Temperature control mechanism and colloid osmotic pressure measuring instrument

Abstract

The application provides a temperature control mechanism and a colloid osmotic pressure measuring instrument, and relates to the technical field of medical instruments.The temperature control mechanism comprises a measuring module, the measuring module comprises a lower measuring body and an upper measuring body, a reference chamber is arranged on the lower measuring body, a sample chamber is arranged on the upper measuring body, a constant-temperature cavity is arranged on the lower measuring body and the annular boss, the constant-temperature cavity on the lower measuring body surrounds the side of the reference chamber, the constant-temperature cavity on the annular boss surrounds the side of the sample chamber after the upper measuring body and the lower measuring body are spliced, and the constant-temperature cavity is filled with heat-conducting liquid; a temperature sensor is used for monitoring the temperature of the heat-conducting liquid in the constant-temperature cavity; and a temperature control unit is used for controlling the temperature of the heat-conducting liquid in the constant-temperature cavity. Since the heat conduction coefficient of the heat-conducting liquid is much higher than that of air, the heat transfer speed is faster and the distribution is more uniform, the temperature of each part of the constant-temperature cavity can be quickly balanced, and the osmotic pressure measurement error caused by the temperature gradient is reduced.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a temperature control mechanism and a colloid osmotic pressure measuring instrument. Background Technology

[0002] A colloid osmometer is an analytical instrument used to measure the osmotic pressure of colloids in a solution. Commonly used methods for measuring colloid osmotic pressure include freezing point depression, boiling point elevation, vapor pressure depression, and semi-permeable membrane method. Among these, colloid osmometers using the semi-permeable membrane method are often used to measure the osmotic pressure of plasma, tissue fluid, protein, or polymer solutions.

[0003] Currently, existing colloid osmotic pressure measuring instruments using the semi-permeable membrane method typically consist of a main unit and a measurement module. The measurement module includes a semi-permeable membrane, a pressure sensing unit, a lower measuring body with a reference chamber, an upper measuring body with a sample chamber, and nuts for fixing and connecting the lower and upper measuring bodies. For example, utility model CN221860222U discloses a high-sealing measuring chamber and a colloid osmotic pressure measuring instrument. The high-sealing measuring chamber (equivalent to the measurement module) includes a first assembly (equivalent to the lower measuring body), a second assembly connected to the first assembly (equivalent to the upper measuring body), and connecting components (equivalent to nuts) connected to both the first and second assemblies. The first assembly is the part of the high-sealing measuring chamber that contains the liquid sample for measurement. The first assembly has a cylindrical hollow structure, with a connecting chamber at the bottom and a detection chamber connected to the connecting chamber. The connecting chamber is adapted to a pressure sensor, thereby placing the pressure sensor inside the connecting chamber to measure the real-time osmotic pressure of the sample.

[0004] When measuring the osmotic pressure of biological samples (such as plasma), the sample temperature must be controlled at the physiological temperature of the human body (around 37°C) to maintain the natural state of colloidal particles. If the temperature deviates from physiological conditions, proteins may denature or aggregate, leading to distortion in the osmotic pressure measurement. Currently, existing semi-permeable membrane colloid osmotic pressure measuring instruments typically use a constant-temperature air bath to control the temperature of the biological sample. The temperature control method involves placing the measuring module of the colloid osmotic pressure measuring instrument inside a constant-temperature chamber, then heating the air inside the chamber using an electric heating element, and monitoring the air temperature in real time using a temperature sensor. When the temperature approaches the set value, the heating power is reduced, and the fan speed is adjusted to maintain thermal balance.

[0005] However, due to the low thermal conductivity of air and its low heat transfer efficiency, forced convection via a fan can easily lead to localized turbulence, creating "temperature dead zones" and resulting in uneven temperature distribution within the thermostatic cavity. Furthermore, when the electric heating element heats up, it must first heat itself to a high temperature before heating the air through radiation and convection. The transition time from startup to maintaining a constant temperature is relatively long. When cooling is required, the air bath relies on natural heat dissipation or a small amount of fan exhaust, resulting in a low cooling rate and thus a slow temperature control response. Utility Model Content

[0006] The purpose of this application is to provide a temperature control mechanism and a colloid osmotic pressure measuring instrument to solve the problems of poor temperature uniformity and slow temperature control response caused by the use of a constant temperature air bath for temperature control in related technologies.

