A cooling device of a multi-mode continuous blow-fill-seal integrated machine

Abstract

This utility model relates to the field of pharmaceutical equipment and discloses a cooling device for a multi-mode continuous blow-fill-seal integrated machine for cooling liquid medicines in plastic bottles. The device includes a ventilation hood fixed above a conveyor belt, with its length aligned with the conveyor belt's direction. The ventilation hood passes through a partition plate, and its two ends connect to the clean area and general area on either side of the partition plate, respectively. A cooling air channel is formed between the ventilation hood and the conveyor belt for the liquid medicines in the plastic bottles to pass through. This utility model, by adding a ventilation hood to the conveyor belt of a conventional blow-fill-seal integrated machine that utilizes the pressure difference between the clean and general areas to efficiently cool the liquid medicines in the plastic bottles, constructs a directional air-cooling channel flowing from the clean area to the general area and close to the liquid medicines in the plastic bottles. This enables efficient cooling of the liquid medicines in the plastic bottles, ensuring the quality of subsequent die-cutting.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment, and in particular to a cooling device for a multi-mode continuous blow-fill-seal integrated machine. Background Technology

[0002] Multi-mode continuous blow-fill-seal integrated machines are core equipment in the pharmaceutical industry for producing plastic-bottled liquid medicines (such as large-volume injections and oral liquids). Their process typically includes blow molding, filling, sealing, cooling, and die-cutting. Cooling the product (such as vials and ampoules) after sealing is an indispensable step. If the product is not fully cooled before entering the die-cutting station, thermal deformation can easily lead to burrs, dimensional deviations, and other problems, affecting the product yield.

[0003] As attached Figure 1 In the prior art shown, the filling and sealing process of the plastic bottle liquid medicine 3 is completed in a clean area X (Class 10,000 or locally Class 100), while the punching station is usually located in a general area Y. The clean area X is classified according to current pharmaceutical production management standards, based on indicators such as air cleanliness, air pressure, air volume, temperature and humidity, noise, and microbial content. After the plastic bottle liquid medicine 3 is filled and sealed, the not-fully-cooled plastic bottle liquid medicine 3 is transported directly from the clean area X through the color steel plate partition 4 to the punching station located in the general area Y via the conveyor belt 2. The plastic bottle liquid medicine 3 undergoes natural cooling during the transportation process.

[0004] However, natural cooling is inefficient and highly susceptible to factors such as ambient temperature and conveying speed, making it difficult to ensure that the liquid medicine 3 in the plastic bottle is completely cooled before entering the punching station. Meanwhile, a positive pressure difference of approximately 30 Pa is typically maintained between the clean area X and the general area Y. Therefore, it is necessary to design a cooling device that is compatible with the current blow-fill-seal machine and can utilize the pressure difference between the clean area X and the general area Y to achieve efficient air cooling, thereby providing timely and effective cooling of the liquid medicine 3 in the plastic bottle to ensure the processing quality of the subsequent punching station. Utility Model Content

[0005] To address the problems existing in the prior art, the natural cooling efficiency of liquid medicines in plastic bottles after filling and sealing by a multi-mode continuous blow-fill-seal machine is low, resulting in unsatisfactory cooling effects. The purpose of this utility model is to provide a cooling device for a multi-mode continuous blow-fill-seal machine. By adding a ventilation hood to the conveyor belt of the existing blow-fill-seal machine, which can utilize the pressure difference between the clean area and the general area to achieve efficient air cooling of the liquid medicines in plastic bottles, a directional air cooling channel is constructed from the clean area to the general area and close to the liquid medicines in the plastic bottles. This enables efficient cooling of the liquid medicines in plastic bottles and ensures the quality of subsequent die-cutting.

[0006] To achieve the above objectives, the technical solution of this utility model is as follows: A cooling device for a multi-mode continuous blow-fill-seal integrated machine, used for cooling liquid medicines in plastic bottles, includes a ventilation hood, which is fixed above a conveyor belt and its length direction is consistent with the conveying direction of the conveyor belt. The ventilation hood passes through a partition plate and its two ends are respectively connected to the clean area and the general area on both sides of the partition plate. A cooling air channel for the liquid medicines in plastic bottles is formed between the ventilation hood and the conveyor belt.

[0007] The present invention is further configured such that: mounting portions are provided on both sides of the ventilation hood in the width direction, and the ventilation hood is fixed above the conveyor belt by the mounting portions.

[0008] The present invention is further configured such that the side of the ventilation hood facing away from the cooling air channel is in close contact with the partition plate.

[0009] The present invention is further configured such that: a guide plate is provided inside the ventilation hood, the guide plate being used to guide the cooling air to blow towards the plastic bottle liquid medicine located on the conveyor belt.

[0010] The present invention is further configured such that the guide plate is located at one end of the ventilation hood near the clean area.

[0011] The present invention is further configured such that: the guide plate is fixed to the top of the ventilation hood, and the guide plate extends downward at an angle along the direction from the clean area to the general area.

