An ultrafiltration device for external phase liquid displacement of phospholipid spheres
By introducing mixing components and stirring blades into the ultrafiltration device, the problem of slow liquid mixing speed is solved, achieving rapid mixing and efficient filtration, and improving the efficiency of external phase liquid replacement of phospholipid spheres.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- CHANGZHOU WUHE BIOMEDICAL CO LTD
- Filing Date
- 2025-08-18
- Publication Date
- 2026-07-31
AI Technical Summary
The existing equipment has a slow mixing speed between the filtered liquid and the raw material liquid, resulting in long mixing time and poor mixing effect, which in turn affects the efficiency of subsequent filtration and extraction.
It adopts a mixing component and stirring blade structure, and the stirring blade is driven by a motor to stir the liquid. During the mixing process, the liquid is filtered by a filter screen, so as to achieve the initial mixing and rapid stirring of the liquid and raw materials.
It improves the speed and effectiveness of liquid mixing, shortens mixing time, and enhances the efficiency of subsequent filtration and extraction.
Smart Images
Figure CN224573636U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of ultrafiltration equipment technology, and in particular to an ultrafiltration device for external phase liquid displacement of phospholipid spheres. Background Technology
[0002] Currently, this device utilizes membrane separation technology to selectively retain phospholipid spheres while allowing the external phase solution to pass through the filter membrane, achieving efficient replacement and purification of the external phase liquid. Its dynamic circulation process can continuously remove the original solvent while replenishing the target buffer or aqueous phase, thereby completing the precise replacement of the external phase medium of the phospholipid carrier under mild conditions, while maintaining the integrity of the phospholipid structure. It is suitable for the preparation and purification processes of drug delivery systems such as liposomes and nanoparticles.
[0003] Existing equipment typically consists of a feed pipe, mixing tank, conveying pipe, filter box, filter screen, and circulation pipe. The liquid raw material is introduced into the mixing tank through the feed pipe, and the liquid in the mixing tank is transported to the filter box through the conveying pipe. The liquid is filtered by the filter screen in the filter box, and the filtered liquid is transported back to the mixing tank through the circulation pipe, so that the filtered liquid and the raw material are mixed. The required buffer liquid is obtained through continuous circulation and filtration.
[0004] However, during use, after the filtered liquid is transported to the mixing tank through the circulation pipe, the filtered liquid in the tank and the raw material liquid in the mixing tank are mixed. However, the mixing speed of the liquid in the mixing tank is slow, resulting in a long mixing time and poor mixing effect, which leads to low subsequent filtration and extraction efficiency. To solve the above problems, an ultrafiltration device for external phase liquid replacement of phospholipid molecular spheres is proposed. Utility Model Content
[0005] To overcome the above shortcomings, this utility model provides an ultrafiltration device for external phase liquid replacement of phospholipid spheres, aiming to improve the problem in the prior art where existing equipment relies on mixing the filtered liquid and the raw material liquid, but the mixing speed in the mixing tank is slow, resulting in long mixing time and poor mixing effect, thus leading to low subsequent filtration and extraction efficiency.
[0006] To achieve the above objectives, the present invention adopts the following technical solution: An ultrafiltration device for external phase liquid displacement of phospholipid spheres includes a mixing tank. A feed pipe is fixedly connected to the top of the mixing tank, a connecting pipe is fixedly connected to the middle of the feed pipe, and a circulation pipe is fixedly connected to the other end of the connecting pipe. A mixing assembly is installed at the other end of the circulation pipe, and the outer side of the mixing assembly is installed on the outside of the mixing tank. The mixing assembly includes a connecting cover, which is fixedly connected to the end of the circulation pipe. A housing is fixedly connected to the top of the connecting cover, and a mixing chamber is opened inside the housing. A guide vane is fixedly connected inside the housing, and an input pipe is fixedly connected to the other end of the housing. The input pipe is fixedly connected to the outside of the mixing tank.
[0007] The above technical solution enables preliminary mixing of the filtered liquid and the raw material liquid, making subsequent mixing more convenient and improving the mixing effect.
[0008] Preferably, a sealing block is fixedly connected to the bottom of the mixing tank, a motor is fixedly connected to the outer side of the sealing block, a rotating shaft is fixedly connected to the output end of the motor, a connecting plate is fixedly connected to the end of the rotating shaft, and a stirring blade is fixedly connected to the middle of the connecting plate.
