A solid phase extraction device
By designing a compact solid-phase extraction device, the problems of complex device structure and high cost in small laboratories have been solved, and efficient and simple automated extraction operations of samples have been achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- BEIJING SUNAC INTELLIGENT INSTR CO LTD
- Filing Date
- 2025-08-13
- Publication Date
- 2026-07-21
AI Technical Summary
Existing solid phase extraction devices are complex in structure, large in area, and expensive, making them unsuitable for the needs of small laboratories.
A compact solid-phase extraction device was designed, including an extraction component, a liquid injection component, a liquid collection component, a sample loading component, and a reagent addition component. The device achieves automated sample and reagent handling through moving and lifting components, and features a simple structure and low cost.
It enables efficient and simple solid-phase extraction of samples in small laboratories, and can process multiple samples at the same time, saving space and reducing costs.
Smart Images
Figure CN224524024U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the technical field of solid phase extraction, and more specifically to a solid phase extraction apparatus. Background Technology
[0002] With environmental issues receiving increasing attention, soil and water quality testing is crucial for understanding environmental quality and ensuring ecological security and human health. Solid-phase extraction (SPE) is a commonly used separation and enrichment technique in sample pretreatment. It purifies and concentrates target analytes in complex matrices through selective interactions between the adsorbent and the analyte (such as hydrophobic interactions, ion exchange, and hydrogen bonding). Compared to traditional liquid-liquid extraction, SPE offers advantages such as lower solvent consumption and higher recovery rates.
[0003] Existing solid phase extraction devices are relatively complex in structure, occupy a large area, and are relatively expensive. They are suitable for large laboratories with ample space, but many places, such as small laboratories, do not have sufficient procurement budgets and have limited space. Therefore, there is an urgent need to design a solid phase extraction device with a more compact structure and lower cost suitable for small laboratories based on specific testing tasks. Summary of the Invention
[0004] To address one of the aforementioned technical deficiencies, this application provides a solid-phase extraction apparatus.
[0005] This application provides a solid-phase extraction device, comprising: an extraction assembly, specifically including: an extraction component with a collection space below it; a liquid injection component, including a liquid injection plate located above the extraction component, the liquid injection plate having at least one set of extraction heads and multiple liquid injection heads, each set of extraction heads including multiple extraction heads; a collection component located within the collection space; a sample loading assembly, specifically including: a sample vial holder with at least one set of sample vial placement slots in its center; at least one set of sample loading components, each set of sample loading components including multiple sample loading components, the total number of sample loading components corresponding to the total number of extraction heads, and the sample loading components connected to the liquid inlet of the corresponding extraction head; any set of sample loading components can be moved directly above any set of sample vial placement slots; and a reagent addition assembly, including liquid injection components corresponding to and connected to the number of liquid injection heads.
[0006] Preferably, the number and spacing of the sample loading components in each group of sample loading components correspond to the number and spacing of the sample bottle placement slots in each group of sample bottle placement slots; the number of groups of sample bottle placement slots is a multiple of the number of groups of sample loading components; the sample loading assembly further includes: a first moving component, the first moving component specifically including: two first moving tracks, arranged parallel to each other on both sides of the sample bottle placement rack; a first moving frame, slidably disposed above the two first moving tracks, the sample loading component being disposed on the first moving frame; two first moving drive components, respectively disposed between the first moving frame and the two first moving tracks, for driving the first moving frame to move the sample loading component along the first moving tracks to directly above any group of sample bottle placement slots.
[0007] More preferably, the sample loading assembly further includes: a cleaning agent collection chamber, which is arranged front to back with the sample bottle placement rack; a first moving component, which specifically includes: two first moving tracks, which are arranged parallel to each other on both sides of the sample bottle placement rack and the cleaning agent collection chamber; a first moving frame, which is slidably disposed above the two first moving tracks, and a liquid extraction mounting plate is disposed on the top of the first moving frame, and the sample loading component is mounted on the liquid extraction mounting plate; and two first moving drive components, which are respectively disposed between the first moving frame and the two first moving tracks, for driving the first moving frame to move the sample loading component along the first moving tracks to directly above any set of sample bottle placement slots or directly above the cleaning agent collection chamber.
[0008] More preferably, the sample loading component includes: a first lifting component and a first peristaltic pump, wherein the first lifting component specifically includes: a first lifting track, disposed on the liquid extraction mounting plate; a first lifting slider, disposed on the side of the first lifting track away from the liquid extraction mounting plate; a first lifting drive component, disposed between the first lifting track and the first lifting slider, for driving the first lifting slider to move up and down along the first lifting track; a liquid extraction needle mounting seat, disposed on the side of the first lifting slider away from the first lifting track; a liquid extraction needle, disposed on the liquid extraction needle mounting seat, the bottom of the liquid extraction needle penetrating the bottom of the liquid extraction mounting plate and extending downward; and the first peristaltic pump is disposed on the liquid extraction mounting plate, wherein the two ends of the peristaltic tube in the first peristaltic pump are respectively connected to the top of the corresponding liquid extraction needle and the liquid inlet of the corresponding extraction head.
[0009] More preferably, the first lifting components in the multiple sample loading components are arranged at the front end of the liquid extraction mounting plate along the setting direction of the first moving track; the multiple first lifting components in each sample loading component are spaced apart in a direction perpendicular to the first moving track; the first peristaltic pumps in the multiple sample loading components are arranged vertically at the rear end of the liquid extraction mounting plate; and the multiple first peristaltic pumps in each sample loading component are spaced apart in a direction perpendicular to the first moving track.
