Regulatory devices for co-loading bioactive proteins for targeted intervention

Abstract

This utility model discloses a regulating device for targeted intervention of co-loaded bioactive proteins, relating to the field of bioprotein technology. It includes a base plate and a storage seat. The storage seat is positioned above the base plate, with multiple placement slots on its upper surface. Insulation cavities are formed on the lower surface of the storage seat between the placement slots. A sealing mechanism is provided above the storage seat. A baffle is slidably installed inside the insulation cavity, with an exhaust pipe fixedly sleeved at the center of the baffle. The lower end of the exhaust pipe is fixedly connected to the base plate, and an exhaust hole is formed on the lower side wall of the exhaust pipe. Reset mechanisms for moving the storage seat downwards are provided on both sides of the storage seat. This utility model can uniformly insulate the loaded bioprotein and allows for real-time monitoring of the remaining dry ice level for timely replenishment, ensuring adequate insulation of the bioprotein.

Description

Technical Field

[0001] This invention relates to the field of bioprotein technology, specifically to a regulatory device for targeted intervention of co-loaded bioactive proteins. Background Technology

[0002] Preservation of bioactive proteins is crucial in biomedical research and clinical applications. Because bioactive proteins are extremely sensitive to temperature, fluctuations in temperature, whether too high or too low, can alter their structure and function, leading to loss of activity. Currently, dry ice insulation is commonly used to store and transport bioactive proteins to maintain their low-temperature environment.

[0003] However, existing storage devices are unable to provide uniform insulation for loaded biological proteins, which can easily lead to uneven local temperatures and affect the activity of the biological proteins. On the other hand, users cannot monitor the remaining dry ice at any time, and there are often situations where the dry ice is exhausted and not replenished in time, which prevents the biological proteins from being adequately insulated and causes irreparable losses. Utility Model Content

[0004] In view of the problems existing in the above-mentioned regulatory devices for targeted intervention of co-loaded bioactive proteins, this utility model is proposed.

[0005] Therefore, the purpose of this invention is to provide a regulatory device for targeted intervention of co-loaded bioactive proteins, which solves the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: A regulating device for targeted intervention of co-loaded bioactive proteins includes a base plate and a storage seat. The storage seat is disposed above the base plate. The upper surface of the storage seat has multiple placement slots. The lower surface of the storage seat, located between the multiple placement slots, has a heat-insulating cavity. A sealing mechanism is disposed above the storage seat. A baffle is slidably disposed inside the heat-insulating cavity. An exhaust pipe is fixedly sleeved in the middle of the baffle. The lower end of the exhaust pipe is fixedly connected to the base plate. An exhaust hole is disposed on the lower side wall of the exhaust pipe. Reset mechanisms that drive the storage seat to move downward are disposed on both sides of the storage seat.

[0007] Preferably, the sealing mechanism includes a first sealing plate and a second sealing plate. The first sealing plate is rotatably disposed on the upper surface of the storage base, and the second sealing plate is rotatably connected to the upper surface of the first sealing plate. A first material extraction hole is provided on one side of the upper surface of the first sealing plate, and a second material extraction hole is provided on the upper surface of the second sealing plate on the side away from the first material extraction hole.

[0008] Preferably, the reset mechanism includes a slide rod and a spring. First connecting blocks are fixedly provided on both sides of the base plate, and second connecting blocks are fixedly provided on both sides of the storage base. A through hole is opened in the middle of the first connecting block. The slide rod is slidably sleeved inside the through hole. The lower end of the slide rod is fixedly connected to the first connecting block. An anti-detachment block is fixedly provided at the top of the slide rod. The spring is fixedly provided on the lower side of the anti-detachment block. The other end of the spring is fixedly connected to the upper side of the second connecting block.

[0009] Preferably, a threaded hole is provided on one side of the second sealing plate, and a threaded rod is threaded inside the threaded hole, with one end of the threaded rod tightly abutting against the upper surface of the first sealing plate.

[0010] Preferably, a knob is fixedly sleeved on the upper end of the threaded rod.

[0011] Preferably, the spring is movably sleeved with the wall of the slide rod.

[0012] Preferably, the outer wall of the baffle is provided with a rubber ring.

[0013] The technical effects and advantages provided by this utility model in the above technical solution are as follows: 1. In this utility model, by loosening the threaded rod, the limiting position between the first and second sealing plates is released, allowing the second sealing plate to rotate relative to the first sealing plate, aligning the second material extraction hole with the first material extraction hole, thereby enabling the extraction of biological protein from the placement tank.

[0014] 2. This utility model uses dry ice placed in the insulation cavity between multiple placement slots to uniformly insulate the biological protein in the placement slots.

