Intracranial artery repair stent and intracranial artery repair system
By designing intracranial artery repair stents with low-porosity and high-porosity regions, combined with contrast markers and a non-axially stretchable monolithic spine, the problems of shortening and displacement during stent implantation were solved, achieving accurate aneurysm localization and patency of branch vessels, thus improving the treatment outcome of intracranial aneurysms.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SUZHOU QUANTONG MEDICAL TECH CO LTD
- Filing Date
- 2025-07-17
- Publication Date
- 2026-07-21
Smart Images
Figure CN224523351U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of medical device technology, and in particular to an intracranial artery repair stent and an intracranial artery repair system. Background Technology
[0002] Intracranial aneurysms are abnormal bulges formed when the walls of intracranial arteries are damaged due to congenital abnormalities or acquired injuries, leading to gradual dilation under hemodynamic load and other factors. The incidence of intracranial aneurysms in the general population is approximately 3%–5%, with an annual rupture probability of about 0.95%. Once an aneurysm forms, it is prone to rupture, ranking third among cerebrovascular accidents after cerebral thrombosis and hypertensive intracerebral hemorrhage. A ruptured aneurysm leading to subarachnoid hemorrhage has a mortality rate of up to 40%. Intracranial aneurysms are the leading cause of subarachnoid hemorrhage (SAH). Statistics show that approximately 10% of patients with aneurysmal SAH die before reaching the hospital, 25% die within 24 hours, and 40–49% die within 3 months. The estimated mortality rate is as high as 65%, with most patients dying in the early clinical stages. Therefore, a cerebral aneurysm is like a time bomb buried in the brain, posing a constant risk of explosion. Therefore, timely intervention for intracranial aneurysms is very important. Common sites for intervention include the internal carotid artery system (85%-95%) and the vertebrobasilar artery system (5%-15%).
[0003] Currently, the main treatment methods for intracranial aneurysms include surgical clipping and endovascular treatment. With advancements in technology and the minimally invasive and rapid recovery advantages of interventional therapy, endovascular treatment of intracranial aneurysms has developed rapidly, and its safety and efficacy have been confirmed by numerous large-scale clinical studies.
[0004] However, the intracranial vascular anatomy is complex, especially the deeper intracranial arteries, such as the middle cerebral artery and anterior cerebral artery, which are tortuous and have numerous small branches, posing challenges to interventional treatment of intracranial aneurysms. Good results from interventional treatment of intracranial aneurysms require precise positioning and deployment of the stent to occlude the aneurysm while maintaining the patency of branch vessels. In current techniques, because implanted stents (such as aneurysm-assisted stents or flow diverters) are prone to shortening and displacement during release from the delivery device, highly skilled operators are required to accurately position and deploy the stent and ensure the patency of branch vessels after stent implantation. Utility Model Content
[0005] To address the problems existing in the prior art, this utility model provides an intracranial artery repair stent and an intracranial artery repair system. The repair stent does not shorten or shift during implantation, enabling accurate positioning and release of the intracranial artery repair stent. At the same time, the repair stent can effectively shorten the design length of the low porosity zone, so that the length of the low porosity zone only covers the opening of the target chamber. This not only achieves the occlusion of the target chamber but also ensures the unobstructed flow of branch tubing.
[0006] To achieve the above objectives, this utility model provides an intracranial artery repair stent for sealing a target chamber in a predetermined pipeline. The repair stent includes a stent body and a continuous spinal column connected to each other, the spinal column extending axially along the stent body. The repair stent has axially arranged low-porosity regions and high-porosity regions sequentially arranged. The high-porosity regions are used for support within the predetermined pipeline, and the low-porosity regions are used for sealing the target chamber. The axial length of the low-porosity regions in the stent body matches the length of the target chamber in the predetermined pipeline.
[0007] Optionally, multiple sets of radiopaque markers are provided on the main body of the support or the entire spine, wherein two sets of radiopaque markers are located at both ends of the low porosity region.
[0008] Optionally, the imaging marker is disposed on the entire spine, or the imaging marker is disposed on the support body in a region close to the entire spine.
[0009] Optionally, the imaging markers are disposed on the entire spine and on the support body in regions close to the entire spine; the entire spine has at least one set of imaging markers, and the at least one set of imaging markers on the entire spine is disposed at the distal and / or proximal ends of the entire spine; the support body is provided with at least three sets of imaging markers, and the imaging markers on the support body are respectively disposed at both ends of the low porosity region and both ends of the high porosity region.
[0010] Optionally, the entire spine is part of the support body, or the entire spine is disposed on the inner or outer wall of the support body.
[0011] Optionally, the entire spine is arc-shaped.
[0012] Optionally, the number of the entire spine is one or more; when the number of the entire spine is multiple, the multiple entire spines are spaced apart in the circumferential direction of the support body.
[0013] Optionally, the cross-sectional shape of the entire spine in the low porosity region is circular or rectangular, and the cross-sectional shape of the entire spine in the high porosity region is also circular or rectangular.
[0014] Optionally, the mesh shape of the low porosity region and / or the mesh shape of the high porosity region is triangular, quadrilateral, hexagonal, or elongated. When the mesh shape of the low porosity region is elongated, it allows large external instruments to enter the target chamber.
[0015] Optionally, the cross-sectional shape of the low porosity zone is annular or partially annular, and the cross-sectional shape of the high porosity zone is also annular or partially annular; the outer diameter of the low porosity zone after release and the outer diameter of the high porosity zone after release both match the inner diameter of the predetermined pipeline.
[0016] Optionally, the number of high-porosity regions is two, and the number of low-porosity regions is one. The two high-porosity regions are respectively connected to the two ends of the low-porosity region.
[0017] Alternatively, the number of high porosity regions is one, the number of low porosity regions is one, and the high porosity region is located at one end of the low porosity region.
[0018] Optionally, the low porosity zone further includes a filter screen, which is attached to the inner or outer wall of the support body in the low porosity zone, and the mesh size of the filter screen is smaller than the mesh size of the support body in the low porosity zone.
[0019] To achieve the above objectives, the present invention also provides an intracranial artery repair system, including a delivery device and an intracranial artery repair stent as described in any one of the present inventions, wherein the delivery device is used to deliver the intracranial artery repair stent.
[0020] Optionally, the delivery device includes a delivery wire, a sleeve, and a shaft, the shaft having two spaced-apart stops, the sleeve being fitted onto the shaft and movably disposed between the two stops; the intracranial artery repair stent is connected to one of the sleeve and the shaft, and the delivery wire is connected to the other of the sleeve and the shaft.
[0021] This invention provides an intracranial artery repair stent and an intracranial artery repair system. The repair stent includes a complete spine. Since the complete spine has the property of not being able to be stretched axially, the axial length of the intracranial artery repair stent remains unchanged in the gripping state and the release state. This can effectively avoid the shortening and displacement of the repair stent during the release process, so as to achieve highly precise positioning and release of the repair stent.
[0022] At the same time, this configuration can effectively shorten the design length of the low porosity zone, so that the length of the low porosity zone only covers the neck of the aneurysm. This not only achieves effective occlusion of the aneurysm, but also reduces the probability of the low porosity zone covering branch vessels. This minimizes the impact of the low porosity zone on branch vessels and the aneurysm-bearing vessel, ensuring the patency of branch vessels on the intracranial aneurysm-bearing artery. It is very suitable for the treatment of intracranial aneurysms, especially those deep intracranial aneurysms with vascular anatomy and numerous branches, and can bring significant clinical benefits to patients.
