A high-performance liquid chromatograph with controllable flow rate

Abstract

This utility model relates to the field of liquid chromatography technology and discloses a high-performance liquid chromatograph with controllable flow rate, including a liquid chromatograph body, a placement frame, and solution bottles. The interior of the placement frame is divided into four accommodating chambers by a spacer assembly. A positioning cylinder is fixed at the center of the bottom wall of each accommodating chamber, and a positioning assembly for placing the solution bottles is also fixed to the bottom wall of the accommodating chamber. A pipeline assembly is provided between the top of the solution bottles and the positioning cylinders. The pipeline assembly includes a U-shaped tube and an outlet tube. When it is necessary to replace the solution bottles, they can be replaced without interrupting the flow and without stopping the machine. This ensures a continuous input of solution while the liquid chromatograph body is working, guaranteeing the normal operation of the liquid chromatograph body and avoiding the need to stop the liquid chromatograph body due to replacing or adding solution to the solution bottles. This saves more time and ultimately allows the liquid chromatograph body to work more efficiently.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, specifically to a high-performance liquid chromatograph with controllable flow rate. Background Technology

[0002] Liquid chromatography (LC) is an analytical instrument based on the principle of molecular separation. It utilizes the differences in solubility, chemical reaction, adsorption, and other properties of substances in liquids to separate components from a mixture and detect their content using a detector. It is widely used in fields such as biochemistry, pharmaceuticals, food, and environmental analysis.

[0003] A Chinese patent, CN221847239U, describes a liquid chromatograph, which includes: "a housing with a placement plate fixedly connected to its top; an installation mechanism located on the inner wall of the placement plate for quickly installing and fixing mobile phase solution bottles; by setting up the installation mechanism and placement components, several clamps can quickly fix and limit the mobile phase solution bottles, preventing them from shaking during installation and improving the limiting effect of the device; the clamps and a first spring telescopic rod can stably support the mobile phase solution bottles; the clamps and a guide block at the top can quickly install the mobile phase solution bottles; the top of the guide block is arc-shaped to guide the mobile phase solution bottles, improving the installation speed of the device; a protective plate on the inner wall of the clamps can protect the mobile phase solution bottles, enabling quick placement and installation of the mobile phase solution bottles, thus improving the installation speed of the mobile phase solution bottles."

[0004] When a liquid chromatograph (LC) is in use, it needs to draw solutions from the solution bottles located at its top. Once the solution in any of these bottles is depleted, the bottle needs to be replaced or replenished promptly to ensure the LC's normal operation. In existing technology, since one pipe for drawing liquid corresponds to one solution bottle, replenishing the solution requires removing the pipe from the bottle, which interrupts the solution supply and may necessitate stopping the LC to accommodate the operation. Ultimately, this affects the normal operation of the LC and reduces its efficiency. Utility Model Content

[0005] To overcome the shortcomings mentioned above, this utility model aims to provide a technical solution that can solve the above problems.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a high-performance liquid chromatograph with controllable flow rate, comprising a liquid chromatograph body, a placement frame, and a solution bottle. The interior of the placement frame is divided into four accommodating chambers by a spacer assembly. A positioning cylinder is fixed at the center of the bottom wall of each accommodating chamber, and a positioning assembly for placing the solution bottle is also fixed at the bottom wall of the accommodating chamber. A pipe assembly is provided between the top of the solution bottle and the top of the positioning cylinder. The pipe assembly includes a U-shaped tube and an outlet tube. The outlet tube is connected to the center of the top of the U-shaped tube, and a flow rate regulator is provided on the outlet tube. The two ends of the U-shaped tube are respectively connected to a suction tube one and a suction tube two, and valves are provided on both suction tube one and suction tube two.

[0007] As a further embodiment of this utility model: the partition component includes a first partition plate and a second partition plate. The first partition plate is fixed in the center position inside the placement frame, and there are two second partition plates, which are respectively fixed on the front and rear sides of the first partition plate.

[0008] As a further embodiment of this utility model: both the first and second suction tubes are provided with sealing caps at the bottom of the valve, and the inner wall of the sealing cap is provided with a thread.

[0009] As a further embodiment of this utility model: the solution bottle and the top of the positioning cylinder have the same diameter, and the bottle mouth of the solution bottle and the top of the side of the positioning cylinder are both provided with a second thread that matches the first thread on the inner wall of the sealing cap.

