Tissue fixation device

Abstract

This invention provides a tissue fixation device, comprising a box body and a lid. The box body has several partitioned cavities forming independent compartments. It also includes pressing parts corresponding to each compartment, which abut against the tissue sample to completely immerse it in the fixative. The compartments allow each tissue sample to fully contact the fixative, reducing localized flow obstruction caused by accumulation, ensuring consistent fixation conditions, improving fixation quality and stability, and preventing similar tissue samples from sticking together and becoming confused. The pressing parts forcefully press all tissue samples into the fixative, preventing floating and incomplete fixation. Furthermore, corresponding to the compartments, they can independently apply pressure to each tissue sample, adapting to tissue samples of different shapes and reducing the risk of cross-contamination.

Description

Technical Field

[0001] This utility model relates to the field of biological experimental equipment technology, and in particular to a tissue fixation device. Background Technology

[0002] In biological experiments, after obtaining animal tissue samples, it is necessary to fix the small tissue pieces promptly to preserve their original morphology and structure, providing reliable samples for subsequent experimental research. Currently, the most common tissue fixation method in laboratories involves placing the tissue sample in a common container filled with fixative. However, current tissue fixation devices have the following problems: when multiple tissue samples are placed in the same container, they are prone to sticking and becoming confused due to contact and stacking, making it difficult for users to distinguish organs and tissues from different animals. Furthermore, when tissue samples are in this type of fixation device, some tissue samples may not be completely submerged in the fixative, resulting in poor fixation.

[0003] Therefore, how to adjust the structure of the tissue fixation device to allow users to easily distinguish different tissue samples in the same tissue fixation device, and to ensure that the tissue samples are completely submerged in the fixation solution, has become a technical problem that urgently needs to be solved in this field. Utility Model Content

[0004] The technical problem to be solved by this utility model is to overcome the defects of existing technology, such as easy adhesion and confusion between tissue samples and easy floating without being completely submerged in the fixative, and to provide a tissue fixation device.

[0005] This utility model solves the above-mentioned technical problems through the following technical solution: a tissue fixation device, comprising a box body and a box cover, wherein a receiving cavity is formed in the box body for placing fixative and tissue sample, and the receiving cavity is provided with a plurality of partitions to divide into a plurality of independent partition spaces, the tissue fixation device further comprising a plurality of pressing parts, the pressing parts being arranged one-to-one with the partition spaces, the pressing parts being able to be positioned within the partition spaces, and the lower surface of the pressing parts being used to abut against the tissue sample in the corresponding partition space to completely press the tissue sample into the fixative.

[0006] The partitioned spaces ensure that each tissue sample has full contact with the fixative, reducing localized fixative blockages caused by sample accumulation. This ensures consistent stress and contact conditions for each sample during fixation, improving the stability of fixation quality. Furthermore, for samples with similar morphologies, a one-to-one correspondence between partitioned spaces prevents adhesion and confusion caused by sample contact and stacking. The pressing section, by contacting and applying pressure to the tissue sample, forcibly submerges the entire sample in the fixative, ensuring full contact and preventing incomplete fixation due to sample floating. Simultaneously, the one-to-one correspondence between the pressing section and the partitioned spaces allows for independent pressure application to the sample within each space, accommodating different tissue morphologies and avoiding the risk of cross-contamination.

[0007] Preferably, the upper surface of the box cover is further provided with a plurality of marking portions, and the plurality of marking portions are provided in a one-to-one correspondence with each of the partition spaces, the marking portions being used to mark the tissue samples in the corresponding partition space.

[0008] The labeling section is set up in a one-to-one correspondence with the partition space. This design binds the information recorded on the labeling section with the tissue sample in the partition space, avoiding operators from misidentifying the type of tissue sample and improving the efficiency of tissue sample identification.

[0009] Preferably, the upper part of the pressing part is provided with a gripping structure.

[0010] When the indentation unit needs to be pressed or removed, the grip structure allows operators to easily complete the indentation and removal actions without touching the entire or lower part of the indentation unit, reducing the difficulty of operation. At the same time, the grip structure on the upper part of the indentation unit prevents the operator's sweat or impurities from contaminating the fixative and tissue sample below the indentation unit, and also prevents corrosive components in the fixative from posing a danger to the operator, thus improving operational safety.

