Medicament mixing device

Abstract

This application discloses a pharmaceutical mixing device, belonging to the field of pharmaceuticals and medical devices. The device includes a mixing section having a first receiving section for accommodating a first container, a second receiving section for accommodating a second container, an isolation section, and a puncture needle. The puncture needle passes through the isolation section, with needle tubes at both ends located within the first and second receiving sections, respectively, for puncturing the first and second containers to connect them and allow the liquid contained in the first container to flow into the second container, resulting in a mixed pharmaceutical solution. Both the first and second receiving sections have a second window that exposes a portion of the container body, allowing the operator to observe the contents of the container. The technical solution provided by this application reduces the number of preparation operations during pharmaceutical mixing, lowers the risk of needle pricks, and prevents accidental use of contaminated pharmaceuticals due to loss of vacuum in the container.

Description

Technical Field

[0001] This application relates to the fields of pharmaceutical and medical device technology, and in particular to a pharmaceutical mixing device. Background Technology

[0002] In the field of biopharmaceuticals, most products are sterile lyophilized formulations. These products need to be dissolved before use. However, biopharmaceuticals such as fibrin adhesives require both components to be dissolved and mixed before use.

[0003] In related technologies, sterile lyophilized formulations are vacuum-sealed in vials, and the reconstituted solution of the sterile lyophilized formulation is sealed in another vial. During the preparation of fibrin adhesive, the operator needs to disassemble a set of injection needles and syringes, assemble the injection needles and syringes, insert the syringe with the needle into the vial containing the reconstituted solution to draw the reconstituted solution from the vial into the syringe, and then insert the needle of the syringe containing the reconstituted solution into the vial containing the sterile lyophilized formulation and push the reconstituted solution into the vial to dissolve the sterile lyophilized formulation, thereby obtaining a dissolved lyophilized formulation of one component.

[0004] Because the preparation of fibrin adhesive requires mixing two components of a lyophilized solution, the operator needs to perform at least one more step to obtain the other component. Following this procedure, medical personnel need to use at least two sets of syringes and needles, performing at least two aspiration operations and at least two injection operations to prepare the two components of the lyophilized solution for the fibrin adhesive.

[0005] The above preparation process involves repeated aspiration and injection, resulting in slow work efficiency, consuming a significant amount of surgical time, and the exposed use of injection needles poses a risk of needlestick injury to operators. It also causes considerable inconvenience for the clinical preparation and use of products such as fibrin adhesives. Furthermore, the excessive use of syringes and needles leads to inconvenience and resource waste in the disposal of used medical devices, and is environmentally unfriendly. Additionally, it is difficult for users to detect when the vacuum seal of the vials containing sterile lyophilized preparations is broken, potentially leading to the accidental use of contaminated sterile lyophilized preparations. Utility Model Content

[0006] This application provides a pharmaceutical mixing device that can reduce the number of preparation operations during the pharmaceutical mixing process, reduce the risk of needle pricks, and prevent the accidental use of contaminated pharmaceuticals due to loss of vacuum in the container.

[0007] According to one aspect of the embodiments of this application, a pharmaceutical mixing device is provided, wherein the pharmaceutical mixing device is connected to a first container and a second container during use, and the pharmaceutical mixing device includes:

[0008] The drug mixing section has a first storage section, a second storage section, an isolation section, and a puncture needle;

[0009] The isolation section is located between the first storage section and the second storage section, and the isolation section has a first side facing the first container and a second side facing the second container;

[0010] The puncture needle is disposed through the isolation portion, and the puncture needle has a first needle tube portion protruding towards the first surface and a second needle tube portion protruding towards the second surface; the first needle tube portion is used to puncture the seal of the first container, and the second needle tube portion is used to puncture the seal of the second container.

[0011] The first receiving portion has a first housing surrounding the first needle portion, the first needle portion being exposed within the first receiving portion; the end of the first housing away from the first surface has a first inlet for inserting the first container into the first receiving portion along a first direction; the first housing has a first window on a first side to expose a portion of the bottle body of the first container.

[0012] The second receiving portion has a second housing surrounding the second needle portion, the second needle portion being exposed within the second receiving portion, and a second inlet portion at one end of the second housing away from the second surface for inserting the second container into the second receiving portion in a second direction; the second housing has a second window on the first side to expose a portion of the bottle body of the second container, the first direction being opposite to the second direction.

[0013] In an exemplary embodiment, the isolation portion has a retrieval slot on the first side, the slot opening of the retrieval slot forms a retrieval opening, and at least one of the first window and the second window is continuously connected to the retrieval opening to expose a portion of the end face of at least one of the first container and the second container.

[0014] In an exemplary embodiment, the first window and the second window at least partially overlap in the axial direction of the puncture needle.

[0015] In an exemplary embodiment, the first housing has a first bend, and / or the second housing has a second bend;

[0016] The first bent portion protrudes inward toward the first storage portion and forms a first protrusion on the inner wall of the first housing. The first protrusion has a first inner edge near the first surface. When in use, the first inner edge engages with the first container to restrict the first container from moving in the second direction.

[0017] The first bending portion is recessed into the outer wall of the first housing to form a first groove towards the inner side of the first receiving portion; the first housing has a first wing portion located on the side of the first groove away from the first surface, and the first wing portion elastically expands outward when the first container is inserted;

[0018] The second bent portion protrudes inward toward the second storage portion and forms a second protrusion on the inner wall of the second housing. The second protrusion has a second inner edge near the second surface. The second inner edge engages with the second container during use to restrict the second container from moving in the first direction.

[0019] The second bending portion is recessed into the inner side of the second receiving portion on the outer wall of the second housing to form a second groove; the second housing has a second wing portion located on the side of the second groove away from the second surface, and the second wing portion elastically expands outward when the second container is inserted.

[0020] In an exemplary embodiment, the first protrusion further has a first outer edge on a side opposite to the first surface, the first outer edge abutting against the lid of the first container when the first container is inserted;

[0021] The second protrusion also has a second outer edge on the side opposite to the second surface, which abuts against the lid of the second container when the second container is inserted.

[0022] In an exemplary embodiment, the first housing is configured with multiple slots from the edge of the first inlet, and the first housing includes a plurality of first elastic walls that are separated by a first gap;

[0023] And / or, the second housing is constructed with multiple slots from the edge of the second inlet, and the second housing includes a plurality of second elastic walls disconnected by a second gap.

[0024] In an exemplary embodiment, the first window has a first pressing port portion and a first dispensing port portion, the first pressing port portion is located on the side of the first dispensing port portion opposite to the first surface, and the opening spacing of the first pressing port portion is greater than the opening spacing of the first dispensing port portion; before the first needle tube portion punctures the first container, the first bottom surface of the first container is located at the first pressing port portion.

[0025] And / or, the second window has a second pressing port portion and a second dispensing port portion, the second pressing port portion being located on the side of the second dispensing port portion opposite to the second surface, the opening spacing of the second pressing port portion being greater than the opening spacing of the second dispensing port portion; before the second needle tube portion punctures the second container, the second bottom surface of the second container is located on the second pressing port portion.

[0026] In an exemplary embodiment, the first storage portion and the second storage portion are detachably connected, the isolation portion is fixedly connected to the first storage portion, and the puncture needle is fixed on the isolation portion;

[0027] The second storage section has a suction port. When the first storage section and the second storage section are separated, the suction port is used to expose the seal of the second container. When the first storage section and the second storage section are connected, the suction port allows the second needle tube to be inserted into the second storage section.

[0028] In an exemplary embodiment, the pharmaceutical mixing unit further includes a connecting portion for connecting to the connecting portion of another pharmaceutical mixing unit, so that the pharmaceutical mixing unit and the other pharmaceutical mixing unit are connected side by side.

[0029] The second storage section is provided with the connecting section, or both the first storage section and the second storage section are provided with the connecting section.

[0030] In an exemplary embodiment, the number of the drug mixing sections is at least two, and the at least two drug mixing sections include a first drug mixing section and a second drug mixing section. The drug mixing device has a mixing use state and a pipetting use state.

[0031] In the mixed use state, one end of the drug mixing device is connected to at least two first containers, and the other end is connected to at least two second containers. The at least two first containers include a first liquid drug container and a second liquid drug container, and the at least two second containers include a first drug container and a second drug container.

