A continuous extraction device for propafenone hydrochloride purification

Abstract

This utility model discloses a continuous extraction device for the purification of propafenone hydrochloride, specifically relating to the field of propafenone hydrochloride production technology. It includes an extraction cylinder and a first vertical pipe, with the top end of the first vertical pipe fixedly connected to the extraction cylinder. A support frame is movably mounted on the outside of the extraction cylinder. A rotating assembly is positioned between the extraction cylinder and the support frame. The rotating assembly includes a stepper motor, a gear rod, a gear ring, a third vertical pipe, and a feed hopper. A material guiding assembly is located at the bottom of the first vertical pipe. This utility model uses a stepper motor to drive the extraction cylinder and the first vertical pipe to rotate, centrifugally extracting propafenone hydrochloride. A water pump draws the propafenone hydrochloride-containing solution from the second vertical pipe through a first water pipe and injects it into the feed hopper through the second water pipe for further extraction. This cycle is repeated multiple times, making the operation simple and convenient for continuous extraction of propafenone hydrochloride.

Description

Technical Field

[0001] This utility model relates to the field of propafenone hydrochloride production technology, and more specifically, to a continuous extraction device for the purification of propafenone hydrochloride. Background Technology

[0002] Propafenone hydrochloride is a commonly used antiarrhythmic drug. Its main function is to inhibit sodium channels in cardiomyocytes, slow down the rise rate of phase 0 of the action potential, thereby prolonging the action potential duration and effective refractory period, and inhibiting abnormal cardiac electrical activity. It is used to treat arrhythmias such as premature ventricular contractions, supraventricular tachycardia, and atrial fibrillation. In the synthesis process of propafenone hydrochloride, the purification process usually requires the removal of impurities through extraction.

[0003] A search revealed that Chinese patent CN212468049U discloses a weighing device for a reaction vessel used in the production of propafenone hydrochloride. The reaction vessel is supported by three support legs, and the weighing sensor assembly under the support legs can accurately measure the weight of the reaction vessel. The structure of the directional sliding ball bearings and sliding grooves under the two sliding support legs ensures that the weighing sensor will not cause weighing errors due to thermal expansion when the reaction vessel expands due to the reaction.

[0004] When the above-mentioned device is in use, propafenone hydrochloride is crystallized through a reaction vessel. However, it is inconvenient to continuously extract propafenone hydrochloride before crystallization. Impurities will dissolve in the reaction solution in molecular form or be adsorbed on the surface of the target substance, resulting in co-precipitation during crystallization, which directly affects the purity of propafenone hydrochloride. Utility Model Content

[0005] In order to overcome the above-mentioned defects of the prior art, the present invention provides a continuous extraction device for the purification of propafenone hydrochloride, which aims to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a continuous extraction device for refining propafenone hydrochloride, comprising an extraction cylinder and a first vertical pipe, wherein the top end of the first vertical pipe is fixedly connected to the extraction cylinder, a support frame is movably arranged on the outside of the extraction cylinder, and a rotating assembly is arranged between the extraction cylinder and the support frame, the rotating assembly comprising a stepper motor, a gear rod, a gear ring, a third vertical pipe and a feed hopper, a material guiding assembly is arranged at the bottom of the first vertical pipe, the material guiding assembly comprising a filter box, a second vertical pipe, a first valve, a first water pipe, a second valve, a water pump, a second water pipe and a square filter screen, the top end of the filter box is movably connected to the first vertical pipe through a bearing, the top end of the second vertical pipe is fixedly connected to the filter box, the first valve is fixedly installed on the second vertical pipe, the second valve is fixedly installed on the first water pipe, the water pump is fixedly installed at the bottom of the support frame, and the square filter screen is movably arranged inside the filter box.

[0007] Furthermore, the two ends of the first water pipe are fixedly connected to the second riser and the water pump, respectively, and the bottom end of the second water pipe is fixedly connected to the output end of the water pump.

[0008] Furthermore, two L-shaped plates are fixedly connected to both the front and rear sides of the filter box, and the tops of the multiple L-shaped plates are fixedly connected to the support frame.

[0009] It can be seen that the above technical solution is designed to facilitate the support of the filter box.

[0010] Furthermore, the stepper motor is fixedly installed on the top of the support frame, and the output shaft end of the stepper motor is fixedly connected to the gear rod. The gear rod meshes with the gear ring, and the gear ring is fixedly sleeved on the third vertical tube. The top and bottom ends of the third vertical tube are fixedly connected to the feed hopper and the extraction cylinder, respectively, and the third vertical tube is movably connected to the support frame through bearings.

[0011] Furthermore, a sealing cover is movably provided on one side of the square filter plate, and the sealing cover is locked to the filter box by a snap fastener.

[0012] It can be seen that the above technical solution is designed to facilitate the removal of the square filter plate.

[0013] Furthermore, the feed hopper is provided with a filter assembly, which includes a threaded sleeve, a circular filter plate, and a rotating sleeve.

