Closed drug delivery system
By designing a closed-loop drug delivery system, utilizing a suction device and multiple closed paths, the system enables the closed transfer and mixing of drugs between containers, solving the problems of drug leakage and dispersion and reducing the harm to medical staff.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SHANGHAI JINTA MEDICAL
- Filing Date
- 2025-04-24
- Publication Date
- 2026-07-21
AI Technical Summary
The existing intravenous infusion medication preparation method has problems with drug leakage and spillage, which can lead to harm to medical staff.
A closed-loop drug delivery system was designed, including a suction device, a first container, a sealed transfer device, and multiple sealed paths. By setting flexible walls and various sealing structures, the system enables the sealed transfer and mixing of drugs between containers, preventing drug leakage and dispersion.
It effectively prevents drug leakage and dispersion, reduces harm to medical staff, and avoids the risks of drug nebulization and injection needle stick injuries.
Smart Images
Figure CN224523623U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to a closed drug delivery system. Background Technology
[0002] Currently, the vast majority of hospitals in China use the traditional method for preparing intravenous infusion medications: draw up an appropriate amount of injection solution with a syringe with a needle, press the rubber stopper of the vial with the bevel of the needle pointing upwards, then puncture the rubber stopper with the syringe vertically, inject the injection solution, and shake until completely dissolved.
[0003] Due to time and space constraints, nurses typically prepare medications in open treatment rooms with inadequate air purification systems. However, for high-risk drugs, such as chemotherapy drugs (antibiotics, anti-tumor drugs, etc.), even the slightest spillage during preparation can cause serious harm to healthcare workers. Traditional medication preparation methods, even in biosafety cabinets, cannot completely eliminate the risk of spillage and needlestick injuries. This is especially true during the preparation of cytotoxic drugs, where the generation of powder mist (spilled medication may produce aerosol / vaporization) offers no protection against this, posing a significant hazard to healthcare workers. Utility Model Content
[0004] The technical problem to be solved by this utility model is to overcome the defects of the existing intravenous infusion drug preparation mode, which has the problem of drug leakage and dispersion, thus causing harm to medical staff, and to provide a closed drug delivery system.
[0005] The present invention solves the above-mentioned technical problems through the following technical solution:
[0006] A closed-loop drug delivery system, characterized in that it comprises:
[0007] A suction device, including a suction device for suctioning or retracting gas;
[0008] A first container, the first container including at least one flexible wall, such that the pressure in the first container is substantially equal to the ambient pressure;
[0009] A sealed transfer device includes a housing, and a first interface, a second interface, and a third interface formed on the housing. The first interface is connected to the suction device and a second container, the second interface is connected to the first container, and the third interface is connected to the second container.
[0010] The system comprises a first forward sealed path, a first reverse sealed path, a second forward sealed path, and a second reverse sealed path. The first forward sealed path flows sequentially through the second container, the first interface of the sealing transfer device, and the suction device. The first reverse sealed path flows in the opposite direction to the first forward sealed path. The second forward sealed path flows sequentially through the first container, the second interface of the sealing transfer device, the third interface, and the second container. The second reverse sealed path flows in the opposite direction to the second forward sealed path.
[0011] In this technical solution, by setting specific structures for a first forward closed path, a first reverse closed path, a second forward closed path, and a second reverse closed path in a closed drug delivery system, the closed transfer of drugs between a first container and a second container, as well as the closed preparation and closed transfer of the mixed liquid drug to be used, are achieved, preventing drug leakage and dispersion and reducing harm to medical personnel. Furthermore, by including at least one flexible wall in the first container, the pressure in the first container is made substantially equal to the ambient pressure, thereby avoiding the risk of drug leakage and atomization caused by moving substances into or out of the rigid second container, which could lead to a pressure imbalance between the ambient air pressure and the pressure inside the second container.
[0012] Preferably, the aspiration device further includes a first needle assembly, the first needle assembly including a first needle tube, the first needle tube being in communication with the aspirator;
[0013] The sealed transfer device also includes a first opening gasket disposed within the first interface;
[0014] The first opening pad has a first opening and includes a plurality of first blocking parts arranged circumferentially. The first opening is formed between two adjacent first blocking parts. The first needle can pass through the first opening, so that the first blocking part moves away from the first initial position to the first working position. After the first needle leaves the first opening, the first blocking part can return to the first initial position.
[0015] In this technical solution, a first needle tube is provided to achieve a sealed connection between the aspirator and the first interface; by providing a first opening pad and a specific structure for providing the first opening inside the first interface, when the first needle tube leaves the first opening pad, the drug on the tip of the first needle tube is scraped off the tip of the first needle tube by the reset of the first blocking part, preventing the drug from entering the environment as the first needle tube leaves.
[0016] Preferably, the sealing transfer device further includes a first sealing gasket disposed within the first interface, the first sealing gasket being used to seal the first interface, and the first opening gasket and the first sealing gasket being stacked sequentially from the outside to the inside along the axis of the first interface.
[0017] In this technical solution, by providing a first sealing gasket within the first interface, the portion of the first interface located inside the first sealing gasket forms a sealed space, thereby preventing leakage and dispersion of the drug. After the first needle is inserted into the first sealing gasket, the first needle achieves communication with the portion of the first interface that forms the sealed space; and after the first needle leaves the first sealing gasket, the first sealing gasket can return to its sealed state before the first needle was inserted.