[0011] Preferably, the pressing part is positioned within the partition space by forming an interference fit between the outer wall and the inner wall of the partition space.

[0012] When the pressing part presses the sample to be completely submerged, the friction generated by the interference fit can prevent the pressing part from moving upward due to external force or sample buoyancy, ensuring that the sample is always in a fully submerged state and will not cause part of the sample to detach from the fixative due to positional displacement.

[0013] Preferably, the pressing part has a plurality of through holes formed therethrough in the pressing part in the vertical direction.

[0014] When the indenter compresses the sample downwards, the fixative beneath the sample experiences an upward reaction force due to spatial compression. If the indenter is solid, this reaction force may concentrate on the contact surface between the sample and the indenter, potentially causing the fragile sample to deform or break. The through-hole allows the fixative to flow, reducing fluid resistance during insertion and removal of the indenter. It allows some fixative to flow upwards through the hole, lowering the localized pressure on the sample and protecting its morphological integrity. For example, when sample removal is required, the fixative can flow back through the through-hole to the area above the indenter, balancing the fluid pressure above and below the indenter and preventing adhesion between the indenter and the sample / container wall due to negative pressure adsorption, thus making the removal process smoother.

[0015] Preferably, the tissue fixation device further includes a sealing part;

[0016] The sealing part is used to seal the receiving cavity;

[0017] And / or, the sealing part includes a sealing ring disposed on the mating surface of the box body and the box cover;

[0018] And / or, the sealing portion comprises a low-permeability material.

[0019] The sealing ring can fill the tiny gaps between the sealing part and other components of the device through its own deformation, blocking the leakage or evaporation path of the stationary liquid through physical gaps. The low-permeability material itself has extremely low gas and liquid permeability, which can block the penetration and diffusion of stationary liquid molecules at the material level. Even in the presence of tiny gaps or local wear, the evaporation can still be reduced by the material's own barrier properties.

[0020] Preferably, the tissue fixation device further includes a connecting portion;

[0021] The connecting part is used to connect the lid and the box body;

[0022] And / or, the connection includes a snap-fit ​​structure and / or a threaded structure.

[0023] The snap-fit ​​structure allows for quick connection or separation of the lid and body without the need for additional tools. It is simple, effortless, and convenient for users to frequently open and close for loading / unloading tissue samples or changing fixatives. The threaded structure achieves a sealed connection through rotation, ensuring stable and controllable operation. Once connected, it is not easily loosened by vibration or impact, balancing convenience and reliability.

[0024] Preferably, the snap-fit ​​structure includes a snap protrusion on the box body and a snap groove on the box lid, and the threaded structure includes an external thread at the opening of the box body and an internal thread on the inner side of the box lid.

[0025] The snap-fit ​​structure achieves quick positioning and locking through the mechanical engagement of the slot and the protrusion, and can withstand a certain axial and radial force to prevent the connection from loosening; the threaded structure generates continuous pre-tightening force through helical engagement, with excellent sealing performance and anti-loosening ability, making it especially suitable for scenarios that require stable fixation; the combination of the two can take into account both mechanical locking and sealing effects, further improving the stability of the connection.

[0026] Preferably, the material of the tissue fixation device includes a corrosion-resistant material.

[0027] Tissue fixation devices are frequently exposed to corrosive chemicals such as fixatives. If the device material is not corrosion-resistant, it may dissolve, peel off, or produce harmful substances upon contact with a corrosive environment. Using corrosion-resistant materials can reduce these risks and prevent harmful substances from contaminating tissues, body fluids, or experimental samples.

[0028] Preferably, the partition spaces are evenly distributed within the receiving cavity.

[0029] The uniformly distributed mold design is simpler, makes it easier to ensure accuracy during production, reduces processing costs, and the standardized structure facilitates mass production and quality control.