[0010] As a further embodiment of this utility model: the U-shaped tube, the liquid outlet tube, the first liquid suction tube and the second liquid suction tube are all transparent flexible tubes, and the diameter and length of the first liquid suction tube and the second liquid suction tube are the same.

[0011] As a further embodiment of this utility model: the placement frame is installed on the top of the liquid chromatograph body.

[0012] As a further embodiment of this utility model: each of the accommodating cavities has two sets of positioning components on its inner bottom wall, and the two sets of positioning components are respectively located on the left and right sides of the positioning cylinder. The positioning component includes a positioning ring, a support ring one is fixed to the inner wall of the positioning ring, and a support ring two is fixed to the inner wall of the support ring one.

[0013] As a further embodiment of this utility model: the interior of the positioning ring is formed into a two-stage stepped shape by support ring one and support ring two, wherein the height of support ring one is lower than the height of the positioning ring, and the height of support ring two is lower than the height of support ring one.

[0014] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0015] I. In this application, through the designed placement frame, positioning components, positioning cylinder, pipeline components and valves, the solution bottle can be replaced without interrupting the flow or stopping the machine when it is necessary. This ensures a continuous input of solution to the liquid chromatograph during operation, thereby guaranteeing the normal operation of the liquid chromatograph and avoiding the need to stop the liquid chromatograph due to replacing or replenishing the solution bottle. This saves more time and ultimately allows the liquid chromatograph to work more efficiently.

[0016] Second, in this application, by setting a flow rate regulator on the outlet tube, the flow rate of the solution output from the outlet tube can be adjusted. The flow rate of the solution entering the liquid chromatograph body can be adjusted according to different detection needs. When there are multiple solution bottles in the plate, the flow rate regulators on the outlet tubes of multiple solution bottles can be adjusted individually, and the flow rate of each outlet tube can be controlled separately, so as to achieve the effect of not affecting each other and convenient control. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall three-dimensional structure of this utility model;

[0018] Figure 2 This is a three-dimensional structural diagram of the placement frame of this utility model;

[0019] Figure 3 This is a three-dimensional structural diagram of the pipe assembly of this utility model;

[0020] Figure 4 This is a side sectional view of the placement frame of this utility model;

[0021] Figure 5 This is a three-dimensional structural diagram of the positioning component of this utility model.

[0022] The reference numerals and names in the figure are as follows:

[0023] 1. Liquid Chromatograph Main Body; 2. Placement Frame; 3. Spare Plate 1; 4. Spare Plate 2; 5. Receiving Cavity; 6. Positioning Assembly; 601. Positioning Ring; 602. Support Ring 1; 603. Support Ring 2; 7. Solution Bottle; 8. Positioning Cylinder; 9. Piping Assembly; 901. U-tube; 902. Discharge Tube; 10. Suction Tube 1; 11. Suction Tube 2; 12. Flow Rate Regulator; 13. Sealing Cap; 14. Valve. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Please see Figure 1-5 A high-performance liquid chromatograph with controllable flow rate includes a liquid chromatograph body 1, a placement frame 2, and a solution bottle 7. The placement frame 2 is installed on top of the liquid chromatograph body 1, and its interior is divided into four receiving cavities 5 by a spacer assembly. A positioning cylinder 8 is fixed at the center of the bottom wall of each receiving cavity 5. The positioning cylinder 8 can protect the idle suction tube 10 or suction tube 2 11, preventing them from becoming messy or contaminated when not in use. A positioning assembly 6 for placing the solution bottle 7 is also fixed to the bottom wall of the receiving cavity 5. A pipe assembly 9 is provided between the solution bottle 7 and the top of the positioning cylinder 8. The pipeline assembly 9 includes a U-shaped tube 901 and an outlet tube 902. The outlet tube 902 is connected to the top center of the U-shaped tube 901. A flow rate regulator 12 is provided on the outlet tube 902. The flow rate regulator 12 can control the flow rate of the solution in the outlet tube 902, thereby controlling the flow rate. The two ends of the U-shaped tube 901 are respectively connected to a first suction tube 10 and a second suction tube 11. A valve 14 is provided on both the first suction tube 10 and the second suction tube 11. By using the valve 14 designed on both the first suction tube 10 and the second suction tube 11, the flow of the first suction tube 10 or the second suction tube 11 can be cut off, or both can be connected to the outlet tube 902.

[0026] Please see Figure 1 , Figure 2 as well as Figure 4 In this embodiment, the spacer assembly includes a first spacer 3 and a second spacer 4. The first spacer 3 is fixed in the center of the placement frame 2, and there are two second spacers 4, which are fixed on the front and rear sides of the first spacer 3 respectively.

