Automated reaction vessel for heparin sodium production

Abstract

This utility model discloses an automated reaction vessel for heparin sodium production, relating to the field of reaction vessel technology. The automated reaction vessel for heparin sodium production is equipped with a drive motor, a rotating drum, a stirring rod, and scrapers. The drive motor rotates the drum, stirring rod, and scrapers, which agitate the solution inside the drum, accelerating the reaction speed. The telescopic end of the electric push rod moves downwards, causing the vertical rod and inclined block to move downwards. As the inclined block moves downwards, it pushes the corresponding stop rod and stirring rod to move horizontally. At this time, the return spring is compressed. Because the inclination angle of each inclined block is different, when the vertical rod moves the same distance downwards, the distance each stop rod and stirring rod moves is different, thus staggering the scraper positions and increasing the stirring efficiency.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology, specifically to an automated reaction vessel for heparin sodium production. Background Technology

[0002] Sodium heparin is an acidic mucopolysaccharide sulfate produced by mast cells of animal connective tissue. It is widely found in the liver, lung, and intestinal mucosa of mammals, often in complexes bound to proteins. Due to its strong anticoagulant effect, it is the first-line drug for the prevention and treatment of thromboembolic diseases such as deep vein thrombosis. The production process of sodium heparin requires the use of a reaction vessel to heat and enzymatically hydrolyze the eroded intestinal mucosa scraped and stirred from the small intestine.

[0003] During the stirring process, some viscous residue remains on the inner wall of the reactor, which is difficult to clean. In ordinary reactors, the stirring rod is fixed and can only rotate in a fixed position during stirring. If the stirring rod is in constant contact with the inner wall of the reactor, it will reduce the efficiency of the stirring rod, especially when the concentration of the solution in the reactor is high. If the stirring rod is not in contact with the inner wall of the reactor, the residual solution on the inner wall of the reactor is difficult to clean. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides an automated reaction vessel for heparin sodium production, which solves the problem of low stirring efficiency due to the inability to rotate and stir in a fixed position during stirring.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an automated reaction vessel for heparin sodium production; comprising a cylinder and a support, the support being located outside the cylinder, a rotating cylinder being provided inside the cylinder, the rotating cylinder having a hollow interior, the top of the rotating cylinder penetrating the top of the cylinder, and the rotating cylinder being rotatably connected to the cylinder, multiple stirring rods being horizontally arranged inside the cylinder, one end of each stirring rod penetrating the rotating cylinder, and the stirring rod and the rotating cylinder being slidably connected along the length of the stirring rod, one end of each stirring rod being provided with a scraper, the scraper being able to contact the inner wall of the cylinder, a feed inlet being provided at the top of the cylinder, and a discharge outlet being provided at the bottom.

[0006] Preferably, a drive motor is provided above the cylinder, the output end of the drive motor is fixedly connected to the rotating drum, and the housing of the drive motor is fixedly connected to the mounting block.

[0007] Preferably, a temperature sensor is provided at the end of the stirring rod away from the scraper, a limiting strip is provided on the stirring rod along the horizontal direction, a corresponding limiting groove is provided on the rotating drum, and a sealing ring is provided at the part of the stirring rod that contacts the rotating drum.

[0008] Preferably, a stop bar is fixedly connected to the outside of the stirring rod. The stop bar is located inside the cavity, is horizontally oriented, and its axis is perpendicular to the axis of the stirring rod.

[0009] Preferably, multiple inclined blocks are fixedly installed on the vertical rod, with each inclined block corresponding to a stirring rod, and the inclined blocks are located above the corresponding stop bars.

[0010] Preferably, the surface in contact between the inclined block and the stop bar is an inclined surface, and the angle of the inclined surface of each inclined block is different.

[0011] Preferably, a return spring is sleeved on the outside of the stirring rod, the return spring is located inside the cavity, and the return spring is located on the side of the stop rod away from the vertical rod.

[0012] Preferably, the bottom of the rotating drum is connected to the rotating drum via a thread, and an electric push rod is provided inside the rotating drum. The top of the electric push rod is fixedly connected to the inner wall of the top of the rotating drum, and the bottom of the electric push rod is fixedly connected to the vertical rod.

