An assemblable drug sensitivity plate

Abstract

The utility model discloses a kind of spliced drug sensitivity plate, it is related to drug sensitivity detection technical field, overcome the defect of the flexibility, cost control and resource utilization of existing integral drug sensitivity plate. Including several strip-shaped drug sensitivity rows;Drug sensitivity row includes a row of several drug bins for accommodating reagent, and the lock catch structure for the adjacent drug sensitivity row splicing assembly;Lock catch structure includes male buckle and female buckle, the male buckle of a drug sensitivity row and the female buckle of adjacent drug sensitivity row are adapted to buckle, the female buckle of a drug sensitivity row and the male buckle of adjacent drug sensitivity row are adapted to buckle. It can be according to the actual demand of the kind of detecting drug in microbiological drug sensitivity test, sample quantity etc., flexibly select the number of spliced drug sensitivity row, avoid the reagent waste caused by the drug bin idling of integral plate body, reduce test consumable cost.

Description

Technical Field

[0001] This utility model relates to the field of drug sensitivity testing technology, and in particular to an assemblable drug sensitivity plate. Background Technology

[0002] In microbial testing, drug susceptibility testing is a crucial method for determining the sensitivity of microorganisms to different drugs. Drug susceptibility testing plates, as the core carrier of this test, directly impact experimental efficiency, cost control, and ease of operation through their structural design. Currently, most widely used drug susceptibility testing plates are monolithic fixed structures, meaning multiple drug chambers for holding drug solutions and microbial samples are pre-integrated onto a single, complete plate. The number, arrangement, and distribution of these chambers are fixed during the manufacturing stage and cannot be adjusted according to actual experimental needs. From a practical application perspective, these integrated antimicrobial susceptibility testing (ABST) plates have significant limitations: Firstly, when conducting small-scale antimicrobial susceptibility tests or when only a small number of drug susceptibility tests are needed for specific microorganisms, many of the drug compartments on the integrated ABST plate remain idle. Since reagents and samples need to be added separately to each compartment during the test, these idle compartments not only result in unnecessary waste of reagents and samples but also increase the cost of subsequent plate cleaning, disinfection, or disposal, which is inconsistent with the current green and efficient operational philosophy of laboratories. Secondly, the fixed size of the integrated ABST plate means that when there are many types of drugs required for the test, and the number of compartments on a single plate cannot meet the testing needs, operators must use multiple independent integrated ABST plates simultaneously. This not only occupies more culture space and lab bench space but may also increase the risk of experimental errors due to issues such as the placement and numbering of different plates. Furthermore, during the transportation and storage of monolithic drug sensitivity plates, since the plate structure is not disassembled and the storage space required for a single plate is fixed, a significant amount of storage resources will be occupied when the laboratory needs to store a certain number of drug sensitivity plates. At the same time, if the monolithic plate is partially damaged, such as individual drug compartments cracking, the entire plate will become unusable, further increasing the cost of use. Utility Model Content

[0003] The purpose of this invention is to overcome the shortcomings of existing integral antimicrobial susceptibility testing plates in terms of flexibility, cost control, and resource utilization, which are no longer able to meet the diverse and efficient application needs of current microbial antimicrobial susceptibility testing. This invention provides an assembly-type antimicrobial susceptibility testing plate that can be flexibly adjusted according to experimental needs, reduces material waste, and is easy to operate and store.

[0004] The technical solution of this utility model includes several strip-shaped drug sensitivity strips; each drug sensitivity strip includes a row of several drug compartments for holding reagents, and a locking structure for splicing and assembling adjacent drug sensitivity strips; the locking structure includes male and female buckles, wherein the male buckle of one drug sensitivity strip is adapted to and engaged with the female buckle of an adjacent drug sensitivity strip, and the female buckle of one drug sensitivity strip is adapted to and engaged with the male buckle of an adjacent drug sensitivity strip.