[0009] The above technical solution uses a motor to power the rotating shaft and connecting plate, which in turn drives the stirring blades to rotate, thus stirring the liquid inside the mixing tank. This ensures thorough mixing of the liquid and improves the subsequent filtration and extraction efficiency of the mixed liquid.
[0010] Preferably, a filter box is fixedly connected to the end of the circulation pipe, and a filter screen is fixedly connected to the inner side of the filter box.
[0011] The above technical solution uses a filter screen and a filter box to work together to filter the mixed liquid, thereby extracting the desired liquid.
[0012] Preferably, a conveying pipe is fixedly connected to the bottom of the filter box, and the other end of the conveying pipe is fixedly connected to the bottom of the mixing tank.
[0013] The above technical solution enables the mixed liquid in the mixing tank to be transported to the filter box column for filtration, thereby achieving the extraction of the desired liquid.
[0014] Preferably, a feeder is fixedly connected to the end of the feed pipe.
[0015] The above technical solution allows for the addition of raw material liquid to the feed pipe via a feeder.
[0016] Preferably, the mixing tank has a stirring chamber inside, the stirring blade is located inside the stirring chamber, and the connection between the input pipe and the mixing tank is located above the stirring blade.
[0017] The above technical solution allows the initially mixed liquid to come into contact with the stirring blades more quickly, thus enabling the liquid to mix faster.
[0018] Preferably, a diversion chamber is provided in the middle of the filter box, and a discharge pipe is fixedly connected to the outside of the filter box.
[0019] The above technical solution enables the separation of the filtered substance from the desired liquid, and the discharge of the separated substance.
[0020] Preferably, a support frame is fixedly connected to the bottom of the mixing tank, and a bracket is fixedly connected to the bottom of the filter box.
[0021] The above technical solutions enable the mixing tank and filter box to operate stably, thus allowing the equipment to reliably filter and extract the required liquid.
[0022] This utility model has the following beneficial effects: 1. In this utility model, the filtered liquid and raw material are initially mixed through the mixing chamber and guide plate in the outer shell, thereby improving the mixing effect, shortening the subsequent mixing time, and allowing the filtered liquid to be fully mixed with the raw material liquid, thereby improving the subsequent filtration and extraction effect.
[0023] 2. In this utility model, the motor and the mixing tank are connected by a sealing block, so that the motor can stably provide power to drive the rotating shaft to rotate. The rotation of the rotating shaft drives the connecting plate and the stirring blade to rotate in the stirring chamber, so that the filtered liquid and the raw material liquid can be fully mixed, thereby improving the subsequent filtration and extraction effect. Attached Figure Description
[0024] Figure 1 This is a three-dimensional schematic diagram of an ultrafiltration device for external phase liquid displacement of phospholipid spheres proposed in this utility model; Figure 2 This is a schematic diagram of the mixing tank of an ultrafiltration device for external phase liquid displacement of phospholipid spheres proposed in this utility model; Figure 3 This is a schematic diagram of the flow guide plate of an ultrafiltration device for external phase liquid displacement of phospholipid spheres proposed in this utility model; Figure 4 This is a schematic diagram of the stirring blade of an ultrafiltration device for external phase liquid displacement of phospholipid spheres proposed in this utility model; Figure 5 This is a schematic diagram of the structure of the filter screen of an ultrafiltration device for external phase liquid displacement of phospholipid spheres proposed in this utility model; Explanation of reference numerals in the attached drawings: 1. Mixing tank; 2. Feed pipe; 3. Feeder; 4. Conveying pipe; 5. Filter box; 6. Discharge pipe; 7. Filter screen; 8. Circulation pipe; 9. Connecting pipe; 10. Connecting cover; 11. Outer shell; 12. Guide vane; 13. Mixing chamber; 14. Input pipe; 15. Motor; 16. Sealing block; 17. Rotating shaft; 18. Connecting plate; 19. Stirring blade; 20. Stirring chamber; 21. Diverting chamber; 22. Support frame; 23. Bracket. Detailed Implementation
[0025] The following is in conjunction with the appendix Figure 1 - Appendix Figure 5 This application will be described in further detail below.