[0010] Preferably, the extraction component includes: an extraction support frame, with the collection space located below the extraction support frame, and a mounting hole provided in the middle of the extraction support frame; an extraction column placement frame, disposed on top of the extraction support frame and installed in the mounting hole; and multiple sets of second through holes for placing multiple sets of extraction columns provided in the middle of the extraction column placement frame; the liquid addition component further includes: a reagent placement frame, with a reagent bottle placement slot in the middle for placing reagent bottles; a second peristaltic pump, with the two ends of the peristaltic tube in the second peristaltic pump respectively connected to the corresponding liquid addition head and the corresponding reagent bottle; the liquid injection component further includes: a second moving component, specifically including: two second moving tracks, arranged parallel to each other on both sides of the extraction component; a second moving frame, slidably disposed above the two second moving tracks; and two second moving drive components, respectively disposed between the second moving frame and the two second moving tracks, for driving the second moving frame to move along the second moving tracks. The vertical component, perpendicular to the second moving component, specifically includes: a vertical rail, located at the top of the second moving frame, with the direction of the vertical rail perpendicular to the direction of the second moving rail; a vertical slider, slidably mounted on the vertical rail; and a vertical drive component, located between the vertical rail and the vertical slider, for driving the vertical slider to move along the vertical rail. The second lifting component specifically includes: a second lifting rail, located on the vertical slider; a second lifting slider, slidably mounted on the second lifting rail and fixedly connected to the injection plate; and a second lifting drive component, located between the second lifting rail and the second lifting slider, for driving the second lifting slider to move the injection plate up and down along the second lifting rail. Through the second moving component, the vertical component, and the second lifting component, any extraction head on the injection plate is moved to the top of any extraction column, and any liquid addition head on the injection plate is moved to the top of any extraction column.
[0011] More preferably, the extraction head is provided with an air inlet; the extraction assembly also includes a pressurizing component, which is provided with multiple air outlets, the total number of air outlets being consistent with the total number of extraction heads, and the air outlets being connected to the air inlets of the corresponding extraction heads.
[0012] More preferably, the liquid collection component includes: at least one test tube rack, which has multiple sets of test tube placement slots for placing multiple sets of liquid collection test tubes; the number and spacing of extraction heads in each set of extraction heads, the number and spacing of extraction columns in each set of extraction columns, and the number and spacing of liquid collection test tubes in each set of liquid collection test tubes are all corresponding, and the top and bottom of the extraction columns are respectively connected to the liquid outlet of the corresponding extraction head and the corresponding liquid collection test tube; the number of extraction columns is a multiple of the number of extraction head sets, and each set of extraction columns and each set of extraction heads are distributed in a front-to-back manner; any set of extraction heads on the liquid injection plate is moved to the top of any set of extraction columns by a second moving component, a vertical component, and a second lifting component.
[0013] More preferably, the liquid collection component further includes a third moving component, which specifically includes: a third moving track disposed within the liquid collection space; a third moving slider slidably disposed on the top of the third moving track, and a test tube holder disposed on the top of the third moving slider; an activated liquid collection chamber disposed on the top of the third moving slider and arranged in a front-to-back configuration with the test tube holder; and a third moving drive component disposed between the third moving track and the third moving slider for driving the third moving slider to move the test tube holder and the activated liquid collection chamber along the third moving track.
[0014] Preferably, the sample loading component and the reagent addition component are respectively disposed on both sides near the extraction component; the sample loading component further includes: a first moving component, the first moving component specifically including: two first moving tracks, arranged parallel to both sides of the sample vial holder; a first moving frame, slidably disposed above the two first moving tracks, the sample loading component being disposed on the first moving frame; two first moving drive components, respectively disposed between the first moving frame and the two first moving tracks, for driving the first moving frame to move the sample loading component along the first moving tracks to directly above any set of sample vial placement slots; the liquid injection component further includes: a second moving component, specifically including: two second moving tracks, arranged parallel to both sides of the extraction component; a second moving frame, slidably disposed on the two second moving tracks. Above, the injection plate is mounted on the second movable frame; two second movable drive components are respectively mounted between the second movable frame and the two second movable tracks, used to drive the second movable frame to move the injection plate along the second movable tracks; the liquid collection component includes a third movable component, which specifically includes: a third movable track, mounted in the liquid collection space; a third movable slider, slidably mounted on the top of the third movable track, with a test tube holder mounted on the top of the third movable slider; a third movable drive component, mounted between the third movable track and the third movable slider, used to drive the third movable slider to move the test tube holder along the third movable track; the first, second, and third movable tracks are all arranged in parallel, and the rear ends of the first and second movable tracks are flush.
[0015] The beneficial effects of this application are as follows: The solid-phase extraction device provided in this application features a simple and compact structure with low manufacturing cost, making it suitable for small laboratories. The sample to be tested is added to the inlet of the extraction head via the sample loading assembly, and activating reagents and elution reagents are added to the liquid addition head via the reagent addition assembly. After extraction by the extraction component, the activation waste liquid and the eluent containing the target substance obtained from the extraction are collected by the liquid collection component. Both the extraction head and the liquid addition head are mounted on a liquid injection plate, facilitating liquid addition operations and resulting in a cleaner structure. Only one set of sample loading components can be used, or multiple sets can be used, with the number of sample loading components matching the number of extraction heads and connected in a one-to-one correspondence. This allows for the simultaneous detection of multiple samples and the simultaneous extraction of multiple samples. Correspondingly, only one set of sample bottle placement slots can be used, or multiple sets can be used, to stably place the sample bottles and prevent tilting during liquid extraction. During use, any set of sample loading components can move directly above any set of sample bottle placement slots to extract the sample to be tested from the placed sample bottles.