[0018] Preferably, the first needle assembly further includes a first sealing needle sleeve for sealing the first needle tube, the first sealing needle sleeve being disposed around the first needle tube.
[0019] In this technical solution, a first sealed needle sleeve is provided to prevent the first needle tube from coming into contact with the external environment, thereby preventing drug leakage and dispersion.
[0020] Preferably, the aspiration device further includes a first needle hub, and the first needle tube and the first sealed needle sleeve are both installed on the side of the first needle hub facing the sealing transfer device;
[0021] The suction device also includes a first protective sleeve, which is installed on the first needle holder and disposed outside the first sealed needle sleeve, with the top of the first protective sleeve higher than the top of the first sealed needle sleeve.
[0022] In this technical solution, a first needle seat is provided to serve as a mounting base for the first sealed needle sleeve of the first needle tube; a first protective sleeve is provided to protect the first sealed needle sleeve and the first needle tube located inside it, thereby preventing accidental puncture.
[0023] Preferably, the suction device and the sealing transfer device are detachably connected via a first snap-fit structure;
[0024] The first snap-fit structure includes a first snap-fit portion disposed on the suction device and a second snap-fit portion disposed on the sealing transfer device corresponding to the first snap-fit portion.
[0025] In this technical solution, a first snap-fit structure is used to achieve a detachable connection between the suction device and the sealing transfer device.
[0026] Preferably, the sealed transfer device further includes a second needle tube disposed within the second interface, the second needle tube connecting the second interface and the first container;
[0027] The closed-loop drug delivery system further includes a needle assembly located between the sealed transfer device and the first container; the needle assembly includes a needle, the tip of which can be inserted into the first container and communicate with a first receiving cavity inside the first container, the tail end of which is detachably connected to a second interface, and the second needle tube communicates with the first receiving cavity through the needle;
[0028] The pin assembly further includes a second opening pad disposed within the tail end of the pin;
[0029] The second opening pad has a second opening and includes a plurality of second blocking parts arranged circumferentially. A second opening is formed between two adjacent second blocking parts. The second needle can pass through the second opening, so that the second blocking part moves away from the second initial position to the second working position. After the second needle leaves the second opening, the second blocking part can return to the second initial position.
[0030] In this technical solution, a second needle tube is provided to achieve a sealed connection between the second interface of the sealed transfer device and the second container. A needle assembly is provided for easier insertion into the first container. By providing a second opening pad and a specific structure for the second opening within the tail end of the needle, when the second needle tube leaves the second opening pad, the resetting of the second blocking part scrapes off the drug at the tip of the second needle tube, preventing the drug from entering the environment as the second needle tube leaves.
[0031] Preferably, the pin assembly further includes a second sealing gasket disposed within the tail end of the pin, the second sealing gasket being used to seal the tail end of the pin, and the second opening gasket and the second sealing gasket being stacked sequentially from the outside to the inside along the axis of the pin.
[0032] In this technical solution, a second sealing gasket is provided inside the tail end of the insertion needle, thereby forming a sealed space in the portion of the needle tail end located inside the second sealing gasket, thus preventing drug leakage and dispersion. After the second needle tube is inserted into the second sealing gasket, the second needle tube communicates with the portion of the needle tail end that forms the sealed space; and after the second needle tube leaves the second sealing gasket, the second sealing gasket can return to the sealed state before the second needle tube was inserted.
[0033] Preferably, the pin assembly and the sealing transfer device are detachably connected via a second snap-fit structure;
[0034] The second latching structure includes a third latching portion disposed on the outside of the insert pin, and a fourth latching portion disposed on the sealing transfer device corresponding to the third latching portion.
[0035] In this technical solution, a second snap-fit structure is provided to achieve a detachable connection between the pin assembly and the sealing transfer device.
[0036] Preferably, the first container includes a first body and a first cover disposed on the first body, the first body having a first receiving cavity, and the first body including at least one of the flexible walls.
[0037] Preferably, the second container includes a second body and a second cover disposed on the second body;
[0038] The sealed transfer device further includes a puncture device for piercing the second cover on the third interface. The puncture device has a puncture channel, and a third needle tube is inserted in the puncture channel. A flow gap is provided between the inner wall of the puncture channel and the outer wall of the third needle tube. The flow gap connects the second container and the third interface, and the third needle tube connects the second container and the first interface.
[0039] In this technical solution, a specific method for setting up the first container is provided as described above. By setting up a puncture device, the second container can be punctured more conveniently; furthermore, by setting up specific structures inside the puncture device, a first forward sealing path, a first reverse sealing path, a second forward sealing path, and a second reverse sealing path are realized.
[0040] Preferably, the closed-loop drug delivery system includes one or more of the first configuration, the second configuration, the third configuration, and the fourth configuration;
[0041] When the closed-loop drug delivery system is in the first configuration, the first container stores a first liquid, and the second container stores a solid drug to be mixed and a first sterilized gas. The first sterilized gas in the second container is drawn in along the first forward closed path using the suction device, causing the first liquid in the first container to enter the second container through the second forward closed path and mix with the solid drug in the second container to form a first mixed liquid drug. Then, the first sterilized gas drawn in is pushed back into the second container along the first reverse closed path using the suction device, causing the first mixed liquid drug to enter the first container for storage through the second reverse closed path; or...
