A high-efficiency enzyme-based catalytic reactor for R-4-cyano-3-hydroxybutyric acid ethyl ester

Abstract

The utility model relates to enzyme base catalytic reaction equipment technical field, concretely to a kind of high-efficiency enzyme base catalytic reaction kettle of R-4-cyanogen-3-hydroxybutyric acid ethyl ester, including reaction kettle body, the top of the reaction kettle body is fixedly connected with the bottom of droping tank, the droping tank is fixedly connected with the inner top wall of reaction kettle body by connecting pipe, the inner top wall of reaction kettle body left side is fixedly connected with the one end of nitrogen pipeline, the inner top wall of reaction kettle body close to nitrogen pipeline is fixedly connected with the one end of feed pipeline, twenty cubic enamel reaction kettle body provides effective reaction space, and stirring motor drives stirring paddle to stirring paddle to the biological enzyme in reaction kettle body is stirred, while temperature control jacket passes circulation water pipe and can be used according to reaction temperature control switching hot water or cool water, matched thermometer, pressure gauge and acid-base meter, the temperature, pressure and pH value of real-time monitoring reaction process can be made adjustment in time according to variation, avoid biological enzyme to lose activity.

Description

Technical Field

[0001] This utility model relates to the technical field of enzyme-based catalytic reaction equipment, specifically a high-efficiency enzyme-based catalytic reaction vessel for ethyl R-4-cyano-3-hydroxybutyrate. Background Technology

[0002] Enzyme-based catalysts can precisely construct the chiral structure of target products through highly selective catalytic reactions, while reducing energy consumption and pollution with mild reaction conditions, thus contributing to the development of green synthesis processes. Ethyl R-4-cyano-3-hydroxybutyrate is a key chiral intermediate for the lipid-lowering drug atorvastatin calcium. The process route is as follows: using ethyl S-4-chloro-3-hydroxybutyrate as a raw material, it reacts with sodium cyanide solution under the catalysis of a halohydrin dehalogenase to obtain the product ethyl R-4-cyano-3-hydroxybutyrate.

[0003] Currently, most enzyme-based catalytic reactors on the market cannot effectively monitor the temperature and pH value inside the reactor during use, which leads to the inactivation of biological enzymes and the inability of the reaction to proceed. At the same time, the size of the space inside the reactor also affects the activity of biological enzymes. Utility Model Content

[0004] The purpose of this invention is to provide a highly efficient enzyme-based catalytic reactor for R-4-cyano-3-hydroxybutyrate ethyl ester, thereby solving the problem of enzyme inactivation mentioned in the background art. To achieve the above objective, this invention provides the following technical solution: A highly efficient enzyme-based catalytic reactor for R-4-cyano-3-hydroxybutyrate ethyl ester, comprising a reactor body, the top of which is fixedly connected to the bottom of a dropping tank, the dropping tank being fixedly connected to the inner top wall of the reactor body via a connecting pipe, the left side of the inner top wall of the reactor body being fixedly connected to one end of a nitrogen pipeline, the inner top wall of the reactor body near the nitrogen pipeline being fixedly connected to one end of a feed pipeline, the right side of the reactor body being fixedly connected to one end of a tail gas pipeline, a pressure gauge being installed on the inner wall of the reactor body near the front, an acid-base meter being installed on the right side of the reactor body, and a thermometer being installed on the front of the reactor body.

[0005] A stirring assembly is fixedly installed on the top of the reactor body. The inner top wall of the reactor body near the feed pipeline is fixedly connected to one end of the circulation assembly. The outer wall of the reactor body is movably sleeved with the inner wall of the temperature control assembly.

[0006] Preferably, one end of the nitrogen pipeline, feed pipeline, tail gas pipeline and connecting pipe is equipped with an electromagnetic control valve, and the other end of the tail gas pipeline is connected to the tail gas treatment equipment. The reactor body is a 20-cubic-meter enamel-lined reactor.