[0016] Other features and advantages of this application will be set forth in the following description, and will be apparent in part from the description, or may be learned by practicing the application. The objectives and other advantages of this application may be realized and obtained by means of what is pointed out in the written description and the accompanying drawings. Attached Figure Description
[0017] The accompanying drawings, which are included to provide a further understanding of this application and form part of this application, illustrate exemplary embodiments and are used to explain this application, but do not constitute an undue limitation of this application. In the drawings: Figure 1 This is a schematic diagram of a solid-phase extraction device provided in this application; Figure 2 This is a schematic diagram of the structure of the injection component provided in this application; Figure 3 A schematic diagram of the structure of the sample loading component provided in this application; Figure 4 for Figure 3 Enlarged view of section A in the middle; Figure 5 A schematic diagram of the rear structure of the sample loading component provided in this application; Figure 6 Schematic diagrams of the extraction component and reagent addition component provided in this application; Figure 7 This is a schematic diagram of the extraction component provided in this application; Figure 8 Another structural schematic diagram of the extraction component provided in this application; Figure 9A top view of a solid-phase extraction apparatus provided in this application; Figure 10 A schematic diagram of the position sensing component provided in this application; In the picture: 10 is the extraction assembly, 101 is the extraction component, 102 is the liquid injection component, 103 is the liquid collection component, 1011 is the extraction support frame, 1012 is the extraction column placement frame, 1013 is the extraction column, 1014 is the limiting component, 1021 is the liquid injection plate, 1022 is the extraction head, 1023 is the liquid addition head, 1024 is the second moving component, 1025 is the vertical component, 1026 is the second lifting component, 1031 is the test tube placement rack, 1032 is the liquid collection test tube, 1033 is the third moving track, 1034 is the third moving slider, and 1035 is the activation solution collection. The cavity is defined as follows: 1036 is the third moving drive component; 10121 is the limiting groove; 10221 is the liquid inlet; 10222 is the air inlet; 10223 is the liquid outlet; 10224 is the sealing ring; 10241 is the second moving track; 10242 is the second moving frame; 10243 is the second moving drive component; 10251 is the vertical track; 10252 is the vertical slider; 10253 is the vertical drive component; 10261 is the second lifting track; 10262 is the second lifting slider; 10263 is the second lifting drive component; and 10311 is the test tube placement slot. 20 is the sample loading component, 201 is the sample bottle placement rack, 202 is the sample bottle, 203 is the sample loading part, 204 is the first moving part, 205 is the cleaning agent collection chamber, 206 is the liquid extraction mounting plate, 2011 is the sample bottle placement slot, 2031 is the first peristaltic pump, 2032 is the first lifting track, 2033 is the first lifting slider, 2034 is the first lifting drive part, 2035 is the liquid extraction needle mounting seat, 2036 is the liquid extraction needle, 2041 is the first moving track, 2042 is the first moving frame, and 2043 is the first moving drive part; 30 is the reagent adding component, 301 is the reagent placement rack, 302 is the reagent bottle, 303 is the second peristaltic pump, and 3011 is the reagent bottle placement slot; 40 is a sensor sheet; 50 is a sensor. Detailed Implementation
[0018] To make the technical solutions and advantages of the embodiments of this application clearer, the exemplary embodiments of this application will be described in further detail below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not an exhaustive list of all embodiments. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this application can be combined with each other.
[0019] like Figure 1 and Figure 2 As shown, to address the above problems, this application provides a solid-phase extraction apparatus, including... Extraction component 10, specifically includes: The extraction component 101 has a liquid collection space at its bottom; The liquid injection component 102 includes a liquid injection plate 1021, which is located above the extraction component 101. The liquid injection plate 1021 is provided with at least one set of extraction heads 1022 and multiple liquid addition heads 1023. Each set of extraction heads 1022 includes multiple extraction heads 1022. The extraction head 1022 includes a liquid inlet 10221, an air inlet 10222, and a liquid outlet 10223. A sealing ring 10224 is provided on the outer wall of the liquid outlet 10223. When the liquid outlet 10223 of the extraction head 1022 adds liquid to the extraction component 101, the sealing ring 10224 can seal the liquid outlet 10223 with the top of the extraction column 1013 in the extraction component 101 to prevent liquid from splashing out or contaminating. The liquid collection component 103 is located within the liquid collection space; Sample component 20, specifically including: The sample bottle rack 201 has at least one set of sample bottle placement slots 2011 for placing sample bottles 202 in its middle part; At least one set of sample loading components 203, each set of sample loading components 203 includes multiple sample loading components 203, the total number of sample loading components 203 corresponds to the total number of extraction heads 1022, and the sample loading components 203 are connected to the liquid inlet 10221 of the corresponding extraction head 1022; any set of sample loading components 203 can be moved to be directly above any set of sample bottle placement slots 2011; The reagent addition assembly 30 includes a dispensing component that corresponds to and is connected to the number of dispensing heads 1023.
[0020] During operation, the sample to be tested is added to the inlet 10221 of the extraction head 1022 through the sample loading component 20, and the activation reagent, elution reagent, etc. are added to the liquid addition head 1023 through the reagent addition component 30. After extraction by the extraction component 101, the liquid collection component 103 collects the activation waste liquid, the eluent containing the target substance obtained by extraction, and other liquids. Both the extraction head 1022 and the liquid addition head 1023 are mounted on the liquid injection plate 1021, facilitating liquid addition operations and resulting in a cleaner structure. Only one set of sample loading components 203 can be used, or multiple sets of sample loading components 203 can be used. The number of sample loading components 203 is consistent with that of the extraction head 1022, and they are connected in a one-to-one correspondence, enabling simultaneous detection of multiple samples and simultaneous extraction of various samples. Correspondingly, only one set of sample bottle placement slots 2011 can be used, or multiple sets of sample bottle placement slots 2011 can be used to stably place the sample bottles 202, preventing them from tilting during liquid extraction. During use, any set of sample loading components 203 can move directly above any set of sample bottle placement slots 2011 to extract the sample from the sample bottle 202 placed therein.
[0021] like Figure 3 As shown, further, the number and spacing of the sample loading components 203 in each group of sample loading components 203 correspond to the number and spacing of the sample bottle placement slots 2011 in each group of sample bottle placement slots 2011; The number of sample bottle placement slots 2011 is a multiple of the number of sample loading components 203. When multiple sample bottle placement slots 2011 are provided, the size of the sample bottles 202 in each sample bottle placement slot 2011 can be the same or different. For example, the size of the sample bottles 202 can be 10mL, 15mL, 250mL, or 1.2L. The sample loading assembly 20 also includes: a first moving part 204 and a cleaning agent collection chamber 205; the cleaning agent collection chamber 205 is arranged in a front-to-back manner with the sample bottle placement rack 201; The first moving component 204 specifically includes: Two first moving tracks 2041 are arranged in parallel on both sides of the sample bottle placement rack 201 and the cleaning agent collection chamber 205; The first movable frame 2042 is slidably disposed above the two first movable tracks 2041. The top of the first movable frame 2042 is provided with a liquid extraction mounting plate 206, and the sample loading component 203 is mounted on the liquid extraction mounting plate 206. Two first moving drive components 2043 are respectively disposed between the first moving frame 2042 and the two first moving tracks 2041, and are used to drive the first moving frame 2042 to move the sample loading component 203 along the first moving track 2041 to directly above any set of sample bottle placement slots 2011 or directly above the cleaning agent collection chamber 205.