[0030] The significant advantages of this invention are as follows: the partitioned spaces ensure that each tissue sample is fully in contact with the fixative, reducing localized obstruction of fixative flow caused by sample accumulation. This ensures consistent stress and contact conditions for each sample during fixation, improving the stability of fixation quality. Furthermore, for samples with similar morphologies, a corresponding partitioned space can be used to place one tissue sample at a time, preventing adhesion and confusion caused by sample contact and stacking. The pressing part, by contacting and applying pressure to the tissue sample, forcibly submerges the entire sample in the fixative, ensuring full contact between all tissue samples and the fixative, thus preventing incomplete fixation due to sample floating. Simultaneously, the one-to-one correspondence between the pressing part and the partitioned spaces allows for independent pressure application to the sample within each space, accommodating different tissue morphologies and avoiding the risk of cross-contamination. Attached Figure Description

[0031] Figure 1 This is a cross-sectional view of the box body and a certain partition space of the tissue fixation device according to an embodiment of the present invention.

[0032] Figure 2 This is a top view of the box body of an embodiment of the tissue fixation device of the present invention.

[0033] Figure 3 This is a top view of the lid of the tissue fixation device according to an embodiment of the present invention.

[0034] Figure 4This is a schematic diagram of the pressing part of the tissue fixation device according to an embodiment of the present invention.

[0035] Explanation of reference numerals in the attached figures:

[0036] Tissue fixation device 1

[0037] Box 10

[0038] 11 Card

[0039] docking surface 12

[0040] Box lid 20

[0041] Card slot 21

[0042] partition 30

[0043] Reception cavity 40

[0044] Divided space 50

[0045] Sealing part 70

[0046] Press-in section 80

[0047] Grip structure 81

[0048] Through hole 82

[0049] 90 tissue samples

[0050] Fixative 100

[0051] Signage Department 110 Detailed Implementation

[0052] The present invention will be described more clearly and completely below with reference to the accompanying drawings, using a preferred embodiment.

[0053] Example 1

[0054] like Figures 1-4 As shown, this utility model provides a tissue fixation device 1, which includes a box body 10 and a matching box cover 20. The box body 10 has a cuboid structure and forms a receiving cavity 40 inside the box body 10. The receiving cavity 40 is used to place the fixative liquid 100 and the tissue sample 90. The receiving cavity 40 is provided with a partition 30, thereby dividing a total of 40 independent partition spaces 50 arranged in a 4×10 pattern. The tissue fixation device 1 also includes forty cylindrical pressing parts 80, and the pressing parts 80 are arranged one-to-one with the partition spaces 50. The pressing parts 80 are positioned in the corresponding partition spaces 50 by an interference fit. Therefore, the lower surface of the pressing part 80 abuts against the tissue sample 90 in the corresponding partition space 50, for completely pressing the tissue sample 90 into the fixative liquid 100.

[0055] In this embodiment, each partition space 50 allows each tissue sample 90 to fully contact the fixative 100, reducing the problem of poor flow of the fixative 100 caused by the accumulation of tissue samples 90. This ensures that the stress and contact conditions of each tissue sample 90 with the fixative 100 are consistent during the fixation process, improving the stability of the fixation quality. Furthermore, for tissue samples 90 with similar morphologies, a corresponding relationship of placing one tissue sample 90 in each partition space 50 can be established, avoiding adhesion and confusion caused by contact and stacking of tissue samples 90. The pressing part 80, by abutting against and applying pressure to the tissue sample 90, can forcibly press all tissue samples 90 into the fixative 100, ensuring that all tissue samples 90 are fully in contact with the fixative 100, thus preventing incomplete fixation caused by tissue samples 90 floating. Simultaneously, the one-to-one correspondence between the pressing part 80 and the partition space 50 allows for independent pressure application to the tissue sample 90 within each partition space 50, adapting to tissue samples 90 with different morphologies and avoiding the risk of cross-contamination.

[0056] like Figures 1-4 As shown, the upper surface of the box cover 20 is also provided with a total of 40 marking sections 110 arranged in a 4×10 pattern. Each marking section 110 is corresponding to one of the partition spaces 50. The marking section 110 is used to mark the tissue sample 90 in the corresponding partition space 50. In this embodiment, the marking section 110 is a tissue identification card provided on the upper surface of the box cover 20. It includes a table composed of at least 40 spaces arranged in a 4×10 pattern. Each space is written with the corresponding number or name of the tissue sample 90. The position of each space in the table corresponds strictly to the position of each tissue sample 90 in the box body 10.