[0032] The first needle portion of the first drug mixing unit punctures the first drug container, and the second needle portion of the first drug mixing unit punctures the first drug container, causing the liquid contained in the first drug container to flow into the first drug container;

[0033] The first needle portion of the second drug mixing section punctures the second drug container, and the second needle portion of the second drug mixing section punctures the second drug container, causing the liquid contained in the second drug container to flow into the second drug container;

[0034] In the pipetting usage state, the first storage part of the first drug mixing part and the second storage part of the first drug mixing part are in the separated state, the first storage part of the second drug mixing part and the second storage part of the second drug mixing part are in the separated state, and the second storage parts of the first drug mixing part and the second storage parts of the second drug mixing part are fixedly connected side by side;

[0035] The second receiving part of the first drug mixing part has a first suction port, which allows the first syringe in the multi-syringe to be inserted into the first drug container.

[0036] The second receiving part of the second drug mixing part has a second suction port, which allows the second syringe in the multi-syringe to be inserted into the second drug container.

[0037] In an exemplary embodiment, the number of the drug mixing sections is at least two, and the at least two drug mixing sections include a first drug mixing section and a second drug mixing section arranged side by side;

[0038] The first window of the first drug mixing section and the first window of the second drug mixing section have a first communication port to simultaneously expose at least a portion of the bottom surface of both the first container connected to the first drug mixing section and the first container connected to the second drug mixing section.

[0039] And / or, the second window of the first drug mixing section and the second window of the second drug mixing section have a second communication port to simultaneously expose at least a portion of the bottom surface of both the second container connected to the first drug mixing section and the second container connected to the second drug mixing section.

[0040] In an exemplary embodiment, the drug mixing device further includes a pressing plate, and the number of drug mixing parts is at least two, with at least two drug mixing parts connected side by side to connect at least two first containers and at least two second containers;

[0041] The pressing plate simultaneously abuts against the bottom surfaces of at least two of the first containers, or simultaneously abuts against the bottom surfaces of at least two of the second containers.

[0042] In an exemplary embodiment, the isolation portion has a perforated hole disposed adjacent to the puncture needle, so as to expose a punctureable area in the seal of the other when one of the first container and the second container leaves the drug mixing portion, so as to allow the injection needle to be inserted into the punctureable area.

[0043] In an exemplary embodiment, a pressure difference exists between the first container and the second container to allow liquid contained in one of the first container to flow into the other when the puncture needle simultaneously punctures the first container and the second container.

[0044] In an exemplary embodiment, the first storage section, the second storage section, and the isolation section are integrally disposed continuously.

[0045] The technical solution provided in this application can bring the following beneficial effects:

[0046] In the aforementioned pharmaceutical mixing device, the first container enters the housing of the first receiving section through the first inlet, and the second container enters the housing of the second receiving section through the second inlet. The operator only needs to simultaneously press the bottom of both the first and second containers; a single press allows the first and second needle tubes at both ends of the puncture needle to simultaneously pierce into the first and second containers, causing the medication from one container to flow into the other. For example, the reconstitution solution in a vial can flow into another vial under the pressure difference between the first and second containers, dissolving the sterile lyophilized preparation in the other vial to obtain a dissolved lyophilized preparation. The first and second needle tubes at both ends of the puncture needle are located within the housings of the first and second receiving sections, respectively, and are not directly exposed, reducing or avoiding the risk of puncture wounds to the operator.

[0047] If it is necessary to dissolve a sterile lyophilized preparation with two components, only two pressing operations are required using the two mixing sections. The entire preparation process does not require repeated aspiration and pushing, which reduces the operation time during surgery, improves the efficiency of dissolving and preparing sterile lyophilized preparations, and eliminates the need for additional syringes and needles, thus reducing resource waste.

[0048] Furthermore, the aforementioned first and second windows allow operators to visually assess drug contamination and check the mixing status during the puncture and mixing of medications in the two containers. If the vial containing the sterile lyophilized preparation loses its vacuum, the reconstituted liquid in the other vial will not smoothly enter the lyophilized product. Operators can observe the flow rate of the reconstituted liquid through the first and second windows. If the flow rate is too slow or there is no flow, it indicates that the vial containing the sterile lyophilized preparation has lost its vacuum, and the sterile lyophilized preparation may be contaminated. Therefore, the medication should not be used, preventing accidental use of contaminated sterile lyophilized preparations due to vacuum loss and protecting patient safety. If the flow rate is normal, operators can observe whether dissolution is complete through the first and second windows. The increased number of steps in the combined upper and lower connector design makes it difficult to effectively monitor drug contamination due to vacuum loss and fails to avoid patient risks. The medication mixing device in this embodiment allows for simultaneous operation by the operator and effectively monitors drug contamination due to vacuum loss.

[0049] Furthermore, if the operator needs to remove the container from the storage section, the operator can directly contact parts of the container through the aforementioned window, such as the neck or body of the vial, making it easier for the operator to exert force to overcome the resistance from the storage section and / or the syringe section, thereby easily removing the container from the storage section. Attached Figure Description

[0050] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0051] Figure 1 This is one of the schematic diagrams of a drug delivery device provided in one embodiment of this application;

[0052] Figure 2 This is a second schematic diagram of a liquid delivery device provided in one embodiment of this application;

[0053] Figure 3 This is the third schematic diagram of a liquid delivery device provided in one embodiment of this application;

[0054] Figure 4 This is a schematic diagram of the second side of a liquid delivery device provided in one embodiment of this application;

[0055] Figure 5 This is one of the schematic diagrams of a pharmaceutical mixing device provided in one embodiment of this application;

[0056] Figure 6 This is a second schematic diagram of a pharmaceutical mixing device provided in one embodiment of this application;

[0057] Figure 7 This is a third schematic diagram of a pharmaceutical mixing device provided in one embodiment of this application;

[0058] Figure 8 This is a fourth schematic diagram of a pharmaceutical mixing device provided in one embodiment of this application;

[0059] Figure 9 This is the fifth schematic diagram of a pharmaceutical mixing device provided in one embodiment of this application;

[0060] Figure 10 This is a schematic diagram of a pharmaceutical mixing device provided in one embodiment of this application.

[0061] The components in the attached diagram are labeled as follows:

[0062] 1000. Liquid delivery device;

[0063] 100. Medication delivery unit; 101. First delivery unit; 102. Second delivery unit; 1011. First substrate; 1012. Second substrate; 111. Substrate; 112. Receiving part; 113. Liquid receiving component; 114. Grip part; 115. Substrate assembly; 1111. First end face; 1112. Second end face; 1113. First settling groove; 1114. Third opening; 1115. Recess; 1116. Second settling groove; 1131. Needle part; 1132. Joint; 1121. First opening; 112 2. Shell wall; 1123. Cavity; 1124. First fold; 1125. Protrusion; 1126. Groove; 1127. Gap; 1128. Elastic sheet; 1129. Second opening; 1141. First grip; 1142. Second grip; 1143. First limiting part; 1144. Second limiting part; 1145. First gripping plane; 1146. Second gripping plane; 1147. Third limiting part; 1148. Fourth limiting part; 116. First curved connection; 117. Second curved connection;

[0064] 200. Container; 201. First container; 202. Second container; 210. Lid; 220. Neck; 221. Groove; 230. Bottle body;

[0065] 300. Multi-injector; 310. Syringe; 311. Push rod; 312. Connector; 320. Handle; 330. Push-pull base;

[0066] 2000, Pharmaceutical mixing device;

[0067] 400, Drug mixing section; 401, First drug mixing section; 402, Second drug mixing section; 410, First storage section; 420, Second storage section; 430, Isolation section; 440, Puncture needle;

[0068] 411. First housing; 412. First inlet; 413. First window; 414. First bend; 415. First protrusion; 4151. First inner edge; 4152. First outer edge; 416. First groove; 417. First wing plate; 4131. First pressing port; 4132. First dispensing port; 418. First gap; 419. First elastic wall;

[0069] 421. Second housing; 422. Second inlet; 423. Second window; 424. Second bend; 425. Second protrusion; 4251. Second inner edge; 4252. Second outer edge; 426. Second groove; 427. Second wing plate; 4231. Second pressing port; 4232. Second dispensing port; 428. Second gap; 429. Second elastic wall;

[0070] 431. First side; 432. Second side; 433. Dispensing slot; 434. Dispensing opening

[0071] 441. First needle tube section; 442. Second needle tube section;

[0072] 450, First connecting port; 460, Second connecting port;

[0073] 51. First liquid container; 52. Second liquid container; 53. First medicine container; 54. Second medicine container; 60. Connecting part; 70. Hole. Detailed Implementation

[0074] To make the objectives, technical solutions, and advantages of this application clearer, the embodiments of this application will be described in further detail below with reference to the accompanying drawings.

