In-situ testing of fluid transport through membrane pores sealing device and system

Abstract

This invention discloses an in-situ testing fluid transmembrane pore transport sealing device and system. The device body has an inlet and an outlet, and an internal accommodating space for accommodating a sheet-like membrane. The device body also has an analytical substance transport channel. A transmembrane channel is provided in the accommodating space opposite the sheet-like membrane and the inlet and outlet, communicating with the inlet and outlet to form a transmembrane transport and separation pathway. An analytical substance flow channel is provided in the accommodating space opposite the sheet-like membrane and the analytical substance transport channel, communicating with the analytical substance transport channel to allow the analytical substance to enter. The analytical substance permeates through the portion of the sheet-like membrane located in the analytical substance flow channel to the portion located in the transmembrane channel, participating in transmembrane transport and separation. This invention enables the analytical substance to participate in transmembrane transport and separation, significantly expanding the applicability of the device and providing higher reliability and flexibility for liquid-gated in-situ testing applications.

Description

Technical Field

[0001] This utility model relates to the field of fluid transport control device design, and in particular to an in-situ test fluid transmembrane channel transport sealing device and system. Background Technology

[0002] Liquid gating technology, as an emerging membrane science-related technology, combines a gated liquid with a porous solid framework. It utilizes changes in the composition of the gated liquid to regulate fluid transport behavior and provides feedback on changes in the concentration of a substance or a specific component within the gated liquid based on the transport results. While this principle is theoretically feasible, in practical applications, device design needs to comprehensively consider key factors such as sealing, versatility, and ease of installation. Particularly in channel design, the interoperability between fluid channels and analyte channels must be strictly limited to achieve truly in-situ material testing. Utility Model Content

[0003] This invention addresses the technical problems existing in the prior art by providing an in-situ testing fluid transmembrane pore transport sealing device and system. It features excellent sealing performance, convenient disassembly, and strong versatility. By setting up an analytical substance transport channel, it directly enables the analytical substance to participate in transmembrane transport and separation, which significantly expands the applicability of the device and provides higher reliability and flexibility for liquid-gated in-situ testing applications.

[0004] The technical solution adopted by this utility model to solve its technical problem is: an in-situ testing fluid transmembrane pore channel sealing device, including a device body, the device body having an inlet and an outlet, and having a accommodating space for accommodating a sheet membrane; the device body also having an analytical substance delivery channel, the accommodating space having a transmembrane channel provided at the position opposite to the sheet membrane and the inlet and outlet, the transmembrane channel being connected to the inlet and outlet to form a transmembrane transport and separation pathway; the accommodating space having an analytical substance flow channel provided at the position opposite to the analytical substance delivery channel, the analytical substance flow channel being connected to the analytical substance delivery channel to allow analytical substances to enter, the analytical substances permeating through the portion of the sheet membrane located in the analytical substance flow channel to the portion of the sheet membrane located in the transmembrane channel to participate in transmembrane transport and separation.

[0005] Furthermore, a support sheet is provided in the accommodating space, and the sheet-like membrane is located on the side of the support sheet opposite to the output port; the support sheet is provided with a plurality of first fine holes corresponding to the transmembrane channel, and the support sheet is provided with a plurality of second fine holes corresponding to the analytical substance flow channel.

[0006] Furthermore, sealing rings are provided on both sides of the support piece, and the sealing rings on both sides abut against the inner wall of the accommodating space and the support piece, respectively.

[0007] Furthermore, the sealing ring includes a first sealing ring and a second sealing ring. The first sealing ring is disposed on the side of the support plate opposite to the inlet, and the first sealing ring is located on the periphery of the inlet. The second sealing ring is disposed on the side of the support plate opposite to the outlet, and the second sealing ring is located on the periphery of the outlet. The first sealing ring and the second sealing ring divide the accommodating space into the transmembrane channel located at the center and the analytical substance flow channel located on the periphery of the transmembrane channel.

[0008] Furthermore, the analytical substance delivery channel and the output port are located on the same side of the device body; the first sealing ring extends radially outward toward the support plate and covers the plurality of second fine holes; the sealing ring also includes a third sealing ring, which is located on the side of the support plate opposite to the output port and at the edge of the support plate.