[0057] In this embodiment, the marking section 110 is configured to correspond one-to-one with the partition space 50. This design binds the information recorded on the marking section 110 to the tissue sample 90 within the partition space 50, preventing operators from misidentifying the type of tissue sample 90 and improving the efficiency of tissue sample identification. In this embodiment, the marking section 110 is a tissue identification card that can be written on by the user. In other embodiments, the marking section 110 can also use pre-printed markings or other methods to indicate the positional relationship of each partition space 50 within the box body 10. This part is prior art and will not be described in detail here.

[0058] like Figures 1-4 As shown, the upper part of the pressing part 80 is provided with a spherical gripping structure 81.

[0059] In this embodiment, when the pressing part 80 needs to be pressed or removed, the grip structure 81 allows the operator to easily complete the pressing and removing actions without touching the entire or lower part of the pressing part 80, reducing the difficulty of operation. Simultaneously, the grip structure 81 on the upper part of the pressing part 80 prevents the operator's sweat or impurities from contaminating the fixative liquid 100 and tissue sample 90 below the pressing part 80, and also prevents corrosive components in the fixative liquid 100 from posing a danger to the operator, thus improving operational safety. In this embodiment, the grip structure 81 is spherical. In other embodiments, the grip structure 81 can be set to other regular or irregular shapes, achieving the same effect of improving ease of operation. This part is prior art and will not be elaborated further here.

[0060] like Figures 1-4 As shown, the outer wall of the press-in part 80 and the inner wall of the partition space 50 form an interference fit, thereby realizing the positioning of the press-in part 80 and the partition space 50.

[0061] In this embodiment, when the pressing part 80 presses the tissue sample 90 until it is completely immersed in the fixative 100, the frictional force generated by the interference fit prevents the pressing part 80 from moving upward due to external force or sample buoyancy, ensuring that the sample is always fully immersed and that no part of it will detach from the fixative 100 due to positional displacement. In this embodiment, the pressing part 80 is positioned by forming an interference fit with the partition space 50. In other embodiments, the pressing part 80 can be positioned in the partition space 50 by gravity, magnetic attraction, or other positioning methods. This part is prior art and will not be described in detail here.

[0062] like Figures 1-4 As shown, five cylindrical through holes 82 are formed on the pressing part 80, and the through holes 82 penetrate the pressing part 80 in the vertical direction.

[0063] In this embodiment, when the pressing part 80 presses down on the tissue sample 90, the fixative 100 below the tissue sample 90 will generate an upward reaction force due to spatial compression. If the pressing part 80 is solid, the reaction force may be concentrated on the contact surface between the tissue sample 90 and the pressing part 80, causing the fragile sample to be squeezed, deformed, or damaged. The through hole 82 is used to allow the fixative 100 to flow, reducing the liquid resistance when pressing or removing the pressing part 80. It allows some of the fixative 100 to flow upward through the hole, reducing the local pressure on the tissue sample 90 and protecting the morphological integrity of the tissue sample 90. For example, when it is necessary to remove the tissue sample 90, the fixative 100 can flow back to the top of the pressing part 80 through the through hole 82, balancing the liquid pressure above and below the pressing part 80, preventing the pressing part 80 from sticking to the sample or the inner wall of the container due to negative pressure adsorption, making the removal process smoother. Meanwhile, in this embodiment, the through hole 82 is cylindrical, while in other embodiments, the through hole 82 may also be a spiral or other form of through hole arranged along the axial direction of the press-in portion 80. This part belongs to the prior art in this field and will not be described in detail here.

[0064] like Figures 1-4 As shown, the tissue fixation device 1 also includes a sealing part 70, which is used to seal the receiving cavity 40. The sealing part 70 includes a sealing ring disposed on the mating surface of the box body 10 and the box cover 20. The sealing part 70 is made of fluororubber with low air permeability.

[0065] In this embodiment, the sealing part 70 includes a sealing ring, which fills the tiny gap between the mating surfaces of the box body 10 and the box cover 20 through its own deformation, thereby blocking the leakage or evaporation path of the fixative liquid 100 through physical gaps. Simultaneously, the sealing part 70 is made of fluororubber, which, as a low-permeability material, has extremely low gas-liquid permeability. It can prevent the fixative liquid 100 from permeating and diffusing in molecular form at the material level. Even in the presence of tiny gaps or localized wear, the material's inherent barrier properties can still reduce evaporation.