[0005] The above technical solution achieves assembly through the matching and interlocking of male and female connectors of adjacent drug sensitivity strips, enabling on-demand combination. This solution firstly solves the problem of fixed drug compartment numbers in existing integrated drug sensitivity plates. It allows for flexible selection of the number of drug sensitivity strips to be assembled based on the actual needs of the drug types and sample quantities in microbial drug sensitivity testing, avoiding reagent waste caused by idle drug compartments in the integrated plate and reducing experimental consumable costs. Secondly, when testing a large number of drugs, it eliminates the need for multiple independent integrated drug sensitivity plates. The total number of drug compartments can be expanded by assembling multiple drug sensitivity strips, reducing the occupation of experimental platform and culture space. Furthermore, the assembled plate has strong integrity, reducing the risk of numbering and recording errors caused by multiple plate operations. Simultaneously, when the drug sensitivity plate is not in use, the drug sensitivity strips can be disassembled and stored separately, reducing storage space occupation. If a single drug sensitivity strip is partially damaged, only the damaged strip needs to be replaced, without discarding the entire plate, effectively reducing usage and maintenance costs and improving the shortcomings of existing integrated drug sensitivity plates in terms of flexibility, cost control, and resource utilization.

[0006] In one possible design, the male buckle is a protruding elastic locking arm located on the side of the drug sensitivity strip, and the female buckle is a recessed locking groove located on the side of the drug sensitivity strip; the elastic locking arm and the locking groove are respectively located on opposite sides in the width direction of the drug sensitivity strip, and the shape of the elastic locking arm is adapted to the interior of the locking groove.

[0007] With the above design, the elastic clamping arm has a certain elastic deformation capability, and can fit tightly against the inner wall of the clamping slot when it is engaged with the slot. This effectively prevents loosening or displacement between adjacent drug sensitivity strips after splicing, ensuring the overall structural stability of the drug sensitivity plate during the test and preventing reagent spillage in the drug chamber. The convex-concave fitting structure does not require additional tools; it can be engaged simply by manual alignment, improving the convenience and efficiency of the splicing operation. In addition, the locking structure is set in the width direction of the drug sensitivity strip, allowing the strips to be assembled into a plate-shaped drug sensitivity plate without occupying space in the length direction. This ensures that a sufficient number of drug chambers can be arranged on a single drug sensitivity strip as needed, achieving the splicing function while fully considering the drug chamber capacity to meet the experimental requirements for the number of drug chambers.

[0008] In one possible design, each of the drug sensitivity strips has two elastic clamping arms, which are arranged symmetrically with respect to the centerline of the drug sensitivity strip along its length.

[0009] With the above design, when adjacent drug sensitivity strips are fastened together, the force can be evenly distributed on both sides of the strip's width, avoiding the tilting and deformation caused by force on one side of the elastic clamping arm. This further ensures the flatness and stability of the plate after splicing multiple strips of drug sensitivity strips, making it particularly suitable for scenarios involving continuous splicing of multiple strips, ensuring that the plate remains in good condition throughout the test. The symmetrical structural arrangement eliminates the need for operators to deliberately distinguish the positions of the elastic clamping arms during splicing; they only need to align the drug sensitivity strips along their center lines to complete the fastening process. This simplifies the alignment steps, reduces the difficulty of operation, and further improves splicing efficiency.

[0010] In one possible design, a bottom groove is provided at the bottom of the card slot, the bottom groove communicating with the interior of the card slot, the bottom groove being configured to provide operating space for releasing the engaged elastic card arm.

[0011] With the above design, when it is necessary to disassemble the drug sensitivity strip, the operator can insert a fine needle, tweezers or other tools through the bottom groove to deform the elastic retaining arm and disengage it from the groove. There is no need to forcibly pry the drug sensitivity strip, which avoids damage to the drug sensitivity strip or the elastic retaining arm during disassembly. At the same time, it reduces the force required for disassembly and improves the ease of use.

[0012] In one possible design, the locking structure is located at the center of the drug sensitivity strip along its length, and the number of drug compartments on both sides of the locking structure is the same.

[0013] With the above design, when the drug sensitivity array is spliced, the force is concentrated in the middle of the array body, avoiding uneven force on both ends of the drug sensitivity array caused by the offset of the locking structure. At the same time, the number of drug compartments on both sides is the same, which ensures that the center of gravity of the drug sensitivity array is in the center. Whether the drug sensitivity array is placed alone or multiple arrays are spliced ​​together and placed as a whole, it is not easy to tip over, which helps to prevent the reagents in the drug compartments from spilling due to tipping.