[0013] Preferably, the scraper is provided with a feeding trough on both sides.

[0014] This invention provides an automated reaction vessel for heparin sodium production. Compared with the prior art, it has the following advantages:

[0015] 1. This automated reactor for heparin sodium production is equipped with a drive motor, a rotating drum, a stirring rod, and scrapers. The drive motor rotates the drum, stirring rod, and scrapers, which stir the solution inside the drum to accelerate the reaction. The telescopic end of the electric push rod moves downward, causing the vertical rod and the inclined block to move downward. As the inclined block moves downward, it pushes the corresponding stop rod and stirring rod to move horizontally. At this time, the return spring is compressed. Since the inclination angle of each inclined block is different, when the vertical rod moves downward the same distance, the distance each stop rod and stirring rod moves is different, thus staggering the position of the scrapers and increasing the stirring efficiency.

[0016] 2. The automated reactor for heparin sodium production is equipped with an electric push rod, a stop rod, and a return spring. When the electric push rod moves upward, the return spring drives the stirring rod, the stop rod, and the scraper to return to their original positions, so that the scraper contacts the inner wall of the cylinder. This ensures that the solution adhering to the inner wall of the cylinder can also be fully stirred, and high stirring efficiency can be guaranteed even when the solution concentration is high.

[0017] 3. The automated reactor for heparin sodium production is equipped with temperature sensors. During the heparin sodium production process, the temperature needs to be controlled more precisely. Temperature sensors at different locations can detect the temperature of the solution at different heights, making the detection results more accurate. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0019] Figure 2 This is a schematic diagram of the internal structure of this utility model.

[0020] Figure 3 This is an internal sectional view of the present invention.

[0021] Figure 4 This utility model Figure 3 Enlarged schematic diagram of part A.

[0022] Figure 5 This is a schematic diagram showing the position of the reset spring of this utility model.

[0023] In the diagram: 1. Cylinder body; 2. Bracket; 3. Rotary drum; 4. Drive motor; 5. Mounting block; 6. Feed inlet; 7. Discharge outlet; 8. Stirring rod; 9. Scraper; 10. Feed chute; 11. Electric push rod; 12. Vertical rod; 13. Inclined block; 14. Stop bar; 15. Return spring; 16. Temperature sensor; 17. Cavity. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Please see Figure 1-5This utility model provides a technical solution: an automated reactor for heparin sodium production, including a cylinder body 1 and a support 2. The support 2 is located outside the cylinder body 1. A rotating cylinder 3 is provided inside the cylinder body 1, and the interior of the rotating cylinder 3 is a cavity 17. The top of the rotating cylinder 3 penetrates the top of the cylinder body 1, and the rotating cylinder 3 is rotatably connected to the cylinder body 1. Multiple stirring rods 8 are horizontally arranged inside the cylinder body 1. One end of each stirring rod 8 penetrates the rotating cylinder 3, and the stirring rod 8 and the rotating cylinder 3 are slidably connected along the length of the stirring rod 8. One end of each stirring rod 8 is provided with a scraper 9, which can contact the inner wall of the cylinder body 1. The top of the cylinder body 1 is provided with a feed inlet 6, and the bottom is provided with a discharge outlet 7. A drive motor 4 is provided above the cylinder body 1, and the output end of the drive motor 4 is fixedly connected to the rotating cylinder 3. The housing of the drive motor 4 is fixedly connected to a mounting block 5. When the drive motor 4 is working, it electrically pushes... The telescopic end at the bottom of rod 11 moves downward, causing the vertical rod 12 and the inclined block 13 to move downward. When the inclined block 13 moves downward, the inclined surface contacts the stop rod 14, and the inclined block 13 pushes the corresponding stop rod 14 to move, thereby causing the stirring rod 8 to move in the horizontal direction. At this time, the return spring 15 is compressed. Since the inclined surface angle of each inclined block 13 is different, when the vertical rod 12 moves downward a distance of the same, the distances moved by each stop rod 14 and the stirring rod 8 are different, thereby causing the position of the scraper 9 to be staggered, increasing the stirring efficiency. When the electric push rod 11 moves upward, the return spring 15 causes the stirring rod 8, the stop rod 14 and the scraper 9 to return to their original positions, so that the scraper 9 contacts the inner wall of the cylinder 1, thereby ensuring that the solution attached to the inner wall of the cylinder 1 can also be fully stirred, and ensuring high stirring efficiency even when the solution concentration is high.