[0027] Specifically, through the designed partition components, the interior of the placement frame 2 can be divided into multiple receiving cavities 5, and each receiving cavity 5 can hold a solution bottle 7. Each solution bottle 7 is connected to an outlet pipe 902, so that different solutions can be delivered to the liquid chromatograph body 1 using multiple outlet pipes 902.

[0028] Please see Figure 2 , Figure 3 as well as Figure 4In this embodiment, a sealing cap 13 is provided on both the first suction tube 10 and the second suction tube 11 at the bottom of the valve 14. The inner wall of the sealing cap 13 is provided with a thread 1. The top diameters of the solution bottle 7 and the positioning cylinder 8 are the same. The bottle mouth of the solution bottle 7 and the top side of the positioning cylinder 8 are provided with a thread 2 that matches the thread 1 on the inner wall of the sealing cap 13.

[0029] Specifically, the sealing caps 13 on the first suction tube 10 and the second suction tube 11 are compatible with the solution bottle 7 and the positioning cylinder 8, so that the first suction tube 10 and the second suction tube 11 can be easily screwed into the solution bottle 7 through their respective sealing caps 13, or screwed into the positioning cylinder 8. When screwed into the solution bottle 7, the solution can be extracted; when screwed into the positioning cylinder 8, the corresponding suction tube can be protected.

[0030] Please see Figure 3 as well as Figure 4 In this embodiment, the U-shaped tube 901, the liquid outlet tube 902, the first suction tube 10 and the second suction tube 11 are all transparent flexible tubes, and the diameter and length of the first suction tube 10 and the second suction tube 11 are the same.

[0031] Specifically, the U-shaped tube 901, the outlet tube 902, the suction tube 10 and the suction tube 2 11, which are made of transparent tubing, can be bent between the tubes to facilitate changes in position. The fact that the diameter and length of the suction tube 10 and the suction tube 2 11 are the same ensures that the amount of liquid absorbed in the solution bottle 7 is the same.

[0032] Please see Figure 1 , Figure 2 as well as Figure 5 In this embodiment, each receiving cavity 5 has two sets of positioning components 6 on its inner bottom wall, and the two sets of positioning components 6 are located on the left and right sides of the positioning cylinder 8 respectively. The positioning component 6 includes a positioning ring 601, a support ring 602 is fixed to the inner wall of the positioning ring 601, and a support ring 603 is fixed to the inner wall of the support ring 602. The interior of the positioning ring 601 is formed into a two-stage stepped shape by the support ring 602 and the support ring 603. The height of the support ring 602 is lower than the height of the positioning ring 601, and the height of the support ring 603 is lower than the height of the support ring 602.

[0033] Specifically, through the designed positioning component 6, the positioning ring 601 is formed into a two-stage stepped shape by support ring one 602 and support ring two 603, which allows solution bottles 7 of different sizes to be directly placed into the positioning ring 601. The support ring one 602 and support ring two 603 directly position and limit the solution bottle 7, making the operation simpler and more convenient, thereby ensuring the stability of the solution bottle 7 after it is placed in the positioning ring 601.

[0034] In use: When the solution in the solution bottle 7 placed in the placement frame 2 reaches the state where it needs to be replenished, since the first suction tube 10 can continuously draw liquid, in this case, the staff can take a new solution bottle 7 containing solution and place it in another positioning component 6 in the receiving cavity 5. Then, unscrew the sealing cap 13 on the second suction tube 11 to remove the sealing cap 13 from the positioning cylinder 8. Then, insert the second suction tube 11 into the solution bottle 7 containing solution and tighten the sealing cap 13 on the second suction tube 11. At this time, the valve 14 on the second suction tube 11 can be opened. After the valve 14 on the second suction tube 11 is opened, the solution can be drawn out from the second suction tube 11 and output through the outlet tube 902.

[0035] Then the valve 14 on the first suction tube 10 can be closed. At this time, the outlet tube 902 draws the solution through the second suction tube 11, the flow of the first suction tube 10 is cut off, and the sealing cap 13 on the first suction tube 10 is loosened. After the first suction tube 10 is taken out from the corresponding solution bottle 7, it is screwed into the positioning cylinder 8 through the sealing cap 13, and the solution bottle 7 is removed from the placement frame 2.