[0012] The present invention is further configured such that: an installation plate is provided on the top of the inner wall of the ventilation hood; the guide plate includes an integrally formed vertical plate and an inclined plate; the vertical plate is fixedly connected to the installation plate by fastening bolts.

[0013] The present invention is further configured such that the ventilation hood is made of metal material.

[0014] In summary, the beneficial effects achieved by this utility model are as follows: (1) The ventilation hood can guide the 30Pa pressure difference wind from the clean area to the general area to form a directional airflow that runs through the cooling air channel formed by the ventilation hood and the conveyor belt. It can achieve forced cooling of the plastic bottle liquid medicine on the conveyor belt without the need for an additional power source and will not generate additional energy consumption. (2) The ventilation hood is directly fixed above the conveyor belt through the installation part, which is compatible with the structural characteristics of the current blow-fill-seal machine. There is no need to modify the main structure of the blow-fill-seal machine, the modification cost is low, the cycle is short, and the installation steps are simple. (3) The close contact between the ventilation hood and the partition plate can prevent airflow from leaking out from the gap between them and maintain the pressure difference between the clean area and the general area; (4) The downward-sloping guide plate inside the ventilation hood can not only guide the airflow to flow evenly and cover the surface of the liquid medicine in the plastic bottle, avoiding uneven local cooling; but also, the guide plate set at the end near the clean area makes the air inlet area of ​​the ventilation hood smaller than the air outlet area. The airflow accelerates at the air inlet and blows towards the liquid medicine in the plastic bottle, quickly taking away a large amount of heat from the liquid medicine in the plastic bottle. After that, the airflow speed slows down and can fully contact the ventilation hood, so that the heat can be evenly radiated outward through the ventilation hood. (5) The ventilation hood made of metal has excellent heat conduction ability, preventing heat from accumulating in the cooling air channel formed by the ventilation hood and the conveyor belt. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the specification will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0016] Figure 1 This is a schematic diagram of the liquid medicine delivery process in a plastic bottle in the background art of this utility model; Figure 2 This is a schematic diagram of the liquid medicine delivery process in the plastic bottle according to an embodiment of the present invention; Figure 3 This is a structural schematic diagram of the ventilation hood. Figure 4 for Figure 3 A magnified view of part A in the middle; Figure 5 This is a right view of the ventilation hood. Figure 6 This is a bottom view of the ventilation hood.

[0017] In the diagram: 1. Frame; 2. Conveyor belt; 3. Plastic bottle liquid medicine; 4. Partition plate; 5. Ventilation hood; 51. Mounting section; 52. Mounting plate; 53. Guide plate; 531. Vertical plate; 532. Inclined plate; 54. Fastening bolts; X. Clean area; Y. General area. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, not all embodiments. For ease of explanation, the terms "vertical", "horizontal", "left", "right", "upper", "lower", "inner", "outer", "bottom", etc., used in this specification indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0019] It should be noted that the embodiments and features involved in the embodiments of this utility model can be combined with each other without conflict. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without inventive effort are within the scope of protection of this utility model.

[0020] As attached Figure 2-6 As shown, a cooling device for a multi-mode continuous blow-fill-seal integrated machine is used to cool liquid medicine 3 in plastic bottles. The cooling device includes a ventilation hood 5.

[0021] Those skilled in the art will recognize that the blow-fill-seal integrated machine is existing equipment. After filling and sealing the liquid medicine 3 in the plastic bottle, it is conveyed by the conveyor belt 2 according to the attached... Figure 2 In the f direction, the uncooled liquid medicine 3 in the plastic bottle is transported directly from the clean area X through the partition plate 4 to the punching station located in the general area Y. Furthermore, a positive pressure difference of approximately 30 Pa is typically maintained between the clean area X and the general area Y.

[0022] A frame 1 of suitable height is set below the conveyor belt 2 to support and install the conveyor belt 2.

[0023] The lower edge of the partition plate 4 is fixed in contact with the ground, the upper edge of the partition plate 4 is fixed in contact with the workshop ceiling, and the four sides of the partition plate 4 are fixed in contact with the walls, thereby completely separating the clean area X and the general area Y located on both sides of the partition plate 4 and maintaining the pressure difference between the clean area X and the general area Y.

[0024] The ventilation hood 5 is a rectangular shell structure with a U-shaped cross-section, and its bottom surface and both ends in the length direction are open. The length direction of the ventilation hood 5 is consistent with the conveying direction of the conveyor belt 2, which is the f direction. Each of the two sides of the ventilation hood 5 in the width direction is provided with a mounting part 51.

[0025] The cross-section of the mounting part 51 is stepped, and the width of the ventilation hood 5 is adapted to the width of the conveyor belt 2, so that when the ventilation hood 5 is located directly above the conveyor belt 2, the two mounting parts 51 on the ventilation hood 5 are just located at the edge of the conveyor belt 2, thereby fixing the ventilation hood 5 above the conveyor belt 2 through the mounting parts 51.