[0007] Preferably, the stirring assembly includes a stirring motor, a mounting block, a stirring rod, and a stirring paddle. The outer wall of the stirring motor is engaged with the inner wall of the mounting block, and the inner wall of the mounting block is fixedly connected to the top of the reactor body by bolts. The output shaft of the stirring motor is fixedly connected to one end of the stirring rod by a coupling, and the other end of the stirring rod is fixedly connected to the inner wall of the stirring paddle.

[0008] Preferably, the circulation assembly includes an injection pipe, a circulation pump, and a suction pipe. One end of the injection pipe is fixedly connected to the inner top wall of the reactor body, and the other end of the injection pipe is fixedly connected to the output end of the circulation pump. The input end of the circulation pump is fixedly connected to one end of the suction pipe, and the other end of the suction pipe is fixedly connected to the inner top wall of the reactor body. The bottom end of the suction pipe is fixedly connected to the top end of the transfer pipeline.

[0009] Preferably, the temperature control component includes a temperature control jacket, a support block, and a circulating water pipe. The inner wall of the temperature control jacket is movably sleeved with the outer wall of the reactor body, and the bottom of the temperature control jacket is fixedly connected to the top of the support block. A temperature control cavity is opened inside the temperature control jacket, and the inside of the temperature control cavity is fixedly connected to one end of the circulating water pipe.

[0010] Preferably, the other end of the circulating water pipe is connected to a water pump, and the water pump can draw in both hot and cold water.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0012] In this invention, the 20-cubic-meter enamel-lined reactor body provides an effective reaction space, and the stirring motor drives the stirring paddle through the stirring rod to stir the biological enzymes in the reactor body. At the same time, the temperature control jacket is connected to the circulating water pipe to switch between hot or cold water according to the reaction temperature control. Equipped with a thermometer, pressure gauge and acid-base meter, it can monitor the temperature, pressure and pH value of the reaction process in real time, and make timely adjustments according to changes to prevent the biological enzymes from losing their activity.

[0013] In this invention, the material is added to the reactor body through the feed pipeline and the dropping tank, and is equipped with a nitrogen pipeline and a tail gas pipeline, which can prevent foreign matter from entering the reactor body and avoid contamination of biological enzymes during the reaction.

[0014] In this invention, an external circulation pipeline is added to the reactor body. During the reaction, a circulation pump is used to draw the reaction liquid from the reactor body through the suction pipe and inject it into the reactor body through the injection pipe to achieve circulation, thereby further improving the mixing effect of the reaction liquid and improving the reaction efficiency. After the reaction is completed, the process is switched to the transfer pipeline for the next process. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0016] Figure 2 This is a cross-sectional view of the present invention;

[0017] Figure 3 This is a partial structural schematic diagram of the present invention;

[0018] Figure 4 This is a schematic diagram of the stirring assembly structure of this utility model;

[0019] Figure 5 This is a schematic diagram of the circulating component structure of this utility model;

[0020] Figure 6 This is a schematic diagram of the temperature control component structure of this utility model.

[0021] In the diagram: 1. Reactor body; 2. Dropping tank; 3. Nitrogen pipeline; 4. Feed pipeline; 5. Exhaust gas pipeline; 6. Pressure gauge; 7. Acid-base meter; 8. Thermometer; 9. Stirring assembly; 901. Stirring motor; 902. Mounting block; 903. Stirring rod; 904. Stirring paddle; 10. Circulation assembly; 1001. Injection pipe; 1002. Circulation pump; 1003. Suction pipe; 1004. Transfer pipeline; 11. Temperature control assembly; 1101. Temperature control jacket; 1102. Support block; 1103. Circulating water pipe. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figures 1 to 6 This utility model provides a technical solution: a high-efficiency enzyme-based catalytic reactor for R-4-cyano-3-hydroxybutyrate ethyl ester, comprising a reactor body 1, the top of the reactor body 1 being fixedly connected to the bottom of a dropping tank 2, the dropping tank 2 being fixedly connected to the inner top wall of the reactor body 1 via a connecting pipe, the left side of the inner top wall of the reactor body 1 being fixedly connected to one end of a nitrogen pipeline 3, the inner top wall of the reactor body 1 near the nitrogen pipeline 3 being fixedly connected to one end of a feed pipeline 4, the right side of the inner top wall of the reactor body 1 being fixedly connected to one end of a tail gas pipeline 5, a pressure gauge 6 being installed on the inner wall of the reactor body 1 near the front, an acid-base meter 7 being installed on the right side of the reactor body 1, and a thermometer 8 being installed on the front of the reactor body 1.