[0007] Firstly, the temperature control mechanism provided in this application adopts the following technical solution:

[0008] A temperature control mechanism, comprising:

[0009] The measurement module includes a lower measuring body and an upper measuring body, which are detachably connected. The lower measuring body has a reference chamber, and the upper measuring body has a sample chamber. The lower measuring body has an annular protrusion that can be embedded inside the upper measuring body. The lower measuring body and the annular protrusion have constant temperature cavities. The constant temperature cavity on the lower measuring body surrounds the reference chamber, and the constant temperature cavity on the annular protrusion surrounds the sample chamber after the upper and lower measuring bodies are connected. The constant temperature cavity is filled with a heat-conducting liquid.

[0010] Temperature sensor, the temperature sensor being used to monitor the temperature of the heat transfer fluid inside the constant temperature cavity;

[0011] A temperature control unit is used to control the temperature of the heat transfer fluid inside the constant temperature cavity.

[0012] Optionally, the temperature control unit includes a liquid storage tank, a heating element, a cooling element, and a circulating pump. The lower measuring body is provided with an inlet and an outlet that communicate with the constant temperature chamber. The liquid storage tank is connected to the inlet and the outlet and stores heat transfer fluid. The heating element is used to heat the heat transfer fluid in the liquid storage tank, the cooling element is used to cool the heat transfer fluid in the liquid storage tank, and the circulating pump is used to drive the heat transfer fluid to circulate between the liquid storage tank and the constant temperature chamber.

[0013] Optionally, the measurement module further includes a housing, a pressure sensing unit, and a connector. The housing is detachably connected to the main unit of the colloid osmotic pressure measuring instrument. The lower measuring body is fixed on the housing. The pressure sensing unit and the temperature sensor are fixed on the lower measuring body. The measuring end of the pressure sensing unit is connected to the interior of the reference chamber. The connector is fixed on the housing and electrically connected to the pressure sensing unit and the temperature sensor. The connector is detachably electrically connected to the main unit of the colloid osmotic pressure measuring instrument.

[0014] Secondly, the colloid osmotic pressure measuring instrument provided in this application adopts the following technical solution:

[0015] A colloidal osmotic pressure measuring instrument, including the aforementioned temperature control mechanism, further includes:

[0016] The instrument host includes a housing, the housing is detachably connected to the main unit, the housing is provided with a locking mechanism for locking the housing and the main unit, and the instrument host is provided with an electrical connector that is detachably electrically connected to the connector.

[0017] Optionally, the temperature control unit is located inside the housing, and the lower measuring body is provided with two tubes that are respectively connected to the liquid inlet and the liquid outlet. The tubes are provided with a first valve, and the liquid storage tank is provided with two connecting pipes that can be detachably connected to the tubes. The connecting pipes are provided with a second valve.

[0018] Optionally, the first valve includes a valve core and a first elastic element. A valve body is provided on the pipe body, and a valve port is provided on the valve body. The first elastic element acts on the valve core, and the valve core can open and close to seal the valve port under the elastic force of the first elastic element. The second valve includes a telescopic tube and a telescopic drive element. The telescopic tube is slidably inserted into the connecting pipe. The telescopic drive element is used to drive the telescopic tube to telescopically move relative to the connecting pipe. When the telescopic tube extends, it can be inserted into the valve port and push the valve core to open. A valve hole is provided on the side wall of the telescopic tube, which communicates with the inside of the valve body when extended.

[0019] Optionally, the locking mechanism includes a wedge block and a second elastic element. The housing is provided with a lock body and a lock hole. The housing is provided with a lock tongue that can be inserted into the lock hole and a lock groove. The wedge block is slidably disposed on the lock body. The second elastic element acts on the wedge block, and the wedge block can be engaged with the lock groove under the elastic force of the second elastic element.

