Drug constant-temperature volatile saturation gas extraction and transfer device

Abstract

The utility model discloses a kind of drug constant-temperature volatile saturated gas extraction transfer devices, device includes rotating caterpillar, sample disc, sample bottle heating groove, electric turntable, heating box, electric sampler, sample feeding mechanical arm, sample bottle tray, electric injector, transmission pipe, sample taking mechanical arm, sample bottle clamp, vertical movement mechanical arm and horizontal movement mechanical arm.Utilize the utility model, the full automation and continuous of heating, extraction, conveying, injection of drug sample can be realized, the accurate control of heating condition can be satisfied, and after heating is completed, drug constant-temperature saturated gas sample is extracted and injected into liquid phase sample bottle quickly, the concentration of constant-temperature saturated gas is deduced by determining drug solution in liquid phase sample bottle, and the whole extraction injection process is safe and controllable, for next step accurate determination drug constant-temperature volatile saturated gas concentration makes collection.

Description

Technical Field

[0001] This utility model relates to the field of drug volatile odor detection technology, specifically to a drug constant-temperature volatile saturated gas extraction and transfer device. Background Technology

[0002] Detecting the concentration of volatile drug gases in the air of enclosed drug storage spaces is a crucial part of the detection limit testing of drug detectors. Drugs are potent central nervous system stimulants and are classified as controlled psychotropic substances. Current methods for detecting the concentration of volatile drug gases include heating the sample to achieve evaporation equilibrium, then extracting a saturated sample of the drug's volatile gases at a constant temperature. After adsorbing the saturated gases using adsorption materials, the target analytes in the gas sample are detected and quantified using techniques such as gas chromatography-mass spectrometry (GC-MS), thus achieving the goal of detecting the concentration of saturated volatile drug gases at a constant temperature.

[0003] However, the current measurement process, including sample heating, post-heating sampling, and transfer, is mainly done manually, making various conditions uncontrollable and easily affecting the accuracy of the measurement. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention aims to provide a device for lifting and transferring saturated gas from the constant temperature volatilization of drugs and a method for determining its concentration.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A drug isothermal volatile saturated gas extraction and transfer device includes a rotating conveyor belt, a sample inlet tray, a sample bottle heating tank, an electric turntable, a heating box, an electric sampler, a sample delivery robotic arm, a sample bottle tray, an electric injector, a transfer tube, a sampling robotic arm, a sample bottle clamp, a vertical moving robotic arm, and a horizontal moving robotic arm.

[0007] The heating chamber is equipped with an electric turntable, which has multiple sample bottle heating slots arranged circumferentially. The top of the heating chamber is equipped with a heating chamber inlet. The rotation of the electric turntable can align any sample bottle heating slot with the heating chamber inlet. The sample bottle heating slots are used to heat the sample bottles placed inside.

[0008] The sample inlet plate is located on one side of the top of the heating box. The sample inlet plate is equipped with a rotating conveyor belt, and a plurality of sample bottle holes are arranged around the rotating conveyor belt. The sample bottle holes are used to place sample bottles.

[0009] The vertical moving robotic arm is connected to the sample bottle clamp and can drive the sample bottle clamp to move up and down; the horizontal moving robotic arm is located on the top of the heating box, is connected to the vertical moving robotic arm and can drive the vertical moving robotic arm to move horizontally, so that the position of the sample bottle clamp corresponds to the position of the sample bottle on the rotating conveyor belt or corresponds to the position of the sample inlet of the heating box.

[0010] The electric sampler and the sampling robotic arm are located inside the heating box. The sampling robotic arm is connected to the electric sampler and can drive the electric sampler to move up and down. The rotation of the electric turntable can make the heating tank of any sample bottle correspond to the position of the electric sampler. The electric sampler is connected to one end of the transmission tube.

[0011] The sample vial tray holds multiple sample vials. The other end of the transfer tube is connected to the electric injector, which is connected to the sample delivery robotic arm. The sample delivery robotic arm can move the electric injector to correspond to any sample vial on the sample vial tray.

[0012] Furthermore, the top of the heating chamber is provided with an openable and closable cover, which has a handle.

[0013] Furthermore, the electric sampler is also connected to one end of an inert gas supply pipe, and the other end of the inert gas supply pipe is connected to an inert gas source.

[0014] Furthermore, the transmission tube includes an outer layer, a middle layer, and an inner layer, wherein the outer layer is made of heat-insulating material, and the middle layer is a flexible heating element.

[0015] Furthermore, the sample vials are arranged concentrically on the sample vial tray; the sample delivery robotic arm includes an upper and lower lifting arm and a horizontal telescopic arm, the sample vial tray is equipped with a rotary motor, the upper and lower lifting arm is equipped with a rotary motor that can drive the upper and lower lifting arm to move up and down by axial rotation; the upper and lower lifting arm is connected to the horizontal telescopic arm and drives the horizontal telescopic arm to move up and down; the electric injector is connected to the upper and lower lifting arm, and the horizontal telescopic arm can extend and retract in the horizontal direction.