[0014] Furthermore, the feed hopper is threadedly connected to the outer side of the threaded sleeve, and the top and bottom ends of the threaded sleeve are fixedly connected to the rotating sleeve and the circular filter plate, respectively.

[0015] The technical effects and advantages of this utility model are as follows: 1. This utility model uses a stepper motor to drive the extraction cylinder and the first vertical pipe to rotate, centrifugally extracting propafenone hydrochloride. The solution containing propafenone hydrochloride is located at the top of the waste liquid. A water pump draws the solution containing propafenone hydrochloride from the second vertical pipe through the first water pipe and injects it into the feed hopper through the second water pipe to extract the solution containing propafenone hydrochloride again. This cycle is repeated multiple times. The operation is simple and convenient for continuous extraction of propafenone hydrochloride. 2. This utility model can filter impurities generated during extraction using a square filter plate. Open the buckle and release the seal between the cover and the filter box, remove the square filter plate and clean and replace it. The circular filter plate can then filter impurities generated during extraction again. Rotate the rotating sleeve to move the threaded sleeve axially and move the circular filter plate away from the feed hopper for cleaning and replacement. The structure is simple and easy to use. Attached Figure Description

[0016] The structures, proportions, sizes, etc. illustrated in this specification are only for the purpose of assisting those skilled in the art in understanding and reading the content disclosed herein, and are not intended to limit the implementation conditions of this utility model. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportions, or adjustments to the size, without affecting the effects and objectives that this utility model can produce, should still fall within the scope of the technical content disclosed in this utility model.

[0017] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a bottom view of the overall structure of this utility model; Figure 3 This is a schematic diagram of the assembly structure of the material guiding component and the L-shaped plate of this utility model; Figure 4 This is a schematic diagram of the assembly structure of the extraction cylinder and rotating component of this utility model. Figure 5 This is a schematic diagram of the filter assembly structure of this utility model.

[0018] In the diagram: 1. Extraction cylinder; 2. First riser; 3. Feed guide assembly; 4. Support frame; 5. Rotating assembly; 6. Filter screen assembly; 7. L-shaped plate; 8. Sealing cover; 301. Filter box; 302. Second riser; 303. First valve; 304. First water pipe; 305. Second valve; 306. Water pump; 307. Second water pipe; 308. Square filter screen plate; 501. Stepper motor; 502. Gear rod; 503. Gear ring; 504. Third riser; 505. Feed hopper; 601. Threaded sleeve; 602. Circular filter screen plate; 603. Rotating sleeve. Detailed Implementation

[0019] The following specific embodiments illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0020] Refer to the instruction manual appendix Figure 1-5 This embodiment describes a continuous extraction apparatus for refining propafenone hydrochloride, comprising an extraction cylinder 1 and a first vertical pipe 2, with the top end of the first vertical pipe 2 fixedly connected to the extraction cylinder 1. A support frame 4 is movably mounted on the outer side of the extraction cylinder 1. A rotating assembly 5 is disposed between the extraction cylinder 1 and the support frame 4. The rotating assembly 5 includes a stepper motor 501, a gear rod 502, a gear ring 503, a third vertical pipe 504, and a feed hopper 505. A material guiding assembly 3 is disposed at the bottom of the first vertical pipe 2, and the material guiding assembly 3 includes a filter box 301, a second vertical pipe 302, and a third vertical pipe 504. The filter box 301 is connected to the first riser 2 via a bearing. The top of the second riser 302 is fixedly connected to the filter box 301. The first valve 303 is fixedly installed on the second riser 302. The second valve 305 is fixedly installed on the first water pipe 304. The water pump 306 is fixedly installed at the bottom of the support frame 4. The square filter plate 308 is movably disposed inside the filter box 301.

[0021] Furthermore, the two ends of the first water pipe 304 are fixedly connected to the second riser 302 and the water pump 306 respectively, the bottom end of the second water pipe 307 is fixedly connected to the output end of the water pump 306, and two L-shaped plates 7 are fixedly connected to the front and rear sides of the filter box 301, and the top ends of the multiple L-shaped plates 7 are fixedly connected to the support frame 4.

[0022] Furthermore, the stepper motor 501 is fixedly installed on the top of the support frame 4, and the output shaft end of the stepper motor 501 is fixedly connected to the gear rod 502. The gear rod 502 meshes with the gear ring 503, and the gear ring 503 is fixedly sleeved on the third vertical tube 504. The top and bottom ends of the third vertical tube 504 are fixedly connected to the feed hopper 505 and the extraction cylinder 1, respectively, and the third vertical tube 504 and the support frame 4 are movably connected through bearings.

[0023] Furthermore, a sealing cover 8 is movably provided on one side of the square filter plate 308, and the sealing cover 8 is locked to the filter box 301 by a snap fastener. A filter assembly 6 is provided on the feed hopper 505. The filter assembly 6 includes a threaded sleeve 601, a circular filter plate 602 and a rotating sleeve 603. The feed hopper 505 is threadedly connected to the outer side of the threaded sleeve 601. The top and bottom ends of the threaded sleeve 601 are fixedly connected to the rotating sleeve 603 and the circular filter plate 602, respectively.