[0014] In one possible design, the bottom surface of the outer side of the medicine compartment is flat.

[0015] With the above design, when used alone, the drug sensitivity array can form a large-area fit with the test bench, incubator tray, and other supporting surfaces, ensuring the stability of the array. When multiple arrays are spliced ​​together to form a drug sensitivity plate, the whole array can also be placed stably, avoiding the tilting or tilting of the array or plate due to unevenness of the bottom of the drug compartment. This effectively prevents reagent spillage or sample contamination in the drug compartment, ensuring the smooth progress of the experiment.

[0016] In one possible design, the bottom of the inside of the medicine compartment is flat or round.

[0017] The above design features a flat bottom that facilitates cleaning and sampling by standardized testing instruments; and a round bottom that allows liquid reagents to pool, promoting colony aggregation and growth, making it easier to identify colony morphology with the naked eye or instruments, improving the accuracy of drug sensitivity results observation, and enhancing product applicability.

[0018] In one possible design, the top surface of the drug sensitivity strip is provided with an identification area, which is located on the top surface of the location of the locking structure.

[0019] With the above design, the identification area corresponds to the relevant information of the culture medium in the drug sensitivity discharge chamber, which serves as a recording benchmark and helps to distinguish the drug chambers on both sides of the discharge body, preventing data recording errors. Furthermore, the unified layout reduces the learning cost and facilitates inventory management and data traceability.

[0020] In one possible design, the number of drug reservoirs contained on a single drug sensitivity row is eight or twelve.

[0021] The above design fully considers the actual needs of existing microbial drug susceptibility testing, ensuring that drug susceptibility testing can be efficiently adapted to most testing scenarios. Attached Figure Description

[0022] Figure 1 This is a structural diagram of the assembled state of this utility model; Figure 2 This is a structural diagram of the present invention before assembly; Figure 3 This is a cross-sectional view of the present invention before assembly. Figure 4 This is a cross-sectional view of the assembled state of this utility model; Among them, 1. Drug sensitivity panel; 2. Locking structure; 21. Elastic locking arm; 22. Locking groove; 23. Bottom groove; 3. Drug compartment; 4. Identification area. Detailed Implementation

[0023] like Figures 1 to 4The illustrated modular antimicrobial susceptibility testing (AMS) plate consists of several independently detachable strip-shaped AMS strips 1 and a locking structure 2 for splicing and connecting them. All AMS strips 1 have identical structure and dimensions, ensuring that any two strips 1 can be fitted together. Each AMS strip 1 is integrally formed along its length and comprises two parts: first, a reagent compartment 3 for holding the reagents and microbial samples required for the AMS test, arranged sequentially along the length of the AMS strip 1 to form a continuous row of reagent-carrying units; second, a locking structure 2 for detachable connection of adjacent AMS strips 1, comprising mutually compatible male and female latches. During assembly, two or more drug sensitivity rows 1 can be assembled into a complete drug sensitivity plate by matching and fastening the male buckle of one drug sensitivity row 1 with the female buckle of the adjacent drug sensitivity row 1, and by matching and fastening the female buckle of one drug sensitivity row 1 with the male buckle of the adjacent drug sensitivity row 1. The number of rows can be flexibly adjusted according to the actual needs of drug sensitivity testing (such as the type of drug to be tested and the number of samples), without being limited by the fixed total number of drug compartments 3, thus solving the limitations of the use of existing integrated drug sensitivity plates.