[0022] During operation, the number and spacing of sample loading components 203 in each group of sample loading components 203 correspond to the number and spacing of sample bottle placement slots 2011 in each group of sample bottle placement slots 2011. The first moving drive component 2043 drives the first moving frame 2042 to move the sample loading components 203 synchronously along the first moving track 2041, moving multiple sample loading components 203 from one or more groups of sample loading components 203 directly above the sample bottles 202 placed in the corresponding group of sample bottle placement slots 2011 for synchronous liquid extraction, thus improving work efficiency. Efficiency; Furthermore, the number of sample bottle placement slots 2011 is a multiple of the number of sample loading components 203. After completing one synchronous extraction, the first moving drive component 2043 can drive the first moving frame 2042 to move the sample loading components 203 synchronously along the first moving track 2041, moving one or more sets of sample loading components 203 to the position of the next extraction, that is, directly above the sample bottles 202 placed in the corresponding set of sample bottle placement slots 2011; this cycle continues until the extraction of the samples to be tested from all sets of sample bottles 202 is completed. For example, when there are two sets of sample loading components 203 and two sets of sample vials 202 corresponding to sample vials 2011, the two sets of sample loading components can simultaneously extract the sample to be tested from the two sets of sample vials 202. When there are two sets of sample loading components 203 and four sets of sample vials 202 corresponding to sample vials 2011, the first moving drive component 2043 can drive the first moving frame 2042 to move the two sets of sample loading components 203 synchronously along the first moving track 2041. The two sets of sample loading components 203 first extract the sample to be tested from the two adjacent sets of sample vials 202, and then extract the sample to be tested from the other two adjacent sets of sample vials 202. This process can be repeated for other multiples of the number of sample vials 2011 that are also multiples of the number of sample loading components 203.
[0023] In the above process, after each liquid extraction, all used sample loading components 203 need to be cleaned to avoid cross-contamination. Cleaning agent, such as water, can be placed in any one or more sample bottles 202. Then, the corresponding cleaning agent is extracted by the sample loading component for cleaning. After cleaning, the first moving drive component 1042 drives the first moving frame 2042 to move the sample loading component 203 synchronously along the first moving track 2041 to directly above the cleaning agent collection chamber 205, and discharges the waste liquid after cleaning into the cleaning agent collection chamber 205 for centralized discharge.
[0024] like Figure 4 As shown, further, the sample loading component 203 includes: a first lifting component and a first peristaltic pump 2031, wherein the first lifting component specifically includes: The first lifting track 2032 is set on the liquid extraction mounting plate 206; The first lifting slider 2033 is located on the side of the first lifting track 2032 away from the liquid extraction mounting plate 206; The first lifting drive component 2034 is disposed between the first lifting track 2032 and the first lifting slider 2033, and is used to drive the first lifting slider 2033 to move up and down along the first lifting track 2032. The aspiration needle mounting base 2035 is located on the side of the first lifting slider 2033 away from the first lifting track 2032; A suction needle 2036 is mounted on a suction needle mounting base 2035. The bottom of the suction needle 2036 penetrates the bottom of the suction mounting plate 206 and extends downward. The first peristaltic pump 2031 is mounted on the liquid extraction mounting plate 206. The two ends of the peristaltic tube in the first peristaltic pump 2031 are respectively connected to the top of the corresponding liquid extraction needle 2036 and the liquid inlet 10221 of the corresponding extraction head 1022.
[0025] During operation, the first lifting drive component 2034 drives the first lifting slider 2033 to move the suction needle mounting base 2035 and the suction needle 2036 up and down, allowing the bottom of the suction needle 2036 to penetrate into the corresponding sample bottle 202. The corresponding first peristaltic pump 2031 then extracts the sample to be tested from the sample bottle 202 into the corresponding extraction head 1022. The first lifting component and the first peristaltic pump 2031 enable smooth extraction of the sample to be tested. Each loading component 203 can be lifted and lowered independently. Through the coordinated use of the first moving component 204 and the first lifting component, extraction of the sample to be tested from any sample bottle 202 can be achieved. All loading components 203 can be lifted and lowered synchronously, enabling synchronous extraction from all loading components 203.
[0026] like Figure 5 As shown, further, the first lifting components in the multiple sets of sample loading components 203 are arranged at the front end of the liquid extraction mounting plate 206 along the setting direction of the first moving track 2041; the multiple first lifting components in each set of sample loading components 203 are spaced apart along a direction perpendicular to the first moving track 2041. The first peristaltic pumps 2031 in the multiple sample loading components 203 are arranged vertically at the rear end of the liquid extraction mounting plate 206; the multiple first peristaltic pumps 2031 in each sample loading component 203 are spaced apart in a direction perpendicular to the first moving track 2041.
[0027] The sample loading component 203 in this application has a compact design. All the first lifting components are located at the front end of the liquid extraction mounting plate 206, and all the first peristaltic pumps 2031 are located at the rear end of the liquid extraction mounting plate 206. All the first lifting components are arranged in an array, which saves space and facilitates extraction. The first peristaltic pumps 2031 in the multiple sample loading components 203 are arranged vertically, which also saves space and makes the layout neat.
[0028] like Figure 6 and Figure 7 As shown, the extraction component 101 further includes: Extraction support frame 1011, liquid collection space is located below extraction support frame 1011, and mounting hole is provided in the middle of extraction support frame 1011; An extraction column holder 1012 is disposed on top of the extraction support frame 1011 and installed in the mounting hole; the middle part of the extraction column holder 1012 is provided with multiple sets of second through holes for placing multiple sets of extraction columns 1013. Two limiting components 1014 are respectively disposed on both sides of the extraction column placement rack 1012, including a fixed end and a movable end, wherein the movable ends of the two limiting components 1014 can respectively extend into either limiting groove 10121 disposed on both sides of the extraction column placement rack 1012; the limiting component 1014 can be a cylinder or an electric push rod, etc. The liquid dispensing component also includes: The reagent rack 301 has a reagent bottle placement slot 3011 in its middle for placing reagent bottles 302; The second peristaltic pump 303 has two ends of the peristaltic tube connected to the corresponding liquid dispensing head 1023 and the corresponding reagent bottle 302, respectively. The liquid injection component 102 further includes: The second moving part 1024 specifically includes: Two second moving tracks 10241 are arranged in parallel on both sides of the extraction component 101; The second movable frame 10242 is slidably disposed above the two second movable tracks 10241; Two second moving drive components 10243 are respectively disposed between the second moving frame 10242 and the two second moving tracks 10241, and are used to drive the second moving frame 10242 to move along the second moving tracks 10241; The vertical component 1025, which is perpendicular to the second moving component 1024, specifically includes: A vertical track 10251 is disposed on the top of the second movable frame 10242, and the setting direction of the vertical track 10251 is perpendicular to the setting direction of the second movable track 10241. The vertical slider 10252 is slidably mounted on the vertical track 10251; A vertical drive component 10253 is disposed between a vertical track 10251 and a vertical slider 10252, and is used to drive the vertical slider 10252 to move along the vertical track 10251. The second lifting component 1026 specifically includes: The second lifting track 10261 is set on the vertical slider 10252; The second lifting slider 10262 is slidably mounted on the second lifting rail 10261 and is fixedly connected to the liquid injection plate 1021; The second lifting drive component 10263 is disposed between the second lifting rail 10261 and the second lifting slider 10262, and is used to drive the second lifting slider 10262 to move the liquid injection plate 1021 up and down along the second lifting rail 10261. The second moving component 1024, the vertical component 1025, and the second lifting component 1026 drive any extraction head 1022 on the injection plate 1021 to the top of any extraction column 1013, and drive any liquid filling head 1023 on the injection plate 1021 to the top of any extraction column 1013.