[0042] When the closed-loop drug delivery system is in the second configuration, the first container stores a first liquid, the second container stores a second liquid to be mixed, and the aspirator contains a second sterilized gas. The second sterilized gas is pushed into the second container along the first reverse closed path via the aspirator, causing the second liquid in the second container to enter the first container along the second reverse closed path and mix with the first liquid in the first container to form a second mixed liquid drug; or...
[0043] When the closed-loop drug delivery system is in the third configuration, the first container stores a third sterilized gas, the second container stores a solid drug to be mixed under vacuum, and the aspirator stores a third liquid. By connecting the aspirator and the second container to the sealed transfer device, the third liquid flows along the first reverse closed path to the second container under negative pressure and mixes with the solid drug in the second container to form a third mixed liquid drug. Then, the first container is connected to the sealed transfer device, and the aspirator draws the third mixed liquid drug in the second container along the first forward closed path into the aspirator for storage, allowing the third sterilized gas in the first container to enter the second container along the second forward closed path; or...
[0044] When the closed-loop drug delivery system is in the fourth configuration, the first container stores a third sterilized gas, the second container stores a second liquid to be mixed in a vacuum, and the aspirator stores a third liquid. By connecting the aspirator and the second container to the sealed transfer device, the third liquid flows to the second container along the first reverse closed path under negative pressure and mixes with the second liquid in the second container to form a fourth mixed liquid drug. Then, the first container is connected to the sealed transfer device, and the aspirator draws the fourth mixed liquid drug in the second container into the aspirator for storage along the first forward closed path, so that the third sterilized gas in the first container enters the second container along the second forward closed path.
[0045] The positive and progressive effects of this utility model are as follows:
[0046] This invention, through the specific structure of a closed-loop drug delivery system comprising a first forward closed path, a first reverse closed path, a second forward closed path, and a second reverse closed path, achieves closed-loop transfer of drugs between a first container and a second container, as well as closed-loop preparation and transfer of ready-to-use mixed liquid drugs, preventing drug leakage and dispersion and reducing harm to medical personnel. Furthermore, by incorporating at least one flexible wall into the first container, the pressure within the first container is made substantially equal to the ambient pressure. This avoids the risk of drug leakage and atomization that could occur when the second container is made of a rigid material, leading to a pressure imbalance between the ambient air pressure and the pressure within the second container caused by moving substances into or out of the rigid material. Attached Figure Description
[0047] Figure 1 This is a partial three-dimensional structural schematic diagram of a closed drug delivery system according to a preferred embodiment of the present invention.
[0048] Figure 2 This is a partial three-dimensional exploded structural diagram of a closed drug delivery system according to a preferred embodiment of the present invention.
[0049] Figure 3 This is a partial three-dimensional structural diagram of the suction device according to a preferred embodiment of the present invention.
[0050] Figure 4 This is a partial cross-sectional view of the suction device according to a preferred embodiment of the present invention.
[0051] Figure 5 This is a three-dimensional structural diagram of a sealed transfer device according to a preferred embodiment of the present invention.
[0052] Figure 6 This is a cross-sectional structural schematic diagram of a preferred embodiment of the sealed transfer device of this utility model.
[0053] Figure 7 for Figure 6 A magnified schematic diagram of part A in the middle.
[0054] Figure 8 This is a three-dimensional structural diagram of the pin assembly according to a preferred embodiment of the present invention.
[0055] Figure 9 This is a cross-sectional view of a pin assembly according to a preferred embodiment of the present invention.
[0056] Figure 10 This is a three-dimensional structural diagram of the first opening pad according to a preferred embodiment of the present invention.
[0057] Figure 11This is a three-dimensional structural diagram of the second opening pad according to a preferred embodiment of the present invention.
[0058] Figure 12 This is a partial cross-sectional view of a preferred embodiment of the closed drug delivery system of the present invention.
[0059] Figure 13 for Figure 12 A magnified schematic diagram of part B in the middle section.
[0060] Figure 14 This is a partial structural diagram of a closed drug delivery system with the first container inverted in a preferred embodiment of the present invention.
[0061] Figure 15 This is a partial structural diagram of a closed drug delivery system with the second container inverted in a preferred embodiment of the present invention.
[0062] Explanation of reference numerals in the attached figures
[0063] Closed-loop drug delivery system 1
[0064] Suction device 10
[0065] First needle assembly 11
[0066] First syringe 12
[0067] First sealed needle sleeve 13
[0068] First needle seat 14
[0069] First protective cover 15
[0070] First buckle part 16
[0071] First container 20
[0072] First subject 21
[0073] First cover 22
[0074] First accommodating cavity 23
[0075] Sealed transfer device 30
[0076] Casing 31
[0077] First interface 311
[0078] Second interface 312
[0079] Third interface 313
[0080] First opening pad 32
[0081] First opening 321
[0082] First blocking section 322
[0083] First sealing gasket 33
[0084] Second syringe 34
[0085] Second closed needle sheath 35
[0086] Second buckle part 36
[0087] Fourth buckle part 37
[0088] 38 puncture device
[0089] Puncture Channel 381
[0090] Flow gap 382
[0091] Third syringe 39
[0092] Second container 40
[0093] Second subject 41
[0094] Second cover 42
[0095] Second accommodating cavity 43
[0096] Pin assembly 50
[0097] Pin 51
[0098] Second opening pad 52
[0099] Second opening 521
[0100] Second blocking section 522
[0101] Second sealing gasket 53
[0102] Third buckle part 57 Detailed Implementation
[0103] The embodiments of this utility model are described in detail below. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this utility model, and should not be construed as limiting this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without inventive effort are within the protection scope of this utility model.