[0024] Regarding the specific form of the locking structure 2, the male buckle is a protruding elastic locking arm 21 located on the side of the drug sensitivity strip 1, and the female buckle is a recessed locking groove 22 located on the side of the drug sensitivity strip 1. The elastic locking arm 21 and the locking groove 22 are located on opposite sides of the same width direction of the drug sensitivity strip 1. For example, the male buckle is located on the left side of the drug sensitivity strip 1, and the female buckle is located on the right side. When two drug sensitivity strips 1 are joined laterally, the elastic locking arm 21 of one drug sensitivity strip 1 is inserted into the locking groove 22 of the adjacent drug sensitivity strip 1, and is locked in place by the elastic recovery action, thereby completing the rapid splicing. The elastic locking arm 21 has a certain elastic deformation capability, and its shape is adapted to the internal shape of the locking groove 22, ensuring that the elastic locking arm 21 can fit tightly against the inner wall of the locking groove 22 when fastened, avoiding loosening or displacement of adjacent drug sensitivity rows 1 after splicing; at the same time, the position of the width direction relative to the two sides is limited, which clarifies that adjacent drug sensitivity rows 1 can only be spliced ​​along the width direction, and the convex and concave adapted structure does not require additional tools, and fastening can be completed by manual alignment, taking into account both splicing stability and operation convenience.

[0025] To improve the stability and symmetry of the connection, each drug sensitivity strip 1 has two elastic locking arms 21, which are arranged symmetrically with the center line of the length direction of the drug sensitivity strip 1 as the axis of symmetry. Correspondingly, the two elastic locking arms 21 are locked on both sides of the groove wall of the locking groove 22. This symmetrical arrangement ensures that when adjacent drug sensitivity strips 1 are fastened, the force is evenly distributed on both sides of the width direction of the drug sensitivity strip 1, avoiding tilting and deformation of the drug sensitivity strip 1 caused by the force on one side of the elastic locking arm 21. This further ensures the overall flatness and structural stability of the drug sensitivity plate after splicing, and ensures that the drug sensitivity strips 1 will not loosen during culture and transportation. At the same time, fastening can be completed simply by aligning the drug sensitivity strips 1 along the center line of the length direction, reducing the difficulty of operation and improving the splicing efficiency.

[0026] To facilitate disassembly, a bottom groove 23 is provided at the bottom of the slot 22, which is located along the height direction of the drug sensitivity strip 1 and opposite to the opening of the drug compartment 3. The bottom groove 23 is completely connected to the internal space of the slot 22. Its function is to provide operating space for releasing the engaged elastic locking arm 21. When it is necessary to disassemble an adjacent drug sensitivity strip 1, the operator can access the elastic locking arm 21 in the slot 22 through the bottom groove 23. If a fine needle, tweezers, or other tools are used to insert into the bottom groove 23, a slight force can be applied to the elastic locking arm 21 to deform it and release it from the contact state with the inner wall of the slot 22. The bottom groove 23 avoids damage to the strip body or elastic locking arm 21 caused by forcibly prying the drug sensitivity strip 1, ensuring convenient disassembly without damaging the locking structure 2, and enabling repeated disassembly and reassembly of the drug sensitivity strip 1.

[0027] The locking structure 2 is positioned at the center of the drug sensitivity array 1 along its length, and the number of drug compartments 3 on both sides of the locking structure 2 is exactly the same. For example, if the drug sensitivity array 1 has an eight-compartment design, the locking structure 2 is located between the fourth and fifth drug compartments 3, with four drug compartments 3 on each side; if it has a twelve-compartment design, the locking structure 2 is located between the sixth and seventh drug compartments 3, with six drug compartments 3 on each side. This central positioning keeps the center of gravity of the drug sensitivity array 1 centered, preventing it from tipping over whether a single drug sensitivity array 1 is placed independently or multiple arrays are assembled together. Simultaneously, the equal distribution of drug compartments 3 on both sides facilitates the symmetrical addition of reagents and recording of experimental data by operators, making it particularly suitable for multi-group drug comparison experiments and reducing the risk of operational confusion and data recording errors.

[0028] All drug compartments 3 have a flat bottom surface, which is flush with the bottom surface of the drug susceptibility strip 1, without any protrusions, depressions, or other irregular structures, making each drug compartment 3 rectangular in shape. The flat bottom surface allows the drug susceptibility strip 1 to form a stable fit with the test bench, incubator tray, and instrument stage, preventing tipping or displacement due to uneven bottom surfaces and preventing reagent spillage from the drug compartment 3. At the same time, this design is compatible with the stage structure of existing standardized equipment in the field of microbial detection, such as incubators, centrifuges, and ELISA readers, ensuring that the drug susceptibility strips can be smoothly placed in various devices to complete the test process without the need for additional adapters.

