tanks, lifting cylinders, and other components are not regularly disinfected, or when disinfection is inadequate, microorganisms may grow (some microorganisms can survive at low temperatures, such as Bacillus). When cryovials come into contact with these contaminated components, contaminants may adhere to the cryovials and then enter the cryovials through gaps in the cap or cracks, causing contamination of biological samples.
[0007] Therefore, how to reduce the risk of pollution is a technical problem that needs to be solved. Utility Model Content
[0008] To address the aforementioned shortcomings of existing technologies, this invention proposes a cryopreservation tube clamp, which can reduce the risk of contamination and improve cryopreservation safety.
[0009] To achieve the above objectives, the technical solution adopted by this utility model is as follows:
[0010] A cryopreservation tube clamp includes a clamp body with multiple clamping positions and multiple discharge holes along the vertical direction. The clamping positions are used to clamp the cryopreservation tubes, and the discharge holes are used to push the cryopreservation tubes out of the clamping positions. An isolation cylinder is sleeved on the outside of the clamp body. The top of the clamp body is provided with a first bend that abuts against the top of the isolation cylinder. The bottom of the clamp body is provided with a second bend. A limit block is horizontally slidably connected inside the second bend. When the limit block extends horizontally from inside the second bend, the limit block abuts against the bottom of the isolation cylinder.
[0011] Furthermore, the second bending portion is provided with a limiting hole and a positioning protrusion. The limiting block slides horizontally with the limiting hole. The limiting block is provided with a first positioning hole and a second positioning hole. When the positioning protrusion is located in the first positioning hole, the limiting block is located in the second bending portion. When the positioning protrusion is located in the second positioning hole, the limiting block extends horizontally from the second bending portion.
[0012] Furthermore, the second bending portion includes a first transverse segment, a connecting segment, and a second transverse segment connected in sequence. The second transverse segment is located below the first transverse segment. The connecting segment is provided with the limiting hole. The first transverse segment and / or the second transverse segment are provided with the positioning protrusion.
[0013] Furthermore, at least two pipe clamp bodies are provided, and all pipe clamp bodies are sequentially nested from the inside to the outside. The top of the innermost pipe clamp body is provided with the first bending part, and the bottom of the outermost pipe clamp body is provided with the second bending part.
[0014] Furthermore, in the two adjacent sleeved pipe clamp bodies, the inner pipe clamp body is provided with multiple buckles distributed in the vertical direction, and the outer pipe clamp body is provided with locking holes, with the buckles cooperating with the locking holes.
[0015] Furthermore, the isolation cylinder is a telescopic cylinder.
[0016] Furthermore, the telescopic cylinder includes several sleeves, with adjacent sleeves being threadedly connected.
[0017] The beneficial effects of this utility model are:
[0018] 1. During cryopreservation, because the outside of the clamp body is covered with an isolation sleeve, the cryopreservation tube on the clamp body can be prevented from directly contacting the contaminated parts inside the liquid nitrogen tank, thus preventing contaminants on the contaminated parts from adhering to the cryopreservation tube. This reduces the risk of contamination of the biological samples inside the cryopreservation tube and helps to improve cryopreservation safety.
[0019] 2. Because each clamp body has an isolation sleeve, even if the cryopreservation tube on one clamp body in the liquid nitrogen tank is contaminated, the contamination can be confined to the isolation sleeve where the contamination occurred because other clamp bodies also have isolation sleeves. This reduces the risk of spreading contamination, narrows the contamination range, and also helps to improve cryopreservation safety.
[0020] 3. The first bend prevents the isolation cylinder from moving upwards relative to the pipe clamp body; the limiting block on the second bend prevents the isolation cylinder from moving downwards relative to the pipe clamp body when it extends out of the second bend. When workers handle the pipe clamp body or the isolation cylinder, the use of the first bend and the limiting block prevents accidental separation of the isolation cylinder from the pipe clamp body, improving the stability and reliability of the isolation cylinder fitted onto the outside of the pipe clamp body.
[0021] 4. When the limiting block extends out of the second bend, it can support the isolation cylinder and prevent the isolation cylinder from falling off the pipe clamp body. When the limiting block retracts into the second bend, it will not prevent the pipe clamp body from being taken out of the isolation cylinder, making it easy to separate the isolation cylinder from the pipe clamp body.
