A system for in-situ cleaning of a freeze dryer

Abstract

This utility model relates to a system for in-situ cleaning of a freeze dryer, comprising a base plate, an air compressor, a water generator, a buffer tank, and a sterilizing filter. The air compressor, water generator, buffer tank, and sterilizing filter are all located at the top of the base plate. The air compressor's outlet is connected to an inlet pipe. The water generator's steam outlet and water outlet are respectively connected to an inlet pipe and an inlet pipe. The outlets of the air inlet pipe, steam inlet pipe, and inlet pipe are all connected to the inlet of the buffer tank. The outlet of the buffer tank is connected to a second pipe, the outlet of which is connected to the inlet of the sterilizing filter. An electric pump and a second electric control valve are installed on the second pipe, and the second electric control valve is located between the buffer tank and the electric pump. The outlet of the sterilizing filter is connected to a third pipe, the outlet of which is connected to the freeze dryer. This utility model ensures a sterile environment inside the freeze dryer after cleaning.

Description

Technical Field

[0001] This utility model relates to the field of in-situ cleaning technology for freeze dryers, and in particular to a system for in-situ cleaning of freeze dryers. Background Technology

[0002] A freeze dryer is a device that uses the principle of freeze drying. It can first freeze water-containing substances (such as food, medicine, biological samples, etc.) into a solid state, and then sublimate the ice on the substance directly into water vapor in a vacuum environment. This allows for the efficient removal of moisture from the substance without damaging its original structure and activity.

[0003] After the freeze dryer is used (i.e., after freeze-drying production is completed), it needs to be cleaned in place (CIP) using water for injection. However, the traditional CIP process usually involves introducing water for injection into the freeze dryer through a CIP system to clean it. However, water for injection is not non-sterile, and existing CIP systems cannot effectively sterilize themselves or the water for injection. Therefore, a sterile environment inside the freeze dryer cannot be guaranteed after CIP.

[0004] Therefore, there is an urgent need for an in-situ cleaning system for freeze dryers that can sterilize itself and the water for injection, in order to ensure a sterile environment inside the freeze dryer after cleaning. Utility Model Content

[0005] The purpose of this invention is to provide a system for in-situ cleaning of a freeze dryer, in order to solve the problems existing in the prior art.

[0006] To achieve the above objectives, this utility model provides the following solution: This utility model provides a system for in-situ cleaning of a freeze dryer, including a base plate, an air compressor, a water generator, a buffer tank, and a sterilization filter, wherein: The air compressor, the water purifier, the buffer tank, and the sterilization filter are all located at the top of the base plate; The air compressor's outlet end is connected to an air inlet pipe, and the water purifier's steam outlet end and water outlet end are respectively connected to a steam inlet pipe and a water inlet pipe. The outlet end of the air inlet pipe, the outlet end of the steam inlet pipe, and the outlet end of the water inlet pipe are all connected to the inlet end of the buffer tank. The outlet end of the buffer tank is connected to a second pipeline, the outlet end of the second pipeline is connected to the inlet end of the sterilization filter, an electric pump and a second pipeline electric control valve are installed on the second pipeline, and the second pipeline electric control valve is located between the buffer tank and the electric pump. The outlet end of the sterilization filter is connected to a third pipeline, and the outlet end of the third pipeline is connected to a freeze dryer.

[0007] According to one embodiment of the present invention, the inlet end of the buffer tank is connected to a first pipeline, the inlet end of the first pipeline is connected to a four-way pipe, and the other three ports of the four-way pipe are respectively connected to and communicate with the outlet end of the air inlet pipeline, the outlet end of the steam inlet pipeline, and the outlet end of the water inlet pipeline.

[0008] According to one embodiment of the present invention, an electric control valve for air intake is installed on the air intake pipe, an electric control valve for steam intake is installed on the steam intake pipe, an electric control valve for water intake is installed on the water intake pipe, and a first pipe electric control valve is installed on the first pipe.

[0009] According to one embodiment of the present invention, a first parallel pipeline is installed on the second pipeline. The first parallel pipeline is arranged in parallel with the second pipeline and is connected and communicated with the second pipeline. The first parallel pipeline is located between the electric pump and the sterilization filter. The first parallel pipeline is equipped with a first parallel pipeline electric control valve and a first temperature sensor, and the first parallel pipeline electric control valve is located between the electric pump and the first temperature sensor, and the monitoring end of the first temperature sensor is located inside the first parallel pipeline.

[0010] According to one embodiment of the present invention, a first pressure probe is installed on the second pipeline. The monitoring end of the first pressure probe is located inside the second pipeline. The first pressure probe is located between the first parallel pipeline and the sterilization filter, and the first pressure probe is correspondingly arranged with the inlet end of the sterilization filter. A first pressure transmitter is installed on the outer wall of the second pipeline, and the first pressure probe is communicatively connected to the electric control valve of the second pipeline through the first pressure transmitter.

