A quick detection device for anticoagulant activity of limulus polyphemus

Abstract

This utility model relates to the field of detecting the anticoagulant activity of Hirudo medicinalis, and discloses a rapid detection device for the anticoagulant activity of Hirudo medicinalis. The device includes a base plate, a column fixedly connected to the upper side of the base plate, a shelf fixedly connected to the upper side of the column, a sliding plate elastically connected to the inner wall of the shelf via a spring, a limiting plate fixedly connected to the left side of the sliding plate, a base elastically connected to the upper inner wall of the base via a torsion spring, and a rotating column fixedly connected to the outer wall of the base. In this utility model, the bottom of a test tube is inserted into the base, and the test tube is rotated. The outer wall of the test tube presses against the inclined surface of the limiting plate, causing the limiting plate to move towards the sliding plate and open the opening of the inner groove of the shelf. Once the test tube leaves the outer wall of the limiting plate and enters the shelf, the spring force causes the sliding plate to return the limiting plate to its original position, limiting the test tube. The test tube can then be pulled out directly upwards, facilitating the insertion and removal of the test tube.

Description

Technical Field

[0001] This utility model relates to the field of detecting the anticoagulant activity of Hirudo medicinalis, and in particular to a rapid detection device for the anticoagulant activity of Hirudo medicinalis. Background Technology

[0002] The golden-edged leech is an animal belonging to the genus Hirudo of the family Hirudinidae in the order Hirudo order. It is also known as the golden-edged leech. It has a long and flat body, with a yellowish-brown or olive-green back, a light yellow abdomen, and golden-yellow edges on both sides.

[0003] The anticoagulant effect of leeches primarily stems from hirudin, a natural antithrombin secreted by their salivary glands. Hirudin is currently known as a potent natural antithrombin substance. It binds tightly to the active site (serine residues) of thrombin, forming an irreversible complex that blocks the catalytic action of thrombin. Thrombin is a key enzyme in the coagulation process, promoting the conversion of fibrinogen to fibrin and activating factors V, VIII, and XIII, thus accelerating the coagulation process. Hirudin's inhibition of thrombin effectively prevents blood clotting.

[0004] Rapid detection of the anticoagulant activity of Hirudo medicinalis requires mixing a Hirudo medicinalis sample solution with blood in a test tube and allowing it to stand for observation. This standing process necessitates placing the test tube on a device. Most existing devices use double-layered plates, requiring the test tube to pass through holes in both layers from top to bottom for stable placement. This operation is inconvenient, requiring the test tube to be aligned with the holes in both layers. Therefore, a rapid detection device for the anticoagulant activity of Hirudo medicinalis is proposed to address these issues. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a rapid detection device for the anticoagulant activity of Hirudo medicinalis, which aims to improve the problem of inconvenient test tube placement in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a rapid detection device for the anticoagulant activity of Hirudo medicinalis, comprising a base plate, a column fixedly connected to the upper side of the base plate, a shelf fixedly connected to the upper side of the column, a sliding plate elastically connected to the inner wall of the shelf plate by a spring, a limiting plate fixedly connected to the left side of the sliding plate, a base elastically connected to the upper inner wall of the base plate by a torsion spring, a rotating column fixedly connected to the outer wall of the base, and a support assembly provided on the upper inner wall of the base plate, the support assembly being used to make the device more stable.

[0007] As a further description of the above technical solution:

[0008] The support assembly includes a rotating shaft, the outer wall of which is rotatably connected to the upper inner wall of the base plate. A support plate is fixedly connected to the bottom end of the rotating shaft, a magnetic block is fixedly connected inside the support plate, and a metal block is fixedly connected to the lower inner wall of the base plate.

[0009] As a further description of the above technical solution:

[0010] One end of the spring is fixedly connected to the inner wall of the shelf, and the other end of the spring is fixedly connected to the right side of the slide plate.

[0011] As a further description of the above technical solution:

[0012] The outer wall of the slide plate is slidably connected to the inner wall of the layer plate.

[0013] As a further description of the above technical solution:

[0014] The front side of the limiting plate is inclined, and the rear side of the limiting plate is arc-shaped. Two symmetrical limiting plates form a set.

[0015] As a further description of the above technical solution:

[0016] One end of the torsion spring is fixedly connected to the inner wall of the base plate, and the other end of the torsion spring is fixedly connected to the outer wall of the base.

[0017] As a further description of the above technical solution:

[0018] The upper side of the base has a mounting hole, and the opening diameter of the mounting hole in the base is larger than the diameter of the test tube.