[0023] Furthermore, this repair stent features a zoned design with varying porosities. A certain length of high-porosity zone is designed at one or both ends of the low-porosity zone. The low-porosity zone is used for accurate occlusion of the aneurysm ostium via contrast markers, while the high-porosity zone is anchored in the vessel near the aneurysm. This ensures stable anchoring of the repair stent within the predetermined vessel, guaranteeing the occlusion effect of the low-porosity zone, improving the stability of stent implantation and the effectiveness of treatment. Simultaneously, the larger mesh size in the high-porosity zone ensures the patency of branch vessels and preserves the possibility of secondary interventional treatment, further enhancing the therapeutic outcome. Attached Figure Description
[0024] Figure 1 This is a schematic diagram of the intracranial artery repair stent in a preferred embodiment of the present invention;
[0025] Figure 2 This is a schematic diagram of the use scenario of the intracranial artery repair stent in a preferred embodiment of the present invention, wherein the shape of the predetermined pipeline is arc-shaped;
[0026] Figure 3a This is a schematic diagram of the structure of the support body in a preferred embodiment of the present invention;
[0027] Figure 3b This is a schematic diagram of the structure of the support body in another preferred embodiment of the present invention;
[0028] Figure 3c This is a schematic diagram of the structure of the support body in another preferred embodiment of the present invention;
[0029] Figure 3d This is a schematic diagram of the structure of the support body in another preferred embodiment of the present invention;
[0030] Figure 3e This is a schematic diagram of the structure of the support body in another preferred embodiment of the present invention;
[0031] Figure 3f This is a schematic diagram of the structure of the support body in another preferred embodiment of the present invention;
[0032] Figure 4aThis is a schematic diagram of the entire spine in a preferred embodiment of the present invention;
[0033] Figure 4b This is a schematic diagram of the entire spine in another preferred embodiment of the present invention;
[0034] Figure 4c This is a schematic diagram of the entire spine in another preferred embodiment of the present invention;
[0035] Figure 5a This is a front view of a preferred embodiment of the intracranial artery repair stent, wherein the arrow y indicates that the intracranial artery repair stent is subjected to a bending moment in the y direction (horizontal direction) and bends vertically.
[0036] Figure 5b This is a side view of the intracranial artery repair stent in a preferred embodiment of the present invention, wherein arrow z indicates that the intracranial artery repair stent is subjected to circumferential torsion due to torque.
[0037] Figure 5c This is a top view of a preferred embodiment of the intracranial artery repair stent of the present invention, wherein the arrow x indicates that the intracranial artery repair stent is subjected to a bending moment in the x-direction (vertical direction) and bends to the left or right;
[0038] Figure 6 This is a schematic diagram of the use scenario of the intracranial artery repair stent in a preferred embodiment of the present invention, wherein the shape of the predetermined pipeline is S-shaped;
[0039] Figure 7a This is a schematic diagram of the intracranial artery repair stent in another preferred embodiment of the present invention;
[0040] Figure 7b This is a schematic diagram of the intracranial artery repair stent in another preferred embodiment of the present invention;
[0041] Figure 8a This is a schematic diagram of the use scenario of the intracranial artery repair stent in a preferred embodiment of the present invention, wherein both the low porosity region and the high porosity region are non-circular designs;
[0042] Figure 8b This is a schematic diagram of the use scenario of the intracranial artery repair stent in another preferred embodiment of the present invention, wherein the low porosity area is a non-circular design and the high porosity area is a circular design;
[0043] Figure 9 This is a schematic diagram of the conveying device in a preferred embodiment of the present invention;
[0044] Figure 10 This is a schematic diagram of the intracranial artery repair stent in another preferred embodiment of the present invention;
[0045] Figure 11a This is a schematic diagram of the use scenario of an intracranial artery stent before release in a preferred embodiment of the present invention, wherein the imaging markers at both ends of the low porosity region before stent release are located on both sides of the entrance to the target chamber;
[0046] Figure 11b This is a schematic diagram of the usage scenario after the high porosity region of the distal end of the intracranial artery repair stent is released in the preferred embodiment of this utility model;
[0047] Figure 11c This is a schematic diagram of the usage scenario after the intracranial artery repair stent is fully deployed in the preferred embodiment of this utility model;
[0048] Figure 11d This is a schematic diagram illustrating the final implantation state of the intracranial artery repair stent in the preferred embodiment of this utility model.
[0049] Figure 12a This is a schematic diagram of the use scenario of an intracranial artery stent before release in a preferred embodiment of the present invention, wherein the imaging markers at both ends of the low porosity region before stent release are located on both sides of the entrance to the target chamber;
[0050] Figure 12b This is a schematic diagram of the usage scenario after the release of the high porosity region at the distal end of the intracranial artery repair stent in the preferred embodiment of this utility model;
[0051] Figure 12c This is a schematic diagram of the usage scenario after the intracranial artery repair stent is fully released in the preferred embodiment of this utility model;
[0052] Figure 12d This is a schematic diagram illustrating the final implantation state of the intracranial artery repair stent in the preferred embodiment of this utility model.
[0053] Figure 13a This is a schematic diagram of the use scenario of an intracranial artery stent before release in a preferred embodiment of the present invention, wherein the imaging markers at both ends of the low porosity region before stent release are located on both sides of the entrance to the target chamber;
[0054] Figure 13b This is a schematic diagram of the usage scenario after the release of the distal low porosity region of the intracranial artery repair stent in the preferred embodiment of this utility model;
[0055] Figure 13c This is a schematic diagram of the usage scenario after the intracranial artery repair stent is fully released in the preferred embodiment of this utility model;
[0056] Figure 13d This is a schematic diagram illustrating the final implantation state of the intracranial artery repair stent in the preferred embodiment of this utility model.
[0057] Figure 14a This is a schematic diagram of the structure of an intracranial artery repair stent according to a preferred embodiment of the present invention;
[0058] Figure 14b This is a schematic diagram of another intracranial artery repair stent in the preferred embodiment four of this utility model;
[0059] Figure 15a This is a schematic diagram of the usage scenario of the intracranial artery stent before its release in the preferred embodiment of this utility model;
[0060] Figure 15b This is a schematic diagram of the usage scenario after the release of the high porosity region at the distal end of the intracranial artery repair stent in the preferred embodiment of this utility model;
[0061] Figure 15c This is a schematic diagram illustrating the use scenario of complete release of the intracranial artery repair stent in the preferred embodiment of this utility model;
[0062] Figure 15d This is a schematic diagram illustrating the application scenario of the intracranial artery repair stent proximal anchoring to the tubing on the other side of the target chamber in the preferred embodiment of the present invention;
[0063] Figure 15e This is a schematic diagram illustrating the final implantation state of the intracranial artery repair stent in the preferred embodiment of this utility model.
[0064] Figure 16a This is a schematic diagram of the usage scenario of the intracranial artery stent before its release in the preferred embodiment of the present invention;
[0065] Figure 16b This is a schematic diagram of the usage scenario after the release of the high porosity region at the distal end of the intracranial artery repair stent in the preferred embodiment of the present invention (Sixth Embodiment).
[0066] Figure 16c This is a schematic diagram of the usage scenario after the intracranial artery repair stent is fully deployed in the preferred embodiment of this utility model;
[0067] Figure 16d This is a schematic diagram illustrating the application scenario of the intracranial artery repair stent proximal anchoring to the tubing on the other side of the target chamber in the preferred embodiment of the present invention;
[0068] Figure 16e This is a schematic diagram illustrating the final implantation state of the intracranial artery repair stent in the preferred embodiment of this utility model.
[0069] Figure 17aThis is a schematic diagram of the use scenario of the intracranial artery repair stent with a straight spine throughout the body in the preferred embodiment of the present invention, wherein the predetermined pipeline has a bifurcated aneurysm at the tip of an arc-shaped branch;
[0070] Figure 17b This is a schematic diagram of the use scenario of the intracranial artery repair stent with the entire spine in the preferred embodiment of the present invention, wherein the predetermined pipeline has a bifurcated aneurysm at the tip of the arc-shaped branch;
[0071] Figure 18a This is a schematic diagram of the structure of an intracranial artery repair stent according to a preferred embodiment of the present invention, wherein the cross-sectional shape of both the low porosity region and the high porosity region of the intracranial artery repair stent are annular.