[0075] In view of the preparation process and its drawbacks mentioned in the background art, this application provides a liquid drug delivery device, such as... Figures 1 to 4 As shown, the drug delivery device 1000 can be connected to at least two containers 200 and a multi-syringe 300 during use, so that at least two containers 200 and at least two syringes 310 in the multi-syringe 300 are connected in a one-to-one correspondence. This facilitates the synchronous flow of drug solutions contained in multiple containers 200 into multiple syringes 310 of the multi-syringe 300, thereby improving the preparation efficiency and safety of related preparations and reducing the waste of consumables such as syringes and injection needles.

[0076] In an exemplary embodiment, please refer to Figures 1 to 4The drug delivery device 1000 includes at least two drug delivery sections 100 fixedly arranged relative to each other. One end of each drug delivery section 100 is connected to a container 200, and the other end is connected to a syringe 310, thus bridging the container 200 and the syringe 310. Optionally, the container 200 includes a vial, which includes a cap 210, a neck 220, and a body 230. Optionally, the multi-syringe 300 includes a dual-chamber injector, specifically including multiple syringes 310 and a handle 320 for fixing the multiple syringes 310. The proximal end of the plunger 311 in each syringe 310 is fixed to a push-pull seat 330. An operator can control the push-pull seat 330 to simultaneously control the multiple plungers 311 to move axially, thereby synchronously drawing or pushing liquid. The diameters of the multiple syringes 310 can be the same or different, specifically determined according to the proportions of different drug solutions; this embodiment does not limit this.

[0077] The drug delivery unit 100 includes a base 111, a receiving portion 112, and a liquid dispensing member 113; wherein the base 111 has a first end face 1111 facing the container 200 and a second end face 1112 facing the syringe.

[0078] The liquid-collecting component 113 is disposed through the base 111. The liquid-collecting component 113 has a needle tube portion 1131 protruding to the first end face 1111 and a joint portion 1132 penetrating the second end face 1112. The needle tube portion 1131 is used for puncturing the seal of the container 200, and the joint portion 1132 is used for connecting the connector 312 of the syringe 310. Optionally, the liquid-collecting component 113 is an injection needle, and the joint portion 1132 is a Luer connector of the injection needle.

[0079] The receiving portion 112 is located on the side of the first end face 1111 near the container 200, and the needle portion 1131 is exposed inside the receiving portion 112; as Figure 2 As shown, the receiving portion 112 has a first opening 1121 for the container 200 to be inserted into the receiving portion 112.

[0080] In the aforementioned liquid delivery unit 100, a liquid-collecting component 113 is provided through the base 111. The needle portion 1131 on one side of the liquid-collecting component 113 can puncture the seal of the container 200 after the container 200 enters the receiving portion 112 to a certain depth through the first opening 1121, thereby making the interior of the container 200 and the joint portion 1132 on the other side of the base 111 interconnected. The needle portion 1131 of the liquid-collecting component 113 is located inside the receiving portion 112 and is not directly exposed to the outside, reducing or avoiding the risk of puncture to the operator.

[0081] The drug delivery device 1000 has at least two of the aforementioned drug delivery sections 100. After multiple containers 200 are installed in their respective receiving sections 112, the operator can directly insert the connectors 312 of each syringe 310 in the multi-syringe 300 into their respective connecting sections 1132 to simultaneously draw out the drug solution contained in each container 200 and directly obtain equal or quantitative amounts of different drug solutions. This facilitates the preparation of new agents, such as obtaining equal amounts of lyophilized preparations of different components in a single aspiration operation. It achieves equal aspiration balance of two different component products in one operation, making the operation simpler and more convenient, shortening the preparation time, reducing the risk of bacterial contamination, and facilitating the subsequent preparation of fibrin adhesives.

[0082] Throughout the entire preparation process described above, operators do not need to perform repeated aspiration, transfer, or quantitative operations, nor do they need to use additional syringes for drug transfer. After installing the containers 200 and the multi-syringe 300 on the drug delivery device 1000, a single aspiration operation can be performed by pulling the push-pull seat 330 that fixes each push rod 311. This allows for the preparation of equal or quantitative amounts of different lyophilized preparations in the multi-syringe 300, reducing the time spent preparing drugs during surgery, improving work efficiency, and minimizing the waste of syringes and injection needles.

[0083] Optionally, the drug delivery device 1000 can be sterilized and reused, reducing the use of ordinary syringes and needles.

[0084] like Figure 2 As shown, the receiving portion 112 has a shell wall 1122 surrounding the needle tube portion 1131, and the inner wall of the shell wall 1122 defines a cavity 1123 for receiving a container. After the container 200 enters the cavity 1123 within the receiving portion 112 through the first opening 1121, in order to restrict the container 200 from moving undesirably within the receiving portion 112, the shell wall 1122 is constructed to have a first pleat 1124.

[0085] The first pleated portion 1124 protrudes into the cavity 1123 to form a ridge 1125. The edge E1 of the ridge 1125 near the first end face 1111 engages with the container 200 during use. Specifically, the ridge 1125 can engage in the groove 221 formed in the neck 220 of the vial, thereby confining the vial cap 210 between the ridge 1125 and the first end face 1111.

[0086] In order to restrict the movement of the vial, the minimum distance L1 between the aforementioned protrusion 1125 and the axis of the needle tube 1131 is less than the distance L2 between the outer peripheral surface of the vial cap 210 and the axis of the needle tube 1131. The protrusion 1125 also has an edge E2 on the side opposite to the first end face 1111. Because the minimum distance L1 between the aforementioned protrusion 1125 and the axis of the needle tube 1131 is less than the distance L2 between the outer peripheral surface of the vial cap 210 and the axis of the needle tube 1131, this edge E2 will abut against the edge of the top surface of the vial cap 210 when the vial enters the receiving part 112, forming resistance.

[0087] In order for the vial to be smoothly inserted into the receiving part 112 and punctured by the needle part 1131, the first pleated part 1124 can be recessed into the cavity 1123 from the outside of the shell wall 1122 to form a groove 1126. The part of the shell wall 1122 located on the side of the groove 1126 away from the first end face 1111 elastically expands outward when the container 200 enters, thereby elastically increasing the minimum distance L1 between the protrusion 1125 and the axis of the needle part 1131, so that the vial cap 210 can pass smoothly through the protrusion 1125, and elastically returns to its original size after the vial cap 210 passes smoothly through the protrusion 1125, so as to restrict the movement of the vial cap 210.

[0088] Furthermore, in order to improve the passability of the container 200 in the receiving part, the shell wall 1122 is formed by multiple slots from the edge of the first opening 1121. The shell wall 1122 includes multiple elastic pieces 1128 that are separated by gaps 1127. The multiple elastic pieces 1128 can more easily expand outward elastically when the container 200 enters.

[0089] Furthermore, to facilitate the retrieval of the container 200 within the receiving section 112 and the observation of the medication within it, the receiving section 112 is configured with a shell wall 1122 surrounding the needle tube section 1131, and the shell wall 1122 has a second opening 1129 on its first side. The inner wall of the shell wall 1122 defines a cavity 1123 for receiving the container 200, within which the container 200 can be housed. The second opening 1129 is axially aligned with the needle tube section 1131, thus exposing a portion of the bottle body 230 of the container 200.

[0090] The operator can visually observe the remaining liquid level in the container 200 while aspirating liquid through the portion of the container body exposed by the second opening 1129, thus facilitating the check of whether aspiration is complete. Furthermore, if the operator needs to remove the container 200 from the receiving section 112, the operator can directly contact a portion of the container 200 body 230, such as the neck 220 of a vial, through the second opening 1129, making it easier for the operator to apply force to overcome the resistance from the receiving section 112 and / or the syringe section 1131, thereby easily removing the container 200 from the receiving section 112.

[0091] The second opening 1129 exposes the neck 220 of the vial. For vials with a wider groove 221 in the neck 220, the operator can use their fingers to grip the wider groove 221 to remove the vial. However, for vials with a narrower groove 221, the operator's fingers mainly press against the wall of the vial body 230, and the vial can be removed by the friction between the fingers and the vial wall, which may be more difficult.

[0092] Furthermore, such as Figure 2 , Figure 3 As shown, in order to more conveniently remove the container 200 from the receiving part 112, the base 111 may have a first groove 1113 through the first end face 1111 and the second end face 1112 on the first side. The first groove 1113 is arranged along the axial direction of the needle tube part 1131. The first groove 1113 has a third opening 1114. The third opening 1114 is continuously arranged with the second opening 1129. A recess 1115 is formed at the edge where the first groove 1113 and the first end face 1111 meet, which is recessed into the needle tube part 1131 to expose part of the end face of the container 200.