[0104] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "circumferential", "radial", etc., indicating the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.
[0105] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.
[0106] like Figures 1-13 As shown, this embodiment provides a closed drug delivery system 1, which includes: a suction device 10, a first container 20, a sealed transfer device 30, a first forward sealed path, a first reverse sealed path, a second forward sealed path, and a second reverse sealed path.
[0107] The suction device 10 includes a suction device (not shown) for suctioning or retracting gas.
[0108] The first container 20 includes at least one flexible wall such that the pressure in the first container 20 is substantially equal to the ambient pressure.
[0109] The sealed transfer device 30 includes a housing 31 and a first interface 311, a second interface 312 and a third interface 313 opened on the housing 31. The first interface 311 is connected to the suction device and the second container 40, the second interface 312 is connected to the first container 20, and the third interface 313 is connected to the second container 40.
[0110] The first forward sealed path flows sequentially through the second container 40, the first interface 311 of the sealing transfer device 30, and the suction device; the first reverse sealed path flows in the opposite direction to the first forward sealed path; the second forward sealed path flows sequentially through the first container 20, the second interface 312 and the third interface 313 of the sealing transfer device 30, and the second container 40; the second reverse sealed path flows in the opposite direction to the second forward sealed path.
[0111] In this way, by setting the specific structures of the first forward closed path, the first reverse closed path, the second forward closed path, and the second reverse closed path of the closed drug delivery system 1, the suction device 10, the sealed transfer device 30, the first container 20, and the second container 40 form a closed delivery space. This enables the closed transfer of drugs between the first container 20 and the second container 40, as well as the closed preparation and transfer of ready-to-use mixed liquid drugs, preventing drug leakage and dispersion and reducing harm to medical personnel. Furthermore, by including at least one flexible wall in the first container 20, the pressure in the first container 20 is made substantially equal to the ambient pressure. This avoids the risk of drug leakage and atomization caused by moving substances into or out of the rigid second container 40, which could lead to a pressure imbalance between the ambient air pressure and the pressure inside the second container 40.
[0112] In this embodiment, the suction device 10 further includes a first needle assembly 11, which includes a first needle tube 12 that is connected to the suction device. Thus, by providing the first needle tube 12, a sealed connection between the suction device and the first interface 311 is achieved.
[0113] The sealed transfer device 30 also includes a first opening pad 32 disposed within the first interface 311. The first opening pad 32 has a first opening 321 and includes multiple circumferentially arranged first blocking portions 322. A first opening 321 is formed between two adjacent first blocking portions 322. The first needle tube 12 can pass through the first opening 321, causing the first blocking portion 322 to move from its initial position to its working position. After the first needle tube 12 leaves the first opening 321, the first blocking portion 322 can return to its initial position. Thus, by providing the first opening pad 32 within the first interface 311 and the specific structure of the first opening 321, when the first needle tube 12 leaves the first opening pad 32, the resetting of the first blocking portion 322 scrapes off any medication carried at the tip of the first needle tube 12 from the tip, preventing the medication from entering the environment as the first needle tube 12 leaves.
[0114] The sealing transfer device 30 also includes a first sealing gasket 33 disposed in the first interface 311. The first sealing gasket 33 is used to seal the first opening gasket 32 of the first interface 311. The first sealing gasket 33 and the first opening gasket 32 are stacked sequentially from the outside to the inside along the axis of the first interface 311.
[0115] Thus, by providing a first sealing gasket 33 within the first interface 311, the portion of the first interface 311 located inside the first sealing gasket 33 forms a sealed space, thereby preventing leakage and dispersion of the drug. After the first needle 12 is inserted into the first sealing gasket 33, the first needle 12 achieves communication with the portion of the first interface 311 that forms the sealed space; and after the first needle 12 is removed from the first sealing gasket 33, the first sealing gasket 33 can return to its sealed state before the first needle 12 was inserted. The first sealing gasket 33 is made of rubber or other materials with elastic resilience.
[0116] The first opening pad 32 is made of silicone or other materials with elastic resilience. The first sealing pad 33 has a first recess on the side facing the first opening pad 32. The cross-section of the first recess is trapezoidal to better guide and limit the insertion of the first needle tube 12.
[0117] The first needle assembly 11 also includes a first sealing needle sleeve 13 for sealing the first needle tube 12, the first sealing needle sleeve 13 being disposed around the first needle tube 12. In this way, by providing the first sealing needle sleeve 13, contact between the first needle tube 12 and the external environment is prevented, thereby preventing drug leakage and dispersion.