[0024] A stirring assembly 9 is fixedly installed on the top of the reactor body 1. The inner top wall of the reactor body 1 near the feed pipeline 4 is fixedly connected to one end of the circulation assembly 10. The outer wall of the reactor body 1 is movably sleeved with the inner wall of the temperature control assembly 11.

[0025] In this embodiment, as Figures 1 to 6 As shown, one end of the nitrogen pipeline 3, feed pipeline 4, tail gas pipeline 5 and connecting pipe is equipped with an electromagnetic control valve, and the other end of the tail gas pipeline 5 is connected to the tail gas treatment equipment. The reactor body 1 is a 20-cubic-meter enamel-lined reactor.

[0026] In this embodiment, as Figures 1 to 6 As shown, the stirring assembly 9 includes a stirring motor 901, a mounting block 902, a stirring rod 903, and a stirring paddle 904. The outer wall of the stirring motor 901 is engaged with the inner wall of the mounting block 902, and the inner wall of the mounting block 902 is fixedly connected to the top of the reactor body 1 by bolts. The output shaft of the stirring motor 901 is fixedly connected to one end of the stirring rod 903 by a coupling, and the other end of the stirring rod 903 is fixedly connected to the inner wall of the stirring paddle 904.

[0027] In this embodiment, as Figures 1 to 6 As shown, the circulation assembly 10 includes an injection pipe 1001, a circulation pump 1002, and a suction pipe 1003. One end of the injection pipe 1001 is fixedly connected to the inner top wall of the reactor body 1, and the other end of the injection pipe 1001 is fixedly connected to the output end of the circulation pump 1002. The input end of the circulation pump 1002 is fixedly connected to one end of the suction pipe 1003, and the other end of the suction pipe 1003 is fixedly connected to the inner top wall of the reactor body 1. The bottom end of the suction pipe 1003 is fixedly connected to the top end of the transfer pipeline 1004.

[0028] In this embodiment, as Figures 1 to 6 As shown, the temperature control assembly 11 includes a temperature control jacket 1101, a support block 1102, and a circulating water pipe 1103. The inner wall of the temperature control jacket 1101 is movably sleeved with the outer wall of the reactor body 1, and the bottom of the temperature control jacket 1101 is fixedly connected with the top of the support block 1102. A temperature control cavity is opened inside the temperature control jacket 1101, and the inside of the temperature control cavity is fixedly connected to one end of the circulating water pipe 1103.

[0029] In this embodiment, as Figures 1 to 6 As shown, the other end of the circulating water pipe 1103 is connected to a water pump, which can draw in both hot and cold water.

[0030] The method of use and advantages of this utility model: The working process of this highly efficient enzyme-based catalytic reactor for R-4-cyano-3-hydroxybutyrate is as follows:

[0031] like Figures 1 to 6As shown, the 20-cubic-meter enamel-lined reactor body 1 provides an effective reaction space, and the stirring motor 901 drives the stirring paddle 904 through the stirring rod 903 to stir the biological enzymes in the reactor body 1. At the same time, the temperature control jacket 1101 is connected to the circulating water pipe 1103 to switch between hot or cold water according to the reaction temperature control. It is equipped with a thermometer 8, a pressure gauge 6 and a pH meter 7, which can monitor the temperature, pressure and pH value of the reaction process in real time and make timely adjustments according to the changes to prevent the biological enzymes from losing their activity.

[0032] The material is added to the reactor body 1 through the feed line 4 and the drop tank 2, and is equipped with a nitrogen line 3 and a tail gas line 5, which can prevent foreign objects from entering the reactor body 1 and prevent the biological enzymes from being contaminated during the reaction.