[0022] 5. The positioning protrusion, the first positioning hole, and the second positioning hole facilitate the positioning of the relative positions of the limiting block and the second bend. When the positioning protrusion enters the first positioning hole, the limiting block is located inside the second bend and will not interfere with the isolation cylinder; when the positioning protrusion enters the second positioning hole, the limiting block extends out of the second bend and can abut against the bottom end of the isolation cylinder.
[0023] 6. When the positioning protrusion enters the first positioning hole or the second positioning hole, without force pushing the limiting block, the engagement between the positioning protrusion and the first positioning hole or the second positioning hole can prevent the limiting block from moving easily, which helps to improve the stability of the limiting block and further improves the reliability of the isolation sleeve on the outside of the pipe clamp body.
[0024] 7. By connecting at least two tube clamp bodies, the number of effective clamping positions can be adjusted by adjusting the positions of two adjacent tube clamp bodies, so as to flexibly adjust the number of frozen tubes clamped, which is beneficial to improving the flexibility of use.
[0025] 8. By using a telescopic cylinder as an isolation cylinder, the overall length of the inner and outer pipe clamp bodies can be adapted, further improving the flexibility of use.
[0026] 9. By setting a buckle on the inner pipe clamp body and a locking hole on the outer pipe clamp body, the stability of the relative position of the inner and outer pipe clamp bodies can be improved by utilizing the cooperation of the buckle and the locking hole. Attached Figure Description
[0027] Figure 1 In the background technology, the three-dimensional shape of the pipe clamp body Figure 1 ;
[0028] Figure 2 In the background technology, the three-dimensional shape of the pipe clamp body Figure 2 ;
[0029] Figure 3 This is a three-dimensional view of the assembly of the tube clamp body and the cryopreservation tube in the background art;
[0030] Figure 4 It is the three-dimensional form of the inner pipe clamp body among two adjacent pipe clamp bodies. Figure 1 ;
[0031] Figure 5 It is the three-dimensional form of the inner pipe clamp body among two adjacent pipe clamp bodies. Figure 2 ;
[0032] Figure 6 It is the three-dimensional form of the outermost pipe clamp body among two adjacent pipe clamp bodies. Figure 1 ;
[0033] Figure 7 It is the three-dimensional form of the outermost pipe clamp body among two adjacent pipe clamp bodies. Figure 2 ;
[0034] Figure 8 It is a partial three-dimensional view of the outermost pipe clamp body among two adjacent pipe clamp bodies;
[0035] Figure 9 This is a 3D view of the limit block;
[0036] Figure 10 This refers to the assembled state of the outer pipe clamp body and the limiting block. Figure 1 ;
[0037] Figure 11 This refers to the assembled state of the outer pipe clamp body and the limiting block. Figure 2 ;
[0038] Figure 12 This is the assembly front view of two adjacent pipe clamp bodies;
[0039] Figure 13 It is a three-dimensional view of the assembly of two adjacent tube clamp bodies and cryopreservation tubes;
[0040] Figure 14 It is a 3D diagram of the telescopic cylinder;
[0041] Figure 15 This is a three-dimensional diagram of a cryopreservation tube clamp;
[0042] Figure 16 yes Figure 15 A magnified view of a section at point A in the middle;
[0043] Figure 17 This is a front view of a cryopreservation tube clamp;
[0044] Figure 18 yes Figure 17 A magnified view of a section at point B in the middle.
[0045] Explanation of reference numerals in the attached figures:
[0046] 1-Pipe clamp body, 11-Clamping position, 12-Discharge hole, 13-Snap fastener, 14-Snap hole,
[0047] 2-Cryopreservation tubes
[0048] 3-Isolation cylinder,
[0049] 4- First bend,
[0050] 5-Second bend, 51-First transverse section, 52-Connecting section, 521-Limiting hole, 53-Second transverse section, 54-Positioning protrusion.
[0051] 6-Limiting block, 61-First positioning hole, 62-Second positioning hole. Detailed Implementation
[0052] To better understand this utility model, it will be further described below with reference to the accompanying drawings. It is worth noting that in the description of this utility model, terms such as "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," indicating orientation or positional relationships, are based on the orientation or positional relationships shown in the accompanying drawings. They are used for the convenience of describing this utility model and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0053] Example 1:
[0054] A cryopreservation tube clamp includes a clamp body 1, which is made of stainless steel.