[0072] Figure 18b This is a schematic diagram of another intracranial artery repair stent in the preferred embodiment seven of this utility model, wherein the cross-sectional shape of the low porosity region and the cross-sectional shape of the high porosity region of the intracranial artery repair stent are both annular.
[0073] Figure 19a This is a schematic diagram of the structure of an intracranial artery repair stent according to a preferred embodiment of the present invention, wherein the cross-sectional shape of the low porosity region and the cross-sectional shape of the high porosity region of the intracranial artery repair stent are both partially annular.
[0074] Figure 19b This is a schematic diagram of another intracranial artery repair stent in the preferred embodiment seven of this utility model, wherein the cross-sectional shape of the low porosity region of the intracranial artery repair stent is partially annular, and the cross-sectional shape of the high porosity region of the intracranial artery repair stent is annular.
[0075] Figure 19c for Figure 19a A three-dimensional structural diagram of a stent for repairing intracranial arteries;
[0076] Figure 20a This is a schematic diagram of the structure of an intracranial artery repair stent according to the preferred embodiment eight of this utility model, wherein the entire spine of the intracranial artery repair stent is straight.
[0077] Figure 20b This is a schematic diagram of another intracranial artery repair stent in the preferred embodiment eight of this utility model, wherein the entire spine of the intracranial artery repair stent is arc-shaped;
[0078] Figure 21a This is a schematic diagram of the use scenario of the intracranial artery stent before its release in the preferred embodiment nine of this utility model;
[0079] Figure 21bThis is a schematic diagram of the usage scenario after the release of the high porosity region at the distal end of the intracranial artery repair stent in the preferred embodiment nine of this utility model;
[0080] Figure 21c This is a schematic diagram of the usage scenario after the intracranial artery repair stent is fully deployed in the preferred embodiment nine of this utility model;
[0081] Figure 21d This is a schematic diagram of the scenario in which the intracranial artery repair stent is anchored to the tubing on the other side of the target chamber in the preferred embodiment nine of this utility model;
[0082] Figure 21e This is a schematic diagram illustrating the application scenario of the intracranial artery repair stent anchoring device penetrating the target cavity to fill the packing medium after anchoring;
[0083] Figure 21f This is a schematic diagram of the use scenario after the tamping device in the preferred embodiment nine of this utility model has completed tamping.
[0084] In the picture:
[0085] Pre-planned pipeline 10; target chamber 20;
[0086] Repair stent 100; delivery catheter 200;
[0087] Low porosity zone 1; High porosity zone 2; Whole-body spine 3; Whole-body spine in low porosity zone 31; Whole-body spine in high porosity zone 32; Stent body 4; Stent body in low porosity zone 41; Stent body in high porosity zone 42; Imaging marker 5; Sleeve 61; Shaft 62; Block 63; Filter screen 7; Aneurysm embolization device 8. Detailed Implementation
[0088] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become clearer from the following description. It should be noted that the drawings are all in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.
[0089] The terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the mechanism or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. The term "proximal end" usually refers to the end closer to the operator; "distal end" is the end opposite to "proximal end," usually referring to the end farther away from the operator.
[0090] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "fixation," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between the components; they can refer to a direct connection or a connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.
[0091] The present invention will now be described in detail with reference to the accompanying drawings and preferred embodiments. Unless otherwise specified, the following embodiments and features can complement or combine with each other.
[0092] Reference Figure 1 and Figure 2 As shown, a preferred embodiment of this utility model provides an intracranial artery repair stent for sealing a target chamber 20 on a predetermined conduit 10. The repair stent 100 includes a continuous spine 3 and a stent body 4 connected to each other. The continuous spine 3 extends along the axial direction of the stent body 4, and the length of the continuous spine 3 matches the length of the stent body 4.
[0093] Furthermore, the repair scaffold 100 has axially arranged low-porosity regions 1 and high-porosity regions 2. In one example, the low-porosity regions 1 and high-porosity regions 2 are connected axially along the scaffold body 4. In another example, the low-porosity regions 1 and high-porosity regions 2 are spaced apart axially along the scaffold body 4 and connected through the entire spine 3.
[0094] Furthermore, the axial length of the low-porosity region 1 in the support body 4 matches the opening length of the target chamber 20 in the predetermined conduit 10. The high-porosity region 2 serves to support the target chamber 20 within the predetermined conduit 10, while the low-porosity region 1 serves to seal the target chamber 20. Preferably, the low-porosity region 1 includes a region of the entire spine 3 used to seal the target chamber 20. The entire spine 3 serves to prevent axial shortening of the low-porosity region 1 and the high-porosity region 2 during release.
[0095] Reference Figure 1 and Figure 2 Multiple sets of radiopaque markers 5 are provided on the main body 4 of the support or the entire spine 3. Two sets of radiopaque markers 5 are located at both ends of the low porosity zone 1 along its own axis.
[0096] It should be understood that the predetermined conduit 10 usually refers to an intracranial artery, and the target chamber 20 on the predetermined conduit 10 usually refers to an aneurysm on an intracranial artery.
[0097] Typically, intracranial artery repair stents are inserted into intracranial arteries via the internal carotid artery system or the vertebrobasilar artery system. The stents can be released at the aneurysm site of the intracranial artery and block the artery.
[0098] More specifically, the support body 4 has a compressed state and a released state. When the support body 4 is loaded into the conveying device, the support body 4 is in a compressed state. After at least a portion of the support body 4 is removed from the conveying device, the support body 4 changes from a compressed state to a released state and is located in the predetermined pipeline 10.
[0099] Furthermore, the outer diameter of the support body 4 after release matches the inner diameter of the predetermined pipeline 10, so that the support body 4 can be anchored in the predetermined pipeline 10 after release.
[0100] This application provides an intracranial artery repair stent 100, which includes a whole-body spine 3. Since the whole-body spine 3 has the property of not being axially stretched, the axial length of the intracranial artery repair stent remains unchanged in the gripping state and the release state. This can effectively avoid the shortening and displacement of the repair stent 100 during the release process, so as to achieve highly precise positioning and release of the repair stent 100.
[0101] Simultaneously, this configuration effectively shortens the length of the low porosity zone 1, ensuring that its design length only covers the neck of the aneurysm. This not only achieves effective occlusion of the aneurysm but also avoids the phenomenon of blocking nearby branch vessels by increasing the design length of the low porosity zone 1 in order to completely occlude the aneurysm. It reduces the probability of the low porosity zone 1 covering branch vessels, minimizing its impact on branch vessels and the aneurysm-bearing vessel. This ensures the patency of branch vessels on the intracranial aneurysm-bearing artery and is very suitable for treating intracranial aneurysms, especially those deep intracranial aneurysms with complex vascular anatomy and numerous branches, bringing significant clinical benefits to patients.
[0102] Furthermore, the repair stent 100 features a zoned design with different porosities. A high-porosity zone 2 of a certain length is designed at one or both ends of the low-porosity zone 1. The low-porosity zone 1 is used to accurately seal the aneurysm ostium via the contrast marker 5, while the high-porosity zone 2 is anchored to the conduit 10 near the aneurysm. This ensures the repair stent 100 is stably anchored within the predetermined conduit 10, guaranteeing the sealing effect of the low-porosity zone 1, improving the stability of the repair stent 100 implantation and the effectiveness of the treatment. Simultaneously, the larger mesh size in the high-porosity zone 2 ensures the patency of branch vessels and retains the possibility of secondary interventional treatment, further enhancing the treatment outcome.
[0103] This application does not limit the material used to prepare the scaffold body 4. Preferably, the scaffold body 4 can be made of metallic materials, such as shape memory alloys, stainless steel, and biodegradable metals. Alternatively, the scaffold body 4 can also be made of polymeric materials, such as biodegradable polymers.