[0016] Furthermore, a tray support is connected to one side of the surface of the heating chamber, and the sample bottle tray is fixed to the tray support.

[0017] The beneficial effects of this utility model are as follows: By using this utility model, the heating, extraction, transportation and injection of drug samples can be fully automated and continuous, the heating conditions can be precisely controlled, and the drug volatile saturated gas sample can be quickly transferred to the injection bottle after heating, so that the whole process is controllable and gas collection can be carried out for the next step of determining the concentration of drug isothermal volatile saturated gas. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the drug isothermal volatile saturated gas extraction and transfer device in Embodiment 1 of this utility model;

[0019] Figure 2 This is a cross-sectional schematic diagram of the transmission tube in Embodiment 1 of this utility model.

[0020] Figure 3 This is a schematic diagram showing the connection between the sample inlet plate 3, the rotating conveyor belt 2, and the top of the heating box 7 in Embodiment 1 of this utility model.

[0021] Figure 4 This is a schematic diagram of the connection between the rotary motor and the sample tray 11, and the lifting arm 21 in Embodiment 1 of this utility model. Detailed Implementation

[0022] The present invention will be further described below with reference to the accompanying drawings. It should be noted that this embodiment is based on the present technical solution and provides detailed implementation methods and specific operation processes, but the protection scope of the present invention is not limited to this embodiment.

[0023] Example 1

[0024] This embodiment provides a drug isothermal volatile saturated gas extraction and transfer device, such as... Figure 1 As shown, it includes a rotating track 2, a sample inlet tray 3, a sample bottle heating tank 5, an electric turntable 6, a heating box 7, an electric sampler 8, a sample delivery robotic arm 10, a sample bottle tray 11, an electric injector 12, a transfer tube 13, a sampling robotic arm 15, a sample bottle clamp 18, a vertical moving robotic arm 19, and a horizontal moving robotic arm 20.

[0025] The heating chamber 7 is equipped with an electric turntable 6, which has multiple sample bottle heating slots 5 arranged circumferentially. The top of the heating chamber 7 is equipped with a heating chamber inlet 17. The rotation of the electric turntable 6 can drive any sample bottle heating slot 5 to correspond to the position of the heating chamber inlet 17. The sample bottle heating slots 5 are used to heat the sample bottles placed in them.

[0026] The sample inlet plate 3 is located on one side of the top of the heating box 7. The sample inlet plate 3 is equipped with a rotating conveyor belt 2, and a plurality of sample bottle holes 1 are arranged around the rotating conveyor belt 2. The sample bottle holes 1 are used to place sample bottles.

[0027] The vertical moving robotic arm 19 is connected to the sample bottle clamp 18 and can drive the sample bottle clamp 18 to move up and down; the horizontal moving robotic arm 20 is located on the top of the heating box 7, is connected to the vertical moving robotic arm 19 and can drive the vertical moving robotic arm 19 to move horizontally, so that the position of the sample bottle clamp 18 corresponds to the position of the sample bottle on the rotating conveyor 2 or to the position of the sample inlet 17 of the heating box.

[0028] The electric sampler 8 and the sampling robotic arm 15 are located inside the heating box 7. The sampling robotic arm 15 is connected to the electric sampler 8 and can drive the electric sampler 8 to move up and down. The rotation of the electric turntable 6 can make any sample bottle heating tank 5 correspond to the position of the electric sampler 8. The electric sampler 8 is connected to one end of the transfer tube 13. Multiple sample bottles are placed on the sample bottle tray 11. The other end of the transfer tube 13 is connected to the electric injector 12. The electric injector 12 is connected to the sample delivery robotic arm 10. The sample delivery robotic arm 10 can drive the electric injector 12 to move to correspond to any sample bottle on the sample bottle tray 11.

[0029] In this embodiment, the top of the heating box 7 is provided with an openable cover, which has a handle 16 for opening and closing.

[0030] In this embodiment, the electric sampler 8 is also connected to one end of an inert gas supply pipe 14, and the other end of the inert gas supply pipe 14 is connected to an inert gas source. The inert gas can be helium or nitrogen.

[0031] In this embodiment, as Figure 2 As shown, the transmission tube 13 includes an outer layer 131, a middle layer 132, and an inner layer 133. The outer layer 131 is made of thermal insulation material, and the middle layer 132 is a flexible heating element. By wrapping the surface of the inner layer with thermal insulation material and a flexible heating element, the extracted gas sample can be prevented from cooling and adsorbing onto the tube wall during transmission.