[0093] like Figure 3 As shown, the edge E3 at the junction of the bottom surface of the first settling groove 1113 and the first end face 1111 is located on the inner side of the inner circumferential surface of the shell wall 1122. The edge E3 and the groove sidewall of the first settling groove 1113 near the first end face 1111 form the above-mentioned recess. When the operator takes out the container 200, his / her fingers can enter the recess through the third opening 1114 and abut against a part of the end face of the container 200, such as a part of the top surface of the vial cap 210. By squeezing the part of the top surface, an axial pushing or pulling force can be applied to the vial, making it easier to take the vial out of the receiving part 112.

[0094] In addition, by opening the first settling tank 1113, the amount of materials used can be reduced without affecting the structural stability and strength, thus saving material costs and reducing resource waste.

[0095] The first settling groove 1113 may or may not penetrate the second end face 1112. This application embodiment does not limit this.

[0096] To facilitate the installation of the liquid extraction component 113, such as Figure 2 , Figure 3 As shown, the bottom of the first settling tank 1113 can be provided with a second settling tank 1116 that penetrates the first end face 1111 and the second end face 1112. The second settling tank 1116 has an opening at the bottom of the first settling tank 1113, through which the liquid-collecting component 113 can be directly placed into the second settling tank 1116, reducing the installation difficulty of the liquid-collecting component. Furthermore, the second settling tank 1116 can be a contoured tank adapted to the shape of the liquid-collecting component 113. By providing the second settling tank 1116 for placing the liquid-collecting component 113, various shapes of liquid-collecting components 113 can be accommodated.

[0097] The liquid extraction component 113 can be connected to the substrate 111 in the second settling tank 1116 with an interference fit, or it can be connected in other ways. This application does not limit this.

[0098] Furthermore, in order to secure the liquid-collecting component 113, a fixing part is also provided in the second settling tank 1116 to fix the liquid-collecting component. The fixing part can be an adhesive material to fix the liquid-collecting component 113 to the second settling tank 1116. The fixing part can also be a cover to fix the liquid-collecting component 113 tightly to the second settling tank 1116.

[0099] Once the liquid extraction device 113 is fixed inside the second settling tank 1116, it can effectively puncture and enter the container 200 of the receiving section 112. After the liquid delivery device 1000 is connected to multiple containers 200, the operator can hold the liquid delivery device 1000 with one hand and the multi-syringe 300 with the other hand to prepare for liquid extraction or injection.

[0100] To make it easier for operators to hold, such as Figures 1 to 4 As shown, the above-mentioned liquid delivery device 1000 may be provided with a gripping portion 114. In an exemplary embodiment, at least two liquid delivery portions 100 include a first delivery portion 101 and a second delivery portion 102. The first base 1011 of the first delivery portion 101 and the second base 1012 of the second delivery portion 102 are fixedly connected to form a base assembly 115, and the wall of the base assembly 115 is provided with a gripping portion 114.

[0101] By providing a gripping part 114 on the base assembly 115, the gripping part 114 can have a larger gripping area, making it easier for operators to grip.

[0102] Optionally, the wall of the substrate assembly 115 has a first grip portion 1141 on a first side, and a second grip portion 1142 on a second side opposite to the first side. The first grip portion 1141 and the second grip portion 1142 on both sides of the substrate assembly 115 conform to the gripping habits of the operator's hand and are easy to use. For example, the operator's thumb can rest on the first grip portion 1141, and at least one of the other four fingers can rest on the second grip portion 1142, facilitating the operator's grip and use.

[0103] In one implementation, such as Figure 2 As shown, the first grip portion 1141 has a recessed structure, with a groove portion located on the first base 1011 and a groove portion located on the second base 1012. The bottom of the recessed structure forms the first gripping plane 1145. The shape of the grip portion can be adjusted to different styles according to the user's habits and is not limited to this fixed style.

[0104] By creating a sinking structure that spans the first base 1011 and the second base 1012, the bottom of the sinking structure can form a first gripping plane 1145 with a larger area and a longer length, making it easier for operators to grip.

[0105] Optionally, the first gripping plane 1145 has a first limiting portion 1143 on the side near the container 200, and a second limiting portion 1144 on the side near the syringe. The aforementioned groove structure can extend in a radial direction S2 perpendicular to the axial direction S1 of the needle tube 1131, facilitating finger placement in the radial direction S2. Simultaneously, by providing the first limiting portion 1143 near the container 200 and the second limiting portion 1144 near the syringe 310 on the first gripping plane 1145, the operator's fingers can be limited on both sides of the first gripping plane 1145 along the axial direction S1, reducing or avoiding relative sliding displacement between the fingers and the first gripping plane 1145, thus improving grip stability.

[0106] The first limiting part 1143 and the second limiting part 1144 described above have limiting curved surfaces facing the sinkhole structure, which improves grip comfort.

[0107] In the aforementioned embodiment, the base 111 is further provided with a first recess 1113 arranged along the axial direction S1 of the needle tube portion 1131. Based on this, the recess structure of the first grip portion 1141 can penetrate the first recess 1113A of the first base 1011 and the first recess 1113B of the second base 1012, so that the first gripping plane 1145 at the bottom of the first gripping portion 1141 is coplanar with the bottom of the first recesses 1113A and 1113B on both sides, forming a larger area and a longer length of the first gripping plane 1145, which is more convenient for the operator to grip.

[0108] like Figure 4 As shown, similar to the first grip portion 1141, the second grip portion 1142 can also be a groove structure. The bottom of the groove structure forms the second gripping plane 1146. The groove structure can also extend in a radial direction S2 perpendicular to the axial direction S1 of the needle tube portion 131, facilitating the placement of fingers in the radial direction S2. The groove sidewall near the container side of the groove structure forms a third limiting portion 1147, and the groove sidewall near the syringe side of the groove structure forms a fourth limiting portion 1148. By using the groove sidewalls on both sides of the needle tube portion axial direction S1 as the third limiting portion 1147 and the fourth limiting portion 1148 respectively, the fingers of the operator gripping the second side can be limited, reducing or avoiding relative sliding displacement between the fingers and the second gripping plane 1146, thus improving grip stability.

[0109] In addition to the above structural design of the liquid delivery device 1000, considering that the axial distance between the two containers 200 may be different from the axial distance between adjacent syringes 310 in the multi-syringe 300, this application further adjusts the distance between adjacent needle tubes 1131 and the distance between adjacent joints 1132 in the liquid delivery device 1000 in order to adapt to containers and multi-syringes of different sizes.

[0110] In an exemplary embodiment, such as Figure 1 As shown, the first delivery unit 101 is provided with a first liquid taking member 113A, which includes a first needle tube portion 1131A and a first connecting portion 1132A. The second delivery unit 102 is provided with a second liquid taking member 113B, which includes a second needle tube portion 1131B and a second connecting portion 1132B.

[0111] There is a first distance L3 between the axis of the first needle tube 1131A and the axis of the second needle tube 1131B, and there is a second distance L4 between the axis of the first joint 1132A and the axis of the second joint 1132B.

[0112] At least one of the first liquid dispensing member 113A and the second liquid dispensing member 113B has its needle portion and connecting portion eccentrically offset, so that the first distance L3 and the second distance L4 are different. By eccentrically offsetting the needle portion and the connecting portion of the liquid dispensing member, the axis of the needle portion and the axis of the connecting portion can be axially offset, thus forming a first distance L3 and a second distance L4 of different lengths. The second distance L4 can be kept the same as the axial distance between the connectors 312 of adjacent syringes 310 in the multi-syringe 300, so that the connectors 312 of the multiple syringes 310 in the multi-syringe 300 can be accurately inserted into the respective connecting portions 1132.

[0113] Optionally, the first spacing L3 is greater than the second spacing. In actual use by operators, the syringes 310 in the multi-injector 300, such as the syringes in a dual-chamber syringe, are usually thinner, making them easier for operators to hold. In contrast, the diameter of the vials is larger, resulting in a greater axial distance between adjacent vials than the axial distance between adjacent syringes 310 in the multi-injector 300. If a straight injection needle is used as the liquid dispensing device, the axial distance between the two ends of adjacent injection needles is consistent. If a larger vial is to be fitted, the distance between adjacent injection needles needs to be increased. Correspondingly, the distance between adjacent syringes 310 in the multi-syringe 300 will also increase. However, the operator's fingers have limited opening and closing range, and the increased distance between adjacent syringes 310 will make it inconvenient for the operator to hold the multi-syringe. But by making the first distance greater than the second distance, it is possible to insert vials with larger diameters into adjacent needle tubes while the operator can still choose a narrower multi-syringe 300 to fit the liquid delivery device 1000, such as a multi-syringe 300 with a narrower handle 320, thus improving the ease of use and versatility of the liquid delivery device 1000.