[0009] Furthermore, the number of analytical substance delivery channels is two, one of which is for injecting analytical substances and the other is for excluding unpermeated analytical substances from flowing out.

[0010] Furthermore, the device body includes a pool body and a sealing cover. The pool body is provided with a protrusion and a groove. The sealing cover is detachably fixedly installed outside the protrusion and surrounds the groove to form the accommodating space. The pool body is provided with the inlet, and the sealing cover is provided with the outlet and the analytical substance delivery channel.

[0011] Furthermore, the sealing cap includes a cap body and a pressing block. The cap body is connected to the protrusion of the pool body to form an installation cavity. One end of the pressing block is located in the installation cavity and forms the receiving space with the groove. The other end of the pressing block extends out of the installation cavity. The pressing block is provided with the output port and the analytical substance delivery channel.

[0012] Furthermore, the device body is made of transparent material; the device body has an elastic buckle at the end where the input port is located.

[0013] This utility model also provides an in-situ test fluid transmembrane pore transport system, including a pressure supply unit and an in-situ test fluid transmembrane pore transport sealing device as described in any one of the above-mentioned methods, wherein the pressure supply unit is connected to the input port.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] 1. By setting up an analytical substance delivery channel, this utility model can directly realize the cross-membrane transport and separation of analytical substances, which can significantly expand the applicability of the device and provide higher reliability and flexibility for liquid-gated in-situ testing applications.

[0016] 2. The present invention is equipped with a support plate, which effectively avoids the problem of the sheet film being clamped too tightly or too loosely, resulting in better sealing reliability. Moreover, the accommodating space can be adapted to sheet films of different sizes, shapes and types, making it highly versatile.

[0017] 3. This utility model achieves the sealing of the device and the sealing between the transmembrane channel and the analytical substance flow channel through the first sealing ring, the second sealing ring, the third sealing ring, and the support plate. The structure is simple, the sealing performance is good, and the testing accuracy is high.

[0018] 4. The main body of the device of this utility model is made of transparent material. Through the transparent main body of the device, the operator can observe the transmembrane transport process of the fluid, thus achieving visualization.

[0019] 5. This utility model can realize the transport and separation of single-phase or multi-phase fluids with the same set of devices. It can complete transmembrane transport and separation in different phase channels such as gas, liquid, gas-liquid, and liquid-liquid. The device has strong versatility and greatly improves the efficiency of transport and separation.

[0020] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments; however, the in-situ test fluid transmembrane pore transport sealing device and system of the present invention is not limited to the embodiments. Attached Figure Description

[0021] Figure 1 This is an exploded schematic diagram of the in-situ test fluid transmembrane pore transport sealing device of this utility model;

[0022] Figure 2 This is a cross-sectional schematic diagram of the in-situ test fluid transmembrane pore transport sealing device of this utility model;

[0023] Figure 3 yes Figure 2 Enlarged view of point A;

[0024] Figure 4 This is a schematic diagram of the principle of the in-situ test fluid transmembrane pore transport sealing device of this utility model;

[0025] Figure 5 This is a schematic diagram of the working principle of the in-situ testing fluid transmembrane pore transport system of this utility model;

[0026] In the diagram: 1. Pool body; 11. Inlet; 12. Accommodation space; 121. Transmembrane channel; 122. Analytical substance flow channel; 13. Protrusion; 14. Groove; 15. Mounting cavity; 16. Elastic buckle; 2. Cover; 3. Clamping block; 31. Outlet; 32. Analytical substance delivery channel; 4. Support plate; 41. First fine hole; 42. Second fine hole; 5. First sealing ring; 6. Second sealing ring; 7. Third sealing ring; 81. Analytical substance delivery pipe; 82. Outlet pipe; 9. Sheet membrane; 10. Pressure supply unit; 20. Sealing device; 30. Pressure supply pipeline; 40. Pressure sensing module; 50. Intelligent control system; 60. Solenoid valve; 70. In-situ test pipeline. Detailed Implementation

[0027] In this invention, the terms "first," "second," etc., are used only to distinguish similar objects, not to describe a specific order or sequence, nor should they be construed as indicating or implying relative importance. Furthermore, in the description of this invention, unless otherwise stated, "multiple" refers to two or more.