[0104] In addition, the support body 4 can be manufactured in a variety of ways, such as by laser cutting, weaving and chemical etching, but is not limited to these methods.
[0105] Reference Figures 3a-3f The mesh shape of the support body 41 in the low porosity region and / or the mesh shape of the support body 42 in the high porosity region are triangular, quadrilateral, hexagonal or strip-shaped.
[0106] Reference Figures 3a-3c As shown, the mesh shape of the stent body 4 is preferably triangular, quadrilateral, or hexagonal. In this case, the stent body 4 has an array mesh structure with the same size in both the axial and circumferential directions, which makes the structure more stable and can more effectively block the aneurysm opening.
[0107] Reference Figures 3d to 3fAs shown, the mesh shape of the stent body 4 is preferably elongated. The stent body 42 in the high porosity region has a mesh structure with an axial dimension much smaller or much larger than the circumferential dimension. This structure allows microcatheters to pass through the stent body 42 in the high porosity region, enabling secondary intervention in branch vessels. When the mesh shape of the low porosity region 1 is elongated, it allows larger external instruments (such as aneurysm embolization devices) to enter the target chamber 20, thereby achieving aneurysm embolization treatment.
[0108] Reference Figure 1 and Figure 2 As shown, in some embodiments, the radiopaque marker 5 is disposed on the entire spine 3. In other embodiments, the radiopaque marker 5 is disposed in the region of the support body 4 near the entire spine 3. For example, the low porosity region 1 includes the support body 41 of the low porosity region, and the high porosity region 2 includes the support body 42 of the high porosity region. The radiopaque marker 5 may be disposed on the support body 41 of the low porosity region and / or the support body 42 of the high porosity region near the entire spine 3 (i.e., the radiopaque marker 5 is disposed in the vicinity of the entire spine 3).
[0109] In some other embodiments, radiopaque markers 5 are disposed on the entire spine 3 and on the support body 41 in regions adjacent to the entire spine 3. The entire spine 3 has at least one set of radiopaque markers 5, which are disposed at the distal and / or proximal ends of the entire spine 3. The support body 41 has at least three sets of radiopaque markers 5, which are respectively disposed at both ends of the low porosity region 1 and both ends of the high porosity region 2.
[0110] Continue to refer to Figure 1 and Figure 2 As shown, in one example, there are two sets of imaging markers 5. The two sets of imaging markers 5 are set at both ends of the low porosity region 1 along its own axis. The distance between the imaging markers 5 at both ends of the low porosity region 1 matches the distance between the two ends of the neck of the aneurysm, so that the low porosity region 1 of the repair stent 100 can effectively block the aneurysm.
[0111] During actual implantation, the low porosity zone 1 can be positioned at the aneurysm opening by using the contrast marker 5. The advantage of designing the contrast marker 5 is that, on the one hand, it can achieve high-precision positioning and release of the repair stent 100, and on the other hand, it can shorten the length of the low porosity zone 1 during the design so that the low porosity zone 1 just covers the aneurysm neck opening. The shorter low porosity zone 1 can better ensure the patency of branch vessels.
[0112] Reference Figure 10As shown, in another example, there are four sets of imaging markers 5. Imaging markers 5 are provided at both ends of the low porosity region 1 and at both ends of the stent body 4, which helps to accurately position the low porosity region 1 of the repair stent 100 at the aneurysm on the intracranial artery.
[0113] As a preferred embodiment, the entire spine 3 is part of the support body 4. In this case, the repair support 100 can be formed into the support body 4 containing the entire spine 3 by laser cutting.
[0114] As another preferred embodiment, the entire spine 3 is disposed on the inner or outer wall of the support body 3. In this case, the repair support 100 can be formed into the support body 4 by laser cutting or weaving, and then the columnar or sheet-like entire spine 3 is fixed to the inner or outer wall of the support body 4 to form the repair support 100.
[0115] The repair stent 100 provided by this invention can achieve aneurysm closure treatment solely through the low porosity region 1. When the circumferential dimension of the mesh in the low porosity region 1 is much larger or much smaller than its axial dimension, the low porosity region 1 can be used as a support-assisted embolization device for aneurysm tamponade. Simultaneously, when the low porosity region 1 is changed to a mesoporosity region or a high porosity region, the low porosity region 1 can also be used as a support-assisted embolization device for aneurysm tamponade.
[0116] In a preferred embodiment, there are two high-porosity regions 2 and one low-porosity region 1, that is, the repair scaffold 100 includes one low-porosity region 1 and two high-porosity regions 2 (see reference). Figure 1 The two high porosity zones 2 are connected to the two ends of the low porosity zone 1, respectively. That is, the two high porosity zones 2 are respectively set at the near end and far end of the low porosity zone 1, so as to better support the repair support 100 in the predetermined pipeline 10.
[0117] In another preferred embodiment, the number of high-porosity regions 2 is one, and the number of low-porosity regions 1 is one, that is, the repair scaffold 100 includes one low-porosity region 1 and one high-porosity region 2 (see reference). Figure 1 The high porosity region 2 is located at one end of the low porosity region 1, meaning that the high porosity region 2 can be located at the proximal or distal end of the low porosity region 1 to accommodate the complex vascular anatomy.
[0118] Reference Figures 4a-4c As shown, the cross-sectional shape of the entire spine 31 in the low porosity region is circular or rectangular, and the cross-sectional shape of the entire spine 32 in the high porosity region is also circular or rectangular.
[0119] Reference Figure 4a and Figure 4bIn some embodiments, the number of integral spines 31 in the low porosity region is one, and the number of integral spines 32 in the high porosity region is two, with the two integral spines 32 in the high porosity region respectively disposed at both ends of the integral spine 31 in the low porosity region.
[0120] As one option, the cross-sectional shape of the entire spine 31 in the low porosity region is circular, and the cross-sectional shape of the entire spine 32 in the high porosity region is rectangular. As another option, the cross-sectional shape of the entire spine 31 in the low porosity region is rectangular, and the cross-sectional shape of the entire spine 32 in the high porosity region is circular.
[0121] Reference Figure 4c In other embodiments, the number of transverse spines 31 in the low porosity region is one, and the number of transverse spines 32 in the high porosity region is one. The transverse spine 32 in the high porosity region may be located at one end (e.g., proximal or distal) of the transverse spine 31 in the low porosity region.
[0122] Reference Figures 5a-5c As shown, the entire spine 3 of the repair frame 100 can have different cross-sectional designs, so that the repair frame 100 has designed torsional stiffness (refer to...). Figure 5b ), Upward and downward bending stiffness (refer to) Figure 5a ) and left and right bending stiffness (refer to Figure 5c This allows the repair stent 100 to have better vascular anatomy compliance, thereby achieving high-precision release of the repair stent 100 and improving the occlusion effect of the low porosity region 1.
[0123] More specifically, when the cross-sectional shape of the whole spine 31 in the low porosity region and / or the cross-sectional shape of the whole spine 32 in the high porosity region are circular, the whole spine 31 in the low porosity region and / or the whole spine 32 in the high porosity region have isotropic bending stiffness and excellent torsional stiffness, which makes the repair scaffold 100 have better overall stability.
[0124] When the cross-sectional shape of the whole spine 31 in the low porosity region and / or the cross-sectional shape of the whole spine 32 in the high porosity region are rectangular, the whole spine 31 in the low porosity region and / or the whole spine 32 in the high porosity region have anisotropic bending stiffness, which can better control the bending stiffness of the repair stent 100 in a specific direction and improve the compliance of the repair stent 100 with blood vessels of specific anatomical structures.
[0125] Reference Figure 6 As shown, when the repair stent 100 needs to be delivered to the bend of an S-shaped intracranial artery to occlude an aneurysm, the vessels on both sides bend in opposite directions, and there may be spatial distortion between the proximal and distal vessels of the aneurysm. Preferably, the entire spine 3 can be used as... Figure 6The design is optimized to give the repair stent 100 better therapeutic effects.