[0020] Optionally, the locking mechanism further includes a locking pin, which is fixedly connected to the telescopic tube via a connecting bracket. The wedge block is provided with a pin hole. When the telescopic drive drives the telescopic tube to extend relative to the connecting tube, it can push the locking pin to engage with the pin hole to restrict the wedge block from sliding relative to the lock body.

[0021] In summary, this application includes at least the following beneficial technical effects: When the colloid osmotic pressure measuring instrument performs osmotic pressure measurement, the temperature of the heat transfer fluid in the constant temperature chamber is monitored by a temperature sensor. When the temperature is lower than the set temperature, the heat transfer fluid in the storage tank is heated by a heating element; when the temperature is higher than the set temperature, the heat transfer fluid in the storage tank is cooled by a cooling element. A circulating pump drives the heat transfer fluid to circulate between the storage tank and the constant temperature chamber, precisely controlling the temperature of the heat transfer fluid in the constant temperature chamber, thereby maintaining the sample temperature at the physiological temperature of the human body and improving the accuracy of osmotic pressure measurement. Because the thermal conductivity of the heat transfer fluid is much higher than that of air, the heat transfer speed is faster and the distribution is more uniform, which can quickly balance the temperature of various parts of the constant temperature chamber and reduce osmotic pressure measurement errors caused by temperature gradients. Furthermore, the high fluidity of the heat transfer fluid further eliminates local hot spots through convection energy, reducing temperature blind spots caused by uneven fluid distribution. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the structure of the colloid osmotic pressure measuring instrument in the embodiments of this application;

[0023] Figure 2 This is a cross-sectional view of the colloidal osmotic pressure measuring instrument in the embodiments of this application from a first perspective;

[0024] Figure 3 for Figure 2 A magnified view of part A in the middle;

[0025] Figure 4 This is a cross-sectional view of the colloid osmotic pressure measuring instrument in the embodiments of this application from a second perspective;

[0026] Figure 5 for Figure 4 A magnified view of part C1 in the middle;

[0027] Figure 6 for Figure 4 A magnified view of part C2 in the middle;

[0028] Figure 7 This is a cross-sectional view of the colloidal osmotic pressure measuring instrument in the embodiments of this application from a third perspective;

[0029] Figure 8 for Figure 7 A magnified view of part B in the diagram.

[0030] Explanation of reference numerals in the attached figures:

[0031] 10. Measurement module; 11. Housing; 111. Locking tongue; 112. Locking groove; 12. Lower measuring body; 121. Reference chamber; 122. Annular boss; 123. Constant temperature chamber; 124. Groove; 125. Liquid inlet; 126. Liquid outlet; 127. Tube body; 128. Positioning pin; 13. Upper measuring body; 131. Sample chamber; 132. Shoulder surface; 133. Liquid inlet channel; 134. Liquid outlet channel; 135. Interface; 136. Connecting pipe; 14. Semi-permeable membrane; 15. Support sieve plate; 16. Sealing ring; 17. Sealing plug; 18. Locking cover; 19. Pressure sensing unit; 110. Connector;

[0032] 20. Main unit of the instrument; 21. Housing; 211. Guide rail; 212. Baffle; 213. Limiting plate; 22. Electrical connector; 30. Liquid storage tank; 31. Connecting pipe; 311. First sealing gasket; 312. Clearance groove; 40. Heating element; 50. Cooling element; 60. Circulating pump; 70. Locking mechanism; 71. Wedge block; 711. Control lever; 712. Handle head; 713. Pin hole; 72. Second spring; 73. Lock body; 731. Lock hole; 732. Guide groove; 733. Clearance hole; 74. Locking pin;

[0033] 80. First valve; 81. Valve core; 811. Valve stem; 82. First spring; 83. Valve body; 831. Valve port; 832. Guide sleeve; 84. Second sealing gasket; 90. Second valve; 91. Telescopic tube; 911. Valve hole; 912. Connecting frame; 92. Telescopic drive component; 93. Sealing ring; 100. Temperature sensor. Detailed Implementation

[0034] The following is in conjunction with the appendix Figure 1 -Appendix Figure 8 This application will be described in further detail below.