[0028] like Figures 1-4 As shown, this utility model discloses an in-situ testing fluid transmembrane pore transport sealing device, comprising a device body with an inlet 11 and an outlet 31, and an accommodating space 12 for accommodating a sheet-like membrane 9. The device body also includes an analytical substance transport channel 32. A transmembrane channel 121 is provided in the accommodating space 12 at the location opposite the sheet-like membrane 9 to the inlet 11 and outlet 31. The transmembrane channel 121 communicates with the inlet 11 and outlet 31 to form a transmembrane transport and separation pathway. An analytical substance flow channel 122 is provided in the accommodating space 12 at the location opposite the sheet-like membrane 9 to the analytical substance transport channel 32. The analytical substance flow channel 122 communicates with the analytical substance transport channel 32 to allow analytical substances to enter. The analytical substance permeates through the portion of the sheet-like membrane 9 located in the analytical substance flow channel 122 to the portion of the sheet-like membrane 9 located in the transmembrane channel 121, participating in transmembrane transport and separation.

[0029] A support sheet 4 is provided in the accommodating space 12, and the sheet membrane 9 is located on the side of the support sheet 4 opposite to the output port 31. The support sheet 4 is provided with a plurality of first fine holes 41 corresponding to the transmembrane channel 121, and the support sheet 4 is provided with a plurality of second fine holes 42 corresponding to the analytical substance flow channel 122.

[0030] The support plate 4 is provided with sealing rings on both sides, and the sealing rings on both sides abut against the inner wall of the accommodating space 12 and the support plate 4 respectively.

[0031] Specifically, the sealing ring includes a first sealing ring 5 and a second sealing ring 6. The first sealing ring 5 is disposed on the side of the support plate 4 opposite to the inlet 11, and the first sealing ring 5 is located on the periphery of the inlet 11. The second sealing ring 6 is disposed on the side of the support plate 4 opposite to the outlet 31, and the second sealing ring 6 is located on the periphery of the outlet 31. The first sealing ring 5 and the second sealing ring 6 divide the accommodating space 12 into the transmembrane channel 121 located in the center and the analytical substance flow channel 122 located on the periphery of the transmembrane channel 121.

[0032] The analytical substance delivery channel 32 and the output port 31 are located on the same side of the device body. The first sealing ring 5 extends radially outward toward the support plate 4 and covers the plurality of second fine holes 42, which facilitate easier penetration of the analytical substance into the sheet membrane 9. The sealing ring also includes a third sealing ring 7, which is located on the side of the support plate 4 opposite to the output port 31 and at the edge of the support plate 4.

[0033] The number of analytical substance delivery channels 32 is two. One analytical substance delivery channel 32 is for injecting analytical substances, and the other analytical substance delivery channel 32 is for outflow of unpermeated analytical substances. However, it is not limited to this and multiple channels can be designed by relying on microfluidic technology.

[0034] The device body includes a pool body 1 and a sealing cover. The pool body 1 is provided with a protrusion 13 and a groove 14. The sealing cover is detachably fixedly covered outside the protrusion 13 and surrounds the groove 14 to form the accommodating space 12. The pool body 1 is provided with the inlet 11, and the sealing cover is provided with the outlet 31 and the analytical substance delivery channel 32.

[0035] Specifically, the sealing cover includes a cover body 2 and a pressing block 3. The cover body 2 is connected to the protrusion 13 of the pool body 1 to form an installation cavity 15. One end of the pressing block 3 is located inside the installation cavity 15 and is surrounded by the groove 14 to form the accommodating space 12. The sealing between the pressing block 3 and the pool body 1, i.e., the sealing of the accommodating space 12, is achieved by the third sealing ring 7. The other end of the pressing block 3 extends out of the installation cavity 15. The pressing block 3 is provided with an output port 31 and an analytical substance delivery channel 32. The output port 31 is connected to an output pipe 82, and the analytical substance delivery channel 32 is connected to an analytical substance delivery pipe 81.

[0036] The materials of the first sealing ring 5, the second sealing ring 6, and the third sealing ring 7 include elastic materials such as silicone, rubber, urethane, and Parafilm. The connection method between the pool body 1 and the sealing cover includes threaded connection, snap-fit ​​connection, and screw fixing. In this embodiment, the pool body 1 and the sealing cover are connected by a threaded connection.