[0033] An external circulation pipeline is added to the reactor body 1. During the reaction, the circulation pump 1002 draws the reaction liquid in the reactor body 1 from the suction pipe 1003 and injects it into the reactor body 1 from the injection pipe 1001 to achieve circulation, thereby further improving the mixing effect of the reaction liquid and improving the reaction efficiency. After the reaction is completed, the process is switched to the transfer pipeline 1004 to go to the next process.

[0034] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A highly efficient enzyme-based catalytic reactor for ethyl R-4-cyano-3-hydroxybutyrate, comprising a reactor body (1), characterized in that: The top of the reactor body (1) is fixedly connected to the bottom of the dripping tank (2). The dripping tank (2) is fixedly connected to the inner top wall of the reactor body (1) through a connecting pipe. The inner top wall on the left side of the reactor body (1) is fixedly connected to one end of the nitrogen pipeline (3). The inner top wall of the reactor body (1) near the nitrogen pipeline (3) is fixedly connected to one end of the feed pipeline (4). The inner top wall on the right side of the reactor body (1) is fixedly connected to one end of the tail gas pipeline (5). A pressure gauge (6) is installed on the inner wall of the reactor body (1) near the front. An acid-base meter (7) is installed on the right side of the reactor body (1). A thermometer (8) is installed on the front of the reactor body (1). The top of the reactor body (1) is fixedly equipped with a stirring assembly (9). The inner top wall of the reactor body (1) near the feed pipeline (4) is fixedly connected to one end of the circulation assembly (10). The outer wall of the reactor body (1) is movably sleeved with the inner wall of the temperature control assembly (11).

2. The highly efficient enzyme-based catalytic reactor for ethyl R-4-cyano-3-hydroxybutyrate according to claim 1, characterized in that: The nitrogen pipeline (3), feed pipeline (4), tail gas pipeline (5) and connecting pipe are all equipped with electromagnetic control valves at one end, and the other end of the tail gas pipeline (5) is connected to the tail gas treatment equipment. The reactor body (1) is a 20 cubic meter enamel reactor.

3. The highly efficient enzyme-based catalytic reactor for ethyl R-4-cyano-3-hydroxybutyrate according to claim 1, characterized in that: The stirring assembly (9) includes a stirring motor (901), a mounting block (902), a stirring rod (903), and a stirring paddle (904). The outer wall of the stirring motor (901) is engaged with the inner wall of the mounting block (902), and the inner wall of the mounting block (902) is fixedly connected to the top of the reactor body (1) by bolts. The output shaft of the stirring motor (901) is fixedly connected to one end of the stirring rod (903) by a coupling, and the other end of the stirring rod (903) is fixedly connected to the inner wall of the stirring paddle (904).

4. The highly efficient enzyme-based catalytic reactor for ethyl R-4-cyano-3-hydroxybutyrate according to claim 1, characterized in that: The circulation assembly (10) includes an injection pipe (1001), a circulation pump (1002), a suction pipe (1003), and a transfer line (1004). One end of the injection pipe (1001) is fixedly connected to the inner top wall of the reactor body (1), and the other end of the injection pipe (1001) is fixedly connected to the output end of the circulation pump (1002). The input end of the circulation pump (1002) is fixedly connected to one end of the suction pipe (1003), and the other end of the suction pipe (1003) is fixedly connected to the inner top wall of the reactor body (1). The bottom end of the suction pipe (1003) is fixedly connected to the top end of the transfer line (1004).

5. The highly efficient enzyme-based catalytic reactor for ethyl R-4-cyano-3-hydroxybutyrate according to claim 1, characterized in that: The temperature control component (11) includes a temperature control jacket (1101), a support block (1102), and a circulating water pipe (1103). The inner wall of the temperature control jacket (1101) is movably sleeved with the outer wall of the reactor body (1), and the bottom of the temperature control jacket (1101) is fixedly connected to the top of the support block (1102). A temperature control cavity is opened inside the temperature control jacket (1101), and the inside of the temperature control cavity is fixedly connected to one end of the circulating water pipe (1103).

6. The highly efficient enzyme-based catalytic reactor for ethyl R-4-cyano-3-hydroxybutyrate according to claim 5, characterized in that: The other end of the circulating water pipe (1103) is connected to a water pump, which can draw in hot and cold water.

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