[0029] During operation, the extraction column placement rack 1012 is supported by the extraction support rack 1011, forming a liquid collection space below the extraction support rack 1011. The extraction support rack 1011 has a mounting hole in its center to accommodate the extraction column placement rack 1012. Two limiting components 1014 then limit the sides of the extraction column placement rack 1012, making the structure more stable. This allows the bottom of the extraction column 1013 to extend beyond the mounting hole and the corresponding second through hole, facilitating the collection component 103 below to collect the activation waste liquid flowing from the bottom of the extraction column 1013, the eluent containing the target substance obtained from the extraction, and other liquids. The liquid addition component includes a reagent placement rack 301, with a reagent bottle placement slot 3011 in its center for placing reagent bottles 302. The reagents placed in the reagent bottles 302 of different liquid addition components include activation reagents and elution reagents, enabling activation, extraction, and elution steps. In specific implementation, the injection plate 1021 can move horizontally via the mutually perpendicular second moving component 1024 and vertical component 1025, and vertically via the second lifting component 1026, so that any extraction head 1022 on the injection plate 1021 can move to the top of any extraction column 1013, and any liquid addition head 1023 on the injection plate 1021 can move to the top of any extraction column 1013, thereby realizing the synchronous liquid addition operation of the same group or multiple groups of extraction heads 1022 to the corresponding group of extraction columns 1013, and realizing the liquid addition operation of each liquid addition head 1023 to any extraction column 1013.
[0030] Furthermore, an air inlet 10222 is provided on the extraction head 1022; The extraction assembly 10 also includes a pressurizing component, which is provided with multiple air outlets. The total number of air outlets is consistent with the total number of extraction heads 1022, and the air outlets are connected to the air inlets 10222 of the corresponding extraction heads 1022.
[0031] During operation, there may be a need for pressurized extraction. In this case, a pressurizing component can be set up to pressurize the air inlet 10222 of the corresponding extraction head 1022 through multiple air outlets on the pressurizing component. Nitrogen gas is usually used for pressurization.
[0032] like Figure 7 As shown, further, the liquid collection component 103 includes: at least one test tube rack 1031, which has multiple sets of test tube placement slots 10311 for placing multiple sets of liquid collection test tubes 1032; specifically, one test tube rack 1031 or two test tube racks 1031 can be provided. When two test tube racks 1013 are provided, one is used to collect waste liquid and the other is used to collect the eluent containing the target substance obtained from the extraction; when the sample to be tested is added to the extraction column 1013 and it is necessary to retain the liquid flowing out of the extraction column 1013, it can be collected by the test tube rack 1031 for collecting waste liquid and the corresponding liquid collection test tubes 1032; The number and spacing of extraction heads 1022 in each group of extraction heads 1022, the number and spacing of extraction columns 1013 in each group of extraction columns 1013, and the number and spacing of collection tubes 1032 in each group of collection tubes 1032 are all corresponding, and the top and bottom of the extraction column 1013 are connected to the liquid outlet 10223 of the corresponding extraction head 1022 and the corresponding collection tube 1032, respectively. The number of extraction columns 1013 is a multiple of the number of extraction heads 1022. The number of test tube placement slots 10311 is the same as the number of extraction columns 1013. Each set of test tube placement slots 10311, each set of extraction columns 1013, and each set of extraction heads 1022 are distributed in a front-to-back manner. The second moving component 1024, the vertical component 1025, and the second lifting component 1026 drive any set of extraction heads 1022 on the injection plate 1021 to the top of any set of extraction columns 1013.
[0033] During operation, the number and spacing of extraction heads 1022 in each group of extraction heads 1022, the number and spacing of extraction columns 1013 in each group of extraction columns 1013, and the number and spacing of collection tubes 1032 in each group of collection tubes 1032 are all corresponding. This ensures that the sample to be tested, extracted by the sample loading component 203 of the same group, enters the inlet 10221 of the corresponding extraction head 1022, and then flows through the corresponding outlet 10223 to the corresponding extraction column 1013. After extraction, the eluent containing the target substance and other liquids obtained through extraction are collected through the corresponding collection tubes 1032, completing one collection cycle. Because the extraction column 1013... The number of groups is a multiple of the number of extraction heads 1022. The number of groups in the test tube placement tank 10311 is the same as the number of groups in the extraction column 1013. Each group of test tube placement tank 10311, each group of extraction column 1013, and each group of extraction heads 1022 are arranged in a front-to-back manner. The extraction heads 1022 on the liquid injection plate 1021 are moved to the position of the next extraction by the second moving part 1024, the vertical part 1025, and the second lifting part 1026, which is directly above the extraction column 1013 of the corresponding group. This cycle is repeated until the extraction operation of all groups of extraction columns 1013 and the liquid collection of all groups of collection test tubes 1032 are completed, which can quickly improve the extraction efficiency. For example, when there are two sets of extraction heads 1022, two sets of extraction columns 1013, and two sets of test tube placement tanks 10311 (i.e., two sets of collection test tubes 1032), the two sets of extraction heads 1022 can simultaneously add liquid to the two sets of extraction columns 1013, and the two sets of collection test tubes 1032 can simultaneously collect liquid from the two sets of extraction columns 1013. When there are two sets of extraction heads 1022, and six sets of extraction columns 1013 and test tube placement tanks 10311 (i.e., six sets of collection test tubes 1032), the two sets of extraction heads 1022 can simultaneously add liquid to two adjacent sets of extraction columns 1013, and the two sets of collection test tubes 1032 can simultaneously collect liquid from the corresponding two sets of extraction columns 1013. Then, the two sets of extraction heads 1022 move to the top of the next two adjacent sets of extraction columns 1013 to add liquid, until all six sets of extractions are completed. By analogy, we can obtain working processes where the number of extraction column 1013 groups and the number of test tube placement tanks 10311 (i.e., the number of liquid collection test tubes 1032) are other multiples of the number of extraction head 1022 groups.