[0035] Example 1

[0036] This application discloses a temperature control mechanism.

[0037] A temperature control mechanism includes a measurement module 10, a temperature sensor 100, and a temperature control unit.

[0038] Reference Figures 1 to 7The measurement module 10 includes a housing 11, a lower measuring body 12, an upper measuring body 13, a semi-permeable membrane 14, a supporting sieve plate 15, a sealing ring 16, a sealing plug 17, a locking cover 18, a pressure sensing unit 19, and a connector 110. The housing 11 is detachably connected to the instrument host 20 of the colloid osmotic pressure measuring instrument. The lower measuring body 12 is fixed on the housing 11, and the upper measuring body 13 is detachably spliced ​​with the lower measuring body 12. More specifically, the upper measuring body 13 is placed on the lower measuring body 12. The lower measuring body 12 is provided with a positioning pin 128 that is inserted into the upper measuring body 13. The upper measuring body 13 is provided with a shoulder surface 132. The locking cover 18 is provided with an internal thread, and the periphery of the lower measuring body 12 is provided with an external thread. The locking cover 18 is screwed to the external thread of the lower measuring body 12 through the internal thread, and the inner end face of the locking cover 18 abuts against the shoulder surface 132.

[0039] The lower measuring body 12 is provided with a reference chamber 121, which is used to contain physiological saline or buffer solution. The upper measuring body 13 is provided with a sample chamber 131, which is used to contain the sample to be tested, such as plasma or ascites. The reference chamber 121 and the sample chamber 131 are separated by a semi-permeable membrane 14 to form an osmotic system, allowing only water molecules to pass through. The upper surface of the reference chamber 121 of the lower measuring body 12 is provided with a groove 124. A supporting sieve plate 15 is placed in the groove 124 of the lower measuring body 12. The semi-permeable membrane 14 is attached to the upper surface of the supporting sieve plate 15. A sealing ring 16 is placed on the upper surface of the semi-permeable membrane 14. The lower end of the upper measuring body 13 abuts against the sealing ring 16. The upper measuring body 13 is provided with an inlet channel 133 and an outlet channel 134 that communicate with the sample chamber 131, as well as an interface 135 that is connected to the inlet channel 133 and the outlet channel 134 respectively. The interface 135 is connected to the cleaning liquid bottle and the waste liquid bottle of the instrument host 20 through the connecting pipe 136 respectively. The sealing plug 17 can be snapped into the sample chamber 131.

[0040] The lower measuring body 12 is provided with an annular protrusion 122 that can be embedded inside the upper measuring body 13. A constant temperature cavity 123 is provided on the lower measuring body 12 and the annular protrusion 122. The constant temperature cavity 123 on the lower measuring body 12 surrounds the reference chamber 121. After the upper measuring body 13 and the lower measuring body 12 are joined, the constant temperature cavity 123 surrounds the sample chamber 131. The constant temperature cavity 123 is filled with a heat-conducting liquid. A pressure sensing unit 19 and a temperature sensor 100 are fixed on the lower measuring body 12. The measuring end of the pressure sensing unit 19 is connected to the interior of the reference chamber 121. The temperature sensor 100 is used to monitor the temperature of the heat-conducting liquid inside the constant temperature cavity 123. A connector 110 is fixed on the housing 11 and electrically connected to the pressure sensing unit 19 and the temperature sensor 100. The connector 110 is detachably electrically connected to the instrument main unit 20 of the colloid osmotic pressure measuring instrument. The pressure difference between the sample chamber 131 and the reference chamber 121 can be measured in real time through the pressure sensing unit 19, and the measurement signal is transmitted to the data processing system of the instrument host 20 through the connector 110. The pressure difference measurement signal is then converted into the colloidal osmotic pressure of the sample through the osmotic balance algorithm built into the microprocessor of the data processing system.