[0011] According to one embodiment of the present invention, a second parallel pipeline is installed on the third pipeline, and the second parallel pipeline is arranged in parallel with the third pipeline and connected to and communicates with the third pipeline; The second parallel pipeline is equipped with a second parallel pipeline electric control valve and a second temperature sensor, and the second parallel pipeline electric control valve is located between the sterilization filter and the second temperature sensor, and the monitoring end of the second temperature sensor is located inside the second parallel pipeline.

[0012] According to one embodiment of the present invention, a second pressure probe is installed on the third pipeline, the monitoring end of the second pressure probe is located inside the third pipeline, the second pressure probe is located between the sterilization filter and the second parallel pipeline, and the second pressure probe is correspondingly arranged with the outlet end of the sterilization filter; A second pressure transmitter is installed on the outer wall of the third pipeline, and the second pressure probe is communicatively connected to the electric control valve of the second pipeline through the second pressure transmitter.

[0013] According to one embodiment of the present invention, a bracket is installed at the top of the base plate, and a lifting mechanism is installed on the bracket, the lifting mechanism being located directly above the sterilization filter; The hoisting mechanism includes a power unit and a hoisting rope. One end of the hoisting rope near the sterilizing filter is detachably connected to the top of the sterilizing filter housing of the sterilizing filter, and the other end of the hoisting rope away from the sterilizing filter is connected to the power unit. The power unit is configured to be able to lift the sterilizing filter housing via the hoisting rope.

[0014] According to one embodiment of the present invention, the power unit includes a motor mounted on the bracket, a spool coaxially mounted on the output shaft of the motor, and the end of the suspension rope away from the sterilization filter is mounted on the spool and configured to be able to be wound around the spool.

[0015] According to one embodiment of the present invention, a second lifting ring is installed at one end of the suspension rope near the sterilization filter, and a first lifting ring is threaded onto the top end of the sterilization filter housing, with the first lifting ring and the second lifting ring being nested together.

[0016] Beneficial effects This utility model has at least the following technical effects: This invention, through the inclusion of a water purifier and an air compressor, allows for pre-heat sterilization of the system's interior; the inclusion of a sterilization filter allows for sterilization of the water for injection, thereby effectively sterilizing the outflowing water for injection and ensuring a sterile environment inside the freeze dryer after cleaning. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 for Figure 1 A magnified view of a section at point A in the middle; Figure 3 for Figure 1 A magnified view of a section at point B in the middle; Figure 4 for Figure 1 A magnified view of a section at point C; Figure 5 for Figure 1 A magnified view of a section at point D; Figure 6 for Figure 1 A magnified view of a section at point E in the middle; Figure 7 for Figure 1 A magnified view of a section at point F in the middle; Figure 8 for Figure 1 A schematic diagram of the overall structure from another angle; Figure 9 for Figure 8 A magnified view of a section at point G in the middle; Figure 10 for Figure 8 A schematic diagram of the overall structure from another angle; Figure 11 This is a schematic diagram of the overall structure of the first lifting ring in this utility model.

[0019] Explanation of reference numerals in the attached figures: 1. Base plate; 2. Air compressor; 201. Inlet pipe; 202. Inlet electric control valve; 3. Water purifier; 301. Steam inlet pipe; 302. Water inlet pipe; 303. Steam inlet electric control valve; 304. Water inlet electric control valve; 4. Four-way pipe; 5. First pipe; 501. First pipe electric control valve; 6. Buffer tank; 7. Second pipe; 701. Second pipe electric control valve; 8. Electric pump; 9. First parallel pipe; 901. First parallel pipe electric control valve; 902. First temperature sensor; 10. First pressure probe; 11. First pressure transmitter 12. Sterilizing filter housing; 13. Sterilizing filter base; 14. Sterilizing filter support leg; 15. Third pipeline; 16. Second pressure probe; 17. Second pressure transmitter; 18. First locking block; 19. Second locking block; 20. Rotating rod; 21. Rotating nut; 22. Locking rod; 23. Third locking block; 24. Rotating ring; 25. First lifting ring; 26. Second lifting ring; 27. Lifting rope; 28. I-beam reel; 29. ​​Motor; 30. Second parallel pipeline; 3001. Electric control valve for the second parallel pipeline; 3002. Second temperature sensor; 31. Support. Detailed Implementation

[0020] The features and exemplary embodiments of various aspects of this utility model will now be described in detail. To make the objectives, technical solutions, and advantages of this utility model clearer, the following description, in conjunction with the accompanying drawings and specific embodiments, will provide a further detailed description of this utility model. It should be understood that the specific embodiments described herein are merely configured to explain this utility model and to exemplarily illustrate the principles of this utility model, and are not intended to limit this utility model.

