Temperature control device for tissue dissociator

Abstract

The utility model discloses a temperature control device for tissue dissociation appearance, including dissociation mechanism, heating mechanism, guide mechanism and lifting mechanism, the dissociation mechanism includes tissue dissociator, multiple dissociation cavities of being located on the tissue dissociator, heating mechanism, the heating mechanism includes multiple ring body with the tissue dissociator top adhesion, multiple electric heating wires of being connected between the dissociation cavity inner wall and ring body inner wall, guide mechanism, the guide mechanism includes the guide rod of being located in the ring body outside. In the utility model, the dissociation tube that is equipped with dissociation liquid, cell is inserted dissociation cavity inside, then according to the height of dissociation liquid in dissociation tube, rotates the thread rod, and the ring body that is limited by guide rod is driven to go up, then the electric heating wire is lengthened, and is even surrounded in dissociation tube outside, thereby when the electric heating wire is electrified, can even heat the inside of dissociation tube, then starts tissue dissociator, realizes the acquisition of cell suspension.

Description

Technical Field

[0001] This utility model relates to the field of tissue dissociation instrument technology, specifically a temperature control device for a tissue dissociation instrument. Background Technology

[0002] A tissue dissociation device is a device that uses tissue dissociation technology to dissociate biological tissues to obtain highly active, high-quality cell suspensions. To obtain a cell suspension, the tissue dissociation device first needs to disrupt the extracellular matrix to release the cells from it, and then it needs to disrupt the connections between cells to obtain the cell suspension.

[0003] During tissue dissociation, the liquid level in the dissociation tube often varies due to differences in sample volume or operational factors. This variation poses a significant challenge to traditional contact heating structures (such as metal baths or Peltier heating plates). The heating surface of these structures may not adequately reach the higher dissociation liquid levels, leading to uneven heating and temperature control failure. Utility Model Content

[0004] This utility model aims to solve one of the technical problems existing in the prior art or related technologies.

[0005] Therefore, the technical solution adopted by this utility model is as follows:

[0006] A temperature control device for a tissue dissociation apparatus includes a dissociation mechanism, a heating mechanism, a guiding mechanism, and a lifting mechanism. The dissociation mechanism includes a tissue dissociator and multiple dissociation chambers disposed on the tissue dissociator. The heating mechanism includes multiple rings that fit against the top of the tissue dissociator and multiple heating wires connected between the inner wall of the dissociation chamber and the inner wall of the rings. The guiding mechanism includes a guide rod disposed on the outside of the rings and a sliding sleeve slidably sleeved on the outside of the guide rod and connected to the outer wall of the rings. The lifting mechanism includes a threaded rod rotatably connected to the top of the tissue dissociator via a bearing and a threaded sleeve sleeved on the outside of the threaded rod and connected to the outer wall of the rings.

[0007] By adopting the above technical solution, a dissociation tube containing dissociation fluid and cells is inserted into the dissociation chamber. Then, according to the height of the dissociation fluid in the dissociation tube, the threaded rod is rotated, and the threaded sleeve drives the ring body limited by the guide rod to rise. Then, the heating wire is stretched and evenly surrounds the outside of the dissociation tube. Thus, when the heating wire is energized, the inside of the dissociation tube can be heated evenly. Then, the tissue dissociator is activated to obtain the cell suspension.

[0008] In a preferred embodiment, the present invention can be further configured such that: multiple ring bodies are vertically coaxial with multiple dissociation cavities, and the inner diameter of the ring bodies is equal to the diameter of the dissociation cavities.

[0009] In a preferred embodiment, the present invention can be further configured such that: the plurality of heating wires in the dissociation cavity are equally spaced and arranged in a ring, and the sum of the depth of the dissociation cavity and the thickness of the ring is less than the length of the heating wires.

[0010] In a preferred embodiment, the present invention can be further configured such that: the thickness of the sliding sleeve is equal to the thickness of the threaded sleeve, the bottom of the sliding sleeve is flush with the bottom of the ring body, and the top of the threaded sleeve is flush with the top of the ring body.