[0041] The temperature control unit is used to control the temperature of the heat transfer fluid in the constant temperature cavity 123. In an optional embodiment, the temperature control unit may adopt the following structure: the temperature control unit includes a liquid storage tank 30, a heating element 40, a cooling element 50 and a circulating pump 60. The lower measuring body 12 is provided with an inlet 125 and an outlet 126 that communicate with the constant temperature cavity 123. The liquid storage tank 30 is connected to the inlet 125 and the outlet 126. The storage tank 30 stores a heat transfer fluid, which can be a water-based or oil-based temperature-controlled liquid. The heating element 40 is used to heat the heat transfer fluid in the storage tank 30. The heating element 40 can be an electric heating tube, which is fixedly installed inside the storage tank 30. The cooling element 50 is used to cool the heat transfer fluid in the storage tank 30. The cooling element 50 can be a semiconductor cooler, which is fixedly attached to the bottom wall of the storage tank 30. The circulation pump 60 is used to drive the heat transfer fluid to circulate between the storage tank 30 and the constant temperature chamber 123.

[0042] The implementation principle of the temperature control mechanism in this embodiment is as follows: When the colloidal osmotic pressure measuring instrument performs osmotic pressure measurement, the temperature sensor 100 monitors the temperature of the heat transfer fluid in the constant temperature chamber 123. When the temperature is lower than the set temperature, the heating element 40 heats the heat transfer fluid in the storage tank 30. When the temperature is higher than the set temperature, the cooling element 50 cools the heat transfer fluid in the storage tank 30. A circulating pump 60 drives the heat transfer fluid to circulate between the storage tank 30 and the constant temperature chamber 123, precisely controlling the temperature of the heat transfer fluid in the constant temperature chamber 123, thereby controlling the sample temperature at the physiological temperature of the human body and improving the accuracy of osmotic pressure measurement. Because the thermal conductivity of the heat transfer fluid is much higher than that of air, the heat transfer speed is faster and the distribution is more uniform, which can quickly balance the temperature of various parts of the constant temperature chamber 123 and reduce the osmotic pressure measurement error caused by temperature gradients. Furthermore, the heat transfer fluid has strong fluidity, which further eliminates local hot spots through convection energy and reduces temperature blind spots caused by uneven fluid distribution.

[0043] Example 2

[0044] This application discloses a colloidal osmotic pressure measuring instrument.

[0045] A colloidal osmotic pressure measuring instrument includes an instrument main unit 20 and a temperature control mechanism.

[0046] Reference Figures 3 to 8 The instrument host 20 includes a housing 21, with a housing 11 detachably connected to the housing 21. More specifically, the housing 21 has a guide rail 211 and a sliding groove at its bottom, allowing the housing 11 to slide and engage with the guide rail 211 via the sliding groove. A baffle 212 is provided on the housing 21 to limit the sliding travel of the housing 11 along the guide rail 211. A locking mechanism 70 is provided on the housing 21 to lock the housing 11 and the housing 21 together. When the housing 11 slides along the guide rail 211 until it abuts against the baffle 212, the locking mechanism 70 locks the housing 11 and the housing 21 together. The instrument host 20 also has an electrical connector 22 detachably electrically connected to the connector 110. The electrical connector 22 is fixed to the baffle 212 and is connected to the data processing system of the instrument host 20.

[0047] The temperature control unit is located inside the housing 21, and the liquid storage tank 30 is fixed to the inner wall of the housing 21. The lower measuring body 12 has two tubes 127 connected to the inlet 125 and outlet 126 respectively. A first valve 80 is installed on each tube 127. The liquid storage tank 30 has two connecting pipes 31 that can be detachably connected to each tube 127. The end face of the tube 127 can abut against the end face of the connecting pipe 31. A first sealing gasket 311 is fixed to the end face of the connecting pipe 31. When the end face of the tube 127 abuts against the end face of the connecting pipe 31, the first sealing gasket 311 contacts the end face of the tube 127. A circulating pump 60 is installed on one of the connecting pipes 31, and a second valve 90 is installed on the connecting pipe 31.