[0037] The main body of the device is made of transparent material. The main body of the device has an elastic buckle 16 at the end where the input port 11 is located, that is, the pool body 1 has an elastic buckle 16.

[0038] like Figure 2 , Figure 3 As shown, the clamping block 3 has an output port 31 in the middle and analytical substance delivery channels 32 on both sides. The first sealing ring 5, the second sealing ring 6, the third sealing ring 7, and the support plate 4 are installed in the accommodating space 12, dividing the accommodating space 12 into a transmembrane channel 121 and an analytical substance flow channel 122. Figure 4 As shown, the analytical substance delivery channel 32, the analytical substance flow channel 122, and the sheet membrane 9 form a channel for the analytical substance to participate in transmembrane transport and separation. The analytical substance is injected from one of the analytical substance delivery channels 32, passes through the analytical substance flow channel 122, and flows out from the other analytical substance delivery channel 32 (e.g., Figure 4 (As shown by the large arrow in the solid line). During the flow of the analyte, it slowly permeates from the periphery to the middle of the sheet membrane 9 through capillary action (e.g., ...). Figure 4 (As shown by the small arrow in the solid line), and exists on the sheet-like membrane 9, when fluids undergo transmembrane transport and separation (such as...). Figure 4 The large dashed arrow in the middle indicates the direction of fluid transport across the membrane. It will react with the analyte that has already penetrated into the middle part, thus affecting the result of transmembrane transport.

[0039] Before the instrument starts working, first place the first sealing ring 5 and the support plate 4 into the accommodating space 12 in sequence. Then, place the impregnated sheet membrane 9 on the support plate 4, followed by the third sealing ring 7, the second sealing ring 6, and the clamping block 3 in sequence. Finally, tighten the cover 2 to the pool body 1 using the threaded structure to seal the accommodating space 12. When the analyte needs to participate in transmembrane transport separation, one of the analyte delivery channels 32 can be opened. After injecting the analyte, the channel is closed. The analyte permeates through the portion of the sheet membrane 9 located in the analyte flow channel 122 to the portion of the sheet membrane 9 located in the transmembrane channel 121 (i.e., slowly permeates from the periphery of the sheet membrane 9 to the middle part of the sheet membrane 9) to participate in transmembrane transport separation. After transmembrane separation, the analyte that has permeated to the middle part of the sheet membrane 9 will flow out from the output port 31, while the analyte that has not permeated will flow out from the other analyte delivery channel 32. When replacing the sheet membrane 9, simply open the cover 2 by rotating the thread, remove the clamping block 3, the second sealing ring 6, and the third sealing ring 7 in sequence, replace the membrane, reinstall the cover 2, and then test again.

[0040] Please see Figure 5 As shown, the present invention provides an in-situ test fluid transmembrane pore transport system, which includes a pressure supply unit 10 and an in-situ test fluid transmembrane pore transport sealing device 20. The pressure supply unit 10 is connected to the input port 11 of the sealing device 20.

[0041] The pressure supply unit 10 provides pressure, which can be achieved through a syringe pump, peristaltic pump, pneumatic storage, or other methods. The pressure supply unit 10 can provide one or more pressure supply lines 30 to drive single-phase or multi-phase fluids such as gas, liquid, gas-liquid, or liquid-liquid into the in-situ test line 70, and finally achieve cross-membrane pore separation and transport of the single-phase or multi-phase fluid through the sealing device 20. The in-situ test fluid cross-membrane pore transport system also includes a pressure sensing module 40, an intelligent control system 50, and a solenoid valve 60. The pressure sensing module 40 is connected to the pressure supply line 30 and can acquire pressure data in the line in real time, reporting the data to the intelligent control system 50. Simultaneously, the solenoid valve 60 is installed in the in-situ test line 70, and the intelligent control system 50 can control the opening and closing of the pressure sensing module 40 and the in-situ test line 70 by controlling the opening and closing of the solenoid valve 60. This sealing device 20 has strong versatility. It can be used for transmembrane channel transport and separation in various phase testing pathways, including gas, liquid, gas-liquid mixtures, and liquid-liquid mixtures. It is convenient and quick to use. When transporting liquids across the membrane channel, a liquid pool can be installed on the pressure supply line 30, or liquid can be supplied by injecting liquid between the pressure supply units 10.