[0021] The directional terms used in the following description refer to the directions shown in the figures and are not intended to limit the specific structure of the embodiments of this utility model. In the description of this utility model, it should be noted that, unless otherwise stated, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0022] Furthermore, the terms "comprising," "including," "having," or any other variations thereof are intended to cover non-exclusive inclusion, such that a structure or component that includes a list of elements includes not only those elements but also other structural elements that are not expressly listed or inherent to the structure or component. Without further limitations, an element defined by the phrase "comprising..." does not exclude the presence of other identical elements in the article or apparatus that includes the element.

[0023] Spatial relation terms such as "below," "under," "under," "low," "above," "on," and "high" are used for descriptive convenience to explain the positioning of one element relative to a second element, indicating that these terms are intended to cover different orientations of the device, in addition to those different from those shown in the figure. Furthermore, phrases such as "one element on / below another element" can indicate that two elements are in direct contact, or that there are other elements between the two elements. In addition, terms such as "first" and "second" are also used to describe individual elements, areas, parts, etc., without specifically indicating order or sequence, and should not be considered restrictive. Similar terms are used throughout the description to represent similar elements.

[0024] For those skilled in the art, this invention can be implemented without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the invention by illustrating examples.

[0025] It should be understood that the structural components in the accompanying drawings are not necessarily drawn to scale. For example, the dimensions of some structural components or regions in the drawings may be enlarged for the sake of better presentation of the drawings and to aid in the understanding of the embodiments of this utility model.

[0026] In the following embodiments, there may be descriptions such as "this system" or "the system". It should be understood that "this system" or "the system" refers to a system for in-situ cleaning of a freeze dryer provided by this utility model.

[0027] Sterilization filter like Figure 1 , Figure 4 , Figure 9 and Figure 10 As shown, the sterilizing filter includes at least a sterilizing filter housing 12, a sterilizing filter base 13, and a sterilizing filter support leg 14 arranged sequentially from top to bottom. The bottom end of the sterilizing filter support leg 14 is located at the top of the base plate 1 to support the sterilizing filter. The filter element (i.e., the filter element used for sterilization) is installed inside the sterilizing filter housing 12. Wherein, as... Figure 9 or Figure 10 As shown, the outlet end of the second pipeline 7 and the inlet end of the third pipeline 15 can both be installed on the sterilization filter base 13 and connected to the filter element (not shown in the figure) inside the sterilization filter housing 12.

[0028] like Figure 4 As shown, the sterilization filter also includes a mechanism capable of locking the sterilization filter housing 12 and the sterilization filter base 13; for ease of description, this mechanism is referred to as the locking mechanism. Figure 1 , Figure 9 and Figure 10 As shown, the number of locking mechanisms can be six, and they are arranged evenly along the circumference of the sterilization filter.

[0029] like Figure 4 As shown, the locking mechanism includes a second locking block 19 mounted on the bottom of the outer wall of the sterilizing filter housing 12 and a first locking block 18 mounted on the outer wall of the sterilizing filter base 13. Both the second locking block 19 and the first locking block 18 are U-shaped structures (or concave structures) with openings facing outwards from the sterilizing filter. Along the first locking block 18... Figure 4 A rotating rod 20 extends horizontally through the first locking block 18, and the rotating rod 20 is in sliding engagement (or rotational engagement) with the first locking block 18. One end of the rotating rod 20 (i.e....) Figure 4A stop block is fixedly installed at the left end of the first locking block 18. The end of the stop block near the first locking block 18 is configured to slide against the outer wall of the first locking block 18. The other end of the rotating rod 20 has an external thread, and a rotating nut 21 is threaded onto the external thread of the rotating rod 20. The end of the rotating nut 21 near the first locking block 18 is configured to slide against the outer wall of the first locking block 18. A locking rod 22 perpendicular to the rotating rod 20 is fixedly installed on the rotating rod 20. The locking rod 22 has an external thread, and a third locking block 23 is threaded onto the locking rod 22. The third locking block 23 is configured to abut against the top of the second locking block 19 to lock the sterilizing filter housing 12 and the sterilizing filter base 13. A rotating ring 24 is fixedly installed at the top of the third locking block 23.

[0030] When the sterilization filter housing 12 is installed on the sterilization filter base 13, the locking rod 22 is rotated through the rotating rod 20 to a position where... Figure 4 When the filter housing 12 is in a vertical position, the rotating ring 24 is turned so that the top of the third locking block 23 abuts against the top of the second locking block 19, thereby locking the sterilizing filter housing 12 and the sterilizing filter base 13. Conversely, when it is necessary to remove the sterilizing filter housing 12 from the sterilizing filter base 13, the rotating ring 24 is turned in the opposite direction to separate the top of the third locking block 23 from the top of the second locking block 19. Then, the locking rod 22 is rotated through the rotating rod 20 to be located outside the second locking block 19 and the first locking block 18, thereby removing the sterilizing filter housing 12 from the sterilizing filter base 13.

[0031] It should be understood that since sterilization filters are existing technology known in the art, the above content is all existing technology known in the art and will not be elaborated further here.