[0126] Specifically, the entire spine 32 with a rectangular cross-sectional shape and high porosity is a rectangular region. Figure 6 The AB and CD segments (in the aneurysm) can better match the spatial tortuous shape of the intracranial arteries at the proximal and distal ends of the aneurysm, thus allowing the transverse spine 32 in the high porosity region to better conform to the inner wall of the vessel on the aneurysm side. Meanwhile, the transverse spine 31 in the low porosity region (with a circular cross-section) Figure 6 The BC segment of the aneurysm has isotropic bending stiffness and high torsional stiffness, thus maintaining good structural stability even when the vascular space on both sides of the aneurysm is tortuous, further improving the closure effect of the aneurysm.
[0127] like Figure 1 and Figure 2 As shown, the entire spine 3 can be configured as a straight line or an arc. The cross-sectional shape of the entire spine 3 is preferably matched to the cross-sectional shape of the predetermined conduit 10, so that the repair stent 100 fits more closely to the inner wall of the predetermined conduit 10. For example, when the entire spine 3 of the repair stent 100 is designed as an arc, the entire spine 3 allows the repair stent 100 to better fit the aneurysm on the greater curvature side of the arc-shaped vessel, thereby achieving a better occlusion effect (see reference). Figure 2 ).
[0128] The entire spine 3 of the repair stent 100 provided in this application can have a specific shape design. For example, the entire spine 3 can be set as a straight line or an arc so that the shape of the entire spine 3 matches the structure of the tumor-bearing artery. This helps the repair stent 100 to adapt to the complex intracranial vascular anatomy and further improves the adhesion of the low porosity region 1 of the repair stent 100 to the intracranial artery, thereby achieving more effective occlusion.
[0129] Reference Figure 1 , Figure 7a and Figure 7b As shown, the number of the entire spine 3 is one or more. When the number of the entire spine 3 is multiple, the multiple entire spines 3 are spaced apart in the circumferential direction of the support body 4, which further improves the release stability of the repair support 100.
[0130] like Figure 7a As shown, in a specific example, there are two spindles 3, which are arranged on opposite sides of the support body 4.
[0131] like Figure 7b As shown, in another specific example, there are four spindles 3, which are evenly or non-uniformly arranged around the circumference of the support body 4.
[0132] Furthermore, the cross-sectional shape of the low porosity zone can be set as an annular or partially annular, and the cross-sectional shape of the high porosity zone can also be set as an annular or partially annular (i.e., a circular arc structure less than 360 degrees). The outer diameter of the low porosity zone 1 after release and the outer diameter of the high porosity zone 2 after release are both matched with the inner diameter of the predetermined pipeline 10, so that the repair support 100 can achieve sealing and anchoring within the predetermined pipeline 10.
[0133] Reference Figure 8a and Figure 8b As shown, in a preferred embodiment, the cross-sectional area of the low porosity region 1 and / or the cross-sectional area of the high porosity region 2 gradually change along the axial direction of the support body 4.
[0134] In a specific example, the cross-sectional shape of both the high-porosity region 2 and the low-porosity region 1 is partially annular. The cross-sectional shape of the low-porosity region 1 gradually increases from the middle to both ends along the axial direction of the support body 4, and the cross-sectional shapes at both ends of the low-porosity region 1 are partially annular (see reference). Figure 8a In another specific example, the cross-sectional shape of the high-porosity region 2 is annular, and the cross-sectional shape of the low-porosity region 1 is partially annular. The cross-sectional shape of the low-porosity region 1 gradually increases from the middle position to both ends along the axial direction of the support body 4, and the cross-sectional shapes at both ends of the low-porosity region 1 are annular (see reference). Figure 8b Both of the above embodiments can meet the treatment needs of aneurysms at the bifurcation of intracranial arteries, and can maintain the patency of the main blood vessels and branch vessels to the maximum extent while effectively sealing the aneurysm with the repair stent 100.
[0135] Reference Figure 1 As shown, the cross-sectional shape of the low porosity region 1 and the cross-sectional shape of the high porosity region 2 can both be set as annular to ensure that the repair stent 100 is firmly fixed in the blood vessel.
[0136] A preferred embodiment of the present invention also provides an intracranial artery repair system, including a delivery device and an intracranial artery repair stent as described in any one of the present inventions, wherein the delivery device is used to deliver the intracranial artery repair stent.
[0137] Reference Figure 9As shown, in a preferred embodiment, the delivery system includes a delivery wire (not shown), a sleeve 61, and a shaft 62. The shaft 62 has two spaced-apart stops 63. The sleeve 61 is fitted onto the shaft 62 and movably positioned between the two stops 63. The intracranial artery repair stent is connected to one of the sleeve 61 and the shaft 62, and the delivery wire is connected to the other. In this configuration, the repair stent 100 and the delivery wire can move and rotate relative to each other, preventing twisting and deformation of the repair stent 100 during delivery and achieving a limited axial displacement constraint connection between the repair stent 100 and the delivery device. This method helps the repair stent 100 conform to the vascular anatomy, especially for non-circularly designed repair stents 100, enabling effective delivery and enhancing the aneurysm-sealing ability of the low-porosity region 1 of the repair stent 100, further improving the effectiveness of the intracranial artery repair system.
[0138] The structure of the intracranial artery repair stent is described below through specific embodiments.
[0139] <Example 1>
[0140] Reference Figure 10 As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and two high-porosity regions 2. The two high-porosity regions 2 are respectively connected to both ends of the low-porosity region 1. Development marks 5 are respectively disposed at both ends of the low-porosity region 1 and both ends of the repair stent 100.
[0141] Furthermore, the repair scaffold 100 is preferably laser-cut from a shape memory alloy material. The low porosity region 1 is preferably configured with a fine diamond pattern and small-sized diamond mesh; the high porosity region 2 is preferably configured with a sparse diamond pattern and larger-sized diamond mesh.
[0142] Figures 11a-11d The process of accurately positioning and releasing the repair stent 100 via the delivery catheter 200 is illustrated. When the repair stent 100 is delivered via the delivery catheter 200, it is first implanted into the predetermined conduit 10. During the delivery and positioning of the repair stent 100, the contrast markers 5 at both ends of the low porosity region 1 of the repair stent 100 are positioned on both sides of the target chamber 20 so that the low porosity region 1 can occlude the aneurysm. At this point, preparation can be made for the release of the repair stent 100 (see reference). Figure 11a ).
[0143] Then, the delivery conduit 200 can be retracted to achieve the gradual release of the repair stent 100. During the retraction of the delivery conduit 200, the high porosity region 2 at the distal end of the repair stent 100 begins in-situ release first (refer to...). Figure 11bBecause of the role of the entire spine 3, the repair stent 100 will not shorten during release. The length of the repair stent 100 in its own axis remains unchanged before and after release. At this time, the repair stent 100 can still maintain the delivery position during the release process. That is to say, after the high porosity region 2 at the distal end of the repair stent 100 is released, the position of the low porosity region 1 of the repair stent 100 will not change. The low porosity region 1 can block the aneurysm orifice, realizing the precise in-situ release of the repair stent 100.
[0144] Subsequently, as the delivery catheter 200 is gradually withdrawn, the low-porosity region 1 and the proximal high-porosity region 2 of the repair stent 100 are gradually released. The low-porosity region 1 and the proximal high-porosity region 2 do not shorten during release. After the repair stent 100 is completely released, the low-porosity region 1 remains precisely distributed at the aneurysm ostium (refer to...). Figure 11c ).