[0114] In one possible implementation, a first bent connection 116 is provided between the first needle tube portion 1131A and the first connecting portion 1132A, with the first connecting portion 1132A located on the side of the first needle tube portion 1131A near the second delivery portion 102.

[0115] Correspondingly, a second curved connection 117 is provided between the second needle tube portion 1131B and the second connecting portion 1132B, with the second connecting portion 1132B located on the side of the second needle tube portion 1131B near the first delivery portion 101.

[0116] This configuration allows the first distance between adjacent needle sections to be greater than the second distance between adjacent joint sections. At the same time, although the first liquid-taking component 113A and the second liquid-taking component 113B are axially symmetrical when placed, the first liquid-taking component 113A and the second liquid-taking component 113B can be injection needles with the same bending, eliminating the need to produce two types of bending injection needles and effectively reducing the cost of the drug delivery device.

[0117] The above-mentioned drug delivery device 1000 is used to transfer the mixed drug solution in the vial, such as dissolved lyophilized preparation, into the multi-syringe 300. However, before the transfer, the drug in the vial, such as sterile lyophilized preparation, needs to be dissolved in advance.

[0118] Sterile lyophilized formulations are typically vacuum-sealed in vials. The reconstituted solution of the sterile lyophilized formulation is sealed in another vial. During the preparation of fibrin adhesive, the operator needs to disassemble a set of injection needles and syringes, assemble them, and then insert a syringe with a needle into the vial containing the reconstituted solution to draw the reconstituted solution from the vial into the syringe. The needle of the syringe containing the reconstituted solution is then inserted into the vial containing the sterile lyophilized formulation, and the reconstituted solution is pushed into the vial to dissolve the sterile lyophilized formulation, resulting in a dissolved lyophilized formulation of one component.

[0119] Because the preparation of fibrin adhesive requires mixing two components of a lyophilized solution, the operator needs to perform at least one more step to obtain the other component. Following this procedure, medical personnel need to use at least two sets of syringes and needles, performing at least two aspiration operations and at least two injection operations to prepare the two components of the lyophilized solution for the fibrin adhesive.

[0120] The above preparation process involves repeated aspiration and injection, resulting in slow work efficiency, consuming a significant amount of surgical time, and the exposed use of injection needles poses a risk of needlestick injury to operators. It also causes considerable inconvenience for the clinical preparation and use of products such as fibrin adhesives. Furthermore, the excessive use of syringes and needles leads to inconvenience and resource waste in the disposal of used medical devices, and is environmentally unfriendly. Additionally, it is difficult for users to detect when the vacuum seal of the vials containing sterile lyophilized preparations is broken, potentially leading to the accidental use of contaminated sterile lyophilized preparations.

[0121] In view of this, this application also provides a pharmaceutical mixing device, such as... Figures 5 to 6 As shown, the drug mixing device 2000 is connected to a first container 201 and a second container 202 during use. The drug mixing device 2000 has a double-ended puncture needle to penetrate the first container 201 and the second container 202, allowing the liquid contained in the first container 201 to flow into the second container 202 to obtain a mixed drug solution. A pressure difference exists between the first container 201 and the second container 202, so that when the puncture needle simultaneously punctures the first container 201 and the second container 202, the liquid contained in one container can smoothly flow into the other. For example, the liquid contained in one container can be drawn into the other container under negative pressure or a vacuum environment.

[0122] In an exemplary embodiment, the drug mixing device 2000 includes a drug mixing section 400, which has a first receiving section 410, a second receiving section 420, an isolation section 430, and a puncture needle 440.

[0123] The isolation section 430 is located between the first storage section 410 and the second storage section 420. The isolation section 430 has a first surface 431 facing the first container 201 and a second surface 432 facing the second container.

[0124] The puncture needle 440 is disposed through the isolation section 430. The puncture needle 440 has a first needle tube portion 441 protruding to a first surface 431 and a second needle tube portion 442 protruding to a second surface 432. The first needle tube portion 441 is used to puncture the seal of the first container 201, and the second needle tube portion 442 is used to puncture the seal of the second container 202.

[0125] The first storage section 410 has a first housing 411 surrounding the first needle tube section 441, with the first needle tube section 441 exposed inside the first storage section 410; the first housing 411 has a first inlet 412 at one end away from the first surface 431 for inserting the first container 201 into the first storage section 410 along a first direction; the first housing 411 has a first window 413 on the first side to expose part of the bottle body of the first container 201.

[0126] The second storage section 420 has a second housing 421 disposed around the second needle tube section 442. The second needle tube section 442 is exposed inside the second storage section 420. The second housing 421 has a second inlet 422 at one end away from the second surface 432, so that the second container 202 can be inserted into the second storage section 420 in a second direction. The second housing 421 has a second window 423 on the first side to expose part of the bottle body of the second container 202. The first direction is opposite to the second direction.

[0127] In the above-mentioned drug mixing device 2000, the first container 201 can enter the housing of the first receiving part 410 through the first inlet 412, and the second container 202 can enter the housing of the second receiving part 420 through the second inlet 422. The operator only needs to press the bottom of the first container 201 and the second container 202 at the same time. By performing a single pressing operation, the first needle tube 441 and the second needle tube 442 at both ends of the puncture needle 440 can be inserted into the first container 201 and the second container 202 at the same time, so that the drug in one container flows into the other. For example, the reconstitution solution in the vial can flow into the other vial under the pressure difference between the first container 201 and the second container 202 to dissolve the sterile lyophilized preparation in the other vial and obtain the dissolved lyophilized preparation. The first needle tube section 441 and the second needle tube section 442 at both ends of the puncture needle 440 are located inside the housings of the first receiving section 410 and the second receiving section 420, respectively, and are not directly exposed, reducing or avoiding the risk of puncture wounds to operators. The lyophilized product vial and the dissolving solution vial are aseptically connected by the needle, which greatly improves the sterility assurance level of the dissolved product.

[0128] If it is necessary to dissolve a sterile lyophilized preparation of two components, only two pressing operations are required using the two mixing units 400. The entire preparation process does not require repeated aspiration and repeated pushing, which reduces the operation time during surgery, improves the efficiency of dissolving and preparing sterile lyophilized preparations, and eliminates the need for additional syringes and needles, thus reducing resource waste.

[0129] Furthermore, the aforementioned first and second windows allow operators to visually assess drug contamination and check the mixing status during the puncture and mixing of medications in the two containers. If the vial containing the sterile lyophilized preparation loses its vacuum, the reconstituted liquid in the other vial will not smoothly enter the lyophilized product. Operators can observe the flow rate of the reconstituted liquid through the first and second windows. If the flow rate is too slow or there is no flow, it indicates that the vial containing the sterile lyophilized preparation has lost its vacuum, and the sterile lyophilized preparation may be contaminated. Therefore, the medication should not be used, preventing accidental use of contaminated sterile lyophilized preparations due to vacuum loss and protecting patient safety. If the flow rate is normal, operators can observe whether dissolution is complete through the first and second windows. The increased number of steps in the combined upper and lower connector design makes it difficult to effectively monitor drug contamination due to vacuum loss and fails to avoid patient risks. The medication mixing device in this embodiment allows for simultaneous operation by the operator and effectively monitors drug contamination due to vacuum loss.

[0130] Furthermore, if the operator needs to remove the container from the storage section, the operator can directly contact parts of the container through the aforementioned window, such as the neck or body of the vial, making it easier for the operator to exert force to overcome the resistance from the storage section and / or the syringe section, thereby easily removing the container from the storage section.

[0131] The height of the first storage section 410 can be lower than the overall height of the first container 201, and the height of the second storage section 420 can be lower than the overall height of the second container 202. In this way, the bottoms of the first container 201 and the second container 202 can be completely exposed on the outside of the two storage sections, making it convenient for the operator to press the bottoms of the first container 201 and the second container 202 at the same time.

[0132] To facilitate the operator's retrieval of containers from the storage section, the isolation section 430 has a retrieval groove 433 on the first side. The opening of the retrieval groove forms a retrieval port 434. At least one of the first window 413 and the second window 423 is continuously connected to the retrieval port 434 to expose a portion of the end face of at least one of the first container 201 and the second container 202. In this way, when the operator retrieves the container, their fingers can enter the retrieval groove 433 through the retrieval port 434 and abut against a portion of the end face of the container, such as the top surface of the cap 210 of the vial. By squeezing this top surface, an axial pushing or pulling force can be applied to the vial. At the same time, the retrieval port 434 is connected to the window, making it convenient for the operator to remove the vial from the storage section along the axis of the puncture needle.