[0032] air compressor The air compressor, specifically air compressor 2 in this invention, is capable of producing sterile compressed air (also known as compressed sterile air). The sterile compressed air produced by air compressor 2 can be introduced into the system through intake pipe 201. Air compressors are existing technology known in the art and will not be described in detail here.

[0033] Water purifier The water purifier, specifically water purifier 3 in this invention, is capable of producing pure steam and water for injection. The pure steam produced by water purifier 3 can be introduced into the system through steam inlet pipe 301, and the water for injection produced by water purifier 3 can be introduced into the system through water inlet pipe 302. The water purifier is prior art known in the field and will not be described in detail here.

[0034] Example like Figures 1-11 As shown, this utility model provides a system for in-situ cleaning of a freeze dryer. The system includes at least a base plate 1, an air compressor 2, a water purifier 3, a buffer tank 6, and a sterilization filter, wherein: like Figure 1 , Figure 9 and Figure 10 As shown, the air compressor 2, water purifier 3, buffer tank 6, and sterilization filter are all located at the top of the base plate 1.

[0035] In this embodiment, the volume of the buffer tank 6 can be six tons, and no particular limitation is made here.

[0036] In this embodiment, the air compressor 2, water purifier 3, buffer tank 6, and sterilization filter can all be installed on the top of the base plate 1 by means of bolt connection (not shown in the figure) as known in the art. Alternatively, the air compressor 2, water purifier 3, buffer tank 6, and sterilization filter can all be placed on the top of the base plate 1 by their own weight. No particular limitation is made here.

[0037] like Figure 1 , Figure 9 and Figure 10 As shown, the air compressor 2's outlet is connected to and connected to an air inlet pipe 201, and the water purifier 3's steam outlet and water outlet are respectively connected to and connected to an air inlet pipe 301 and an air inlet pipe 302. The outlet ends of the air inlet pipe 201, the air inlet pipe 301, and the water inlet pipe 302 (i.e.,...) Figure 1 The top ends of the air inlet pipe 201, the steam inlet pipe 301, and the water inlet pipe 302 are all connected to the inlet end of the buffer tank 6 (i.e., Figure 1 The top of the buffer tank 6 is connected and interconnected.

[0038] Specifically, such as Figure 2 As shown, the inlet end of the buffer tank 6 is connected to and connected to the first pipe 5, and the inlet end of the first pipe 5 (i.e. Figure 1 and Figure 2 The left end of the first pipe 5 is connected to a four-way pipe 4. The other three ports of the four-way pipe 4 are connected to the outlet end of the air inlet pipe 201, the outlet end of the steam inlet pipe 301, and the outlet end of the water inlet pipe 302, respectively.

[0039] In this embodiment, the four-way pipe 4 can be a four-way pipe of equal diameter known in the art, or it can be another four-way pipe, as long as it can achieve mutual connection between the first pipe 5, the air inlet pipe 201, the steam inlet pipe 301 and the water inlet pipe 302, and there is no special limitation here.

[0040] like Figure 1 As shown, the outlet end of buffer tank 6 (i.e. Figure 1The bottom end of the buffer tank 6 is connected to and connected to the second pipe 7, and the outlet end of the second pipe 7 (i.e. Figure 1 The right end of the second pipe 7 is connected to the inlet end of the sterilization filter. For example... Figure 3 As shown, an electric pump 8 and a second-line electric control valve 701 are installed on the second pipeline 7, and the second-line electric control valve 701 is located between the buffer tank 6 and the electric pump 8. The electric pump 8 can provide pumping force for the gas or liquid in the second pipeline 7, and the second-line electric control valve 701 can open and close the second pipeline 7.

[0041] In this embodiment, the electric pump 8 is a prior art known in the art, and will not be described in detail here.

[0042] like Figure 1 , Figure 4 , Figure 5 , Figures 8-10 As shown, the outlet end of the sterilization filter is connected to a third pipe 15, and the outlet end of the third pipe 15 is configured to be connected to a freeze dryer (not shown in the figure) for in-situ cleaning of the freeze dryer.

[0043] like Figure 2 As shown, an electric air intake control valve 202 is installed on the air intake pipe 201, which can open and close the air intake pipe 201; an electric steam intake control valve 303 is installed on the steam intake pipe 301, which can open and close the steam intake pipe 301; an electric water intake control valve 304 is installed on the water intake pipe 302, which can open and close the water intake pipe 302; and a first pipe electric control valve 501 is installed on the first pipe 5, which can open and close the first pipe 5.

[0044] Furthermore, such as Figure 3 , Figure 8 and Figure 10 As shown, a first parallel pipe 9 is installed on the second pipe 7, and the first parallel pipe 9 is arranged in parallel with the second pipe 7 and connected to and communicates with the second pipe 7 (that is, both ends of the first parallel pipe 9 are connected to and communicate with the second pipe 7). Preferably, the first parallel pipe 9 is located between the electric pump 8 and the sterilization filter.

[0045] In this embodiment, as Figure 3 As shown, the first parallel pipeline 9 can be a U-shaped structure or roughly a U-shaped structure, without any particular limitation.