[0118] The suction device 10 also includes a first needle holder 14, with the first needle tube 12 and the first sealed needle sleeve 13 both mounted on the side of the first needle holder 14 facing the sealing transfer device 30. In this way, by setting the first needle holder 14, a mounting base is provided for the first sealed needle sleeve 13 of the first needle tube 12.
[0119] The suction device 10 also includes a first protective sleeve 15, which is mounted on the first needle holder 14 and positioned outside the first sealed needle sheath 13. The top of the first protective sleeve 15 is higher than the top of the first sealed needle sheath 13. In this way, by setting the first protective sleeve 15, the first sealed needle sheath 13 and the first needle tube 12 located inside it are protected, thus preventing accidental puncture.
[0120] In this embodiment, the suction device 10 and the sealing transfer device 30 are detachably connected via a first snap-fit structure. The first snap-fit structure includes a first snap-fit portion 16 disposed on the suction device 10 and a second snap-fit portion 36 disposed on the sealing transfer device 30 corresponding to the first snap-fit portion 16. Thus, the first snap-fit structure enables a detachable connection between the suction device 10 and the sealing transfer device 30. Specifically, the first snap-fit portion 16 is a snap-fit, and the second snap-fit portion 36 is a slot; the two cooperate to achieve engagement. However, this is not a limitation; in other embodiments, the first snap-fit portion 16 may be a slot, and the second snap-fit portion 36 may be a snap-fit.
[0121] The sealed transfer device 30 also includes a second needle tube 34 disposed within the second interface 312, the second needle tube 34 connecting the second interface 312 and the first container 20. In this way, the second needle tube 34 is provided to achieve a sealed connection between the second interface 312 and the second container 40 of the sealed transfer device 30.
[0122] The closed-loop drug delivery system 1 also includes a needle assembly 50, located between the sealed transfer device 30 and the first container 20. The needle assembly 50 includes a needle 51, the tip of which can be inserted into the first cover 22 and communicates with the first receiving cavity 23 within the first main body 21. The tail end of the needle 51 is detachably connected to the second interface 312, and the second needle tube 34 communicates with the first receiving cavity 23 through the needle 51. Thus, the above provides a specific method for setting up the first container 20. By providing the needle assembly 50, the insertion of the first container 20 is made more convenient.
[0123] The pin assembly 50 also includes a second opening pad 52 disposed within the tail end of the pin 51. The second opening pad 52 is made of silicone or other materials with elastic resilience.
[0124] Specifically, the second opening pad 52 has a second opening 521, and the second opening pad 52 includes a plurality of second blocking portions 522 arranged circumferentially. A second opening 521 is formed between two adjacent second blocking portions 522. The second needle tube 34 can pass through the second opening 521, causing the second blocking portion 522 to move from the second initial position to the second working position. After the second needle tube 34 leaves the second opening 521, the second blocking portion 522 can return to the second initial position. In this way, by providing the second opening pad 52 inside the tail end of the needle 51 and the specific structure of providing the second opening 521, when the second needle tube 34 leaves the second opening pad 52, the resetting of the second blocking portion 522 scrapes off the drug on the tip of the second needle tube 34 from the tip of the second needle tube 34, preventing the drug from entering the environment as the second needle tube 34 leaves.
[0125] The needle assembly 50 also includes a second sealing gasket 53 disposed within the tail end of the needle 51. The second sealing gasket 53 seals the tail end of the needle 51. The second opening gasket 52 and the second sealing gasket 53 are stacked sequentially from the outside to the inside along the axis of the needle 51. Thus, by providing the second sealing gasket 53 within the tail end of the needle 51, a sealed space is formed in the portion of the tail end of the needle 51 located inside the second sealing gasket 53, thereby preventing leakage and dispersion of the drug. After the second needle tube 34 is inserted into the second sealing gasket 53, the second needle tube 34 communicates with the portion of the tail end of the needle 51 that forms the sealed space; and after the second needle tube 34 is removed from the second sealing gasket 53, the second sealing gasket 53 returns to its sealed state before the second needle tube 34 was inserted. The second sealing gasket 53 is made of rubber or other materials with elastic resilience.
[0126] The second sealing gasket 53 has a second recess on the side facing the second opening gasket 52. The cross-section of the second recess is trapezoidal to better guide and limit the insertion of the second needle tube 34.
[0127] The sealed transfer device 30 also includes a second sealing needle sleeve 35 for sealing the second needle tube 34, the second sealing needle sleeve 35 being disposed around the second needle tube 34. In this way, by providing the second sealing needle sleeve 35, contact between the second needle tube 34 and the external environment is prevented, thereby preventing drug leakage and escape.
[0128] The pin assembly 50 and the sealing transfer device 30 are detachably connected via a second snap-fit structure. The second snap-fit structure includes a third snap-fit portion 57 disposed on the outside of the pin 51, and a fourth snap-fit portion 37 disposed on the sealing transfer device 30 corresponding to the third snap-fit portion 57. Thus, the second snap-fit structure enables a detachable connection between the pin assembly 50 and the sealing transfer device 30. Specifically, the fourth snap-fit portion 37 is a snap, and the third snap-fit portion 57 is a slot; the two cooperate to achieve engagement. However, this is not a limitation; in other embodiments, the fourth snap-fit portion 37 may be a slot, and the third snap-fit portion 57 may be a snap.