[0026] Reference Figures 1-4 This utility model provides an embodiment of an ultrafiltration device for external phase liquid displacement of phospholipid spheres, comprising a mixing tank 1. A feed pipe 2 is fixedly connected to the top of the mixing tank 1, allowing raw materials to be input and processed within the mixing tank 1. A connecting pipe 9 is fixedly connected to the middle of the feed pipe 2, and a circulation pipe 8 is fixedly connected to the other end of the connecting pipe 9. A mixing assembly is installed at the other end of the circulation pipe 8, allowing the raw materials to be transported to the circulation pipe 8 via the connecting pipe 9. This mixes the filtered buffer liquid with the raw materials and transports them to the mixing assembly, where the mixing assembly ensures thorough mixing of the raw materials and the buffer liquid, thereby improving the mixing effect. The mixing assembly is installed on the outside of the mixing tank 1 and includes a connecting cover 10 fixedly connected to the end of the circulation pipe 8. A housing 11 is fixedly connected to the top of the connecting cover 10. The mixing chamber 13 is internally connected to the outer casing 11 via a connecting cover 10 and a circulation pipe 8, thus forming a whole. This allows the raw material and buffer liquid to enter the mixing chamber 13 inside the outer casing 11 for mixing. A guide vane 12 is fixedly connected inside the outer casing 11, and an input pipe 14 is fixedly connected to the other end of the outer casing 11. The input pipe 14 is fixedly connected to the outside of the mixing tank 1. The guide vane 12 allows the raw material and buffer liquid to rotate multiple times in different directions within the mixing chamber 13, thereby mixing the raw material and buffer liquid. The mixed liquid is then input into the mixing tank 1 via the input pipe 14 for further mixing, facilitating subsequent processing. Through the cooperation between the various structures of the mixing component, the raw material and the filtered buffer liquid are initially mixed, facilitating further mixing in the future.
[0027] Reference Figures 1-5 A sealing block 16 is fixedly connected to the bottom of the mixing tank 1. A motor 15 is fixedly connected to the outside of the sealing block 16. A rotating shaft 17 is fixedly connected to the output end of the motor 15. A connecting plate 18 is fixedly connected to the end of the rotating shaft 17. A stirring blade 19 is fixedly connected to the middle of the connecting plate 18. The sealing block 16 seals the connection between the motor 15 and the mixing tank 1, preventing leakage of the liquid inside the mixing tank 1. The mixing tank 1 provides support for the motor 15, allowing it to operate stably. The motor 15 provides power to drive the rotating shaft 17 to rotate, which in turn drives the connecting plate 18 and the stirring blade 19 to rotate, thus stirring the liquid inside the mixing tank 1. This ensures that the raw materials and liquids inside the mixing tank 1 are mixed evenly. The filtrate is thoroughly mixed to facilitate subsequent processing. A filter box 5 is fixedly connected to the end of the circulation pipe 8, and a filter screen 7 is fixedly connected to the inside of the filter box 5. A conveying pipe 4 is fixedly connected to the bottom of the filter box 5, and the other end of the conveying pipe 4 is fixedly connected to the bottom of the mixing tank 1. The liquid mixed inside the mixing tank 1 is conveyed to the filter box 5 by the conveying pipe 4. The filter screen 7 in the filter box 5 filters the mixed liquid, thereby achieving the filtration treatment of the mixed liquid. The filtered liquid is conveyed to the mixing tank 1 by the circulation pipe 8, thereby achieving the circulation filtration of the liquid and improving the purity of the liquid. A feeder 3 is fixedly connected to the end of the feed pipe 2, and raw materials are added to the feed pipe 2 through the feeder 3. The mixing tank 1 has an internal stirring chamber 20, with stirring blades 19 located inside. The connection between the input pipe 14 and the mixing tank 1 is located above the stirring blades 19. Through the stirring chamber 20, the stirring blades 19 can better stir the liquid to be mixed, thus ensuring thorough mixing. The filter box 5 has a flow divider 21 in the middle, and a discharge pipe 6 is fixedly connected to the outside of the filter box 5. The flow divider 21 separates the filtered liquid from the filtered material, and the discharge pipe 6 discharges the filtered material. The bottom of the mixing tank 1 is fixedly connected to a support frame 22, and the bottom of the filter box 5 is fixedly connected to a bracket 23. The support frame 22 provides stable support for the mixing tank 1, allowing it to operate stably, and the bracket 23 provides support for the filter box 5, ensuring stable operation and better filtration of the liquid to be filtered.