[0055] The tube clamp body 1 is provided with multiple clamping positions 11 and multiple unloading holes 12 along the vertical direction. The positions of the clamping positions 11 and the unloading holes 12 correspond one-to-one. The clamping positions 11 are used to clamp the cryopreservation tube 2. When it is necessary to remove the cryopreservation tube 2, the staff can push the cryopreservation tube 2 out of the clamping position 11 through the unloading hole 12.
[0056] The top end of the pipe clamp body 1 is provided with a first bending part 4, and the bottom end of the pipe clamp body 1 is provided with a second bending part 5. The first bending part 4 and the second bending part 5 are integral with the pipe clamp body 1.
[0057] See Figure 8The second bending portion 5 includes a first transverse segment 51, a connecting segment 52, and a second transverse segment 53 connected in sequence. The second transverse segment 53 is located below the first transverse segment 51. The connecting segment 52 is provided with a limiting hole 521. Both the first transverse segment 51 and the second transverse segment 53 are provided with positioning protrusions 54, or only the first transverse segment 51 is provided with positioning protrusions 54, or only the second transverse segment 53 is provided with positioning protrusions 54.
[0058] See Figure 10 and Figure 11 A limiting block 6 is horizontally slidably connected within the limiting hole 521. (See also...) Figure 9 The limiting block 6 is provided with a first positioning hole 61 and a second positioning hole 62. (See also...) Figure 10 and Figure 11 The first positioning hole 61 and the second positioning hole 62 are both used to cooperate with the positioning protrusion 54.
[0059] An isolation cylinder 3 is fitted on the outside of the pipe clamp body 1. The isolation cylinder 3 can be made of transparent plastic.
[0060] The working principle of this embodiment 1 is as follows:
[0061] (1) When it is necessary to freeze biological samples in batches:
[0062] ① The staff clamped multiple cryopreservation tubes 2 containing biological samples onto the clamping position 11 of the tube clamp body 1.
[0063] ② The worker pushes the limiting block 6 horizontally, causing the positioning convex 54 to enter the first positioning hole 61 on the limiting block 6, see [link / reference] Figure 10 At this time, the limiting block 6 is hidden inside the second bend 5, and the limiting block 6 will not prevent the pipe clamp body 1 from being inserted into the isolation cylinder 3; the operator inserts the pipe clamp body 1 into the isolation cylinder 3 from top to bottom until the first bend 4 at the top of the pipe clamp body 1 abuts against the top of the isolation cylinder 3.
[0064] ③ The worker pushes the limiting block 6 horizontally, and the positioning protrusion 54 first disengages from the first positioning hole 61, and then the positioning protrusion 54 enters the second positioning hole 62. See below. Figure 11 This causes the limiting block 6 to extend horizontally from within the second bend 5, see [reference]. Figure 16 and Figure 18 At this time, the limiting block 6 can abut against the bottom end of the isolation cylinder 3.
[0065] ④ The staff put multiple pipe clamp bodies 1 equipped with isolation cylinders 3 into the lifting cylinder of the liquid nitrogen tank.
[0066] (2) When it is necessary to separate the pipe clamp body 1 and the isolation cylinder 3:
[0067] First, the operator pushes the limiting block 6 horizontally, and the positioning protrusion 54 first comes out of the second positioning hole 62, and then the positioning protrusion 54 enters the first positioning hole 61. The limiting block 6 retracts into the second bend 5. At this time, the limiting block 6 will not prevent the pipe clamp body 1 from being taken out of the isolation cylinder 3. Then, the operator takes the pipe clamp body 1 out of the isolation cylinder 3 and separates the pipe clamp body 1 and the isolation cylinder 3. The operation is convenient.
[0068] Based on the working principle described above in Embodiment 1, it can be seen that Embodiment 1 has the following advantages:
[0069] First, during the cryopreservation process, because the outside of the clamp body 1 is covered by an isolation cylinder 3, the cryopreservation tube 2 on the clamp body 1 can be prevented from directly contacting the contaminated parts inside the liquid nitrogen tank, and the contaminants on the contaminated parts can be prevented from adhering to the cryopreservation tube 2. This can reduce the risk of contamination of the biological samples inside the cryopreservation tube 2 and help improve the safety of cryopreservation.
[0070] Secondly, because each clamp body 1 is equipped with an isolation cylinder 3, even if the cryopreservation tube 2 on a certain clamp body 1 in the liquid nitrogen tank is contaminated, the contamination can be confined to the isolation cylinder 3 where the contamination occurred because the other clamp bodies 1 are also equipped with isolation cylinders 3. This reduces the risk of spreading contamination, narrows the contamination range, and also helps to improve cryopreservation safety.