[0036] When it is necessary to adjust the flow rate of the outlet tube 902, the operator can turn the flow rate regulator 12 to control the flow rate of the outlet tube 902, thereby adjusting the flow rate entering the liquid chromatograph body 1.

[0037] It should be noted that by setting two positioning components 6 in each receiving cavity 5, the two positioning components 6 can alternately place the solution bottle 7 for outputting the solution. When the solution bottle 7 containing the solution is placed in the positioning component 6 on the left side inside the receiving cavity 5, the positioning component 6 on the left side inside the receiving cavity 5 can cooperate with the first suction tube 10, and the second suction tube 11 is screwed into the positioning cylinder 8 for protection. When the solution bottle 7 containing the solution is placed in the positioning component 6 on the right side inside the receiving cavity 5, the positioning component 6 on the right side inside the receiving cavity 5 can cooperate with the second suction tube 11, and the first suction tube 10 is screwed into the positioning cylinder 8 for protection. Through the above operation, in conjunction with the valve 14 on the first suction tube 10 and the second suction tube 11, the solution can be continuously delivered by the liquid outlet tube 902, ensuring that the liquid chromatograph main body 1 does not stop and that the liquid chromatograph main body 1 works efficiently.

[0038] It should also be noted that liquid chromatographs are common knowledge in the field, and their working principle and corresponding working structure are well-known technologies. Therefore, liquid chromatographs will not be described in detail in this application.

[0039] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A high performance liquid chromatograph capable of controlling flow rate, comprising a liquid chromatograph main body (1), a placement frame (2) and a solution bottle (7), characterized in that, The interior of the placement frame (2) is divided into four receiving cavities (5) by a spacer assembly; A positioning cylinder (8) is fixed at the center of the bottom wall of the receiving cavity (5). A positioning component (6) for placing a solution bottle (7) is also fixed on the bottom wall of the receiving cavity (5). A pipe assembly (9) is provided between the top of the solution bottle (7) and the positioning cylinder (8). The pipeline assembly (9) includes a U-shaped pipe (901) and an outlet pipe (902). The outlet pipe (902) is connected to the top center of the U-shaped pipe (901). A flow rate regulator (12) is provided on the outlet pipe (902). The two ends of the U-shaped pipe (901) are respectively connected to a first suction pipe (10) and a second suction pipe (11). A valve (14) is provided on both the first suction pipe (10) and the second suction pipe (11).

2. The high performance liquid chromatograph with controllable flow rate according to claim 1, characterized in that, The partition assembly includes a first partition plate (3) and a second partition plate (4). The first partition plate (3) is fixed in the center of the placement frame (2). There are two second partition plates (4), which are fixed on the front and back sides of the first partition plate (3) respectively.

3. The high performance liquid chromatograph with controllable flow rate according to claim 1, wherein, Both the first suction tube (10) and the second suction tube (11) are provided with a sealing cap (13) located at the bottom of the valve (14), and the inner wall of the sealing cap (13) is provided with a thread.

4. The high performance liquid chromatograph with controllable flow rate according to claim 1, wherein, The solution bottle (7) and the positioning cylinder (8) have the same diameter at the top. The bottle mouth of the solution bottle (7) and the top of the side of the positioning cylinder (8) are provided with a thread two that matches the thread one of the inner wall of the sealing cap (13).

5. A high-performance liquid chromatograph with controllable flow rate according to claim 1, characterized in that, The U-shaped tube (901), the liquid outlet tube (902), the first suction tube (10) and the second suction tube (11) are all transparent flexible tubes, and the diameter and length of the first suction tube (10) and the second suction tube (11) are the same.

6. The high performance liquid chromatograph with controllable flow rate according to claim 1, wherein, The placement frame (2) is installed on top of the liquid chromatograph body (1).

7. The high performance liquid chromatograph with controllable flow rate according to claim 1, wherein, Each of the accommodating cavities (5) has two sets of positioning components (6) on its inner bottom wall, and the two sets of positioning components (6) are located on the left and right sides of the positioning cylinder (8). The positioning component (6) includes a positioning ring (601), and a support ring one (602) is fixed to the inner wall of the positioning ring (601). A support ring two (603) is fixed to the inner wall of the support ring one (602).

8. The high performance liquid chromatograph with controllable flow rate according to claim 7, characterized in that, The interior of the positioning ring (601) is formed into a two-stage stepped shape by support ring one (602) and support ring two (603). The height of support ring one (602) is lower than the height of positioning ring (601), and the height of support ring two (603) is lower than the height of support ring one (602).

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