[0029] The inner bottom of the reagent compartment 3 can be either flat or rounded. If flat, the inner cavity bottom of the reagent compartment 3 is injection molded into a smooth plane without any protrusions or depressions, ensuring uniform reagent distribution, facilitating sampling instruments, and allowing for easy rinsing with water after testing. If rounded, the bottom surface is concave, with an arc shape to accommodate liquid convergence. During injection molding, a smooth transition to the curved surface is ensured, seamlessly connecting with the sidewall of the reagent compartment 3. This promotes colony aggregation and avoids cleaning dead zones. Both structures can be integrally molded as needed.

[0030] A marking area 4 is provided on the top surface of each strip-shaped drug sensitivity strip 1, corresponding to the location of the locking structure 2. This marking area 4 is a flat or slightly concave marking area located at the center of the length of the drug sensitivity strip 1, directly above the locking structure 2. Positioning the marking area 4 at the center of the top surface directly above the locking structure 2 maintains the symmetry and aesthetics of the overall layout, while avoiding the drug compartment 3 area to prevent label contamination of reagents and ensure testing safety.

[0031] The number of reagent bins 3 contained in a single drug susceptibility test saturation unit 1 can be selected as either eight or twelve, with these two designs adapting to different scales of drug susceptibility testing needs. The single-use volume of most commercially available drug susceptibility test reagents matches the total capacity of eight or twelve reagent bins 3. Using this number of reagent bins 3 in the drug susceptibility test saturation unit 1 avoids situations where reagents are left over or insufficient during dispensing, further reducing reagent waste. It also simplifies the reagent addition process and improves the efficiency of the testing operation.

Claims

1. An assemblable drug sensitivity plate, characterized in that: It includes several strip-shaped drug sensitivity strips (1); each drug sensitivity strip (1) includes a row of several drug compartments (3) for holding reagents, and a locking structure (2) for splicing and assembling adjacent drug sensitivity strips (1); the locking structure (2) includes male and female buckles, the male buckle of one drug sensitivity strip (1) is adapted and fastened to the female buckle of the adjacent drug sensitivity strip (1), and the female buckle of one drug sensitivity strip (1) is adapted and fastened to the male buckle of the adjacent drug sensitivity strip (1).

2. The modular drug sensitivity test strip according to claim 1, characterized in that: The male buckle is a protruding elastic locking arm (21) provided on the side of the drug sensitivity strip (1), and the female buckle is a recessed locking groove (22) provided on the side of the drug sensitivity strip (1); the elastic locking arm (21) and the locking groove (22) are respectively located on opposite sides of the drug sensitivity strip (1) in the width direction, and the shape of the elastic locking arm (21) is adapted to the interior of the locking groove (22).

3. The modular drug sensitivity test strip according to claim 2, characterized in that: Each of the drug sensitivity strips (1) has two elastic clips (21), and the two elastic clips (21) are arranged symmetrically with respect to the center line of the length direction of the drug sensitivity strip (1).

4. The assemblable drug sensitivity plate according to claim 2 or 3, characterized in that: The bottom of the card slot (22) is provided with a bottom groove (23), which is connected to the inside of the card slot (22). The bottom groove (23) is configured to provide operating space for releasing the engaged elastic card arm (21).

5. The assemblable drug sensitivity plate according to claim 1 or 2, characterized in that: The locking structure (2) is located at the center of the drug sensitivity row (1) along its length direction, and the number of drug compartments (3) on both sides of the locking structure (2) is the same.

6. The assemblable drug sensitivity plate according to claim 1 or 2, characterized in that: The bottom surface of the outer side of the medicine compartment (3) is a plane.

7. The modular drug sensitivity test strip according to claim 1 or 2, characterized in that: The bottom surface inside the medicine compartment (3) is flat or round.

8. The assembleable drug sensitivity plate according to claim 1 or 2, characterized in that: The top surface of the drug sensitivity panel (1) is provided with an identification area (4), which is located on the top surface of the locking structure (2).

9. The assembleable drug sensitivity plate according to claim 1 or 2, characterized in that: The number of drug reservoirs (3) contained on a single drug sensitivity row (1) is eight or twelve.

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