[0034] like Figure 8 As shown, the liquid collecting component 103 further includes a third moving component, which specifically includes: The third moving track 1033 is set in the liquid collection space; The third movable slider 1034 is slidably disposed on the top of the third movable track 1033, and the test tube holder 1031 is disposed on the top of the third movable slider 1034; The activation liquid collection chamber 1035 is located on top of the third movable slider 1034 and is arranged in a front-to-back manner with the test tube placement rack 1031; The third moving drive component 1036 is disposed between the third moving track 1033 and the third moving slider 1034, and is used to drive the third moving slider 1034 to move the test tube rack 1031 and the activation liquid collection chamber 1035 along the third moving track 1033.
[0035] During operation, the liquid activated by the extraction column 1013 needs to be collected for centralized processing. Therefore, an activation liquid collection chamber 1035 is provided and is set on top of the third moving slider 1034. The third moving drive component 1036 drives the third moving slider 1034 to move the test tube rack 1031 and the activation liquid collection chamber 1035 along the third moving track 1033, so that the test tube rack 1031 moves directly below the extraction column rack 1012, or the activation liquid collection chamber 1035 moves directly below any group of extraction columns 1013. Then, the activation liquid generated by activating the extraction columns 1013 is collected one group at a time.
[0036] like Figure 9 As shown, the sample loading component 20 and the reagent addition component 30 are respectively disposed on both sides close to the extraction component 10; the first moving track 2041, the second moving track 10241 and the third moving track 1033 are all arranged in parallel, and the rear ends of the first moving track 2041 and the second moving track 10241 are flush.
[0037] In this application, since both the sample loading component 20 and the reagent adding component 30 need to add liquid to the extraction component 10, they are respectively set on both sides of the extraction component 10 to shorten the distance, and consequently the corresponding liquid adding pipeline is also shortened. The first moving track 2041, the second moving track 10241 and the third moving track 1033 involved in this application are all arranged in parallel, and the rear ends of the first moving track 2041 and the second moving track 10241 are flush, resulting in a compact overall structure and a cleaner working environment.
[0038] In practical applications, the first moving component 204, the second moving component 1024, the third moving component, the vertical component 1025, the first lifting component, and the second lifting component 1026 can all include a power output unit and a transmission unit. The power output unit provides power to the transmission unit, where the power output unit can be a motor, and the transmission unit can be an existing structure such as a ball screw, rack and pinion, transmission chain, or transmission belt. Alternatively, the first moving component 204, the second moving component 1024, the third moving component, the vertical component 1025, the first lifting component, and the second lifting component 1026 can also be a linear motor module, a hydraulic cylinder, or a pneumatic cylinder. In this application, the above structures are described in detail using a linear motor module as an example.
[0039] like Figure 10 As shown, this application also provides a position sensing component, which can be selectively disposed on the first lifting component and / or the second lifting component 1026. The position sensing component includes a sensing plate 40 and a plurality of sensors 50. The sensing plate 40 is disposed on the first lifting slider 2033 and / or the second lifting slider 10262. The plurality of sensors 50 are disposed vertically on one side of the first lifting track 2032 and / or one side of the second lifting track 10261. The sensing plate 40 disposed on the first lifting slider 2033 is adapted to any sensor 50 disposed on one side of the first lifting track 2032. The sensing plate 40 disposed on the second lifting slider 10262 is adapted to any sensor 50 disposed on one side of the second lifting track 10261. This allows the position of the first lifting slider 2033 and / or the second lifting slider 10262 to be sensed by the sensors, facilitating better activation or deactivation of the first lifting drive component 2034 and / or the second lifting drive component 10263.
[0040] All pipelines in this application are made of polyetheretherketone (PEEK), which has strong corrosion resistance and a long service life.
[0041] Working principle: The reagent addition component 30 activates the extraction column 1013 in the extraction component 101 through the liquid addition head 1023 on the liquid addition component 102. Specifically, the liquid addition plate 1021 can move horizontally through the mutually perpendicular second moving component 1024 and vertical component 1025, and move vertically through the second lifting component 1026, so that the liquid addition head 1023 on the liquid addition plate 1021 (the liquid addition head 1023 corresponding to the reagent bottle 302 containing the activation reagent) is moved to the top of any extraction column 1013, and then the corresponding second peristaltic pump 303 is turned on to realize the activation of any extraction column 1013 by the liquid addition head 1023.
[0042] The third moving drive component 1036 drives the third moving slider 1034 to move the activation liquid collection chamber 1035 along the third moving track 1033, so that the activation liquid collection chamber 1035 moves to directly below any set of extraction columns 1013 (extraction columns 1013 injected with activation reagent), and then collects the activation liquid generated by the activation of the extraction columns 1013.
[0043] The sample to be tested is added to the extraction column 1013. Specifically, the injection plate 1021 moves horizontally via the mutually perpendicular second moving part 1024 and vertical part 1025, allowing any extraction head 1022 to move directly above any extraction column 1013; the second lifting part 1026 moves vertically, allowing any extraction head 1022 on the injection plate 1021 to move to the top of any extraction column 1013. The sealing ring 10224 seals the outlet 10223 with the top of the corresponding extraction column 1013, allowing the sample to be tested to be injected into the extraction column 1013 under sealed conditions. Nitrogen gas is introduced to pressurize the column, thereby controlling the extraction rate. Precise control of the rate; the first moving drive component 2043 drives the first moving frame 2042 to move the sample loading component 203 synchronously along the first moving track 2041, moving multiple sample loading components 203 in one or more groups of sample loading components 203 to directly above the sample bottle 202 placed in the corresponding sample bottle placement slot 2011; then the first lifting drive component 2034 drives the first lifting slider 2033 to lift the liquid extraction needle mounting seat 2035 and the liquid extraction needle 2036, so that the bottom of the liquid extraction needle 2036 can penetrate into the corresponding sample bottle 202, and the corresponding first peristaltic pump 2031 is activated to extract the sample to be tested from the sample bottle 202 into the corresponding extraction head 1022. After this step is completed, when the liquid flowing out of the extraction column 1013 does not need to be retained, it can be collected through the activation liquid collection chamber 1035; when it needs to be retained, it can also be collected through the test tube rack 1031 for collecting waste liquid and the corresponding collection test tube 1032.