[0042] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Although the present utility model has been disclosed above with reference to preferred embodiments, it is not intended to limit the present utility model. Any person skilled in the art can make many possible variations and modifications to the technical solution of the present utility model, or modify it into equivalent embodiments, based on the disclosed technical content, without departing from the scope of the technical solution of the present utility model. Therefore, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the content of the technical solution of the present utility model should fall within the protection scope of the technical solution of the present utility model.

Claims

1. An in-situ testing fluid transmembrane channel transport sealing device, comprising a device body, the device body is provided with an input port and an output port, and a containing space for containing a sheet-shaped membrane is arranged in the device body; characterized in that: The device body is also provided with an analytical substance delivery channel. The accommodating space is provided with a transmembrane channel at the position opposite to the sheet membrane and the input port and the output port. The transmembrane channel is connected to the input port and the output port to form a transmembrane transport separation pathway. The containment space is provided with an analytical substance flow channel at the position opposite to the analytical substance delivery channel of the sheet membrane. The analytical substance flow channel is connected to the analytical substance delivery channel to allow the analytical substance to enter. The analytical substance permeates through the portion of the sheet membrane located in the analytical substance flow channel to the portion of the sheet membrane located in the transmembrane channel to participate in transmembrane transport and separation.

2. The in-situ test fluid transmembrane pore transport sealing device according to claim 1, characterized in that: A support sheet is provided in the accommodating space, and the sheet-like membrane is located on the side of the support sheet opposite to the output port; the support sheet is provided with a plurality of first fine holes corresponding to the transmembrane channel, and the support sheet is provided with a plurality of second fine holes corresponding to the analytical substance flow channel.

3. The in-situ test fluid transmembrane pore transport sealing device according to claim 2, characterized in that: The support plate is provided with sealing rings on both sides, and the sealing rings on both sides abut against the inner wall of the accommodating space and the support plate, respectively.

4. The in-situ test fluid transmembrane pore transport sealing device according to claim 3, characterized in that: The sealing ring includes a first sealing ring and a second sealing ring. The first sealing ring is disposed on the side of the support plate opposite to the inlet and is located on the periphery of the inlet. The second sealing ring is disposed on the side of the support plate opposite to the outlet and is located on the periphery of the outlet. The first sealing ring and the second sealing ring divide the accommodating space into the transmembrane channel located in the center and the analytical substance flow channel located on the periphery of the transmembrane channel.

5. The in-situ test fluid transmembrane pore transport sealing device according to claim 4, characterized in that: The analytical substance delivery channel and the output port are located on the same side of the device body; the first sealing ring extends radially outward toward the support plate and covers the plurality of second fine holes; the sealing ring also includes a third sealing ring, which is located on the side of the support plate opposite to the output port and at the edge of the support plate.

6. The in-situ test fluid transmembrane pore transport sealing device according to claim 1, characterized in that: The analytical substance delivery channel has two channels, one for injecting analytical substance and the other for excluding impregnated analytical substance.

7. The in-situ test fluid transmembrane pore transport sealing device according to any one of claims 1-6, characterized in that: The device body includes a pool and a sealing cover. The pool has a protrusion and a groove. The sealing cover is detachably fixed to cover the protrusion and encloses the groove to form the accommodating space. The pool has the inlet and the sealing cover has the outlet and the analytical substance delivery channel.

8. The in-situ test fluid transmembrane pore transport sealing device according to claim 7, characterized in that: The sealing cap includes a cap body and a clamping block. The cap body is connected to the protrusion of the pool body to form an installation cavity. One end of the clamping block is located in the installation cavity and is enclosed by the groove to form the receiving space. The other end of the clamping block extends out of the installation cavity. The clamping block is provided with the output port and the analytical substance delivery channel.

9. The in-situ test fluid transmembrane pore transport sealing device according to claim 1, characterized in that: The device body is made of transparent material; the device body has an elastic buckle at the end where the input port is located.

10. An in-situ test fluid transmembrane pore transport system, comprising a pressure supply unit, characterized in that: It also includes an in-situ test fluid transmembrane pore transport sealing device as described in any one of claims 1-9, wherein the pressure supply unit is connected to the inlet.

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