[0133] Optionally, the first window 413 and the second window 423 at least partially overlap in the axial direction of the puncture needle 440, which allows the operator to simultaneously observe the medication in both containers through the overlapping portions of the two windows. Specifically, the first window 413 and the second window 423 completely overlap in the axial direction of the puncture needle 440.

[0134] After the first container 201 enters the first storage section 410 through the first inlet 412, in order to restrict the first container 201 from moving undesirably within the first storage section 410, the first housing 411 is configured to have a first bend 414, and / or, after the second container 202 enters the second storage section 420 through the second inlet 422, in order to restrict the second container 202 from moving undesirably within the second storage section 420, the second housing 421 has a second bend 424.

[0135] The first bent portion 414 protrudes inward toward the first receiving portion 410 and forms a first protrusion 415 on the inner wall of the first housing 411. The first protrusion 415 has a first inner edge 4151 near the first surface. The first inner edge 4151 engages with the first container 201 during use to restrict the first container 201 from moving in the second direction. Specifically, the first protrusion 415 is similar to the aforementioned protrusion 1125, which can engage in the neck groove of the vial. When the vial is fully inserted into the first receiving portion 410, the first inner edge 4151 can abut against the bottom edge of the vial cap, thereby restricting the vial cap within the first protrusion 415 and the first surface 431 to limit the movement of the vial within the first receiving portion 410.

[0136] Similar to the first bend 414, the second bend 424 protrudes inward toward the second receiving portion 420 and forms a second protrusion 425 on the inner wall of the second housing 421. The second protrusion 425 has a second inner edge 4251 near the second surface 432. The second inner edge 4251 engages with the second container 202 during use to restrict the movement of the second container 202 in the first direction. The function of the second protrusion 425 is similar to that of the first protrusion 415, and will not be described again here.

[0137] In order to allow the first container 201 to smoothly enter the first receiving part 410 and be punctured by the first needle part 441, the first bending part 414 is recessed into the inner side of the first receiving part 410 on the outer wall of the first housing 411 to form a first groove 416; the first housing 411 has a first wing part 417 located on the side of the first groove 416 opposite to the first surface 431. When the first container 201 is inserted, the first wing part 417 elastically expands outward, thereby elastically increasing the minimum distance between the first protrusion 415 and the axis of the first needle part 441, so that the cap 210 of the vial can smoothly pass through the first protrusion 415. After the cap 210 of the vial smoothly passes through the first protrusion 415, the first wing part 417 elastically returns to its original size to restrict the movement of the cap 210 of the vial.

[0138] Similar to the first bend 414, in order to allow the second container 202 to smoothly enter the second storage section 420 and be punctured by the second needle section 442, the second bend 424 can also be recessed into the inner side of the second storage section 420 on the outer wall of the second housing 421 to form a second groove 426; the second housing 421 has a second wing plate section 427 located on the side of the second groove 426 opposite to the second surface 432. When the second container 202 is inserted, the second wing plate section 427 elastically expands outward, thereby elastically increasing the minimum distance between the second protrusion 425 and the axis of the second needle section 442, so that the cap 210 of the other vial can smoothly pass through the second protrusion 425. After the cap 210 of the vial smoothly passes through the second protrusion 425, the second wing plate section 427 elastically returns to its original size to restrict the movement of the cap 210 of the other vial.

[0139] To facilitate simultaneous pressing of the first container 201 and the second container 202 by the operator, ensuring that the first container 201 and the second container 202 are pierced and connected at the same time, thus ensuring the mixing effect and preventing leakage or depressurization, the first protrusion 415 also has a first outer edge 4152 on the side opposite to the first surface, which abuts against the lid of the first container 201 when the first container 201 is inserted; correspondingly, the second protrusion 425 also has a second outer edge 4252 on the side opposite to the second surface 432, which abuts against the lid of the second container 202 when the second container 202 is inserted.

[0140] In this way, before puncture, the operator can press the bottom of the first container 201 so that the cap of the first container 201 abuts against the first outer edge 4152. At the same time, the operator also presses the bottom of the second container 202 so that the cap of the second container 202 abuts against the second outer edge 4252, so that the first container 201 and the second container 202 are both in the predetermined position before puncture. At this time, when the operator presses the bottom of the first container 201 and the second container 202 at the same time, the first container 201 and the second container 202 can be inserted into the needle tubes at both ends of the puncture needle 440 in opposite axial directions (first direction and second direction) at the same time, so that the first container 201 and the second container 202 can be pierced at the same time.

[0141] In order to prevent the first container 201 and the second container 202 from shaking when they are in the predetermined positions before the puncture, such as Figure 7 As shown, the lengths of the first storage portion 410 and the second storage portion 420 can be extended so that the first window 413 has a first pressing port portion 4131 and a first dispensing port portion 4132. The first pressing port portion 4131 is located on the side of the first dispensing port portion 4132 that is away from the first surface 431. The opening spacing D1 of the first pressing port portion 4131 is greater than the opening spacing D2 of the first dispensing port portion 4132. Before the first needle tube portion 441 punctures the first container 201, if the cover of the first container 201 abuts against the first outer edge 4152, the first bottom surface of the first container 201 is located in the first pressing port portion 4131. In this way, when the first container 201 is in the predetermined position before puncture, it is still located in the first storage portion 410 and is not easy to shake.

[0142] And / or, the second window 423 has a second pressing port portion 4231 and a second dispensing port portion 4232. The second pressing port portion 4231 is located on the side of the second dispensing port portion 4232 away from the second surface. The opening spacing D3 of the second pressing port portion 4231 is greater than the opening spacing D4 of the second dispensing port portion 4232. Before the second needle tube portion 442 punctures the second container 202, if the cap of the second container 202 abuts against the second outer edge 4252, the second bottom surface of the second container 202 is located in the second pressing port portion 4231. In this way, when the second container 202 is in the predetermined position before puncture, it is also located in the second storage portion 420 and is not easy to shake.

[0143] At this time, the operator's finger can enter the first storage part 410 through the first pressing port 4131 to press the first bottom surface of the first container 201, and another finger can enter the second storage part 420 through the second pressing port 4231 to press the first bottom surface of the second container 202, thereby pressing the bottom surfaces of the two containers simultaneously.

[0144] Furthermore, in order to further improve the container's passability in the storage section, such as... Figure 6 As shown, the first housing 411 is constructed with multiple slots starting from the edge of the first inlet 412. The first housing 411 includes multiple first elastic walls 419 that are separated by a first gap 418. The multiple first elastic walls 419 can more easily expand outward elastically when the first container 201 enters, making it easier for the first container 201 to enter the first storage part 410, and the operator does not need to use too much force when pressing.

[0145] And / or, the second housing 421 is constructed with multiple slots starting from the edge of the second inlet 422, and the second housing 421 includes a plurality of second elastic walls 429 disconnected by a second gap 428. The plurality of second elastic walls 429 can also more easily expand outward elastically when the second container 202 enters, facilitating the entry of the second container 202 into the second receiving section 420, without requiring excessive force when the operator presses it.

[0146] If it is necessary to dissolve and obtain a sterile lyophilized preparation of at least two components, the number of pharmaceutical mixing units 400 is at least two, and the at least two pharmaceutical mixing units 400 can be connected side by side to connect at least two first containers 201 and at least two second containers 202.

[0147] The at least two drug mixing sections include a first drug mixing section 401 and a second drug mixing section 402 arranged side-by-side. For example... Figure 8 As shown, a first connecting port 450 is provided between the first window 413A of the first drug mixing section 401 and the first window 413B of the second drug mixing section 402, so as to simultaneously expose at least part of the bottom surface of both the first container connected to the first drug mixing section 401 and the first container connected to the second drug mixing section 402, so that the operator can press the bottom surface of the two adjacent first containers at the same time through the first connecting port 450.

[0148] And / or, a second communication port 460 is provided between the second window 423A of the first drug mixing section 401 and the second window 423B of the second drug mixing section 402, so as to simultaneously expose at least part of the bottom surface of both the second container connected to the first drug mixing section 401 and the second container connected to the second drug mixing section 402, so that the operator can press the bottom surface of the two adjacent second containers simultaneously through the second communication port 460.

[0149] If either the first connection port 450 or the second connection port 460 is present, the operator can mix the two sets of containers (four containers inserted in pairs) using only three fingers. If both the first connection port 450 and the second connection port 460 are present, the operator can mix the two sets of containers (four containers inserted in pairs) using only two fingers, further reducing the number of steps required.