[0026] The ventilation hood 5 passes vertically through the partition plate 4, and its two ends are connected to the clean area X and the general area Y on both sides of the partition plate 4, respectively. A cooling air channel for the plastic bottle liquid medicine 3 to pass through is formed between the ventilation hood 5 and the conveyor belt 2.

[0027] The outer side of the ventilation hood 5, that is, the side facing away from the cooling air duct, is in close contact with the partition plate 4 to prevent airflow from leaking from the gap between the ventilation hood 5 and the partition plate 4, thereby maintaining the pressure difference between the clean area X and the general area Y.

[0028] A baffle plate 53 is installed inside the ventilation hood 5, and the baffle plate 53 is located at one end of the ventilation hood 5 near the clean area X.

[0029] The guide plate 53 includes an integrally formed vertical plate 531 and an inclined plate 532. A vertically mounted mounting plate 52 is provided at the top of the inner wall of the ventilation hood 5, near the clean area X. The vertical plate 531 is fixedly connected to the mounting plate 52 by fastening bolts 54, thereby fixing the guide plate 53 to the top of the ventilation hood 5. In this state, the inclined plate 532 of the guide plate 53 extends downwards at an angle along the direction from the clean area X to the general area Y, thereby guiding the cooling air towards the plastic bottle liquid medicine 3 located on the conveyor belt 2.

[0030] Specifically, the ventilation hood 5 in this embodiment is made of a metal material with high thermal conductivity, preferably stainless steel. Stainless steel not only has excellent heat dissipation capabilities, but also has a smooth surface that is easy to clean, avoiding dust accumulation and contamination, and meets the GMP cleanroom standards for the pharmaceutical industry.

[0031] The implementation principle of the above embodiments is as follows: As the conveyor belt 2 transports the liquid medicine 3 from the plastic bottle into the cooling air channel, the airflow naturally flowing from the clean area X to the general area Y is guided by the guide plate 53. The airflow accelerates and covers the surface of the liquid medicine 3, quickly carrying away a large amount of heat from the liquid medicine 3. Afterward, the airflow speed slows down, making full contact with the stainless steel ventilation hood 5, and the heat is evenly radiated outward through the ventilation hood 5, ensuring that the liquid medicine 3 in the plastic bottle is fully cooled within the ventilation hood 5.

[0032] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including both the preferred embodiments and all changes and modifications falling within the scope of the present invention. Clearly, those skilled in the art can make various alterations and modifications to the present invention without departing from its spirit and scope. Thus, if such modifications and modifications fall within the scope of the claims of the present invention and their equivalents, the present invention also intends to include such modifications and modifications.

Claims

1. A cooling device for a multi-mode continuous blow-fill-seal machine for cooling a liquid drug product (3) in a plastic bottle, characterized in that, Includes a ventilation hood (5), which is fixed above the conveyor belt (2) and the length direction of the ventilation hood (5) is consistent with the conveying direction of the conveyor belt (2). The ventilation hood (5) passes through the partition plate (4) and the two ends of the ventilation hood (5) are respectively connected to the clean area (X) and the general area (Y) on both sides of the partition plate (4). A cooling air channel for the plastic bottle liquid medicine (3) to pass through is formed between the ventilation hood (5) and the conveyor belt (2).

2. The cooling device of a multi-mode continuous blow-fill-seal machine according to claim 1, characterized in that, The ventilation hood (5) has mounting parts (51) on both sides of its width direction, and the ventilation hood (5) is fixed above the conveyor belt (2) by the mounting parts (51).

3. The cooling device of a multi-mode continuous blow-fill-seal machine according to claim 1, wherein The ventilation hood (5) is in close contact with the partition plate (4) on the side facing away from the cooling air channel.

4. The cooling device of a multi-mode continuous blow-fill-seal machine according to claim 1, wherein The ventilation hood (5) is equipped with a guide plate (53) inside, which is used to guide the cooling air to the plastic bottle liquid medicine (3) located on the conveyor belt (2).

5. The cooling device of a multi-mode continuous blow-fill-seal machine according to claim 4, characterized in that, The baffle (53) is located on the ventilation hood (5) at one end near the clean area (X).

6. The cooling device of the multi-mode continuous blow-fill-seal machine according to claim 4, characterized in that, The guide plate (53) is fixed to the top of the ventilation hood (5), and the guide plate (53) extends downward at an angle along the direction from the clean area (X) to the general area (Y).

7. The cooling device of a multi-mode continuous blow-fill-seal machine according to claim 6, characterized in that, The top of the inner wall of the ventilation hood (5) is provided with an installation plate (52). The guide plate (53) includes an integrally formed vertical plate (531) and an inclined plate (532). The vertical plate (531) is fixedly connected to the installation plate (52) by fastening bolts (54).

8. The cooling device of a multi-mode continuous blow-fill-seal machine according to claim 1, wherein, The ventilation hood (5) is made of metal.

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