[0046] like Figure 3As shown, a first parallel pipeline electric control valve 901 and a first temperature sensor 902 are installed on the first parallel pipeline 9, and the first parallel pipeline electric control valve 901 is located between the electric pump 8 and the first temperature sensor 902. The monitoring end of the first temperature sensor 902 is located inside the first parallel pipeline 9.

[0047] In this embodiment, the first parallel pipeline electric control valve 901 is configured to open and close the first parallel pipeline 9. Since the monitoring end of the first temperature sensor 902 is located inside the first parallel pipeline 9, the first temperature sensor 902 can monitor the temperature inside the first parallel pipeline 9, and thus monitor the temperature inside the second pipeline 7. The first temperature sensor 902 is prior art known in the art and will not be described in detail here.

[0048] Furthermore, such as Figure 3 As shown, a first pressure probe 10 is installed on the second pipeline 7. The monitoring end of the first pressure probe 10 is located inside the second pipeline 7. The first pressure probe 10 is located between the first parallel pipeline 9 and the sterilization filter, and the first pressure probe 10 is correspondingly set to the inlet end of the sterilization filter. A first pressure transmitter 11 is installed on the outer wall of the second pipeline 7. The first pressure probe 10 is configured to communicate with the electric control valve 701 of the second pipeline through the first pressure transmitter 11.

[0049] In this embodiment, since the monitoring end of the first pressure probe 10 is located inside the second pipeline 7, and the first pressure probe 10 is correspondingly set to the inlet end of the sterilization filter, the first pressure probe 10 is set to be able to monitor the pressure value at the inlet end of the sterilization filter (i.e., the pressure value inside the second pipeline 7 at the inlet end of the sterilization filter).

[0050] In this embodiment, the pressure value monitored by the first pressure probe 10 is configured to be transmitted to the second pipeline electric control valve 701 via the first pressure transmitter 11. This allows for automatic control of the second pipeline electric control valve 701 based on the monitored pressure value at the inlet of the sterilization filter, thereby achieving automatic on / off control of the second pipeline 7. The first pressure probe 10, the first pressure transmitter 11, and the above-described components are all prior art known in the art and will not be elaborated upon further here.

[0051] Furthermore, such as Figure 5 and Figure 9 As shown, a second parallel pipe 30 is installed on the third pipe 15, and the second parallel pipe 30 is connected in parallel with the third pipe 15 and is connected to the third pipe 15. That is, both ends of the second parallel pipe 30 are connected to the third pipe 15.

[0052] In this embodiment, as Figure 9As shown, the second parallel pipeline 30 can also be a U-shaped structure or roughly a U-shaped structure, which is not particularly limited here.

[0053] like Figure 9 As shown, a second parallel pipeline electric control valve 3001 and a second temperature sensor 3002 are installed on the second parallel pipeline 30, and the second parallel pipeline electric control valve 3001 is located between the sterilization filter and the second temperature sensor 3002. The monitoring end of the second temperature sensor 3002 is located inside the second parallel pipeline 30.

[0054] In this embodiment, the second parallel pipeline electric control valve 3001 is configured to switch the second parallel pipeline 30 on and off. Since the monitoring end of the second temperature sensor 3002 is located inside the second parallel pipeline 30, the second temperature sensor 3002 can monitor the temperature inside the second parallel pipeline 30, and thus monitor the temperature inside the third pipeline 15. The second temperature sensor 3002 is prior art known in the art and will not be described in detail here.

[0055] Furthermore, such as Figure 5 and Figure 9 As shown, a second pressure probe 16 is installed on the third pipeline 15. The monitoring end of the second pressure probe 16 is located inside the third pipeline 15. The second pressure probe 16 is located between the sterilization filter and the second parallel pipeline 30, and the second pressure probe 16 is correspondingly set to the outlet end of the sterilization filter. A second pressure transmitter 17 is installed on the outer wall of the third pipeline 15. The second pressure probe 16 is configured to communicate with the second pipeline electric control valve 701 through the second pressure transmitter 17.

[0056] In this embodiment, since the monitoring end of the second pressure probe 16 is located inside the third pipeline 15, and the second pressure probe 16 is correspondingly set to the outlet end of the sterilization filter, the second pressure probe 16 is configured to monitor the pressure value at the outlet end of the sterilization filter (i.e., the pressure value inside the third pipeline 15 at the outlet end of the sterilization filter).

[0057] In this embodiment, the pressure value monitored by the second pressure probe 16 is configured to transmit the monitored pressure value signal to the second pipeline electric control valve 701 via the second pressure transmitter 17. This allows for automatic control of the second pipeline electric control valve 701 based on the monitored pressure value at the outlet of the sterilization filter, thereby achieving automatic on / off control of the second pipeline 7. The second pressure probe 16, the second pressure transmitter 17, and the above-described components are all prior art known in the art and will not be elaborated upon further here.