[0150] Furthermore, in order to better simultaneously press two adjacent first containers 201 and / or two adjacent second containers 202, the pharmaceutical mixing device may also include a pressing plate (not shown in the figure), which simultaneously abuts against the bottom surfaces of at least two first containers or at least two second containers. By pressing the pressing plate, the operator can simultaneously press the bottom surfaces of two adjacent second containers or two adjacent first containers.

[0151] The aforementioned drug delivery device 1000 and drug mixing device 2000 can be used together. Therefore, this application also provides a drug preparation device. The drug preparation device includes a drug mixing device 2000 and a drug delivery device 1000. Optionally, the main body material of the drug mixing device 2000 and the drug delivery device 1000 is a translucent or transparent lightweight material that is sterilizable and corrosion-resistant. Optionally, the needle tube portion, such as the needle tip, in the aforementioned puncture needle 440 or liquid collection device 113 is made of hard alloy or hard polymer material, and the puncture end of the needle tube portion is a beveled tip or a droplet-shaped tip that is sterilizable and corrosion-resistant; specifically, it can be a short syringe needle. The drug mixing device 2000 and the drug delivery device 1000 can be used once or reused after cleaning and sterilization.

[0152] The drug mixing device is connected to a first container and a second container during use. The drug mixing device has a puncture needle with a first needle tube facing the first container and a second needle tube facing the second container. The first needle tube is used to puncture the seal of the first container, and the second needle tube is used to puncture the seal of the second container, so as to connect the first container and the second container and allow the liquid contained in the first container to flow into the second container to obtain a mixed drug solution.

[0153] When in use, the drug delivery device is connected to at least two second containers. At least two syringes in the multi-syringe are connected to at least two second containers one by one through the drug delivery device, so that at least two syringes can synchronously draw the mixed drug solution in the second containers.

[0154] In this way, operators can reduce the number of steps involved in both the drug mixing and drug transfer stages. This eliminates the need for repeated aspiration, transfer, and quantitative manipulation. Different dosages of medication can be quickly prepared in a multi-syringe, and then the different solutions can be mixed in proportion and discharged for use via the mixing connector reconnected to the multi-syringe. For example, after separately drawing two different components of dissolved lyophilized medication from a dual-chamber syringe, the connectors of the two syringes can be connected to the mixing connector. The two different components of the dissolved lyophilized medication will then react after mixing, forming a gel-like fibrin adhesive that is discharged and applied to the wound.

[0155] In the above-mentioned pharmaceutical preparation device, in order to facilitate the use of the pharmaceutical mixing device and reduce the cost of the pharmaceutical mixing device, the first receiving part, the second receiving part and the isolation part of the pharmaceutical mixing device can be continuously and integrally set, thereby forming in one step and reducing the complexity of the process.

[0156] In the above-described pharmaceutical preparation device, after the pharmaceuticals in the first and second containers are mixed, they will be stored in one of the containers, such as the second container. At this point, the second containers need to be removed from the aforementioned pharmaceutical mixing device and transferred to the pharmaceutical delivery device. The pharmaceutical delivery device can only be used for pharmaceutical transfer after all the second containers have been installed.

[0157] In view of this, this application also provides a pharmaceutical mixing device that can be used as a pharmaceutical liquid delivery device to deliver pharmaceutical liquid without disassembling the second container after the mixing operation is completed.

[0158] like Figure 9 As shown, in this drug mixing device, the first storage part 410 and the second storage part 420 are detachably connected, the isolation part 430 is fixedly connected to the first storage part 410, and the puncture needle 440 is fixed on the isolation part 430.

[0159] The second storage section 420 also has a suction port (not shown in the figure). When the first storage section 410 and the second storage section 420 are separated, the suction port is used to expose the seal of the second container 202. When the first storage section 410 and the second storage section 420 are connected, the suction port is used for the second needle tube section 442 to be inserted into the second storage section 420.

[0160] The number of the above-mentioned drug mixing units is at least two, and the at least two drug mixing units include a first drug mixing unit 401 and a second drug mixing unit 402. The drug mixing device has a mixing use state and a pipetting use state.

[0161] In the mixed-use state, one end of the drug mixing device is connected to at least two first containers, and the other end is connected to at least two second containers. The at least two first containers include a first drug solution container 51 and a second drug solution container 52, and the at least two second containers include a first drug solution container 53 and a second drug solution container 54. The first drug solution container 51 and the second drug solution container 52 can be two vials containing a reconstituted solution, and the first drug solution container 53 and the second drug solution container 54 can be two vacuum vials containing a sterile lyophilized preparation.

[0162] During the mixing stage, the first needle portion of the first drug mixing unit 401 punctures the first drug container 51, and the second needle portion of the first drug mixing unit 401 punctures the first drug container 53, allowing the liquid contained in the first drug container 51 to flow into the first drug container 53; the first needle portion of the second drug mixing unit 402 punctures the second drug container 52, and the second needle portion of the second drug mixing unit 402 punctures the second drug container 54, allowing the liquid contained in the second drug container 52 to flow into the second drug container 54.

[0163] In the pipetting usage state, the first storage portion 410A of the first drug mixing portion 401 and the second storage portion 420A of the first drug mixing portion 401 are in a separate state, the first storage portion 410B of the second drug mixing portion 402 and the second storage portion 420B of the second drug mixing portion 402 are in a separate state, and the second storage portions 420A and 420B of the first drug mixing portion are fixedly connected side by side;

[0164] The second storage portion 420A of the first drug mixing portion 401 has a first suction port. When the first storage portion 410A of the first drug mixing portion 401 and the second storage portion 420A of the first drug mixing portion 401 are separated, the first suction port allows the first syringe 310A of the multi-syringe 300 to be inserted into the first drug container 53.

[0165] The second storage portion 420B of the second drug mixing section 402 has a second suction port. When the first storage portion 410B of the second drug mixing section 402 and the second storage portion 420B of the second drug mixing section 402 are separated, the second suction port allows the second syringe 310B of the multi-syringe 300 to be inserted into the second drug container 54.

[0166] At this point, the operator can directly hold the two relatively fixedly connected second storage parts 420 without removing the first drug container 53 and the second drug container 54, and insert the needles connected to each syringe in the multi-syringe 300 into each drug container containing the mixed drug solution through each aspiration port, and simultaneously draw the liquid, further reducing the steps of transferring the installation container to the drug delivery device and further improving work efficiency.

[0167] The aforementioned drug mixing unit also has a connecting part for connecting to the connecting part of another drug mixing unit, so that the drug mixing unit and the other drug mixing unit are connected side by side; in this way, the first drug mixing unit and the second drug mixing unit can be fixedly connected side by side.

[0168] Specifically, such as Figure 9 As shown, the second storage section is provided with a connecting part 60, which allows the second storage section 420A of the first drug mixing section 401 and the second storage section 420B of the second drug mixing section 402 to be fixedly connected side by side. This facilitates the operator's grip and also makes it easy to connect to the multi-injector 300. The first storage sections of the two drug mixing sections can be independently detached from the second storage section after the drug solution is mixed.

[0169] Alternatively, both the first and second storage sections are provided with connecting parts. In addition to the second storage section of the first drug mixing section being fixedly connected side by side with the second storage section of the second drug mixing section, the first storage sections of the two drug mixing sections can be disassembled and separated from the second storage section by the operator after the drug solution is mixed, since the two are relatively fixedly connected by the connecting parts, thereby improving the operation efficiency.

[0170] The aforementioned connecting part can be a snap-fit ​​structure, an integrated part connected to another drug mixing part, or a magnetic structure. This application does not limit this aspect.

[0171] In addition to the above solutions, such as Figure 10 As shown, alternatively, a perforated hole 70 can be provided in the isolation section 430 to reuse the drug mixing section for drug transfer. The perforated hole 70 is located adjacent to the puncture needle 440 to expose the punctureable area in the seal of the other container when one of the first and second containers leaves the drug mixing section 400, allowing the injection needle to insert into the punctureable area. For example, after the first container leaves the first receiving section 410, the perforated hole 70 can expose the punctureable area of ​​the seal of the second container. In this way, the needle connected to the syringe can puncture into the second container through the perforated hole 70 to aspirate the mixed drug solution located in the second container, completing the drug transfer without disassembling the second container.

[0172] It should be understood that "multiple" as used herein refers to two or more. "And / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A alone, A and B simultaneously, or B alone. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship. Furthermore, the step numbers described herein are merely illustrative of one possible execution order. In some other embodiments, the steps may not be executed in numerical order, such as two steps with different numbers being executed simultaneously, or two steps with different numbers being executed in the reverse order of the illustration. This application does not limit this.