[0032] In this embodiment, the sample vials are arranged concentrically on the sample vial tray 11. The sample delivery robotic arm 10 includes a vertical lifting arm 21 and a horizontal telescopic arm 22. The sample vial tray 11 is equipped with a rotary motor. The vertical lifting arm 21 is equipped with a rotary motor that can drive the vertical lifting arm 21 to move up and down by axial rotation. The vertical lifting arm 21 is connected to the horizontal telescopic arm 22 and drives the horizontal telescopic arm 22 to move up and down. The electric injector 12 is connected to the vertical lifting arm 21, and the horizontal telescopic arm 22 can extend and retract in the horizontal direction. By using the vertical lifting arm and the horizontal telescopic arm, in conjunction with the axial rotation of the sample vial tray, the electric injector 12 can be driven to move up and down and extend and retract horizontally to correspond to the position of any sample vial. This increases the range of motion of the electric injector 12 and increases the number of sample vials that can be placed on the sample vial tray 11.

[0033] In this embodiment, the rotating track 2, the horizontal moving robotic arm 20, the vertical moving robotic arm 19, the electric turntable 6, the sample bottle heating tank 5, the sample delivery robotic arm 10, the electric sampler 8, the electric injector 12, the transfer tube 13, the sampling robotic arm 15, the sample bottle clamp 18, the rotary motor, and the flexible heating plate are all automatically controlled by the controller. The control panel 4 is located outside the heating box 7 for users to view and set operating parameters.

[0034] In this embodiment, a tray support 9 is connected to one side of the surface of the heating chamber 7, and the sample vial tray 11 is fixed to the tray support 9. The tray support 9 allows the entire device to be integrated into one unit, making it convenient to use.

[0035] Example 2

[0036] This embodiment provides a working method for the drug isothermal volatile saturated gas concentration measuring device as described in Embodiment 1. The specific process is as follows:

[0037] Before use, set the control parameters via control panel 4, including the injection speed of the electric injector, heating temperature, heating time, extraction volume of the gas sample, and whether to introduce nitrogen or helium. After setting the control parameters, place each sample vial into its respective sample vial slot 1 on the rotating conveyor 2, and place each injection vial on the injection vial tray 11. Input the command to the controller via control panel 4, and the controller will start the device. The sample vials contain solid samples, and the injection vials are pre-filled with methanol solution. The horizontal moving robotic arm 20 drives the vertical moving robotic arm 19, along with the sample bottle clamp 18, to move horizontally towards the sample inlet 3. After the sample bottle clamp 18 picks up a sample bottle at the corresponding position on the rotating conveyor belt 2, the horizontal moving robotic arm 20 drives the vertical moving robotic arm 19, along with the sample bottle clamp 18, to move horizontally towards the heating chamber inlet 17. After reaching the position corresponding to the heating chamber inlet 17, the vertical moving robotic arm 19 drives the sample bottle clamp 18 to move downward and extend into the heating chamber 7, and places the sample bottle into the sample bottle heating tank 5 corresponding to the heating chamber inlet 17.

[0038] After the sample bottle clamp 18 removes a sample bottle from the rotating conveyor 2, the rotating conveyor 2 rotates to the position of the sample bottle hole 1, so that the next sample bottle corresponds to the sample bottle clamp 18. After the sample bottle is placed in the sample bottle heating slot 5 corresponding to the heating box inlet 17, the electric turntable 6 rotates to the position of the sample bottle heating slot 5, so that the next empty sample bottle heating slot 5 corresponds to the position of the heating box inlet 17. After the sample bottle clamp 18 places the sample bottle into the sample bottle heating slot 5, the vertical moving robotic arm 19 drives the sample bottle clamp 18 to rise and reset, and the horizontal moving robotic arm 20 drives the vertical moving robotic arm 19 to move horizontally towards the sample inlet plate 3 to clamp the next sample bottle.

[0039] After all the sample bottles are placed in the sample bottle heating tank 5, each sample bottle heating tank 5 starts heating. Once the set heating temperature is reached, the timer starts and the sample bottles are heated for the set heating time (e.g., heating at 70℃ for 8 hours to achieve equilibrium).

[0040] After the sample vial heating tank 5 heats the sample vial, it rotates to the position corresponding to the electric sampler 8 via the electric turntable 6. The sampling robotic arm 15 controls the electric sampler 8 to descend and penetrate into the sample vial, extracting a set volume of gas sample. The gas sample is then transported to the electric injector 12 via the transfer tube 13. If inert gas needs to be introduced according to the control parameters, inert gas (helium or nitrogen) is simultaneously introduced into the electric sampler 8 as a protective gas through the inert gas supply tube 14. After the electric sampler 8 completes sample extraction, it is driven to rise and reset by the sampling robotic arm 15. The electric turntable 6 rotates one sample vial heating tank 5 position, aligning the next sample vial heating tank 5 with the position of the electric sampler 8.