[0071] Third, the first bend 4 prevents the isolation cylinder 3 from moving upward relative to the clamp body 1; when the second bend 5 extends outward, the limiting block 6 on the second bend 5 prevents the isolation cylinder 3 from moving downward relative to the clamp body 1. When the operator handles the clamp body 1 or the isolation cylinder 3, the use of the first bend 4 and the limiting block 6 prevents the isolation cylinder 3 from accidentally separating from the clamp body 1, thus improving the stability and reliability of the isolation cylinder 3 fitted onto the outside of the clamp body 1.
[0072] Fourth, the positioning protrusion 54, the first positioning hole 61, and the second positioning hole 62 facilitate the positioning of the relative positions of the limiting block 6 and the second bent portion 5. When the positioning protrusion 54 enters the first positioning hole 61, the limiting block 6 is located inside the second bent portion 5, and the limiting block 6 will not interfere with the isolation cylinder 3; when the positioning protrusion 54 enters the second positioning hole 62, the limiting block 6 extends out of the second bent portion 5, and the limiting block 6 can abut against the bottom end of the isolation cylinder 3.
[0073] Fifth, when the positioning protrusion 54 enters the first positioning hole 61 or the second positioning hole 62, without forcefully pushing the limiting block 6, the engagement between the positioning protrusion 54 and the first positioning hole 61 or the second positioning hole 62 can prevent the limiting block 6 from moving easily, which is beneficial to improving the stability of the limiting block 6 and further improving the reliability of the isolation cylinder 3 sleeved on the outside of the pipe clamp body 1.
[0074] Example 2:
[0075] This embodiment 2 is an improvement upon embodiment 1:
[0076] At least two pipe clamp bodies 1 are provided, and all pipe clamp bodies 1 are connected sequentially from the inside to the outside. The top of the innermost pipe clamp body 1 is provided with a first bending part 4, and the bottom of the outermost pipe clamp body 1 is provided with a second bending part 5.
[0077] See Figure 12 and Figure 13 In this embodiment 2, only two pipe clamp bodies 1 are provided, and the two pipe clamp bodies 1 are sleeved together. The top of the inner pipe clamp body 1 is provided with a first bending part 4, and the bottom of the outer pipe clamp body 1 is provided with a second bending part 5.
[0078] When the staff member holds the inner tube clamp body 1 with one hand and pulls the outer tube clamp body 1 downward with the other hand, the clamping positions 11 on the inner tube clamp body 1 and the outer tube clamp body 1 are gradually staggered, so that the number of clamping positions 11 that can effectively clamp the cryopreservation tube 2 increases, and more cryopreservation tubes 2 can be clamped.
[0079] When the staff member holds the inner tube clamp body 1 with one hand and pushes the outer tube clamp body 1 upward with the other hand, the overlapping part of the clamping positions 11 on the inner tube clamp body 1 and the outer tube clamp body 1 increases, which reduces the number of clamping positions 11 that can effectively clamp the cryopreservation tube 2, and thus reduces the number of cryopreservation tubes 2 that can be clamped.
[0080] exist Figure 12 and Figure 13 In the middle, both the inner tube clamp body 1 and the outer tube clamp body 1 are provided with four clamping positions 11, and two clamping positions 11 of the inner tube clamp body 1 and the outer tube clamp body 1 overlap, so that the inner and outer tube clamp bodies 1 have a total of six clamping positions 11 that can be used to clamp the cryopreservation tube 2.
[0081] When the outer pipe clamp body 1 is stopped from being pushed or pulled, the relative positions of the inner pipe clamp body 1 and the outer pipe clamp body 1 can be stabilized by the friction between them.
[0082] To further improve the stability of the relative position of the inner and outer pipe clamp bodies 1, in two adjacent sleeved pipe clamp bodies 1, see... Figure 4 and Figure 5 The inner pipe clamp body 1 is provided with multiple buckles 13 distributed vertically; see also Figure 6 and Figure 7 The outer pipe clamp body 1 is provided with a locking hole 14. See also Figure 12 and Figure 13 The buckle 13 and the hole 14 are engaged.