[0129] In this embodiment, the first container 20 includes a first body 21 and a first cover 22 disposed on the first body 21, the first body 21 including at least one flexible wall. Specifically, the second container 40 may be an infusion bag.
[0130] The second container 40 includes a second body 41 and a second cap 42 covering the second body 41. Specifically, the second container 40 may be a vial.
[0131] The sealing transfer device 30 also includes a puncture device 38 on the third interface 313 for piercing the second cover 42. The puncture device 38 has a puncture channel 381, in which a third needle tube 39 is inserted. A flow gap 382 is provided between the inner wall of the puncture channel 381 and the outer wall of the third needle tube 39. The flow gap 382 connects the second container 40 and the third interface 313, and the third needle tube 39 connects the second container 40 and the first interface 311. In this way, by setting the puncture device 38, it is easier to pierce the second container 40. Furthermore, by setting the specific structure inside the puncture device 38, a first forward sealing path, a first reverse sealing path, a second forward sealing path, and a second reverse sealing path can be realized.
[0132] The closed-loop drug delivery system of this embodiment includes one or more of the first configuration, the second configuration, the third configuration, and the fourth configuration.
[0133] When the closed-loop drug delivery system 1 is in the first configuration, the first container 20 stores a first liquid, and the second container 40 stores a solid drug to be mixed and a first sterilized gas. The first sterilized gas located in the second container 40 is drawn in along the first forward closed path by a suction device, so that the first liquid located in the first container 20 enters the second container 40 through the second forward closed path and mixes with the solid drug in the second container 40 to form a first mixed liquid drug. Then, the first sterilized gas drawn in is pushed back to the second container 40 along the first reverse closed path by a suction device, so that the first mixed liquid drug enters the first container 20 for storage through the second reverse closed path.
[0134] When the closed-loop drug delivery system 1 is in the second configuration, the first container 20 stores a first liquid, the second container 40 stores a second liquid to be mixed, and the suction device contains a second sterilized gas. The second sterilized gas is pushed into the second container 40 through the suction device along the first reverse closed path, so that the second liquid in the second container 40 enters the first container 20 along the second reverse closed path and mixes with the first liquid in the first container 20 to form a second mixed liquid drug.
[0135] When the closed-loop drug delivery system is in the third configuration, the first container 20 stores a third sterilized gas, the second container 40 stores a solid drug to be mixed in a vacuum, and the aspirator stores a third liquid. By connecting the aspirator and the second container 40 to the sealed transfer device, the third liquid flows to the second container 40 along the first reverse closed path under negative pressure and mixes with the solid drug in the second container 40 to form a third mixed liquid drug. Then, the first container 20 is connected to the sealed transfer device, and the aspirator draws the third mixed liquid drug in the second container 40 into the aspirator for storage along the first forward closed path, so that the third sterilized gas in the first container 20 enters the second container 40 along the second forward closed path.
[0136] When the closed-loop drug delivery system is in the fourth configuration, the first container 20 stores a third sterilized gas, the second container 40 is vacuum-stored with a second liquid to be mixed, and the aspirator stores a third liquid. By connecting the aspirator and the second container 40 to the sealed transfer device, the third liquid flows to the second container 40 under negative pressure along the first reverse closed path and mixes with the second liquid in the second container 40 to form a fourth mixed liquid drug. Then, the first container 20 is connected to the sealed transfer device, and the aspirator draws the fourth mixed liquid drug in the second container 40 into the aspirator for storage along the first forward closed path, so that the third sterilized gas in the first container 20 enters the second container 40 along the second forward closed path.
[0137] This embodiment also provides a method of using a closed-loop drug delivery system, which is applied to the closed-loop drug delivery system described above.
[0138] When the closed-loop drug delivery system is in its first configuration, a first container stores a first liquid, and a second container stores a solid drug to be mixed and a first sterilized gas. The method of use includes the following steps:
[0139] S100, Invert the first container;
[0140] S200: The first sterilized gas located in the second container is drawn in through the suction device along the first forward closed path, so that the first liquid located in the first container enters the second container through the second forward closed path and mixes with the solid agent in the second container to form the first mixed liquid agent.
[0141] S300, Invert the second container;
[0142] S400, the first sterilized gas is then pushed back to the second container through the suction device along the first reverse sealed path, so that the first mixed liquid agent enters the first container for storage through the second reverse sealed path.
[0143] For details regarding step S100, please refer to [link / reference needed]. Figure 14 The first container 20 is inverted, and gravity is used to complete the subsequent steps.
[0144] After inverting the first container 20, step S200 is performed: the first sterilized gas located in the second container 40 is drawn in through the first forward sealed path by the suction device, so that the first liquid located in the first container 20 enters the second container 40 through the second forward sealed path, and is mixed with the solid agent in the second container 40 to form the first mixed liquid agent.
[0145] Furthermore, in step S200, the method of use further includes:
[0146] The suction device repeatedly draws the first sterilized gas from the second container and pushes the drawn-out first sterilized gas back into the second container, ensuring thorough mixing of the first liquid with the solid agent in the second container. This achieves complete mixing of the first liquid with the solid agent in the second container.
[0147] Next, proceed to step S300: Invert the second container 40, for details please refer to [link / reference needed]. Figure 15 They then use gravity to complete the subsequent steps.