[0028] The implementation principle of this application embodiment is as follows: During use, the feeder 3 and the feed pipe 2 cooperate to adjust the liquid to be mixed in the stirring chamber 20 of the mixing tank 1. The motor 15 provides power to drive the rotating shaft 17 to rotate, which in turn drives the connecting plate 18 to rotate, which in turn drives the stirring blade 19 to rotate, thereby stirring the liquid inside the stirring chamber 20 and ensuring thorough mixing. The mixed liquid is then transported to the diversion chamber 21 in the filter box 5 by the conveying pipe 4 at the bottom of the mixing tank 1. The mixed liquid is then filtered by the filter screen 7 in the filter box 5, and the filtered material is discharged through the discharge outlet. The filtered liquid is discharged through pipe 6 and transported to the mixing chamber 13 in the outer shell 11 by circulation pipe 8. At the same time, the raw material in feed pipe 2 is transported to circulation pipe 8 by connecting pipe 9, so that the filtered buffer liquid and raw material enter the mixing chamber 13 in the outer shell 11 at the same time. The guide vanes 12 in the mixing chamber 13 allow the buffer liquid and raw material to be initially mixed. The mixed liquid is transported to the mixing tank 1 by input pipe 14 at the bottom of the outer shell 11 to achieve further mixing of the liquid. At the same time, the liquid can be circulated and filtered for mixing, so that the external aqueous phase of the resin double separator is transformed from water into the required buffer liquid.
Claims
1. An ultrafiltration device for extragranular phase liquid displacement of phospholipid molecules, comprising a mixing vat (1), characterized in that: The top of the mixing tank (1) is fixedly connected to a feed pipe (2), the middle part of the feed pipe (2) is fixedly connected to a connecting pipe (9), the other end of the connecting pipe (9) is fixedly connected to a circulation pipe (8), the other end of the circulation pipe (8) is equipped with a mixing component, and the outside of the mixing component is installed on the outside of the mixing tank (1). The mixing assembly includes a connecting cover (10), which is fixedly connected to the end of the circulation pipe (8). A housing (11) is fixedly connected to the top of the connecting cover (10). A mixing chamber (13) is opened inside the housing (11). A guide plate (12) is fixedly connected inside the housing (11). An input pipe (14) is fixedly connected to the other end of the housing (11). The input pipe (14) is fixedly connected to the outside of the mixing tank (1).
2. The ultrafiltration device for external phase liquid displacement of phospholipid spheres according to claim 1, characterized in that: A sealing block (16) is fixedly connected to the bottom of the mixing tank (1), a motor (15) is fixedly connected to the outside of the sealing block (16), a rotating shaft (17) is fixedly connected to the output end of the motor (15), a connecting plate (18) is fixedly connected to the end of the rotating shaft (17), and a stirring blade (19) is fixedly connected to the middle of the connecting plate (18).
3. The ultrafiltration device for external phase liquid displacement of phospholipid spheres according to claim 1, characterized in that: A filter box (5) is fixedly connected to the end of the circulation pipe (8), and a filter screen (7) is fixedly connected to the inside of the filter box (5).
4. The ultrafiltration device for external phase liquid displacement of phospholipid spheres according to claim 3, characterized in that: The bottom of the filter box (5) is fixedly connected to a conveying pipe (4), and the other end of the conveying pipe (4) is fixedly connected to the bottom of the mixing tank (1).
5. The ultrafiltration device for external phase liquid displacement of phospholipid spheres according to claim 1, characterized in that: The feed pipe (2) is fixedly connected to a feeder (3) at its end.
6. The ultrafiltration device for external phase liquid displacement of phospholipid spheres according to claim 2, characterized in that: The mixing tank (1) has a stirring chamber (20) inside, the stirring blade (19) is located inside the stirring chamber (20), and the connection between the input pipe (14) and the mixing tank (1) is located above the stirring blade (19).
7. An ultrafiltration device for external phase liquid displacement of phospholipid spheres according to claim 3, characterized in that: A diversion chamber (21) is provided in the middle of the filter box (5), and a discharge pipe (6) is fixedly connected to the outside of the filter box (5).
8. An ultrafiltration device for external phase liquid displacement of phospholipid spheres according to claim 3, characterized in that: The bottom of the mixing tank (1) is fixedly connected to a support frame (22), and the bottom of the filter box (5) is fixedly connected to a bracket (23).