[0024] The square filter plate 308 can filter the impurities generated during extraction. The buckle is opened and the sealing cover 8 is released from the filter box 301. The square filter plate 308 is taken out and cleaned and replaced. The circular filter plate 602 can filter the impurities generated during extraction again. The rotating sleeve 603 is rotated to drive the threaded sleeve 601 to move axially, and the circular filter plate 602 is moved away from the feed hopper 505. The circular filter plate 602 is then cleaned and replaced. The structure is simple and easy to use.

[0025] The usage method of this embodiment is as follows: In operation, propafenone hydrochloride raw material enters the extraction cylinder 1 through the feed hopper 505 and the third riser 504. The stepper motor 501 is started, driving the gear rod 502 to rotate, which in turn drives the gear ring 503 and the third riser 504 to rotate, thereby rotating the extraction cylinder 1 and the first riser 2. This centrifugal extraction of propafenone hydrochloride is performed, with the propafenone hydrochloride-containing solution located at the top of the waste liquid. The first valve 303 is opened and the second valve 305 is closed, allowing the waste liquid in the extraction cylinder 1 to be discharged through the second riser 302. The first valve 303 is then closed and the second valve 305 is opened. The water pump 306 is then started, drawing the propafenone hydrochloride-containing solution from the second riser 302 through the first water pipe 304 and injecting it into the feed hopper 505 through the second water pipe 307 for further extraction. This cycle is repeated multiple times, making the operation simple and convenient for continuous extraction of propafenone hydrochloride.

[0026] All contents not described in detail in the specification are existing technologies known to those skilled in the art, and the model parameters of each electrical appliance are not specifically limited; conventional equipment can be used. Electrical control components not mentioned in this technical solution are not shown in the figures because they are existing technologies, and will not be described here.

[0027] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A continuous extraction apparatus for the purification of propafenone hydrochloride, comprising an extraction cylinder (1) and a first vertical tube (2), wherein the top end of the first vertical tube (2) is fixedly connected to the extraction cylinder (1), characterized in that: A support frame (4) is movably mounted on the outside of the extraction cylinder (1). A rotating assembly (5) is provided between the extraction cylinder (1) and the support frame (4). The rotating assembly (5) includes a stepper motor (501), a gear rod (502), a gear ring (503), a third riser (504), and a feed hopper (505). A guide assembly (3) is provided at the bottom of the first riser (2). The guide assembly (3) includes a filter box (301), a second riser (302), a first valve (303), a first water pipe (304), a second valve (305), and a water pump ( 306), second water pipe (307) and square filter plate (308), the top of the filter box (301) is movably connected to the first riser (2) through a bearing, the top of the second riser (302) is fixedly connected to the filter box (301), the first valve (303) is fixedly installed on the second riser (302), the second valve (305) is fixedly installed on the first water pipe (304), the water pump (306) is fixedly installed at the bottom of the support frame (4), and the square filter plate (308) is movably arranged inside the filter box (301).

2. The continuous extraction apparatus for propafenone hydrochloride purification according to claim 1, characterized in that: The two ends of the first water pipe (304) are fixedly connected to the second riser (302) and the water pump (306) respectively, and the bottom end of the second water pipe (307) is fixedly connected to the output end of the water pump (306).

3. The continuous extraction apparatus for propafenone hydrochloride purification according to claim 1, characterized in that: The filter box (301) has two L-shaped plates (7) fixedly connected to both the front and rear sides, and the top of the multiple L-shaped plates (7) is fixedly connected to the support frame (4).

4. The continuous extraction apparatus for propafenone hydrochloride purification according to claim 1, characterized in that: The stepper motor (501) is fixedly installed on the top of the support frame (4), and the output shaft end of the stepper motor (501) is fixedly connected to the gear rod (502). The gear rod (502) meshes with the gear ring (503). The gear ring (503) is fixedly sleeved on the third vertical tube (504). The top and bottom ends of the third vertical tube (504) are fixedly connected to the feed hopper (505) and the extraction cylinder (1) respectively. The third vertical tube (504) and the support frame (4) are movably connected through bearings.

5. The continuous extraction apparatus for propafenone hydrochloride purification according to claim 1, characterized in that: A sealing cover (8) is movably provided on one side of the square filter plate (308), and the sealing cover (8) is locked to the filter box (301) by a snap fastener.

6. The continuous extraction apparatus for propafenone hydrochloride purification according to claim 1, characterized in that: The feed hopper (505) is provided with a filter assembly (6), which includes a threaded sleeve (601), a circular filter plate (602), and a rotating sleeve (603).

7. The continuous extraction apparatus for propafenone hydrochloride purification according to claim 1, characterized in that: The feed hopper (505) is threadedly connected to the outer side of the threaded sleeve (601), and the top and bottom ends of the threaded sleeve (601) are fixedly connected to the rotating sleeve (603) and the circular filter plate (602) respectively.

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