[0066] like Figures 1-4 As shown, the tissue fixation device 1 also includes a connecting part for connecting the cover 20 and the body 10; the connecting part includes a snap-fit ​​structure and a threaded structure (not shown in the figure).

[0067] like Figures 1-4 As shown, the snap-fit ​​structure includes a snap protrusion 11 on the box body 10 and a snap groove 21 on the box cover 20, and the thread structure includes an external thread (not shown in the figure) on the opening of the box body 10 and an internal thread (not shown in the figure) on the inner side of the box cover 20.

[0068] The snap-fit ​​structure achieves quick positioning and locking through the mechanical engagement of the slot 21 and the protrusion 11, and can withstand certain axial and radial forces to prevent loosening of the connection; the threaded structure generates continuous pre-tightening force through helical engagement, with excellent sealing performance and anti-loosening ability, making it especially suitable for scenarios requiring stable fixation; the combination of the two can take into account both mechanical locking and sealing effects, further improving connection stability.

[0069] like Figures 1-4 As shown, the tissue fixation device 1 is made of glass, which is a corrosion-resistant material.

[0070] In this embodiment, the tissue fixation device 1 is frequently in contact with corrosive chemical reagents such as fixative 100. If the device material is not corrosion-resistant, it may dissolve, peel off, or produce harmful substances after contact with a corrosive environment. Using corrosion-resistant materials can reduce such risks and prevent harmful substances from contaminating tissues, body fluids, or experimental samples. In other embodiments, the tissue fixation device may also be made of other corrosion-resistant materials such as stainless steel. This part is prior art and will not be described in detail here.

[0071] like Figures 1-4 As shown, the partition space 50 is evenly distributed within the receiving cavity 40.

[0072] In this embodiment, the partition space 50 is evenly distributed within the receiving cavity 40. The corresponding evenly distributed mold design is simpler, making it easier to ensure accuracy during production and reducing processing costs. At the same time, the standardized structure facilitates mass production and quality control.

Claims

1. A tissue fixation device, comprising a box body and a box cover, wherein a receiving cavity is formed within the box body for holding a fixative and a tissue sample, characterized in that, The receiving cavity is provided with several partitions to divide it into several independent partition spaces. The tissue fixation device also includes several pressing parts, each of which is arranged in a one-to-one correspondence with a partition space. Each pressing part can be positioned within a partition space, and the lower surface of the pressing part is used to abut against the tissue sample in the corresponding partition space to completely press the tissue sample into the fixation liquid.

2. The tissue fixation device as claimed in claim 1, wherein, The upper surface of the box lid is also provided with a number of marking sections, and each of the marking sections is set in a one-to-one correspondence with each of the partition spaces. The marking sections are used to mark the tissue samples in the corresponding partition spaces.

3. The tissue fixation device as claimed in claim 1, wherein, The upper part of the pressing part is provided with a gripping structure.

4. The tissue fixation device as claimed in claim 1, wherein, The press-in portion is positioned within the partition space by forming an interference fit between its outer wall and the inner wall of the partition space.

5. The tissue fixation device as claimed in claim 1, wherein, The pressing part has a plurality of through holes formed therethrough holes, which penetrate the pressing part in a vertical direction.

6. The tissue fixation device as described in claim 1, characterized in that, The tissue fixation device also includes a sealing part; The sealing part is used to seal the receiving cavity; And / or, the sealing part includes a sealing ring disposed on the mating surface of the box body and the box cover; And / or, the sealing portion comprises a low-permeability material.

7. The tissue fixation device as claimed in claim 1, wherein, The tissue fixation device also includes a connecting part; The connecting part is used to connect the lid and the box body; And / or, the connection includes a snap-fit ​​structure and / or a threaded structure.

8. The tissue fixation device as claimed in claim 7, wherein, The buckle structure includes a buckle protrusion on the box body and a buckle groove on the box lid, and the thread structure includes an external thread at the opening of the box body and an internal thread on the inner side of the box lid.

9. The tissue fixation device as claimed in any one of claims 1-8, wherein, The tissue fixation device is made of corrosion-resistant materials.

10. The tissue fixation device as claimed in any one of claims 1-8, wherein, The partition spaces are evenly distributed within the receiving cavity.

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