[0019] As a further description of the above technical solution:

[0020] The metal block is provided in two parts, and the two metal blocks are arranged symmetrically.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this utility model, the bottom of the test tube is inserted into the base, and the test tube is rotated. The outer wall of the test tube presses against the inclined surface of the limiting plate. The limiting plate is pressed and moves towards the sliding plate to open the opening of the inner groove of the shelf. After the test tube leaves the outer wall of the limiting plate and enters the shelf, the elastic force of the spring causes the sliding plate to drive the limiting plate back to its original position to limit the test tube. The test tube can be pulled out directly upwards, which is convenient for the insertion and removal of the test tube.

[0023] 2. In this utility model, when the support plate is not in use, it rotates back into the bottom plate by rotating the shaft, and the position of the support plate is fixed by magnetic attraction between the magnetic block on the support plate and the metal block in the bottom plate. When it is needed, the support plate is rotated out of the bottom plate by rotating the shaft, and the position of the support plate is fixed by magnetic attraction between the magnetic block on the support plate and another metal block in the bottom plate. The support plate makes the device more stable when placed. Attached Figure Description

[0024] Figure 1 This is a three-dimensional schematic diagram of a rapid detection device for the anticoagulant activity of Hirudo medicinalis proposed in this utility model;

[0025] Figure 2 This is a schematic diagram of the limiting plate of a rapid detection device for the anticoagulant activity of Hirudo medicinalis proposed in this utility model;

[0026] Figure 3 This is a schematic diagram of the base of a rapid detection device for the anticoagulant activity of Hirudo medicinalis proposed in this utility model;

[0027] Figure 4 This is a schematic diagram of the support plate and magnetic block of a rapid detection device for the anticoagulant activity of Hirudo medicinalis proposed in this utility model;

[0028] Figure 5 This is a three-dimensional schematic diagram of the test tube placement for a rapid detection device for the anticoagulant activity of Hirudo medicinalis proposed in this utility model.

[0029] Legend:

[0030] 1. Base plate; 2. Rotating shaft; 3. Column; 4. Shelf; 5. Limiting plate; 6. Base; 7. Support plate; 8. Slide plate; 9. Spring; 10. Torsion spring; 11. Rotating column; 12. Magnetic block; 13. Metal block. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] Reference Figures 1-3This utility model provides an embodiment of a rapid detection device for the anticoagulant activity of Hirudo medicinalis, comprising a base plate 1, which is configured to accommodate a support plate 7 and provide support for the installation of columns 3. Columns 3 are fixedly connected to the upper side of the base plate 1, and four columns 3 are respectively located at the four corners of the upper side of the base plate 1. A shelf 4 is fixedly connected to the upper side of the columns 3, and a groove for accommodating test tubes is opened on the upper side of the shelf 4. The shelf 4 provides support for the placement of the test tubes. A sliding plate 8 is elastically connected to the inner wall of the shelf 4 via a spring 9. The sliding plate 8 moves synchronously with a limiting plate 5. When the outer wall of the test tube presses against the inclined surface of the limiting plate 5, the limiting plate 5 is compressed and moves towards the sliding plate 8, causing the sliding plate 8 to move with the limiting plate 5, compressing the spring 9. When the test tube leaves the outer wall of the limiting plate 5, the elastic force of the spring 9 causes the sliding plate 8 to move. The limiting plate 5 is driven back to its original position. The outer wall of the slide plate 8 is slidably connected to the inner wall of the shelf 4. One end of the spring 9 is fixedly connected to the inner wall of the shelf 4, and the other end of the spring 9 is fixedly connected to the right side of the slide plate 8. The left side of the slide plate 8 is fixedly connected to the limiting plate 5. The thickness of the limiting plate 5 is less than the thickness of the shelf 4. The outer walls of the two symmetrical limiting plates 5 contact each other to close the opening of the groove on the shelf 4. The front side of the limiting plate 5 is inclined, and the rear side of the limiting plate 5 is arc-shaped. The two symmetrical limiting plates 5 form a group. The base 6 is elastically connected to the upper inner wall of the base plate 1 by a torsion spring 10. When the base 6 is not carrying a test tube, it tilts outward by the action of the torsion spring 10. When the base 6 carries a test tube and the test tube is placed vertically in the device as the test tube rotates, the base 6 rotates from the inclined state to the vertical state to support the test tube. Figure 5 The upper side of the base 6 has a mounting hole. The opening diameter of the mounting hole in the base 6 is larger than the diameter of the test tube. One end of the torsion spring 10 is fixedly connected to the inner wall of the base plate 1, and the other end of the torsion spring 10 is fixedly connected to the outer wall of the base 6. A rotating column 11 is fixedly connected to the outer wall of the base 6. The rotating column 11 provides support for the rotation of the base 6. A support assembly is provided on the upper inner wall of the base plate 1. The support assembly is used to make the device more stable.