[0148] After the second container 40 is inverted, step S400 is performed: the first sterilized gas is then pushed back into the second container 40 along the first reverse sealed path by the suction device, so that the first mixed liquid agent enters the first container 20 for storage through the second reverse sealed path.
[0149] This embodiment also provides another method of using the closed-loop drug delivery system, which is also applied to the closed-loop drug delivery system described above.
[0150] When the closed-loop drug delivery system is in the second configuration, the second container stores a second liquid to be mixed, and the aspirator contains a second sterilized gas. The method of use includes the following steps:
[0151] S100', Invert the second container;
[0152] S200' The second sterilized gas is pushed into the second container through the suction device along the first reverse sealed path, so that the second liquid in the second container enters the first container along the second reverse sealed path and mixes with the first liquid in the first container to form a second mixed liquid agent.
[0153] For details regarding step S100', please refer to [link / reference needed]. Figure 15 Invert the second container 40 and use gravity to complete the subsequent steps.
[0154] After the second container 40 is inverted, step S200' is performed: the second sterilized gas is pushed into the second container 40 through a suction device along the first reverse sealed path, so that the second liquid in the second container 40 enters the first container 20 along the second reverse sealed path and mixes with the first liquid in the first container 20 to form a second mixed liquid agent.
[0155] This embodiment also provides another method of using the closed-loop drug delivery system, which is also applied to the closed-loop drug delivery system described above.
[0156] When the closed-loop drug delivery system is in the third configuration, the first container stores a third sterilized gas, the second container contains a vacuum-sealed solid drug to be mixed, and the aspirator stores a third liquid. The method of use includes the following steps:
[0157] S1000: By connecting the suction device and the second container to the sealed transfer device respectively, the third liquid flows to the second container along the first reverse sealed path under negative pressure, and mixes with the solid agent in the second container to form a third mixed liquid agent.
[0158] S2000, then connect the first container to the sealed transfer device, and use the suction device to draw the third mixed liquid agent located in the second container into the suction device for storage along the first forward sealed path, so that the third disinfected gas located in the first container enters the second container along the second forward sealed path.
[0159] This embodiment also provides another method of using the closed-loop drug delivery system, which is also applied to the closed-loop drug delivery system described above.
[0160] When the closed-loop drug delivery system is in the fourth configuration, the first container stores a third sterilized gas, the second container is vacuum-stored with a second liquid to be mixed, and the aspirator stores a third liquid. The method of use includes the following steps:
[0161] S1000' By connecting the suction device and the second container to the sealed transfer device respectively, the third liquid flows to the second container along the first reverse sealed path under negative pressure, and mixes with the second liquid in the second container to form a fourth mixed liquid agent;
[0162] S2000' Then connect the first container to the sealed transfer device, and use the suction device to draw the fourth mixed liquid agent located in the second container into the suction device for storage along the first forward sealed path, so that the third sterilized gas located in the first container enters the second container along the second forward sealed path.
[0163] While specific embodiments of this utility model have been described above, those skilled in the art should understand that these are merely illustrative examples, and the scope of protection of this utility model is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of this utility model, but all such changes and modifications fall within the scope of protection of this utility model.
Claims
1. A closed-loop drug delivery system, characterized in that, It includes: A suction device, including a suction device for suctioning or retracting gas; A first container, the first container including at least one flexible wall, such that the pressure in the first container is substantially equal to the ambient pressure; A sealed transfer device includes a housing, and a first interface, a second interface, and a third interface formed on the housing. The first interface is connected to the suction device and a second container, the second interface is connected to the first container, and the third interface is connected to the second container. The system comprises a first forward sealed path, a first reverse sealed path, a second forward sealed path, and a second reverse sealed path. The first forward sealed path flows sequentially through the second container, the first interface of the sealing transfer device, and the suction device. The first reverse sealed path flows in the opposite direction to the first forward sealed path. The second forward sealed path flows sequentially through the first container, the second interface of the sealing transfer device, the third interface, and the second container. The second reverse closed path flows in the opposite direction to the second forward closed path.
2. The closed-loop drug delivery system as described in claim 1, characterized in that, The suction device further includes a first needle assembly, which includes a first needle tube and is connected to the suction device. The sealed transfer device also includes a first opening gasket disposed within the first interface; The first opening pad has a first opening and includes a plurality of first blocking parts arranged circumferentially. The first opening is formed between two adjacent first blocking parts. The first needle can pass through the first opening, so that the first blocking part moves away from the first initial position to the first working position. After the first needle leaves the first opening, the first blocking part can return to the first initial position.
3. The closed-loop drug delivery system as described in claim 2, characterized in that, The sealed transfer device further includes a first sealing gasket disposed within the first interface. The first sealing gasket is used to seal the first interface, and the first opening gasket and the first sealing gasket are stacked sequentially from the outside to the inside along the axis of the first interface.
4. The closed-loop drug delivery system as described in claim 2, characterized in that, The first needle assembly further includes a first sealing needle sleeve for sealing the first needle tube, the first sealing needle sleeve being disposed around the first needle tube.