[0048] Since the housing 11 and the main unit 21 are detachably connected, the connecting pipe 136 is separated from the interface 135 of the liquid inlet channel 133 and the liquid outlet channel 134. The first valve 80 and the second valve 90 are closed, and the locking mechanism 70 is released from locking the housing 11 and the main unit 21. The housing 11 is removed from the guide rail 211, the tube 127 is separated from the connecting pipe 31, and the connector 110 is separated from the electrical connector 22. The measuring module 10 can then be disassembled from the instrument main unit 20, which facilitates the replacement of the semipermeable membrane 14.

[0049] Reference Figure 7 and Figure 8 In an optional embodiment, the specific structures of the first valve 80 and the second valve 90 are as follows: The first valve 80 includes a valve core 81 and a first elastic element. A valve body 83 is provided on the pipe body 127, and a valve port 831 is provided on the valve body 83. The first elastic element acts on the valve core 81, and the valve core 81 can be opened and closed to seal the valve port 831 under the elastic force of the first elastic element. More specifically, the first elastic element is a first spring 82. A guide sleeve 832 is fixedly provided on the inner wall of the valve body 83. A valve stem 811 is provided on the valve core 81. The valve stem 811 slides through the guide sleeve 832. The first spring 82 is sleeved on the outside of the valve stem 811. The two ends of the first spring 82 abut against the guide sleeve 832 and the valve core 81, respectively. A stepped surface is provided at the end of the valve core 81. A second sealing gasket 84 is fixedly provided on the stepped surface of the valve core 81. The valve core 81 can abut against the inner end face of the valve body 83 around the valve port 831 through the second sealing gasket 84.

[0050] The second valve 90 includes a telescopic tube 91 and a telescopic drive component 92. The telescopic tube 91 is slidably inserted into the connecting tube 31. The telescopic tube 91 is provided with a connecting frame 912 extending to the outside of the connecting tube 31. The connecting tube 31 is provided with a clearance groove 312 for avoiding the connecting frame 912. Two sets of sealing rings 93 are fixedly sleeved on the outer periphery of the telescopic tube 91. The sealing rings 93 are in contact with the inner wall of the connecting tube 31. The two sets of sealing rings 93 are located on the front and rear sides of the clearance groove 312, respectively. The telescopic drive component 92 can be an electric push rod, which is fixedly mounted on the connecting tube 31. The push-pull rod of the electric push rod is fixedly connected to the connecting frame 912. The telescopic drive component 92 is used to drive the telescopic tube 91 to telescopically move relative to the connecting tube 31. When the telescopic tube 91 extends, it can be inserted into the valve port 831 and push the valve core 81 to open. The side wall of the telescopic tube 91 is provided with a valve hole 911 that communicates with the inside of the valve body 83 when extended.

[0051] Reference Figures 4 to 8 In an optional embodiment, the specific structure of the locking mechanism 70 and its specific connection relationship with the housing 11 and the casing 21 are as follows: The locking mechanism 70 includes a wedge block 71, a second elastic element, and a locking pin 74. The casing 21 is provided with a lock body 73, which has a lock hole 731. The housing 11 is provided with a locking tongue 111 that can be inserted into the lock hole 731, which has a locking groove 112. The lock body 73 has a guide groove 732. The wedge block 71 is slidably disposed in the guide groove 732 on the lock body 73. The second elastic element acts on the wedge block 71. The second elastic element can be a second spring 72. The two ends of the second spring 72 abut against the end faces of the wedge block 71 and the guide groove 732, respectively. Under the elastic force of the second elastic element, the wedge block 71 can engage with the locking groove 112. The wedge block 71 is provided with a control lever 711, and the housing 21 is provided with a limiting plate 213. The control lever 711 slides through the lock body 73 and the limiting plate 213. The control lever 711 is provided with a handle head 712 that can abut against the limiting plate 213. The second spring 72 is sleeved on the outside of the control lever 711. By pulling the control lever 711 upward by the handle head 712, the wedge block 71 can be driven out of the lock groove 112 to release the locking connection between the housing 11 and the housing 21.