[0011] In a preferred embodiment, the present invention can be further configured such that the threaded rod is T-shaped, and both the guide rod and the threaded rod are made of plastic material.

[0012] In a preferred embodiment, the present invention can be further configured such that: a plurality of limiting rods are fixedly connected to the bottom of the inner cavity of the dissociation cavity, the plurality of limiting rods are equally spaced and arranged in a ring, and the limiting rods are located inside the heating wire.

[0013] By adopting the above technical solution, the beneficial effects achieved by this utility model are as follows:

[0014] In this invention, a dissociation tube containing dissociation fluid and cells is inserted into the dissociation chamber. Then, according to the height of the dissociation fluid in the dissociation tube, the threaded rod is rotated, and the threaded sleeve drives the ring body limited by the guide rod to rise. Then, the heating wire is stretched and evenly surrounds the outside of the dissociation tube. Thus, when the heating wire is energized, the inside of the dissociation tube can be heated evenly. Then, the tissue dissociator is activated to obtain the cell suspension. Attached Figure Description

[0015] Figure 1 This is a perspective view of the overall structure of this utility model;

[0016] Figure 2 This is a schematic diagram of the dissociation mechanism of this utility model;

[0017] Figure 3 This utility model Figure 1 Enlarged view of the A-section structure;

[0018] Figure 4 This is a schematic diagram showing the cooperation relationship between the guiding mechanism and the lifting mechanism of this utility model.

[0019] Figure label:

[0020] 100. Dissociation mechanism; 110. Tissue dissociator; 120. Dissociation chamber;

[0021] 200. Heating mechanism; 210. Ring body; 220. Heating wire;

[0022] 300. Guiding mechanism; 310. Guide rod; 320. Sliding sleeve;

[0023] 400. Lifting mechanism; 410. Bearing; 420. Threaded rod; 430. Threaded sleeve;

[0024] 500, Limit rod. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to specific embodiments and accompanying drawings. It should be noted that, unless otherwise specified, the embodiments and features of the present utility model can be combined with each other.

[0026] It should be understood that these descriptions are merely exemplary and are not intended to limit the scope of this invention.

[0027] The following describes, with reference to the accompanying drawings, some embodiments of a temperature control device for a tissue dissociation apparatus.

[0028] Example 1:

[0029] Combination Figure 1-4 As shown, the present invention provides a temperature control device for a tissue dissociation apparatus, including a dissociation mechanism 100, a heating mechanism 200, a guiding mechanism 300 and a lifting mechanism 400. The dissociation mechanism 100 includes a tissue dissociator 110 and a plurality of dissociation chambers 120 disposed on the tissue dissociator 110.

[0030] Heating mechanism 200, the heating mechanism 200 includes a plurality of rings 210 that are attached to the top of the tissue dissociator 110, and a plurality of heating wires 220 connected between the inner wall of the dissociation chamber 120 and the inner wall of the rings 210;

[0031] The guide mechanism 300 includes a guide rod 310 disposed on the outside of the ring 210 and a sliding sleeve 320 slidably sleeved on the outside of the guide rod 310 and connected to the outer wall of the ring 210.

[0032] The lifting mechanism 400 includes a threaded rod 420 rotatably connected to the top of the tissue dissociator 110 via a bearing 410, and a threaded sleeve 430 sleeved on the outside of the threaded rod 420 and connected to the outer wall of the ring 210.

[0033] Furthermore, multiple rings 210 are vertically coaxial with multiple dissociation cavities 120 respectively, and the inner diameter of the ring 210 is equal to the diameter of the dissociation cavity 120. The layout design of the rings 210 ensures that the dissociation tube can be smoothly inserted into the dissociation cavity 120.

[0034] Furthermore, the multiple heating wires 220 within the dissociation cavity 120 are equally spaced and arranged in a ring. The sum of the depth of the dissociation cavity 120 and the thickness of the ring 210 is less than the length of the heating wires 220. The size design of the heating wires 220 allows them to adapt to the dissociation tube with a high dissociation liquid level, ensuring the heating effect.