[0083] When pushing or pulling the outer pipe clamp body 1 relative to the inner pipe clamp body 1, it is necessary to overcome the engagement resistance between the buckle 13 and the current locking hole 14. The relative positions of the inner and outer pipe clamp bodies 1 can be stabilized when the outer pipe clamp body 1 moves to the desired position and the buckle 13 enters the new current locking hole 14.
[0084] To accommodate the overall length variation of the inner and outer pipe clamp bodies 1, the isolation cylinder 3 is a telescopic cylinder. The telescopic cylinder consists of several sleeves, with each pair of adjacent sleeves connected by threads.
[0085] In this embodiment 2, see Figure 14 The telescopic cylinder consists of two threaded sleeves. Figure 15 and Figure 17 A schematic diagram showing two threaded sleeves covering two pipe clamp bodies 1.
[0086] When it is necessary to increase the total length of the isolation cylinder 3, the outer sleeve is screwed downward relative to the inner sleeve, so that the length of the overlapping part of the inner and outer sleeves is reduced, thereby increasing the total length of the isolation cylinder 3.
[0087] When it is necessary to reduce the total length of the isolation cylinder 3, the outer sleeve is screwed upward relative to the inner sleeve, so that the length of the overlapping part of the inner and outer sleeves increases, thereby reducing the total length of the isolation cylinder 3.
[0088] As can be seen from the above description, this embodiment 2 has the following advantages:
[0089] First, by connecting at least two tube clamp bodies 1, the number of effective clamping positions 11 can be adjusted by adjusting the positions of two adjacent tube clamp bodies 1, so as to flexibly adjust the number of frozen tubes 2 clamped, which is beneficial to improving the flexibility of use.
[0090] Secondly, by using a telescopic cylinder as the isolation cylinder 3, the overall length of the inner and outer pipe clamp bodies 1 can be adapted, further improving the flexibility of use.
[0091] Third, by setting a buckle 13 on the inner pipe clamp body 1 and a locking hole 14 on the outer pipe clamp body 1, the stability of the relative position of the inner and outer pipe clamp bodies 1 can be improved by utilizing the cooperation of the buckle 13 and the locking hole 14.
[0092] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.
Claims
1. A cryopreservation tube clamp, comprising a clamp body, the clamp body having a plurality of clamping positions and a plurality of unloading holes along a vertical direction, the clamping positions for clamping cryopreservation tubes, and the unloading holes for pushing the cryopreservation tubes out of the clamping positions, characterized in that, An isolation cylinder is sleeved on the outside of the pipe clamp body. The top of the pipe clamp body is provided with a first bend, which abuts against the top of the isolation cylinder. The bottom of the pipe clamp body is provided with a second bend, and a limit block is horizontally slidably connected inside the second bend. When the limit block extends horizontally from inside the second bend, the limit block abuts against the bottom of the isolation cylinder.
2. The cryopreservation tube clamp according to claim 1, characterized in that, The second bending portion is provided with a limiting hole and a positioning protrusion. The limiting block slides horizontally with the limiting hole. The limiting block is provided with a first positioning hole and a second positioning hole. When the positioning protrusion is located in the first positioning hole, the limiting block is located in the second bending portion. When the positioning protrusion is located in the second positioning hole, the limiting block extends horizontally from the second bending portion.
3. The cryopreservation tube clamp according to claim 2, characterized in that, The second bending portion includes a first transverse segment, a connecting segment, and a second transverse segment connected in sequence. The second transverse segment is located below the first transverse segment. The connecting segment is provided with the limiting hole. The first transverse segment and / or the second transverse segment are provided with the positioning protrusion.
4. A cryopreservation tube clamp according to any one of claims 1-3, characterized in that, The pipe clamp body is provided in at least two parts, and all the pipe clamp bodies are connected in sequence from the inside to the outside. The top of the innermost pipe clamp body is provided with the first bending part, and the bottom of the outermost pipe clamp body is provided with the second bending part.
5. A cryopreservation tube clamp according to claim 4, characterized in that, In the two adjacent sleeved pipe clamp bodies, the inner pipe clamp body is provided with multiple buckles distributed in the vertical direction, and the outer pipe clamp body is provided with locking holes, with the buckles cooperating with the locking holes.
6. A cryopreservation tube clamp according to claim 4, characterized in that, The isolation cylinder is a telescopic cylinder.
7. A cryopreservation tube clamp according to claim 6, characterized in that, The telescopic cylinder includes several sleeves, with adjacent sleeves connected by threads.