[0058] According to one embodiment of the present invention, such as Figure 1 , Figure 6 , Figure 7 , Figure 8 and Figure 10 As shown, a bracket 31 is installed at the top of the base plate 1, and a lifting mechanism is installed on the bracket 31. The lifting mechanism is located directly above the sterilization filter.

[0059] In this embodiment, the bottom end of the bracket 31 can be installed on the top end of the base plate 1 by bolt connection as is known in the art, or the bottom end of the bracket 31 can be installed on the top end of the base plate 1 by welding connection as is known in the art, without any particular limitation.

[0060] In this embodiment, the specific structure of the support 31 can be referred to Figure 1 , Figure 8 and Figure 10 It can be composed of multiple square steel beams welded together. It should be understood that the bracket 31 can also be of other shapes, as long as it can install the lifting mechanism directly above the sterilization filter.

[0061] Specifically, such as Figure 6 and Figure 7 As shown, the hoisting mechanism includes at least a power unit and a hoisting rope 27, with the hoisting rope 27 located near one end of the sterilization filter (i.e., Figure 6 The bottom end of the suspension rope 27 is detachably connected to the top end of the sterilization filter housing 12 of the sterilization filter. The end of the suspension rope 27 furthest from the sterilization filter (i.e., the end away from the sterilization filter) Figure 7 The top of the suspension rope 27 is connected to the power unit. The power unit is configured to suspend the sterilization filter housing 12 via the suspension rope 27.

[0062] In this embodiment, the suspension rope 27 can be a steel cable known in the art, and is not particularly limited herein.

[0063] More specifically, the power unit includes a motor 29 mounted on a bracket 31, with a spool 28 coaxially mounted on the output shaft of the motor 29, and the end of the suspension rope 27 away from the sterilization filter is fixedly mounted on the spool 28 and configured to be able to be wound on the spool 28.

[0064] In this embodiment, as Figure 7 As shown, the motor 29 can be mounted on the bracket 31 by welding, which is not particularly limited here. The motor 29 is prior art known in the art and will not be described in detail here.

[0065] In this embodiment, as Figure 7 As shown, the I-beam reel 28 can be regarded as a structure with a central drum body and two side baffles. The end of the suspension rope 27 away from the sterilization filter is fixedly installed on the central drum body of the I-beam reel 28, and the suspension rope 27 is configured to be able to be wound on the central drum body of the I-beam reel 28.

[0066] Furthermore, to prevent the H-beam reel 28 from being pulled off-axis by the weight of the sterilization filter housing 12, such as... Figure 7 As shown, both sides of the I-beam 28 are equipped with I-beam fixing plates. Tapered roller bearings, known in the art, are mounted on both I-beam fixing plates at coaxial positions with the I-beam 28. The two ends of the I-beam 28 are respectively mounted on the inner rings of the two tapered roller bearings, allowing for rotational engagement between the tapered roller bearings and the I-beam fixing plates. The I-beam fixing plates are located at... Figure 7 The top of the component can be connected to the bracket 31 by welding, which is not specifically limited here.

[0067] More specifically, such as Figure 6 As shown, the suspension rope 27 is near one end of the sterilization filter (i.e. Figure 6 A second lifting ring 26 is installed at the bottom of the middle suspension rope 27, and a first lifting ring 25 is threaded onto the top of the sterilization filter housing 12. The first lifting ring 25 and the second lifting ring 26 are interlocked.

[0068] In this embodiment, the end of the suspension rope 27 near the sterilization filter can be tied to the second hanging ring 26 through multiple knots to achieve the connection between the suspension rope 27 and the second hanging ring 26. No particular limitation is made here.

[0069] In this embodiment, as Figure 11 As shown, Figure 11 An exemplary view shows the overall structure of the first lifting ring 25, wherein a first lifting ring connecting rod can be installed at the bottom end of the first lifting ring 25. The outer side wall of the first lifting ring connecting rod is provided with an external thread, and the top end of the sterilization filter housing 12 is provided with an internal thread hole (not shown in the figure) that matches the external thread on the first lifting ring connecting rod. This enables a detachable connection (threaded connection) between the first lifting ring 25 and the top end of the sterilization filter housing 12, that is, to achieve a detachable connection between the end of the lifting rope 27 near the sterilization filter and the top end of the sterilization filter housing 12 of the sterilization filter.

[0070] In this embodiment, as Figure 6 As shown, there can be two first hanging rings 25 and two second hanging rings 26. The two first hanging rings 25 are symmetrically arranged at the top of the sterilization filter housing 12, and each of the two first hanging rings 25 is fitted onto one of the two second hanging rings 26. Wherein, as... Figure 6 As shown, since there are two first rings 25 and two second rings 26, the lifting rope 27 is located at... Figure 6 The bottom end can be a forked structure, and it is connected to two second lifting rings 26 in sequence.