[0145] After the stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body. The high porosity regions 2 at both ends of the stent 100 can be stably anchored within the predetermined tubing 10 (see reference). Figure 11d On the one hand, it ensures that the low porosity zone 1 of the repair stent 100 can always effectively block the aneurysm; on the other hand, the high porosity zone 2 will not block the branch lines of the predetermined conduit 10, thus ensuring the patency of the branch vessels on the intracranial arteries.
[0146] <Example 2>
[0147] In this embodiment, the repair scaffold 100 includes a low-porosity region 1 and a high-porosity region 2. The high-porosity region 2 is disposed at one end of the low-porosity region 1. Figure 12a In the middle, the high porosity zone 2 is located at the distal end of the low porosity zone 1. The development marks 5 are respectively located at the proximal and distal ends of the low porosity zone 1, and at the distal end of the repair scaffold 100.
[0148] Figures 12a-12d The process of accurately positioning and releasing the repair stent 100 via the delivery catheter 200 is illustrated. When the repair stent 100 is delivered via the delivery catheter 200, it is first implanted into the predetermined conduit 10. During the delivery and positioning of the repair stent 100, the contrast markers 5 at both ends of the low porosity region 1 of the repair stent 100 are positioned on both sides of the target chamber 20 so that the low porosity region 1 can occlude the aneurysm. At this point, preparation can be made for the release of the repair stent 100 (see reference). Figure 12a ).
[0149] Then, the delivery conduit 200 can be retracted to achieve the gradual release of the repair stent 100. During the retraction of the delivery conduit 200, the high porosity region 2 at the distal end of the repair stent 100 begins in-situ release first (refer to...). Figure 12b After the high-porosity region 2 at the distal end of the repair stent 100 is released, the position of the low-porosity region 1 of the repair stent 100 will not change. At this time, the low-porosity region 1 can block the aneurysm orifice, realizing the precise in-situ release of the repair stent 100.
[0150] Subsequently, as the delivery catheter 200 is gradually withdrawn, the low-porosity region 1 of the repair stent 100 is gradually released. The low-porosity region 1 and the proximal high-porosity region 2 do not shorten during release. After complete release of the repair stent 100, the low-porosity region 1 remains precisely distributed at the aneurysm ostium (see reference). Figure 12c ).
[0151] After the stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body. The high porosity region 2 at the distal end of the stent 100 can be stably anchored within the predetermined tubing 10 (see reference). Figure 12d On the one hand, it ensures that the low porosity zone 1 of the repair stent 100 can always effectively block the aneurysm; on the other hand, the high porosity zone 2 will not block the branch lines of the predetermined conduit 10, which can ensure the patency of the branch vessels on the intracranial artery. Furthermore, setting the high porosity zone 2 only at the distal end of the low porosity zone 1 further reduces the impact of the repair stent 100 on the proximal branch vessels of the aneurysm and can match more complex aneurysm anatomy.
[0152] <Example 3>
[0153] In this embodiment, the repair scaffold 100 includes a low-porosity region 1 and a high-porosity region 2. The high-porosity region 2 is disposed at one end of the low-porosity region 1. Figure 13a In this design, the high-porosity region 2 is positioned proximal to the low-porosity region 1. Imaging markers 5 are positioned proximal and distal to the low-porosity region 1, and proximal to the repair stent 100. This design minimizes the space occupied by the repair stent 100 on the distal artery of the aneurysm, making it suitable for anatomical structures where the distal artery of the aneurysm is narrowed or extremely tortuous.
[0154] Figures 13a-13d The process of accurately positioning and releasing the repair stent 100 via the delivery conduit 200 is illustrated. During delivery of the repair stent 100 via the delivery conduit 200, the imaging markers 5 at both ends of the low porosity region 1 of the repair stent 100 are first positioned on both sides of the target chamber 20 (see reference). Figure 13a Then, the delivery catheter 200 was gradually retracted, and the low porosity region 1 at the distal end of the repair stent 100 began in-situ release (refer to...). Figure 13b After the stent 100 is fully deployed, the low porosity zone 1 is precisely distributed at the aneurysm ostium (refer to...). Figure 13cThis achieves effective closure of the aneurysm. After the repair stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body. The high porosity region 2 at the proximal end of the repair stent 100 can be stably anchored within the predetermined tubing 10 (see reference). Figure 13d ).
[0155] <Example 4>
[0156] Reference Figure 14a and Figure 14b As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and a high-porosity region 2. Figure 14a In this configuration, the high-porosity region 2 is located near or far from the low-porosity region 1. Development markers 5 are positioned at both ends of the low-porosity region 1 and near the proximal end of the repair scaffold 100.
[0157] Furthermore, the outer diameter of the low porosity region 1 and the outer diameter of the high porosity region 2 are both matched with the inner diameter of the predetermined conduit 10. The cross-sectional shape of the low porosity region 1 and / or the high porosity region 2 of the repair stent 100 is partially annular, that is, both the low porosity region 1 and / or the high porosity region 2 are non-circular designs, which can ensure that the main blood vessel and branch blood vessels are unobstructed after the repair stent 100 is implanted.
[0158] It should be noted that when treating intracranial bifurcation aneurysms, because the aneurysm is located in a location with one main blood vessel and at least two branch vessels, a circumferentially designed repair stent 100 would block the main blood vessel or at least one branch vessel, making secondary interventional treatment impossible. To accommodate the treatment of intracranial bifurcation aneurysms, this embodiment employs a non-circumferential design for at least a portion of the repair stent 100, ensuring that the repair stent 100 does not block the main blood vessel or branch vessels, thereby guaranteeing that the intracranial arteries and branch vessels remain unobstructed.
[0159] Reference Figure 14a As shown, in a preferred embodiment, the cross-sectional shape of both the low-porosity region 1 and the high-porosity region 2 of the repair stent 100 is partially annular, meaning that both the low-porosity region 1 and the high-porosity region 2 are non-circular designs. This configuration allows for a smaller delivery system required for the repair stent 100, enabling the system to reach deeper intracranial arteries, thus making it more suitable for treating deep intracranial aneurysms.
[0160] Reference Figure 14bAs shown, in a preferred embodiment, at least a portion of the low-porosity region 1 of the repair stent 100 has a partially annular cross-sectional shape, while the high-porosity region 2 has an annular cross-sectional shape. In this case, the low-porosity region 1 is a non-circular design, and the high-porosity region 2 is a circular design. With this configuration, the high-porosity region 2 of the repair stent 100 has a stronger radial support force, which allows the repair stent 100 to be more stably anchored at the implantation site.
[0161] <Example 5>
[0162] Reference Figures 15a-15e As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and two high-porosity regions 2. The two high-porosity regions 2 are located at both ends of the low-porosity region 1. Development marks 5 are respectively disposed at both ends of the low-porosity region 1, and at the proximal and distal ends of the repair stent 100.
[0163] Furthermore, the cross-sectional shape of a high porosity region 2 is annular, and the cross-sectional shape of at least a portion of the low porosity region 1 and the cross-sectional shape of the other high porosity region 2 are both partially annular.
[0164] Reference Figure 15a As shown, in a specific example, the cross-sectional shape of at least a portion of the low-porosity region 1, and the cross-sectional shape of the high-porosity region 2 proximal to the low-porosity region 1, are both partially annular, while the cross-sectional shape of the high-porosity region 2 distal to the low-porosity region 1 is annular. That is, both the low-porosity region 1 and the distal high-porosity region 2 are non-circular designs, while the proximal high-porosity region 2 is a circumferential design. The cross-sectional area of the low-porosity region 1 in its own axial direction gradually decreases from the distal end to the proximal end, thus achieving a transition between the annular distal high-porosity region 2 and the partially annular proximal high-porosity region 2. The advantage of this is that it simplifies the release of the repair stent 100 and ensures that all blood vessels remain patent.
[0165] In another specific example, the cross-sectional shape of at least a portion of the low porosity region 1, and the cross-sectional shape of the high porosity region 2 at the distal end of the low porosity region 1, are both partially annular, while the cross-sectional shape of the high porosity region 2 at the proximal end of the low porosity region 1 is annular.