[0026] A temperature sensor 16 is installed at the end of the stirring rod 8 furthest from the scraper 9. A limiting strip is provided on the stirring rod 8 along the horizontal direction, and a corresponding limiting groove is provided on the rotating drum 3. A sealing ring is provided at the contact point between the stirring rod 8 and the rotating drum 3. In the production process of heparin sodium, precise temperature control is required. Temperature sensors 16 at different positions can detect the solution temperature at different heights, making the detection results more accurate.

[0027] A stop rod 14 is fixedly connected to the outside of the stirring rod 8. The stop rod 14 is located in the cavity 17 and is set horizontally. The axis of the stop rod 14 is perpendicular to the axis of the stirring rod 8. Multiple inclined blocks 13 are fixedly installed on the vertical rod 12. Each inclined block 13 corresponds to one of the stirring rods 8 and is located above the corresponding stop rod 14. The surface of the inclined block 13 in contact with the stop rod 14 is an inclined plane. The angle of the inclined plane of each inclined block 13 is different. During the stirring process, the electric push rod 11 moves up and down back and forth, so that the positions of each stop rod 14, stirring rod 8 and scraper 9 are constantly changing. Even when the solution concentration is high, a high stirring efficiency can be maintained.

[0028] A return spring 15 is sleeved on the outside of the stirring rod 8. The return spring 15 is located inside the cavity 17 and is located on the side of the stop rod 14 away from the vertical rod 12.

[0029] The bottom of the rotating drum 3 is connected to the rotating drum 3 by threads. An electric push rod 11 is provided inside the rotating drum 3. The top of the electric push rod 11 is fixedly connected to the inner wall of the top of the rotating drum 3, and the bottom of the electric push rod 11 is fixedly connected to the vertical rod 12.

[0030] Both sides of the scraper 9 are provided with a discharge trough 10. After the heparin sodium reaction is complete, the solution flows out through the discharge port 7 at the bottom of the cylinder 1. Some solution will remain inside the cylinder 1. At this time, the electric push rod 11 moves upward. Under the action of the return spring 15, the stirring rod 8 and the scraper 9 are reset. The scraper 9 contacts the inner wall of the cylinder 1. The drive motor 4 drives the rotating drum 3, stirring rod 8 and scraper 9 to rotate. The scraper 9 can scrape off the solution on the inner wall of the cylinder 1. The scraper 9 is provided with a discharge trough 10. The remaining solution flows downward through the discharge trough 10.

[0031] During operation, the solution to be reacted is poured into the inlet 6 at the top of the cylinder 1. Then, the drive motor 4 drives the rotating drum 3 to rotate, which in turn drives the stirring rod 8 and scraper 9 to rotate. As the stirring rod 8 and scraper 9 rotate, they stir the solution inside the cylinder 1, accelerating the reaction speed. The mounting block 5 is fixedly connected to the external frame.

[0032] When the drive motor 4 is working, the telescopic end at the bottom of the electric push rod 11 moves downward, causing the vertical rod 12 and the inclined block 13 to move downward. When the inclined block 13 moves downward, the inclined surface contacts the stop rod 14, and the inclined block 13 pushes the corresponding stop rod 14 to move, thereby causing the stirring rod 8 to move in the horizontal direction. At this time, the return spring 15 is compressed. Since the inclined surface angle of each inclined block 13 is different, when the vertical rod 12 moves downward the same distance, the distance that each stop rod 14 and the stirring rod 8 moves is different, thereby causing the scraper 9 to be staggered and increasing the stirring efficiency.

[0033] When the electric push rod 11 moves upward, the return spring 15 drives the stirring rod 8, the stop rod 14 and the scraper 9 to return to their original positions, so that the scraper 9 contacts the inner wall of the cylinder 1, thereby ensuring that the solution attached to the inner wall of the cylinder 1 can also be fully stirred, and ensuring high stirring efficiency even when the solution concentration is high.