[0015] 3. In this utility model, the volume of dry ice decreases during the sublimation process, so that the spring force pushes the second connecting block to move closer to the first connecting block, thereby bringing the storage base closer to the bottom plate. This allows for a direct understanding of the remaining dry ice and facilitates timely replenishment. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0017] Figure 1 This is a schematic diagram of the structure of the regulatory device for targeted intervention of co-loaded bioactive proteins proposed in this utility model; Figure 2 for Figure 1 Another structural diagram from a different perspective; Figure 3 This is a first cross-sectional view of the present invention. Figure 4 This is a second cross-sectional view of the present invention.

[0018] Explanation of reference numerals in the attached figures: 1. Base plate; 2. Storage seat; 3. Exhaust pipe; 4. First sealing plate; 5. Second sealing plate; 6. Threaded rod; 7. First connecting block; 8. Sliding rod; 9. Second connecting block; 10. Anti-detachment block; 11. Spring; 12. Placement slot; 13. Insulation cavity; 14. Baffle. Detailed Implementation

[0019] To enable those skilled in the art to better understand the technical solution of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings.

[0020] This utility model discloses a regulatory device for targeted intervention of co-loaded bioactive proteins.

[0021] Reference Figure 1-4 The regulating device for targeted intervention of bioactive proteins includes a base plate 1 and a storage seat 2. The storage seat 2 is located above the base plate 1. Multiple placement slots 12 are formed on the upper surface of the storage seat 2. Insulation cavities 13 are formed on the lower surface of the storage seat 2 between the multiple placement slots 12. A sealing mechanism is provided above the storage seat 2. A baffle 14 is slidably arranged inside the insulation cavity 13. A rubber ring is provided on the outer wall of the baffle 14 to improve the sealing between the baffle 14 and the insulation cavity 13. An exhaust pipe 3 is fixedly sleeved in the middle of the baffle 14. The lower end of the exhaust pipe 3 is fixedly connected to the base plate 1. An exhaust hole is formed on the lower side wall of the exhaust pipe 3. Reset mechanisms that drive the storage seat 2 to move downward are provided on both sides of the storage seat 2.

[0022] Reference Figure 1-4 The sealing mechanism includes a first sealing plate 4 and a second sealing plate 5. The first sealing plate 4 is rotatably disposed on the upper surface of the storage base 2, and the second sealing plate 5 is rotatably connected to the upper surface of the first sealing plate 4. A first material extraction hole is provided on one side of the upper surface of the first sealing plate 4, and a second material extraction hole is provided on the upper surface of the second sealing plate 5 on the side away from the first material extraction hole.

[0023] Reference Figure 1-4The reset mechanism includes a slide rod 8 and a spring 11. A first connecting block 7 is fixedly installed on both sides of the base plate 1, and a second connecting block 9 is fixedly installed on both sides of the storage base 2. A through hole is opened in the middle of the first connecting block 7, and the slide rod 8 is slidably sleeved inside the through hole. The lower end of the slide rod 8 is fixedly connected to the first connecting block 7, and an anti-detachment block 10 is fixedly installed at the top of the slide rod 8. The spring 11 is fixedly installed on the lower side of the anti-detachment block 10, and the other end of the spring 11 is fixedly connected to the upper side of the second connecting block 9. The spring 11 is movably sleeved with the rod wall of the slide rod 8, so that the spring 11 can be stably compressed and reset.

[0024] Reference Figure 1-4 The second sealing plate 5 has a threaded hole on one side, and a threaded rod 6 is threaded inside the threaded hole. One end of the threaded rod 6 is tightly abutted against the upper surface of the first sealing plate 4, so that the second sealing plate 5 will not rotate relative to the first sealing plate 4, and the first and second material extraction holes will not overlap under normal conditions, effectively preventing the leakage of biological protein in the placement tank. A knob is fixedly sleeved on the upper end of the threaded rod 6 for easy rotation of the threaded rod 6.