[0166] Figures 15a-15e The process of accurately positioning and releasing the repair stent 100 via the delivery conduit 200 is illustrated. During delivery of the repair stent 100 via the delivery conduit 200, the imaging marker 5 at the distal end of the low porosity region 1 of the repair stent 100 is positioned on one side of the target chamber 20 (see reference). Figure 15a Then, the delivery catheter 200 was gradually retracted, and the high-porosity region 2 at the distal end of the repair stent 100 began in-situ release (refer to...). Figure 15bAfter the stent 100 was fully deployed, part of it was located in the main vessel and the other part in the first branch vessel. At this point, the stent 100 failed to occlude the aneurysm (see reference). Figure 15c The proximal end of the repair stent 100 is smoothly guided and pushed into the second branch vessel using a pre-shaped delivery wire. The contrast markers 5 at both ends of the low porosity zone 1 are located on both sides of the aneurysm orifice, and the low porosity zone 1 is precisely distributed at the aneurysm orifice to achieve effective occlusion of the aneurysm (refer to...). Figure 15d After the stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body. The high porosity regions 2 at both ends of the stent 100 can be stably anchored within the predetermined tubing 10 (see reference). Figure 15e This improved the overall stability of the repair stent 100.
[0167] <Example 6>
[0168] Reference Figures 16a-16e As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and a high-porosity region 2. The high-porosity region 2 is located at the distal end of the low-porosity region 1. Development marks 5 are respectively disposed at both ends of the low-porosity region 1 and at the distal end of the repair stent 100.
[0169] Furthermore, the cross-sectional shape of the low-porosity region 1 is partially annular, while the cross-sectional shape of the high-porosity region 1 is annular. That is, the low-porosity region 1 is a non-circular design, and the high-porosity region 2 is a circular design. The cross-sectional area of the low-porosity region 1 gradually decreases from the distal end to the proximal end to achieve its non-circular design. This design simplifies the deployment of the repair stent 100 and ensures that all vessels remain patent. Simultaneously, this design eliminates the need to deploy the repair stent 100 into the second branch vessel, making it suitable for scenarios where the anatomy of the second branch vessel is tortuous and the repair stent 100 is difficult to guide into the vessel.
[0170] Figures 16a-16e The process of accurately positioning and releasing the repair stent 100 via the delivery conduit 200 is illustrated. During delivery of the repair stent 100 via the delivery conduit 200, the imaging marker 5 at the distal end of the low porosity region 1 of the repair stent 100 is positioned on one side of the target chamber 20 (see reference). Figure 16a Then, the delivery catheter 200 was gradually retracted, and the high-porosity region 2 at the distal end of the repair stent 100 began in-situ release (refer to...). Figure 16b After the stent 100 was fully deployed, it was in a bent position, with part of it located in the main vessel and the other part in the first branch vessel. At this point, the stent 100 failed to occlude the aneurysm (see reference). Figure 16cThe proximal end of the low-porosity region 1 is smoothly guided to the other side of the aneurysm orifice using a pre-shaped delivery wire. The imaging markers 5 at both ends of the low-porosity region 1 are positioned on both sides of the aneurysm orifice, allowing the low-porosity region 1 to be precisely distributed at the aneurysm orifice, thereby achieving effective occlusion of the aneurysm (refer to...). Figure 16d After the stent 100 is implanted and fully released, the delivery catheter 200 is withdrawn from the body. The high porosity region 2 at the distal end of the stent 100 can be stably anchored within the predetermined tubing 10 (see reference). Figure 16e This improved the overall stability of the repair stent 100.
[0171] <Example 7>
[0172] Reference Figure 17a and Figure 17b As shown, in this embodiment, the repair stent 100 includes a low porosity region 1 and a high porosity region 2. The high porosity region 2 is located at one end (i.e., the proximal or distal end) of the low porosity region 1. Imaging markers 5 are respectively disposed at the proximal and distal ends of the low porosity region 1, and at the proximal or distal end of the repair stent 100.
[0173] In a preferred embodiment, the entire spine 3 is straight. Figure 17a This is a schematic diagram illustrating the application of an intracranial repair stent with a straight spine at the apical bifurcation of an aneurysm with curved branches. (Example) Figure 17a As shown, the straight spine cannot match the arc-shaped branching blood vessels to achieve proper fit between the repair stent and both sides of the aneurysm, thus failing to effectively seal the aneurysm opening.
[0174] In another preferred embodiment, the entire spine 3 is arc-shaped. Figure 17b This is a schematic diagram illustrating the application of an intracranial repair scaffold with an arc-shaped spine at the apical bifurcation of an aneurysm with arc-shaped branches. (Example) Figure 17b As shown, the arc-shaped repair stent 100 can be used to treat apical bifurcation aneurysms of intracranial arteries with arc-shaped branches. The arc-shaped integral spine 3 can closely fit the aneurysm opening, thereby achieving effective closure treatment of the bifurcation aneurysm.
[0175] In some embodiments, the cross-sectional shape of the low porosity region 1 and the high porosity region 2 of the repair stent 100 are both annular. In this case, both the low porosity region 1 and the high porosity region 2 are circumferentially designed, and the overall spine 3 of the repair stent 100 is arc-shaped.
[0176] Reference Figure 18a As shown, in one example, the low porosity region 1 is configured with fine ribs, and the high porosity region 2 is configured with sparse ribs.
[0177] Reference Figure 18bAs shown, in one example, the low porosity region 1 is set with a fine diamond pattern, that is, the low porosity region 1 has small diamond mesh; the high porosity region 2 is set with a sparse diamond pattern, that is, the high porosity region 2 has large diamond mesh.
[0178] Reference Figure 19a and Figure 19c As shown, in some other embodiments, the cross-sectional shape of both the low-porosity region 1 and the high-porosity region 2 of the repair stent 100 is partially annular. In this case, both the low-porosity region 1 and the high-porosity region 2 are non-circular designs, and the overall spine 3 of the repair stent 100 is arc-shaped. The low-porosity region 1 is configured with dense ribs, and the high-porosity region 2 is configured with sparse ribs.
[0179] Reference Figure 19b As shown, in some other embodiments, the cross-sectional shape of the low-porosity region 1 of the repair stent 100 is partially annular, and the cross-sectional shape of the high-porosity region 2 is annular. In this case, the low-porosity region 1 is a non-circular design, the high-porosity region 2 is a circular design, and the overall spine 3 of the repair stent 100 is arc-shaped. The low-porosity region 1 is configured with a fine diamond-shaped mesh, and the high-porosity region 2 is configured with a sparse diamond-shaped mesh.
[0180] <Example 8>
[0181] Reference Figure 20a and Figure 20b As shown, in this embodiment, the repair stent 100 includes a low-porosity region 1 and a high-porosity region 2. The high-porosity region 2 is located at the proximal or distal end of the low-porosity region 1. Imaging markers 5 are respectively disposed at the proximal and distal ends of the low-porosity region 1, and at the proximal or distal end of the repair stent 100.
[0182] Furthermore, the cross-sectional shape of the low-porosity region 1 of the repair scaffold 100 is partially annular, while the cross-sectional shape of the high-porosity region 2 is annular. In this case, the low-porosity region 1 is a non-circular design, and the high-porosity region 2 is a circular design. The overall shape of the spine 3 of the repair scaffold 100 is linear (refer to...). Figure 20a ) or arc (refer to) Figure 20b The low porosity zone 1 is configured with a fine diamond-shaped mesh, while the high porosity zone 2 is configured with a sparse diamond-shaped mesh.