[0034] During the stirring process, the electric push rod 11 moves up and down, causing the positions of each baffle 14, stirring rod 8 and scraper 9 to change continuously, maintaining high stirring efficiency even when the solution concentration is high.

[0035] In the production process of heparin sodium, precise temperature control is required. Temperature sensors 16 at different locations can detect the temperature of the solution at different heights, making the detection results more accurate. When multiple temperature sensors 16 return different temperature information, it may be due to insufficient stirring of the solution.

[0036] After the heparin sodium reaction is complete, the solution flows into the next filtration process through the discharge port 7 at the bottom of the cylinder 1. Some solution will remain inside the cylinder 1. At this time, the electric push rod 11 moves upward. Under the action of the return spring 15, the stirring rod 8 and scraper 9 are reset. The scraper 9 contacts the inner wall of the cylinder 1. The drive motor 4 drives the rotating drum 3, stirring rod 8 and scraper 9 to rotate. The scraper 9 can scrape off the solution on the inner wall of the cylinder 1. The scraper 9 is provided with a discharge trough 10. The remaining solution flows downward through the discharge trough 10.

[0037] The bottom of the rotating cylinder 3 is connected to the rotating cylinder 3 by a thread to prevent the solution from entering the cavity 17 through the bottom of the rotating cylinder 3.

[0038] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0039] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, the phrase "comprising an element defined as..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0040] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An automated reactor for heparin sodium production, comprising a cylinder (1) and a support (2), wherein the support (2) is located outside the cylinder (1), characterized in that, The cylinder (1) is equipped with a rotating drum (3), the inside of which is a cavity (17). The top of the rotating drum (3) passes through the top of the cylinder (1), and the rotating drum (3) is rotatably connected to the cylinder (1). Multiple stirring rods (8) are horizontally arranged inside the cylinder (1). One end of the stirring rod (8) passes through the rotating drum (3), and the stirring rod (8) and the rotating drum (3) are slidably connected along the length of the stirring rod (8). One end of the stirring rod (8) is equipped with a scraper (9), which can contact the inner wall of the cylinder (1). The top of the cylinder (1) is equipped with a feed inlet (6), and the bottom is equipped with a discharge outlet (7). The rotating drum (3) is equipped with an electric push rod (11). The top of the electric push rod (11) is fixedly connected to the inner wall of the top of the rotating drum (3), and the bottom of the electric push rod (11) is fixedly connected to a vertical rod (12). The end of the stirring rod (8) away from the scraper (9) is equipped with a temperature sensor (16). A limiting strip is provided along the horizontal direction at the top, and a limiting groove is provided on the rotating drum (3) accordingly. A sealing ring is provided at the part where the stirring rod (8) contacts the rotating drum (3). A stop rod (14) is fixedly connected to the outside of the stirring rod (8). The stop rod (14) is located in the cavity (17). The stop rod (14) is set in the horizontal direction, and the axis of the stop rod (14) is perpendicular to the axis of the stirring rod (8). Multiple inclined blocks (13) are fixedly installed on the vertical rod (12). The inclined blocks (13) correspond one-to-one with the stirring rod (8). The inclined blocks (13) are located above the corresponding stop rod (14). The surface where the inclined blocks (13) contact the stop rod (14) is an inclined surface. The angle of the inclined surface of each inclined block (13) is different. A return spring (15) is sleeved on the outside of the stirring rod (8). The return spring (15) is located in the cavity (17), and the return spring (15) is located on the side of the stop rod (14) away from the vertical rod (12).

2. The automatic reaction kettle for producing heparin sodium according to claim 1, characterized in that: A drive motor (4) is provided above the cylinder (1). The output end of the drive motor (4) is fixedly connected to the rotating drum (3). The housing of the drive motor (4) is fixedly connected to the mounting block (5).

3. The automatic reaction kettle for producing heparin sodium according to claim 1, characterized in that: The scraper (9) is provided with a feeding trough (10) on both sides.

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