[0025] In this invention, during use, the bioactive protein is first loaded and dry ice is filled: Loosen the threaded rod 6 by turning the knob, separating the lower end of the threaded rod 6 from the upper surface of the first sealing plate 4, thus releasing the restriction on the second sealing plate 5; then rotate the second sealing plate 5 to align the second feeding hole with the first feeding hole, and place the container loaded with the bioactive protein into the placement slot 12 of the storage base 2 through the aligned feeding hole; after loading is complete, rotate the second sealing plate 5 in the opposite direction to misalign the second feeding hole with the first feeding hole, and then retighten the threaded rod 6. The second sealing plate 5 is fixed by the contact between the threaded rod 6 and the first sealing plate 4, thus sealing the placement slot 12 and preventing the biological protein container from detaching or external heat from entering. Then, dry ice is filled into the insulation cavity 13: Since the storage seat 2 can slide along the exhaust pipe 3, in the initial state when the dry ice is filled, the storage seat 2 moves upward under the support force of the dry ice, which drives the second connecting blocks 9 on both sides to move upward along the slide rod 8, compressing the spring 11 below the anti-detachment block 10; after the dry ice is filled, it is located between multiple placement slots 12 and can evenly absorb heat from the placement slots 1 through heat conduction. 2. The surrounding heat provides a stable low-temperature environment for bioactive proteins. Simultaneously, the carbon dioxide gas produced by the sublimation of dry ice is discharged through the exhaust port at the lower end of the exhaust pipe 3, preventing excessive pressure inside the insulation cavity 13. The rubber ring on the outer wall of the baffle 14 prevents gas leakage from the gap between the insulation cavity 13 and the exhaust pipe 3, ensuring smooth exhaust. During use, the remaining dry ice level can be determined by observing the height change of the storage base 2: as the dry ice sublimates, its volume gradually decreases, weakening the supporting force on the storage base 2, and the spring 11 gradually releases its elasticity, pushing the second... Connecting block 9 drives storage seat 2 to move downwards along slide rod 8 and exhaust pipe 3 towards the base plate 1. When storage seat 2 moves down to near the base plate 1, it indicates that the dry ice is insufficient and needs to be replenished in time to avoid the temperature in the placement tank 12 rising due to the depletion of dry ice, which would affect the activity of bioactive protein. If bioactive protein needs to be taken out, repeat the above operation of loosening thread rod 6 and rotating second sealing plate 5, and take out the container through the aligned material taking hole. There is no need to open the overall sealing structure throughout the process, which reduces the exposure time in the low temperature environment and further ensures the activity of bioactive protein.

[0026] The foregoing description only illustrates certain exemplary embodiments of the present invention. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A regulating device for targeted intervention of co-loaded bioactive proteins, comprising a base plate (1) and a storage seat (2), characterized in that, The storage base (2) is located above the base plate (1). The upper surface of the storage base (2) is provided with multiple placement slots (12). The lower surface of the storage base (2) and between the multiple placement slots (12) are provided with heat preservation cavities (13). A sealing mechanism is provided above the storage base (2). A baffle (14) is slidably provided inside the heat preservation cavity (13). An exhaust pipe (3) is fixedly sleeved in the middle of the baffle (14). The lower end of the exhaust pipe (3) is fixedly connected to the base plate (1). An exhaust hole is provided on the lower side wall of the exhaust pipe (3). A reset mechanism for driving the storage base (2) to move down is provided on both sides of the storage base (2).

2. The regulatory device for targeted intervention of co-loaded bioactive proteins according to claim 1, characterized in that, The sealing mechanism includes a first sealing plate (4) and a second sealing plate (5). The first sealing plate (4) is rotatably disposed on the upper surface of the storage base (2), and the second sealing plate (5) is rotatably connected to the upper surface of the first sealing plate (4). A first material extraction hole is provided on one side of the upper surface of the first sealing plate (4), and a second material extraction hole is provided on the upper surface of the second sealing plate (5) on the side away from the first material extraction hole.

3. The regulatory device for targeted intervention of co-loaded bioactive proteins according to claim 1, characterized in that, The reset mechanism includes a slide rod (8) and a spring (11). A first connecting block (7) is fixedly installed on both sides of the base plate (1), and a second connecting block (9) is fixedly installed on both sides of the storage base (2). A through hole is opened in the middle of the first connecting block (7). The slide rod (8) is slidably sleeved inside the through hole. The lower end of the slide rod (8) is fixedly connected to the first connecting block (7). An anti-detachment block (10) is fixedly installed at the top of the slide rod (8). The spring (11) is fixedly installed on the lower side of the anti-detachment block (10). The other end of the spring (11) is fixedly connected to the upper side of the second connecting block (9).

4. The regulatory device for targeted intervention of co-loaded bioactive proteins according to claim 2, characterized in that, The second sealing plate (5) has a threaded hole on one side, and a threaded rod (6) is threaded inside the threaded hole. One end of the threaded rod (6) is tightly abutted against the upper surface of the first sealing plate (4).

5. The regulatory device for targeted intervention of co-loaded bioactive proteins according to claim 4, characterized in that, A knob is fixedly sleeved on the upper end of the threaded rod (6).

6. The regulatory device for targeted intervention of co-loaded bioactive proteins according to claim 3, characterized in that, The spring (11) is movably sleeved with the wall of the slide rod (8).

7. The regulatory device for targeted intervention of co-loaded bioactive proteins according to claim 1, characterized in that, The outer wall of the baffle (14) is provided with a rubber ring.

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