[0044] The reagent addition assembly 30 elutes the sample to be tested in the extraction column 1013 of the extraction assembly 101 via the dispensing head 1023 on the dispensing component 102. Specifically, the dispensing plate 1021 can be moved horizontally by the mutually perpendicular second moving component 1024 and vertical component 1025, and vertically by the second lifting component 1026, so that the dispensing head 1023 on the dispensing plate 1021 (corresponding to the dispensing head 1023 of the reagent bottle 302 containing the elution reagent) is moved to the top of any extraction column 1013. Then, the corresponding second peristaltic pump 303 is turned on to elute the sample to be tested in any extraction column 1013 by the liquid dispensing head 1023. Finally, the third moving drive component 1036 drives the third moving slider 1034 to move the test tube rack 1031 and the corresponding collection test tube 1032, which are used to collect the eluent containing the target substance obtained by extraction, along the third moving track 1033. This moves the collection test tube 1032 to directly below the extraction column rack 1012 to collect the eluent containing the target substance obtained by extraction, which is convenient for subsequent detection.
[0045] In the description of this application, it should be understood that the terms "middle", "upper", "lower", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.
[0046] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.
[0047] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication between two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.
[0048] Although preferred embodiments of this application have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of this application.
[0049] Obviously, those skilled in the art can make various modifications and variations to this application without departing from the spirit and scope of this application. Therefore, if such modifications and variations fall within the scope of the claims of this application and their equivalents, this application also intends to include such modifications and variations.
Claims
1. A solid-phase extraction apparatus, characterized in that, include: Extraction component (10), specifically including: The extraction component (101) has a liquid collection space at its bottom; The liquid injection component (102) includes a liquid injection plate (1021), which is located above the extraction component (101). The liquid injection plate (1021) is provided with at least one set of extraction heads (1022) and multiple liquid injection heads (1023). Each set of extraction heads (1022) includes multiple extraction heads (1022). The liquid collection component (103) is located within the liquid collection space; Sample loading components (20) specifically include: A sample bottle rack (201) has at least one set of sample bottle placement slots (2011) for placing sample bottles (202) in its middle. At least one set of sample loading components (203), each set of sample loading components (203) includes multiple sample loading components (203), the total number of sample loading components (203) corresponds to the total number of extraction heads (1022), and the sample loading components (203) are connected to the liquid inlet (10221) of the corresponding extraction head (1022); any set of sample loading components (203) can be moved to be directly above any set of sample bottle placement slots (2011); The reagent addition assembly (30) includes a number of dispensing parts that correspond to and are connected to the dispensing heads (1023).
2. The solid-phase extraction apparatus according to claim 1, characterized in that, The number and spacing of the sample loading components (203) in each group of sample loading components (203) correspond to the number and spacing of the sample bottle placement slots (2011) in each group of sample bottle placement slots (2011); The number of sample bottle placement slots (2011) is a multiple of the number of sample loading components (203); The sample loading assembly (20) further includes: a first moving component (204), the first moving component (204) specifically including: Two first moving tracks (2041) are set parallel to each other on both sides of the sample bottle holder (201); The first movable frame (2042) is slidably disposed above the two first movable tracks (2041), and the sample loading component (203) is disposed on the first movable frame (2042); Two first moving drive components (2043) are respectively disposed between the first moving frame (2042) and the two first moving tracks (2041) to drive the first moving frame (2042) to move the sample loading component (203) along the first moving track (2041) to directly above any set of sample bottle placement slots (2011).
3. The solid-phase extraction apparatus according to claim 1 or 2, characterized in that, The sample loading component (20) also includes: The cleaning agent collection chamber (205) and the sample bottle rack (201) are arranged in a front-to-back manner; The first moving component (204) specifically includes: Two first moving tracks (2041) are arranged in parallel on both sides of the sample bottle holder (201) and the cleaning agent collection chamber (205); The first movable frame (2042) is slidably disposed above the two first movable tracks (2041). The top of the first movable frame (2042) is provided with a liquid extraction mounting plate (206), and the sample loading component (203) is mounted on the liquid extraction mounting plate (206). Two first moving drive components (2043) are respectively disposed between the first moving frame (2042) and the two first moving tracks (2041) to drive the first moving frame (2042) to move the sample loading component (203) along the first moving track (2041) to directly above any set of sample bottle placement slots (2011) or directly above the cleaning agent collection chamber (205).
4. The solid-phase extraction apparatus according to claim 3, characterized in that, The sample loading component (203) includes: a first lifting component and a first peristaltic pump (2031), wherein the first lifting component specifically includes: The first lifting track (2032) is set on the liquid extraction mounting plate (206); The first lifting slider (2033) is located on the side of the first lifting rail (2032) away from the liquid extraction mounting plate (206); The first lifting drive component (2034) is disposed between the first lifting rail (2032) and the first lifting slider (2033) for driving the first lifting slider (2033) to move up and down along the first lifting rail (2032); A suction needle mounting base (2035) is disposed on the side of the first lifting slider (2033) away from the first lifting track (2032); A suction needle (2036) is mounted on a suction needle mounting base (2035). The bottom of the suction needle (2036) extends downward after penetrating the bottom of the suction mounting plate (206). The first peristaltic pump (2031) is mounted on the liquid extraction mounting plate (206). The two ends of the peristaltic tube in the first peristaltic pump (2031) are respectively connected to the top of the corresponding liquid extraction needle (2036) and the liquid inlet (10221) of the corresponding extraction head (1022).
5. The solid-phase extraction apparatus according to claim 4, characterized in that, The first lifting components in the multiple sample loading components (203) are arranged at the front end of the liquid extraction mounting plate (206) along the setting direction of the first moving track (2041); the multiple first lifting components in each sample loading component (203) are spaced apart along a direction perpendicular to the first moving track (2041). The first peristaltic pumps (2031) in the multiple sample loading components (203) are arranged vertically at the rear end of the liquid extraction mounting plate (206); the multiple first peristaltic pumps (2031) in each sample loading component (203) are spaced apart in a direction perpendicular to the first moving track (2041).