[0071] Typically, the sterilizing filter housing 12 weighs approximately 30 kg and is installed at a relatively high position (usually about 1.5 m above the ground). Therefore, replacing the filter housing 12 is not only inconvenient but also increases the risk, compromising worker safety. However, by using a hoisting mechanism, the motor 29 can be automatically controlled, enabling the automatic hoisting of the sterilizing filter housing 12. This facilitates replacement, reduces the risk, and ensures worker safety. The method for automatically controlling the motor 29 is existing technology known in the art and will not be elaborated upon here.

[0072] In this embodiment, all the above-mentioned electrically controlled valves are existing technologies known in the art. For example, they can all be known pneumatic solenoid valves or other valves that can receive signals and realize automatic control of opening and closing through electricity. They will not be described in detail here.

[0073] In this embodiment, all the above pipelines can be circular pipe structures, and each pipeline can be connected to the others through pipe flanges known in the art, without any particular limitation.

[0074] The working process of this system will be briefly described below with reference to the above embodiments: First, before proceeding with the in-situ cleaning process in the freeze dryer, the system must be sterilized. Specific procedures include, but are not limited to: The first step is to start the water purifier 3 and make it produce pure steam. Close the air inlet electric control valve 202 and the water inlet electric control valve 304, and open the steam inlet electric control valve 303, the first pipeline electric control valve 501, the second pipeline electric control valve 701, the first parallel pipeline electric control valve 901, the first temperature sensor 902, the second parallel pipeline electric control valve 3001, and the second temperature sensor 3002. At this time, the pure steam produced by the water purifier 3 will enter the system, thereby enabling high-temperature sterilization of the system's interior.

[0075] In the first step, the first temperature sensor 902 and the second temperature sensor 3002 can monitor the temperature of the second pipeline 7 and the third pipeline 15 in real time, and can also monitor the temperature of the sterilization filter in real time, thereby preventing damage to the system due to abnormal temperature.

[0076] In the first step, the first pressure probe 10, the first pressure transmitter 11, the second pressure probe 16, and the second pressure transmitter 17 can also be activated simultaneously. Since the first pressure probe 10 and the second pressure probe 16 can monitor the pressure at the inlet and outlet of the sterilizing filter respectively, when the internal pressure of the sterilizing filter is too high during the high-temperature sterilization process, the first pressure transmitter 11 and the second pressure transmitter 17 will send signals and close the second pipeline electric control valve 701, thereby allowing the pressure inside the sterilizing filter to be discharged through the third pipeline 15. When the internal pressure of the sterilizing filter returns to normal, the first pressure transmitter 11 and the second pressure transmitter 17 will send signals and open the second pipeline electric control valve 701, thus allowing the high-temperature sterilization process within the system to continue.

[0077] The second step is to close the steam inlet electric control valve 303 and open the air inlet electric control valve 202 after the high-temperature sterilization is completed, and start the air compressor 2. At this time, the sterile compressed air produced by the air compressor 2 can enter the system, thereby drying and purging the condensate water remaining in the system during the high-temperature sterilization process.

[0078] Then, after the drying and purging work is completed, close the air inlet electric control valve 202, the first parallel pipeline electric control valve 901 and the second parallel pipeline electric control valve 3001, and open the water inlet electric control valve 304. At the same time, stop the water generator 3 from producing pure steam and start producing water for injection. At this time, the water for injection produced by the water generator 3 can enter the system through the water inlet pipeline 302. After being sterilized by the sterilization filter, it flows out from the outlet end of the third pipeline 15, thus enabling in-situ cleaning of the freeze dryer.

[0079] During the above process, it should be understood that if the internal system is not sterilized and water for injection is directly introduced, the water for injection will carry the bacteria inside the system and its own bacteria into the sterilization filter for sterilization. However, due to the limited sterilization capacity of the sterilization filter, it is not possible to sterilize and filter the water for injection and the bacteria inside the system at the same time. As a result, the water for injection that flows out will still contain bacteria, and the in-situ cleaning of the freeze dryer cannot be carried out smoothly.

[0080] By pre-sterilizing the system with high temperature, when water for injection is introduced into the system, the sterilization filter will only filter bacteria from the water for injection, thus ensuring that the final outflowing water for injection is sterile. This allows for smooth in-situ cleaning of the freeze dryer.

[0081] It should be understood that the above-described embodiments or examples of this utility model can be combined with each other and have corresponding technical effects.

[0082] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. A system for in-situ cleaning of a freeze dryer, characterized in that, Includes a base plate (1), an air compressor (2), a water purifier (3), a buffer tank (6), and a sterilization filter, wherein: The air compressor (2), the water purifier (3), the buffer tank (6), and the sterilization filter are all located at the top of the base plate (1); The air compressor (2) has an air inlet pipe (201) connected to its outlet end. The water purifier (3) has a steam outlet pipe (301) and a water inlet pipe (302) connected to its steam outlet end and water outlet end, respectively. The outlet end of the air inlet pipe (201), the outlet end of the steam inlet pipe (301), and the outlet end of the water inlet pipe (302) are all connected to the inlet end of the buffer tank (6). The outlet end of the buffer tank (6) is connected to a second pipeline (7), the outlet end of the second pipeline (7) is connected to the inlet end of the sterilization filter, an electric pump (8) and a second pipeline electric control valve (701) are installed on the second pipeline (7), and the second pipeline electric control valve (701) is located between the buffer tank (6) and the electric pump (8). The outlet end of the sterilization filter is connected to a third pipeline (15), and the outlet end of the third pipeline (15) is connected to a freeze dryer.