[0173] In the description of this application, it should be noted that, in the embodiments of this application, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature.

[0174] In the description of the embodiments of this application, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, "linking" can be a detachable connection or a non-detachable connection; it can be a direct connection or an indirect connection through an intermediate medium. "Fixed connection" refers to a connection where the relative positional relationship remains unchanged after the connection.

[0175] The directional terms used in the embodiments of this application, such as "inner" and "outer," are merely for reference to the directions in the accompanying drawings. Therefore, the directional terms used are for better and clearer explanation and understanding of the embodiments of this application, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of this application. Furthermore, unless otherwise stated in this application, "multiple" as used in this application refers to two or more.

[0176] In the description of embodiments of this application, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes that element.

[0177] The above description is merely an exemplary embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A medicament mixing device, characterized by, The pharmaceutical mixing device is connected to a first container and a second container during use, and the pharmaceutical mixing device includes: The drug mixing section has a first storage section, a second storage section, an isolation section, and a puncture needle; The isolation section is located between the first storage section and the second storage section, and the isolation section has a first side facing the first container and a second side facing the second container; The puncture needle is disposed through the isolation portion, and the puncture needle has a first needle tube portion protruding towards the first surface and a second needle tube portion protruding towards the second surface; the first needle tube portion is used to puncture the seal of the first container, and the second needle tube portion is used to puncture the seal of the second container. The first receiving portion has a first housing surrounding the first needle portion, the first needle portion being exposed within the first receiving portion; the end of the first housing away from the first surface has a first inlet for inserting the first container into the first receiving portion along a first direction; the first housing has a first window on a first side to expose a portion of the bottle body of the first container. The second receiving portion has a second housing surrounding the second needle portion, the second needle portion being exposed within the second receiving portion, and a second inlet portion at one end of the second housing away from the second surface for inserting the second container into the second receiving portion in a second direction; the second housing has a second window on the first side to expose a portion of the bottle body of the second container, the first direction being opposite to the second direction.

2. The medicine mixing device according to claim 1, characterized by The isolation section has a retrieval slot on the first side, and the slot opening forms a retrieval port. At least one of the first window and the second window is continuously connected to the retrieval port to expose a portion of the end face of at least one of the first container and the second container.

3. The medicine mixing device according to claim 1, characterized by The first window and the second window at least partially overlap in the axial direction of the puncture needle.

4. The medicine mixing device according to claim 1, characterized by The first housing has a first bend, and / or the second housing has a second bend; The first bent portion protrudes inward toward the first storage portion and forms a first protrusion on the inner wall of the first housing. The first protrusion has a first inner edge near the first surface. When in use, the first inner edge engages with the first container to restrict the first container from moving in the second direction. The first bending portion is recessed into the outer wall of the first housing to form a first groove towards the inner side of the first receiving portion; the first housing has a first wing portion located on the side of the first groove away from the first surface, and the first wing portion elastically expands outward when the first container is inserted; The second bent portion protrudes inward toward the second storage portion and forms a second protrusion on the inner wall of the second housing. The second protrusion has a second inner edge near the second surface. The second inner edge engages with the second container during use to restrict the second container from moving in the first direction. The second bending portion is recessed into the inner side of the second receiving portion on the outer wall of the second housing to form a second groove; the second housing has a second wing portion located on the side of the second groove away from the second surface, and the second wing portion elastically expands outward when the second container is inserted.

5. The pharmaceutical mixing device according to claim 4, characterized in that, The first protrusion also has a first outer edge on the side opposite to the first surface, which abuts against the lid of the first container when the first container is inserted. The second protrusion also has a second outer edge on the side opposite to the second surface, which abuts against the lid of the second container when the second container is inserted.

6. The medicament mixing device of claim 1, wherein The first housing is formed by multiple slots from the edge of the first inlet, and the first housing includes a plurality of first elastic walls that are separated by a first gap; And / or, the second housing is constructed with multiple slots from the edge of the second inlet, and the second housing includes a plurality of second elastic walls disconnected by a second gap.

7. The medicament mixing device according to any one of claims 1 to 6, characterized in that The first window has a first pressing port portion and a first dispensing port portion. The first pressing port portion is located on the side of the first dispensing port portion opposite to the first surface. The opening spacing of the first pressing port portion is greater than the opening spacing of the first dispensing port portion. Before the first needle tube punctures the first container, the first bottom surface of the first container is located at the first pressing port portion; And / or, the second window has a second pressing port portion and a second dispensing port portion, the second pressing port portion being located on the side of the second dispensing port portion opposite to the second surface, and the opening spacing of the second pressing port portion being greater than the opening spacing of the second dispensing port portion; Before the second needle tube punctures the second container, the second bottom surface of the second container is located at the second press port portion.

8. The medicament mixing device of any one of claims 1 to 6, wherein, The first storage part and the second storage part are detachably connected, the isolation part is fixedly connected to the first storage part, and the puncture needle is fixed on the isolation part; The second storage section has a suction port. When the first storage section and the second storage section are separated, the suction port is used to expose the seal of the second container. When the first storage section and the second storage section are connected, the suction port allows the second needle tube to be inserted into the second storage section.

9. The medicament mixing device of claim 8, wherein, The pharmaceutical mixing unit also has a connecting part for connecting to the connecting part of another pharmaceutical mixing unit, so that the pharmaceutical mixing unit and the other pharmaceutical mixing unit are connected side by side; The second storage section is provided with the connecting section, or both the first storage section and the second storage section are provided with the connecting section.

10. The medicament mixing device of claim 8, wherein, The number of the drug mixing section is at least two, and the at least two drug mixing sections include a first drug mixing section and a second drug mixing section. The drug mixing device has a mixing use state and a pipetting use state. In the mixed use state, one end of the drug mixing device is connected to at least two first containers, and the other end is connected to at least two second containers. The at least two first containers include a first liquid drug container and a second liquid drug container, and the at least two second containers include a first drug container and a second drug container. The first needle portion of the first drug mixing unit punctures the first drug container, and the second needle portion of the first drug mixing unit punctures the first drug container, causing the liquid contained in the first drug container to flow into the first drug container; The first needle portion of the second drug mixing section punctures the second drug container, and the second needle portion of the second drug mixing section punctures the second drug container, causing the liquid contained in the second drug container to flow into the second drug container; In the pipetting usage state, the first storage part of the first drug mixing part and the second storage part of the first drug mixing part are in the separated state, the first storage part of the second drug mixing part and the second storage part of the second drug mixing part are in the separated state, and the second storage parts of the first drug mixing part and the second storage parts of the second drug mixing part are fixedly connected side by side; The second receiving part of the first drug mixing part has a first suction port, which allows the first syringe in the multi-syringe to be inserted into the first drug container. The second receiving part of the second drug mixing part has a second suction port, which allows the second syringe in the multi-syringe to be inserted into the second drug container.

11. The medicament mixing device of any one of claims 1 to 6, wherein, The number of the drug mixing section is at least two, and the at least two drug mixing sections include a first drug mixing section and a second drug mixing section arranged side by side; The first window of the first drug mixing section and the first window of the second drug mixing section have a first communication port to simultaneously expose at least a portion of the bottom surface of both the first container connected to the first drug mixing section and the first container connected to the second drug mixing section. And / or, the second window of the first drug mixing section and the second window of the second drug mixing section have a second communication port to simultaneously expose at least a portion of the bottom surface of both the second container connected to the first drug mixing section and the second container connected to the second drug mixing section.

12. The medicament mixing device of any one of claims 1 to 6, wherein, The drug mixing device further includes a pressing plate, and the number of drug mixing parts is at least two, with at least two drug mixing parts connected side by side to connect at least two first containers and at least two second containers; The pressing plate simultaneously abuts against the bottom surfaces of at least two of the first containers, or simultaneously abuts against the bottom surfaces of at least two of the second containers.

13. The medicament mixing device of any one of claims 1 to 6, wherein, The isolation section has a perforated hole, which is located adjacent to the puncture needle, so as to expose the punctureable area in the seal of the other when one of the first container and the second container leaves the drug mixing section, so that the injection needle can be inserted into the punctureable area.

14. The medicament mixing device of any one of claims 1 to 6, wherein, The first container and the second container have a pressure difference therebetween to cause the liquid contained in one of the first container and the second container to flow into the other when the puncture needle simultaneously punctures the first container and the second container.

15. The medicament mixing device of any one of claims 1 to 6, wherein, The first receiving portion, the second receiving portion, and the partition portion are continuously and integrally provided.

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