[0041] The sample delivery robotic arm 10 drives the electric injector 12 to move to correspond with a sample bottle on the sample bottle tray 11 and inserts it downward into the corresponding sample bottle. The obtained gas sample is injected into the sample bottle at the set injection speed. Then, the sample delivery robotic arm 10 drives the electric injector 12 to rise and reset and move to correspond with the position of the next sample bottle to perform the next gas sample injection.

[0042] The injection vial containing the injected gas sample is sent to a liquid chromatography-mass spectrometry (LC-MS) instrument to determine the concentration of methamphetamine in the methanol solution, and then the absolute concentration of methamphetamine molecules in the gas sample is calculated.

[0043] For those skilled in the art, various corresponding changes and modifications can be made based on the above technical solutions and concepts, and all such changes and modifications should be included within the protection scope of the claims of this invention.

Claims

1. A drug isothermal saturated gas extraction and transfer device, characterized in that, It includes a rotating track (2), a sample inlet tray (3), a sample bottle heating tank (5), an electric turntable (6), a heating box (7), an electric sampler (8), a sample delivery robotic arm (10), a sample bottle tray (11), an electric injector (12), a transfer tube (13), a sampling robotic arm (15), a sample bottle clamp (18), a vertical moving robotic arm (19), and a horizontal moving robotic arm (20); The heating chamber (7) is equipped with an electric turntable (6), and the electric turntable (6) is circumferentially provided with multiple sample bottle heating slots (5); the top of the heating chamber (7) is provided with a heating chamber inlet (17), and the rotation of the electric turntable (6) can drive any sample bottle heating slot (5) to correspond to the position of the heating chamber inlet (17); the sample bottle heating slot (5) is used to heat the sample bottles placed in it; The sample inlet plate (3) is located on one side of the top of the heating box (7). The sample inlet plate (3) is provided with a rotating conveyor belt (2). Multiple sample bottle holes (1) are provided around the rotating conveyor belt (2). The sample bottle holes (1) are used to place sample bottles. The vertical moving robotic arm (19) is connected to the sample bottle clamp (18) and can drive the sample bottle clamp (18) to move up and down; the horizontal moving robotic arm (20) is located on the top of the heating box (7), and is connected to the vertical moving robotic arm (19) and can drive the vertical moving robotic arm (19) to move horizontally, so that the sample bottle clamp (18) corresponds to the position of the sample bottle on the rotating conveyor (2) or corresponds to the position of the sample inlet (17) of the heating box; The electric sampler (8) and the sampling robotic arm (15) are located inside the heating box (7). The sampling robotic arm (15) is connected to the electric sampler (8) and can drive the electric sampler (8) to move up and down. The rotation of the electric turntable (6) can make any sample bottle heating tank (5) correspond to the position of the electric sampler (8). The electric sampler (8) is connected to one end of the transmission tube (13). Multiple sample vials are placed on the sample vial tray (11). The other end of the transfer tube (13) is connected to the electric injector (12). The electric injector (12) is connected to the sample delivery robot arm (10). The sample delivery robot arm (10) can drive the electric injector (12) to move to correspond to any sample vial on the sample vial tray (11).

2. The drug isothermal volatile saturated gas extraction and transfer device according to claim 1, characterized in that, The heating box (7) is provided with an openable cover on the top, and the openable cover has a handle (16).

3. The drug isothermal volatile saturated gas extraction and transfer device according to claim 1, characterized in that, The electric sampler (8) is also connected to one end of an inert gas delivery pipe (14), and the other end of the inert gas delivery pipe (14) is connected to an inert gas source.

4. The drug isothermal volatile saturated gas extraction and transfer device according to claim 1, characterized in that, The transmission tube (13) includes an outer layer (131), a middle layer (132) and an inner layer (133). The outer layer (131) is made of heat-insulating material, and the middle layer (132) is a flexible heating element.

5. The drug isothermal volatile saturated gas extraction and transfer device according to claim 1, characterized in that, Each sample vial is arranged in a concentric circle on the sample vial tray (11); the sample delivery robotic arm (10) includes an up-and-down lifting arm (21) and a horizontal telescopic arm (22). The sample vial tray (11) is equipped with a rotary motor. The up-and-down lifting arm (21) is equipped with a rotary motor that can drive the up-and-down lifting arm (21) to move up and down by rotating axially; the up-and-down lifting arm (21) is connected to the horizontal telescopic arm (22) and drives the horizontal telescopic arm (22) to move up and down; the electric syringe (12) is connected to the up-and-down lifting arm (21), and the horizontal telescopic arm (22) can extend and retract in the horizontal direction.

6. The drug isothermal volatile saturated gas extraction and transfer device according to claim 1, characterized in that, A tray support (9) is connected to one side of the surface of the heating box (7), and the sample bottle tray (11) is fixed to the tray support (9).

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