[0183] In this embodiment, the low-porosity region 1 also includes a filter 7 (e.g., a woven mesh), which is attached to the inner or outer wall of the stent body 41 in the low-porosity region. The mesh size of the filter 7 is smaller than that of the stent body 41 in the low-porosity region. The low-porosity region 1 with the filter 7 can improve the occlusion effect of the aneurysm. This allows for a reduction in the outer diameter of the low-porosity region 1 while maintaining its occlusion effect, thereby reducing the size of the delivery system and making the intracranial artery repair system suitable for treating deeper intracranial aneurysms.
[0184] <Example 9>
[0185] The parts that are the same as in Embodiment 6 will not be described in detail here; only the differences will be described below.
[0186] In this embodiment, the mesh shape of the low porosity region 1 is elongated. The elongated mesh allows the aneurysm embolization device to pass through and enter the target chamber to achieve embolization treatment of the aneurysm.
[0187] Figures 21a-21f The process of accurately positioning and releasing the repair stent 100 via the delivery conduit 200 is illustrated. During delivery of the repair stent 100 via the delivery conduit 200, the imaging marker 5 at the distal end of the low porosity region 1 of the repair stent 100 is positioned on one side of the target chamber 20 (see reference). Figure 21a Then, the delivery catheter 200 was gradually retracted, and the high-porosity region 2 at the distal end of the repair stent 100 began in-situ release (refer to...). Figure 21b After the stent 100 was fully deployed, it was in a bent position, with part of it located in the main vessel and the other part in the first branch vessel. At this point, the stent 100 failed to occlude the aneurysm (see reference). Figure 21c The proximal end of the low-porosity region 1 is smoothly guided to the other side of the aneurysm orifice using a pre-shaped delivery wire. The imaging markers 5 at both ends of the low-porosity region 1 are positioned on both sides of the aneurysm orifice, allowing the low-porosity region 1 to be precisely distributed at the aneurysm orifice, thereby achieving effective occlusion of the aneurysm (refer to...). Figure 21d The delivery catheter 200 can be withdrawn before or after aneurysm tamponade. After the repair stent 100 is implanted and fully released, the catheter is passed through the stent body 41 in the low porosity zone of the aneurysm ostium, and the aneurysm tamponade device 8 is implanted into the aneurysm (see reference). Figure 21e After the aneurysm occlusion device 8 is completely implanted into the aneurysm, the delivery catheter 200 is withdrawn from the body to complete the implantation of the repair stent 100 and the aneurysm occlusion device 8. After implantation, the high-porosity region 2 of the repair stent 100 can be stably anchored within the predetermined conduit 10, and the low-porosity region 1 of the repair stent 100 can seal the target chamber 20 and support the aneurysm occlusion device 8 within the aneurysm (see reference). Figure 21f This improved the stability of aneurysm embolization and the effectiveness of treatment.
[0188] In summary, this utility model provides an intracranial artery repair stent and an intracranial artery repair system. The repair stent 100 includes a whole-body spine 3. Since the whole-body spine 3 has the property of not being axially stretched, the axial length of the intracranial artery repair stent remains unchanged in the gripping state and the release state. This can effectively avoid the shortening and displacement of the repair stent 100 during the release process, so as to achieve highly accurate positioning and release of the repair stent 100.
[0189] Simultaneously, this configuration effectively shortens the length of the low porosity zone 1, ensuring that its length only covers the neck of the aneurysm. This not only achieves effective occlusion of the aneurysm but also effectively avoids the phenomenon of blocking nearby branch vessels due to increasing the design length of the low porosity zone 1 in order to completely occlude the aneurysm. It reduces the probability of the low porosity zone 1 covering branch vessels, minimizing its impact on branch vessels and the aneurysm-bearing vessel. This ensures the patency of branch vessels on the intracranial aneurysm-bearing artery and is very suitable for treating intracranial aneurysms, especially those deep intracranial aneurysms with complex vascular anatomy and numerous branches, bringing significant clinical benefits to patients.
[0190] The above description is only a description of the preferred embodiment of the present utility model and is not intended to limit the scope of the present utility model in any way. Any changes or modifications made by those skilled in the art based on the above disclosure shall fall within the protection scope of the present utility model.
Claims
1. An intracranial artery repair stent for sealing a target chamber in a predetermined conduit, characterized in that, The repair stent includes an interconnected stent body and a continuous spine, the continuous spine extending axially along the stent body; the repair stent has axially arranged low-porosity regions and high-porosity regions; the high-porosity regions are used for support within the predetermined conduit, and the low-porosity regions are used for sealing the target cavity; the length of the low-porosity regions along the axial direction of the stent body matches the length of the target cavity along the predetermined conduit.
2. The intracranial artery repair stent as described in claim 1, characterized in that, Multiple sets of radiopaque markers are provided on the main body of the support or the entire spine, wherein two sets of radiopaque markers are located at the two ends of the low porosity region.
3. The intracranial artery repair stent as described in claim 2, characterized in that, The imaging marker is disposed on the entire spine, or the imaging marker is disposed on the support body in a region close to the entire spine.
4. The intracranial artery repair stent as described in claim 2, characterized in that, The radiopaque markers are disposed on the entire spine and on the support body in areas close to the entire spine; the entire spine has at least one set of radiopaque markers, and the at least one set of radiopaque markers on the entire spine is disposed at the distal end and / or the proximal end of the entire spine; the support body is provided with at least three sets of radiopaque markers, and the radiopaque markers on the support body are respectively disposed at both ends of the low porosity region and both ends of the high porosity region.
5. The intracranial artery repair stent as described in claim 1, characterized in that, The entire spine is part of the main body of the support, or the entire spine is disposed on the inner or outer wall of the main body of the support.
6. The intracranial artery repair stent as described in claim 1, characterized in that, The entire spine is arc-shaped.
7. The intracranial artery repair stent as described in claim 1, characterized in that, The number of the entire spine is one or more; when the number of the entire spine is more than one, the multiple entire spines are arranged at intervals in the circumferential direction of the support body.
8. The intracranial artery repair stent as described in claim 1, characterized in that, The cross-sectional shape of the entire spine in the low porosity region is circular or rectangular, and the cross-sectional shape of the entire spine in the high porosity region is also circular or rectangular.
9. The intracranial artery repair stent according to any one of claims 1 to 8, characterized in that, The mesh shape of the low porosity region and / or the mesh shape of the high porosity region are triangular, quadrilateral, hexagonal, or elongated. When the mesh shape of the low porosity region is elongated, it allows large external instruments to enter the target chamber.
10. The intracranial artery repair stent according to any one of claims 1 to 8, characterized in that, The cross-sectional shape of the low porosity zone is annular or partially annular, and the cross-sectional shape of the high porosity zone is also annular or partially annular; the outer diameter of the low porosity zone after release and the outer diameter of the high porosity zone after release both match the inner diameter of the predetermined pipeline.
11. The intracranial artery repair stent as described in claim 10, characterized in that, There are two high-porosity regions and one low-porosity region. The two high-porosity regions are respectively connected to the two ends of the low-porosity region. Alternatively, the number of high porosity regions is one, the number of low porosity regions is one, and the high porosity region is located at one end of the low porosity region.
12. The intracranial artery repair stent as described in claim 10, characterized in that, The low porosity zone also includes a filter screen, which is attached to the inner or outer wall of the support body in the low porosity zone. The mesh size of the filter screen is smaller than the mesh size of the support body in the low porosity zone.
13. An intracranial artery repair system, characterized in that, It includes a delivery device and an intracranial artery repair stent as described in any one of claims 1 to 12, wherein the delivery device is used to deliver the intracranial artery repair stent.
14. The intracranial artery repair system as described in claim 13, characterized in that, The delivery device includes a delivery wire, a sleeve, and a shaft. The shaft has two spaced-apart stops. The sleeve is fitted onto the shaft and is movably disposed between the two stops. The intracranial artery repair stent is connected to one of the sleeve and the shaft, and the delivery wire is connected to the other of the sleeve and the shaft.