[0052] The locking pin 74 is fixed to the telescopic tube 91 via the connecting bracket 912. The wedge block 71 is provided with a pin hole 713. When the telescopic drive member 92 drives the telescopic tube 91 to extend relative to the connecting tube 31, it can push the locking pin 74 to be inserted into the pin hole 713 to restrict the wedge block 71 from sliding relative to the lock body 73. The lock body 73 is provided with a relief hole 733 for avoiding the locking pin 74.

[0053] The implementation principle of the colloidal osmotic pressure measuring instrument in this embodiment is as follows: When it is necessary to connect the measuring module 10 to the instrument host 20 for colloidal osmotic pressure measurement, the housing 11 is slid along the guide rail 211 until the housing 11 abuts against the baffle 212, so that the connector 110 is connected to the electrical connector 22. At the same time, the locking tongue 111 is inserted into the locking hole 731. Then, the wedge block 71 is engaged with the locking groove 112 under the elastic force of the second elastic element, locking the housing 11 to the machine housing 21. At this time, the end face of the tube body 127 abuts against the end face of the connecting tube 31. Then, the telescopic drive member 92 drives the telescopic tube 91 to extend relative to the connecting tube 31 and insert it into the valve port 831, and pushes the valve core 81 to open, so that the telescopic tube 91 communicates with the inside of the valve body 83 through the valve hole 911, so that the heat transfer fluid can circulate between the storage tank 30 and the constant temperature chamber 123, so that the temperature of the heat transfer fluid in the constant temperature chamber 123 can be controlled by the temperature control unit. When the telescopic drive 92 drives the telescopic tube 91 to extend, it simultaneously drives the locking pin 74 to engage with the pin hole 713 to restrict the wedge block 71 from sliding relative to the lock body 73. At this time, the wedge block 71 cannot exit from the lock groove 112, thus preventing the locking connection between the housing 11 and the housing 21 from being released. This avoids the accidental release of the lock between the housing 11 and the housing 21 when the telescopic tube 91 is connected to the valve body 83 through the valve hole 911, which would cause the housing 11 and the housing 21 to separate, thereby causing the telescopic tube 91 to detach from the valve body 83 and resulting in leakage of the heat transfer fluid.

[0054] The structure of the main unit 20 of the colloid osmotic pressure measuring instrument and the connection relationship of its components in the embodiments of this application are common knowledge in the field and need not be described in detail here. Only the casing 21 and other components are shown in the accompanying drawings.

[0055] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Identical components are represented by the same reference numerals. Therefore, all equivalent changes made to the structure, shape, and principle of this application should be covered within the scope of protection of this application.

Claims

1. A temperature control mechanism, characterized in that, include: The measurement module (10) includes a lower measuring body (12) and an upper measuring body (13). The upper measuring body (13) and the lower measuring body (12) are detachably spliced. The lower measuring body (12) is provided with a reference chamber (121), and the upper measuring body (13) is provided with a sample chamber (131). The lower measuring body (12) is provided with an annular boss (122) that can be embedded inside the upper measuring body (13). The lower measuring body (12) and the annular boss (122) are provided with a constant temperature cavity (123). The constant temperature cavity (123) on the lower measuring body (12) surrounds the reference chamber (121). The constant temperature cavity (123) on the annular boss (122) surrounds the sample chamber (131) after the upper measuring body (13) and the lower measuring body (12) are spliced. The constant temperature cavity (123) is filled with a heat-conducting liquid. Temperature sensor (100) is used to monitor the temperature of the heat transfer fluid in the constant temperature cavity (123); Temperature control unit, the temperature control unit is used to control the temperature of the heat transfer fluid in the constant temperature cavity (123).