6. The solid-phase extraction apparatus according to claim 1, characterized in that, The extraction component (101) includes: An extraction support frame (1011) has a liquid collection space located below it, and an installation hole is provided in the middle of the extraction support frame (1011). An extraction column holder (1012) is located on top of the extraction support frame (1011) and installed in the mounting hole; the middle part of the extraction column holder (1012) is provided with multiple sets of second through holes for placing multiple sets of extraction columns (1013); The liquid dispensing component also includes: The reagent rack (301) has a reagent bottle placement slot (3011) in its middle for placing reagent bottles (302). The second peristaltic pump (303) has two ends of the peristaltic tube connected to the corresponding dispensing head (1023) and the corresponding reagent bottle (302), respectively. The liquid injection component (102) further includes: The second moving part (1024) specifically includes: Two second moving tracks (10241) are arranged in parallel on both sides of the extraction component (101); The second movable frame (10242) is slidably mounted above the two second movable tracks (10241); Two second moving drive components (10243) are respectively disposed between the second moving frame (10242) and the two second moving tracks (10241) for driving the second moving frame (10242) to move along the second moving tracks (10241); The vertical component (1025), which is perpendicular to the second moving component (1024), specifically includes: A vertical track (10251) is installed on top of the second movable frame (10242), and the installation direction of the vertical track (10251) is perpendicular to the installation direction of the second movable track (10241). A vertical slider (10252) is slidably mounted on a vertical track (10251); A vertical drive component (10253) is disposed between a vertical track (10251) and a vertical slider (10252) for driving the vertical slider (10252) to move along the vertical track (10251); The second lifting component (1026) specifically includes: The second lifting track (10261) is set on the vertical slider (10252); The second lifting slider (10262) is slidably mounted on the second lifting rail (10261) and fixedly connected to the liquid injection plate (1021); The second lifting drive component (10263) is disposed between the second lifting rail (10261) and the second lifting slider (10262), and is used to drive the second lifting slider (10262) to move the liquid injection plate (1021) up and down along the second lifting rail (10261); The second moving component (1024), the vertical component (1025), and the second lifting component (1026) drive any extraction head (1022) on the injection plate (1021) to move to the top of any extraction column (1013), and drive any liquid filling head (1023) on the injection plate (1021) to move to the top of any extraction column (1013).
7. The solid-phase extraction apparatus according to claim 6, characterized in that, An air inlet (10222) is provided on the extraction head (1022); The extraction assembly (10) also includes a pressurizing component, which is provided with multiple air outlets. The total number of air outlets is consistent with the total number of extraction heads (1022), and the air outlets are connected to the air inlets (10222) of the corresponding extraction heads (1022).
8. The solid-phase extraction apparatus according to claim 7, characterized in that, The liquid collection component (103) includes: at least one test tube rack (1031), and the test tube rack (1031) is provided with multiple sets of test tube placement slots (10311) for placing multiple sets of liquid collection test tubes (1032). The number and spacing of extraction heads (1022) in each group of extraction heads (1022), the number and spacing of extraction columns (1013) in each group of extraction columns (1013), and the number and spacing of collection tubes (1032) in each group of collection tubes (1032) are all corresponding, and the top and bottom of the extraction column (1013) are connected to the liquid outlet (10223) of the corresponding extraction head (1022) and the corresponding collection tube (1032) respectively; The number of extraction columns (1013) is a multiple of the number of extraction heads (1022), and each extraction column (1013) and each extraction head (1022) is distributed in a front-to-back manner. The second moving component (1024), the vertical component (1025), and the second lifting component (1026) drive any one set of extraction heads (1022) on the injection plate (1021) to move to the top of any one set of extraction columns (1013).
9. The solid-phase extraction apparatus according to claim 8, characterized in that, The liquid collection component (103) also includes a third moving component, which specifically includes: The third moving track (1033) is set in the liquid collection space; The third movable slider (1034) is slidably set on the top of the third movable track (1033), and the test tube rack (1031) is set on the top of the third movable slider (1034); The activation liquid collection chamber (1035) is located on top of the third movable slider (1034) and is positioned in a front-to-back manner with the test tube rack (1031); The third moving drive component (1036) is disposed between the third moving track (1033) and the third moving slider (1034) and is used to drive the third moving slider (1034) to move the test tube rack (1031) and the activation liquid collection chamber (1035) along the third moving track (1033).
10. The solid-phase extraction apparatus according to claim 1, characterized in that, The sample loading assembly (20) and the reagent addition assembly (30) are respectively located on both sides near the extraction assembly (10); The sample loading assembly (20) further includes: a first moving component (204), the first moving component (204) specifically including: Two first moving tracks (2041) are set parallel to each other on both sides of the sample bottle holder (201); The first movable frame (2042) is slidably disposed above the two first movable tracks (2041), and the sample loading component (203) is disposed on the first movable frame (2042); Two first moving drive components (2043) are respectively disposed between the first moving frame (2042) and the two first moving tracks (2041) to drive the first moving frame (2042) to move the sample loading component (203) along the first moving track (2041) to directly above any set of sample bottle placement slots (2011); The liquid injection component (102) further includes: The second moving part (1024) specifically includes: Two second moving tracks (10241) are arranged in parallel on both sides of the extraction component (101); The second movable frame (10242) is slidably disposed above the two second movable tracks (10241), and the liquid injection plate (1021) is disposed on the second movable frame (10242); Two second moving drive components (10243) are respectively disposed between the second moving frame (10242) and the two second moving tracks (10241) for driving the second moving frame (10242) to move the liquid injection plate (1021) along the second moving track (10241); The liquid collection component (103) includes a third moving component, which specifically includes: The third moving track (1033) is set in the liquid collection space; The third movable slider (1034) is slidably set on the top of the third movable track (1033), and a test tube holder (1031) is set on the top of the third movable slider (1034). The third moving drive component (1036) is disposed between the third moving track (1033) and the third moving slider (1034) and is used to drive the third moving slider (1034) to move the test tube holder (1031) along the third moving track (1033); The first moving track (2041), the second moving track (10241), and the third moving track (1033) are all arranged in parallel, and the rear ends of the first moving track (2041) and the second moving track (10241) are flush.