[0033] Reference Figure 1 , Figure 4 and Figure 5The support assembly includes a rotating shaft 2. The rotation of the rotating shaft 2 drives the support plate 7 to rotate. The outer wall of the rotating shaft 2 is rotatably connected to the upper inner wall of the base plate 1. The bottom end of the rotating shaft 2 is fixedly connected to the support plate 7. When not in use, the support plate 7 rotates back into the base plate 1 by rotating the rotating shaft 2, and the position of the support plate 7 is fixed by magnetic attraction between the magnetic block 12 on the support plate 7 and the metal block 13 in the base plate 1. During the detection operation, the rotating shaft 2 is rotated to make the support plate 7 rotate out of the base plate 1. The position of the support plate 7 is fixed by magnetic attraction between the magnetic block 12 on the support plate 7 and another metal block 13 in the base plate 1. The setting of the support plate 7 makes the device more stable when placed. The magnetic block 12 is fixedly connected inside the support plate 7. The magnetic block 12 and the metal block 13 are magnetically attracted to fix the position of the support plate 7. The lower inner wall of the base plate 1 is fixedly connected to the metal block 13. There are two metal blocks 13, which are arranged symmetrically.

[0034] Working principle: In the rapid detection of the anticoagulant activity of Hirudo medicinalis, the support plate 7 is rotated out of the base plate 1 by rotating the shaft 2. The magnetic block 12 on the support plate 7 is magnetically attracted to another metal block 13 in the base plate 1, fixing the position of the support plate 7 and making the device more stable. The sample solution of Hirudo medicinalis and blood are injected into the test tube and mixed. After the test tube is capped, it is shaken well. Then the bottom of the test tube is inserted into the base 6. The test tube is rotated, and the outer wall of the test tube presses the inclined surface of the limiting plate 5. The limiting plate 5 is pressed and moves towards the slide plate 8 to open the opening of the inner groove of the layer plate 4. After the test tube leaves the outer wall of the limiting plate 5 and enters the layer plate 4, the elastic force of the spring 9 causes the slide plate 8 to drive the limiting plate 5 back to its original position to limit the test tube and let it stand. After standing, the test tube can be pulled out upward to observe the test results.

[0035] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A device for rapid detection of anticoagulant activity of leeches of the species Haemopis sanguisuga, comprising a base plate (1), characterised in that: A column (3) is fixedly connected to the upper side of the base plate (1), and a shelf (4) is fixedly connected to the upper side of the column (3). A slide plate (8) is elastically connected to the inner wall of the shelf plate (4) by a spring (9). A limit plate (5) is fixedly connected to the left side of the slide plate (8). A base (6) is elastically connected to the upper inner wall of the base plate (1) by a torsion spring (10). A rotating column (11) is fixedly connected to the outer wall of the base (6). A support assembly is provided on the upper inner wall of the base plate (1). The support assembly is used to make the device more stable.

2. The device for rapid detection of anticoagulant activity of leech according to claim 1, characterized in that: The support assembly includes a rotating shaft (2), the outer wall of which is rotatably connected to the upper inner wall of the base plate (1), a support plate (7) is fixedly connected to the bottom end of the rotating shaft (2), a magnetic block (12) is fixedly connected inside the support plate (7), and a metal block (13) is fixedly connected to the lower inner wall of the base plate (1).

3. The device for rapid detection of anticoagulant activity of leech according to claim 1, characterized in that: One end of the spring (9) is fixedly connected to the inner wall of the shelf (4), and the other end of the spring (9) is fixedly connected to the right side of the slide plate (8).

4. The device for rapid detection of anticoagulant activity of leech according to claim 1, characterized in that: The outer wall of the slide plate (8) is slidably connected to the inner wall of the layer plate (4).

5. The device for rapid detection of anticoagulant activity of leech according to claim 1, characterized in that: The front side of the limiting plate (5) is inclined, and the rear side of the limiting plate (5) is arc-shaped. Two symmetrical limiting plates (5) form a group.

6. The device for rapid detection of anticoagulant activity of leech according to claim 1, characterized in that: One end of the torsion spring (10) is fixedly connected to the inner wall of the base plate (1), and the other end of the torsion spring (10) is fixedly connected to the outer wall of the base (6).

7. The device for rapid detection of anticoagulant activity of leech according to claim 1, characterized in that: The upper side of the base (6) is provided with a placement hole, and the opening diameter of the placement hole in the base (6) is larger than the diameter of the test tube.

8. The device for rapid detection of anticoagulant activity of leech according to claim 2, characterized in that: Two metal blocks (13) are provided, and the two metal blocks (13) are arranged symmetrically.

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