2. The temperature control mechanism according to claim 1, characterized in that, The temperature control unit includes a storage tank (30), a heating element (40), a cooling element (50), and a circulation pump (60). The lower measuring body (12) is provided with an inlet (125) and an outlet (126) that are connected to the constant temperature chamber (123). The storage tank (30) is connected to the inlet (125) and the outlet (126). The storage tank (30) stores heat transfer fluid. The heating element (40) is used to heat the heat transfer fluid in the storage tank (30). The cooling element (50) is used to cool the heat transfer fluid in the storage tank (30). The circulation pump (60) is used to drive the heat transfer fluid to circulate between the storage tank (30) and the constant temperature chamber (123).

3. The temperature control mechanism according to claim 2, characterized in that, The measurement module (10) also includes a housing (11), a pressure sensing unit (19), and a connector (110). The housing (11) is detachably connected to the instrument host (20) of the colloid osmotic pressure measuring instrument. The lower measuring body (12) is fixed on the housing (11). The pressure sensing unit (19) and the temperature sensor (100) are fixed on the lower measuring body (12). The measuring end of the pressure sensing unit (19) is connected to the inside of the reference chamber (121). The connector (110) is fixed on the housing (11) and electrically connected to the pressure sensing unit (19) and the temperature sensor (100). The connector (110) is detachably electrically connected to the instrument host (20) of the colloid osmotic pressure measuring instrument.

4. A colloidal osmotic pressure measuring instrument, characterized in that, Including the temperature control mechanism as described in claim 3, it further includes: The instrument host (20) includes a housing (21), the housing (11) is detachably connected to the housing (21), the housing (21) is provided with a locking mechanism (70) for locking the housing (11) and the housing (21), and the instrument host (20) is provided with an electrical connector (22) that is detachably electrically connected to the connector (110).

5. A colloidal osmotic pressure measuring instrument according to claim 4, characterized in that, The temperature control unit is located inside the housing (21). The lower measuring body (12) is provided with two tubes (127) that are respectively connected to the liquid inlet (125) and the liquid outlet (126). The tubes (127) are provided with a first valve (80). The liquid storage tank (30) is provided with two connecting pipes (31) that can be detachably connected to the tubes (127). The connecting pipes (31) are provided with a second valve (90).

6. A colloidal osmotic pressure measuring instrument according to claim 5, characterized in that, The first valve (80) includes a valve core (81) and a first elastic element. The pipe body (127) is provided with a valve body (83) and a valve port (831) is provided on the valve body (83). The first elastic element acts on the valve core (81). Under the elastic force of the first elastic element, the valve core (81) can open and close to seal the valve port (831). The second valve (90) includes a telescopic tube (91) and a telescopic drive element (92). The telescopic tube (91) is slidably inserted into the connecting pipe (31). The telescopic drive element (92) is used to drive the telescopic tube (91) to telescopically move relative to the connecting pipe (31). When the telescopic tube (91) extends, it can be inserted into the valve port (831) and push the valve core (81) to open. The side wall of the telescopic tube (91) is provided with a valve hole (911) that communicates with the inside of the valve body (83) when it extends.

7. A colloidal osmotic pressure measuring instrument according to claim 6, characterized in that, The locking mechanism (70) includes a wedge block (71) and a second elastic element. The housing (21) is provided with a lock body (73) and a lock hole (731). The housing (11) is provided with a lock tongue (111) that can be inserted into the lock hole (731) and a lock groove (112) on the lock tongue (111). The wedge block (71) is slidably disposed on the lock body (73). The second elastic element acts on the wedge block (71). Under the elastic force of the second elastic element, the wedge block (71) can engage with the lock groove (112).

8. A colloidal osmotic pressure measuring instrument according to claim 7, characterized in that, The locking mechanism (70) also includes a locking pin (74), which is fixed to the telescopic tube (91) via a connecting bracket (912). The wedge block (71) is provided with a pin hole (713). When the telescopic drive (92) drives the telescopic tube (91) to extend relative to the connecting tube (31), it can push the locking pin (74) to engage with the pin hole (713) to restrict the wedge block (71) from sliding relative to the lock body (73).

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