2. The system for in-situ cleaning of a freeze dryer according to claim 1, characterized in that, The inlet end of the buffer tank (6) is connected to the first pipeline (5), and the inlet end of the first pipeline (5) is connected to the four-way pipe (4). The other three ports of the four-way pipe (4) are respectively connected to the outlet end of the air inlet pipeline (201), the outlet end of the steam inlet pipeline (301), and the outlet end of the water inlet pipeline (302).

3. The system for in-situ cleaning of a freeze dryer according to claim 2, characterized in that, An electric control valve (202) for air intake is installed on the air intake pipe (201), an electric control valve (303) for steam intake is installed on the steam intake pipe (301), an electric control valve (304) for water intake is installed on the water intake pipe (302), and an electric control valve (501) for the first pipe (5) is installed on the first pipe.

4. The system for in-situ cleaning of a freeze dryer according to claim 1, characterized in that, A first parallel pipeline (9) is installed on the second pipeline (7). The first parallel pipeline (9) is connected in parallel with the second pipeline (7) and is connected to and communicates with the second pipeline (7). The first parallel pipeline (9) is located between the electric pump (8) and the sterilization filter. The first parallel pipeline (9) is equipped with a first parallel pipeline electric control valve (901) and a first temperature sensor (902), and the first parallel pipeline electric control valve (901) is located between the electric pump (8) and the first temperature sensor (902), and the monitoring end of the first temperature sensor (902) is located inside the first parallel pipeline (9).

5. The system for in-situ cleaning of a freeze dryer according to claim 4, characterized in that, A first pressure probe (10) is installed on the second pipeline (7). The monitoring end of the first pressure probe (10) is located inside the second pipeline (7). The first pressure probe (10) is located between the first parallel pipeline (9) and the sterilization filter. The first pressure probe (10) is correspondingly set with the inlet end of the sterilization filter. A first pressure transmitter (11) is installed on the outer wall of the second pipeline (7), and the first pressure probe (10) is connected to the electric control valve (701) of the second pipeline through the first pressure transmitter (11).

6. The system for in-situ cleaning of a freeze dryer according to claim 1, characterized in that, A second parallel pipeline (30) is installed on the third pipeline (15). The second parallel pipeline (30) is connected in parallel with the third pipeline (15) and is connected to and communicates with the third pipeline (15). The second parallel pipeline (30) is equipped with a second parallel pipeline electric control valve (3001) and a second temperature sensor (3002), and the second parallel pipeline electric control valve (3001) is located between the sterilization filter and the second temperature sensor (3002), and the monitoring end of the second temperature sensor (3002) is located inside the second parallel pipeline (30).

7. The system for in-situ cleaning of a freeze dryer according to claim 6, characterized in that, A second pressure probe (16) is installed on the third pipeline (15). The monitoring end of the second pressure probe (16) is located inside the third pipeline (15). The second pressure probe (16) is located between the sterilization filter and the second parallel pipeline (30), and the second pressure probe (16) is correspondingly set to the outlet end of the sterilization filter. A second pressure transmitter (17) is installed on the outer wall of the third pipeline (15), and the second pressure probe (16) is connected to the electric control valve (701) of the second pipeline through the second pressure transmitter (17).

8. The system for in-situ cleaning of a freeze dryer according to claim 1, characterized in that, A bracket (31) is installed on the top of the base plate (1), and a hoisting mechanism is installed on the bracket (31). The hoisting mechanism is located directly above the sterilization filter. The hoisting mechanism includes a power unit and a hoisting rope (27). The end of the hoisting rope (27) near the sterilizing filter is detachably connected to the top of the sterilizing filter housing (12) of the sterilizing filter. The end of the hoisting rope (27) away from the sterilizing filter is connected to the power unit. The power unit is configured to be able to lift the sterilizing filter housing (12) via the hoisting rope (27).

9. The system for in-situ cleaning of a freeze dryer according to claim 8, characterized in that, The power unit includes a motor (29) mounted on the bracket (31), and a bobbin (28) is coaxially mounted on the output shaft of the motor (29). The end of the suspension rope (27) away from the sterilization filter is mounted on the bobbin (28) and is configured to be able to be wound on the bobbin (28).

10. The system for in-situ cleaning of a freeze dryer according to claim 8, characterized in that, The suspension rope (27) is fitted with a second ring (26) at one end near the sterilization filter, and the top of the sterilization filter housing (12) is threaded with a first ring (25), and the first ring (25) and the second ring (26) are interlocked.

Images