[0035] Furthermore, the thickness of the sliding sleeve 320 is equal to the thickness of the threaded sleeve 430. The bottom of the sliding sleeve 320 is flush with the bottom of the ring body 210, and the top of the threaded sleeve 430 is flush with the top of the ring body 210. The layout design of the sliding sleeve 320 and the threaded sleeve 430, to a certain extent, ensures the aesthetics of the device.

[0036] Example 2:

[0037] Combination Figure 1 , 3 and Figure 4 As shown, based on Embodiment 1, the threaded rod 420 is configured as a T-shape, and both the guide rod 310 and the threaded rod 420 are made of plastic material. The guide rod 310 and the threaded rod 420 made of plastic material are lightweight and will not cause a weight load on the device.

[0038] Example 3:

[0039] Combination Figure 1 and Figure 3 As shown, in the above embodiment, a plurality of limiting rods 500 are fixedly connected to the bottom of the inner cavity of the dissociation chamber 120. The plurality of limiting rods 500 are equally spaced and arranged in a ring. The limiting rods 500 are located inside the heating wire 220. The limiting rods 500 can clamp the dissociation tube to ensure the stability of the tissue dissociation inside the dissociation tube.

[0040] The working principle and usage process of this utility model are as follows: A dissociation tube containing dissociation fluid and cells is inserted into the dissociation chamber 120. Then, multiple limiting rods 500 cooperate to clamp the dissociation tube. Then, according to the height of the dissociation fluid in the dissociation tube, the threaded rod 420 is rotated. Then, under mechanical transmission, the threaded sleeve 430 drives the ring 210, which is limited by the guide rod 310, to rise. Then, the heating wire 220 is stretched and evenly surrounds the outside of the dissociation tube. Thus, when the heating wire 220 is energized, the inside of the dissociation tube can be evenly heated. Then, the tissue dissociator 110 is activated to obtain the cell suspension.

[0041] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A temperature control device for a tissue dissociation apparatus, characterized in that, include: The dissociation mechanism (100) includes a tissue dissociator (110) and a plurality of dissociation chambers (120) disposed on the tissue dissociator (110); Heating mechanism (200) includes a plurality of rings (210) that are attached to the top of the tissue dissociator (110) and a plurality of heating wires (220) connected between the inner wall of the dissociation chamber (120) and the inner wall of the rings (210); The guide mechanism (300) includes a guide rod (310) disposed on the outside of the ring body (210) and a sliding sleeve (320) slidably sleeved on the outside of the guide rod (310) and connected to the outer wall of the ring body (210); The lifting mechanism (400) includes a threaded rod (420) rotatably connected to the top of the tissue dissociator (110) via a bearing (410), and a threaded sleeve (430) sleeved on the outside of the threaded rod (420) and connected to the outer wall of the ring (210).

2. The temperature control device for a tissue dissociation apparatus according to claim 1, characterized in that, Multiple ring bodies (210) are vertically coaxial with multiple dissociation cavities (120), and the inner diameter of the ring body (210) is equal to the diameter of the dissociation cavity (120).

3. The temperature control device for a tissue dissociation apparatus according to claim 1, characterized in that, The multiple heating wires (220) in the dissociation cavity (120) are arranged in a ring with equal spacing. The sum of the depth of the dissociation cavity (120) and the thickness of the ring (210) is less than the length of the heating wires (220).

4. The temperature control device for a tissue dissociation apparatus according to claim 1, characterized in that, The thickness of the sliding sleeve (320) is equal to the thickness of the threaded sleeve (430). The bottom of the sliding sleeve (320) is flush with the bottom of the ring body (210), and the top of the threaded sleeve (430) is flush with the top of the ring body (210).

5. The temperature control device for a tissue dissociation apparatus according to claim 1, characterized in that, The threaded rod (420) is T-shaped, and both the guide rod (310) and the threaded rod (420) are made of plastic material.

6. The temperature control device for a tissue dissociation apparatus according to claim 1, characterized in that, Multiple limiting rods (500) are fixed to the bottom of the inner cavity of the dissociation chamber (120). The multiple limiting rods (500) are equally spaced and arranged in a ring. The limiting rods (500) are located inside the heating wire (220).

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