5. The closed-loop drug delivery system as described in claim 4, characterized in that, The suction device also includes a first needle holder, and the first needle tube and the first sealed needle sleeve are both installed on the side of the first needle holder facing the sealing transfer device. The suction device also includes a first protective sleeve, which is installed on the first needle holder and disposed outside the first sealed needle sleeve, with the top of the first protective sleeve higher than the top of the first sealed needle sleeve.
6. The closed-loop drug delivery system as described in claim 1, characterized in that, The suction device and the sealing transfer device are detachably connected via a first snap-fit structure; The first snap-fit structure includes a first snap-fit portion disposed on the suction device and a second snap-fit portion disposed on the sealing transfer device corresponding to the first snap-fit portion.
7. The closed-loop drug delivery system as described in claim 1, characterized in that, The sealed transfer device further includes a second needle tube disposed in the second interface, the second needle tube being connected to the second interface and the first container; The closed-loop drug delivery system further includes a needle assembly located between the sealed transfer device and the first container; the needle assembly includes a needle, the tip of which can be inserted into the first container and communicate with a first receiving cavity inside the first container, the tail end of which is detachably connected to a second interface, and the second needle tube communicates with the first receiving cavity through the needle; The pin assembly further includes a second opening pad disposed within the tail end of the pin; The second opening pad has a second opening and includes a plurality of second blocking parts arranged circumferentially. A second opening is formed between two adjacent second blocking parts. The second needle can pass through the second opening, so that the second blocking part moves away from the second initial position to the second working position. After the second needle leaves the second opening, the second blocking part can return to the second initial position.
8. The closed-loop drug delivery system as described in claim 7, characterized in that, The pin assembly further includes a second sealing gasket disposed within the tail end of the pin. The second sealing gasket is used to seal the tail end of the pin. The second opening gasket and the second sealing gasket are stacked sequentially from the outside to the inside along the axis of the pin.
9. The closed-loop drug delivery system as described in claim 7, characterized in that, The sealing transfer device further includes a second sealing needle sleeve for sealing the second needle tube, the second sealing needle sleeve being arranged around the second needle tube.
10. The closed-loop drug delivery system as described in claim 7, characterized in that, The pin assembly and the sealing transfer device are detachably connected via a second snap-fit structure; The second latching structure includes a third latching portion disposed on the outside of the insert pin, and a fourth latching portion disposed on the sealing transfer device corresponding to the third latching portion.
11. The closed-loop drug delivery system as described in claim 1, characterized in that, The first container includes a first body and a first cover disposed on the first body. The first body has a first accommodating cavity and includes at least one of the flexible walls.
12. The closed-loop drug delivery system as described in claim 1, characterized in that, The second container includes a second body and a second cover disposed on the second body; The sealed transfer device further includes a puncture device for piercing the second cover on the third interface. The puncture device has a puncture channel, and a third needle tube is inserted in the puncture channel. A flow gap is provided between the inner wall of the puncture channel and the outer wall of the third needle tube. The flow gap connects the second container and the third interface, and the third needle tube connects the second container and the first interface.
13. The closed-loop drug delivery system according to any one of claims 1-12, characterized in that, The closed-loop drug delivery system includes one or more of the following configurations: first configuration, second configuration, third configuration, and fourth configuration. When the closed-loop drug delivery system is in the first configuration, the first container stores a first liquid, and the second container stores a solid drug to be mixed and a first sterilized gas. The first sterilized gas in the second container is drawn in along the first forward closed path by the suction device, so that the first liquid in the first container enters the second container through the second forward closed path and mixes with the solid drug in the second container to form a first mixed liquid drug. Then, the first sterilized gas drawn in is pushed back into the second container along the first reverse closed path by the suction device, so that the first mixed liquid drug enters the first container for storage through the second reverse closed path. or, When the closed-loop drug delivery system is in the second configuration, the first container stores a first liquid, the second container stores a second liquid to be mixed, and the aspirator contains a second sterilized gas. The second sterilized gas is pushed into the second container along the first reverse closed path via the aspirator, causing the second liquid in the second container to enter the first container along the second reverse closed path and mix with the first liquid in the first container to form a second mixed liquid drug; or... When the closed-loop drug delivery system is in the third configuration, the first container stores a third sterilized gas, the second container stores a solid drug to be mixed under vacuum, and the aspirator stores a third liquid. By connecting the aspirator and the second container to the sealed transfer device, the third liquid flows along the first reverse closed path to the second container under negative pressure and mixes with the solid drug in the second container to form a third mixed liquid drug. Then, the first container is connected to the sealed transfer device, and the aspirator draws the third mixed liquid drug in the second container along the first forward closed path into the aspirator for storage, allowing the third sterilized gas in the first container to enter the second container along the second forward closed path; or... When the closed-loop drug delivery system is in the fourth configuration, the first container stores a third sterilized gas, the second container stores a second liquid to be mixed in a vacuum, and the aspirator stores a third liquid. By connecting the aspirator and the second container to the sealed transfer device, the third liquid flows to the second container along the first reverse closed path under negative pressure and mixes with the second liquid in the second container to form a fourth mixed liquid drug. Then, the first container is connected to the sealed transfer device, and the aspirator draws the fourth mixed liquid drug in the second container into the aspirator for storage along the first forward closed path, so that the third sterilized gas in the first container enters the second container along the second forward closed path.