An online monitoring instrument for heparin sodium production

Abstract

This utility model belongs to the field of heparin sodium production technology, specifically an online detection instrument for heparin sodium production. It includes a reaction tank and a discharge pipe connected to its bottom end, and further includes: a dual-channel peristaltic pump, the inlet end of which is connected to the discharge pipe via a sampling pipe, and the inlet end of which is connected to a reagent tank via an inlet pipe; a four-way connector, the two ports of which are respectively connected to the outlet ends of the first and second pump pipes via two connecting pipes; a static mixer, located below the four-way connector, the top of which is connected to one port of the four-way connector via a connecting pipe, and the bottom end of which is connected to a transparent detection tube, with a detection module outside the transparent detection tube; and a water pump, the outlet end of which is connected to one port of the four-way connector via a drain pipe. This utility model can extract and detect the reaction solution during the heparin sodium production process, and furthermore, when the reaction solution and reagent pass through the static mixer, the reagent and reaction solution are uniformly mixed.

Description

Technical Field

[0001] This utility model belongs to the field of heparin sodium production technology, and more specifically, it relates to an online detection instrument for heparin sodium production. Background Technology

[0002] Heparin sodium is an anticoagulant drug, mainly extracted from the intestinal mucosa and lungs of animals such as pigs, cattle, and sheep. It can prevent the formation of new thrombi and the expansion of existing thrombi by inhibiting the coagulation process. Its production process requires multi-index testing of raw materials, intermediates and finished products to ensure quality.

[0003] Currently, most existing heparin sodium production testing methods involve offline sampling and testing. Samples are collected manually from the production line at regular intervals and sent to the laboratory for testing. The test results are delayed and cannot reflect changes in composition during the production process in real time. This makes it impossible for staff to make timely adjustments to the production line, which may lead to batch-to-batch quality deviations or waste of raw materials.

[0004] To address the aforementioned issues, this application proposes an online monitoring instrument for heparin sodium production. Utility Model Content

[0005] The purpose of this invention is to provide an online detection instrument for heparin sodium production, which solves the problems mentioned in the background art.

[0006] To solve the above-mentioned technical problems, this utility model is achieved through the following technical solution:

[0007] This utility model relates to an online detection instrument for heparin sodium production, comprising a reaction vessel and a discharge pipe connected to its bottom end, and further comprising:

[0008] A dual-channel peristaltic pump, wherein the inlet end of the first pump tube of the dual-channel peristaltic pump is connected to the discharge tube through a sampling tube, and the inlet end of the second pump tube of the dual-channel peristaltic pump is connected to the reagent tank through an inlet tube;

[0009] The four-way connector has two ports that are connected to the liquid outlets of the first pump pipe and the second pump pipe respectively through two connecting pipes.

[0010] A static mixer is located below the four-way connector. The top of the static mixer is connected to one interface of the four-way connector through a connecting pipe 2, and the bottom of the static mixer is connected to a transparent detection tube. A detection module is provided outside the transparent detection tube.

[0011] The water pump's outlet is connected to one interface of a four-way connector via a drain pipe.

[0012] Furthermore, the interfaces of the four-way connector are respectively arranged in the four directions of up, down, left, and right. The two connecting pipes are respectively connected to the interfaces on the left and right sides, the connecting pipe is connected to the lower interface of the four-way connector, and the drain pipe is connected to the upper interface of the four-way connector.

[0013] Furthermore, the bottom end of the transparent detection tube is connected to a waste discharge pipe, and a waste liquid tank is provided below the waste discharge pipe.

[0014] Furthermore, the dual-channel peristaltic pump and reagent box are mounted on the top surface of the mounting frame, and a mounting plate is fixed to the side of the mounting frame, with the transparent detection tube fixed above the mounting plate.

[0015] Furthermore, the detection module includes a light source emitter and a light source receiver arranged opposite to each other, a light shield is fixed on the top surface of the fixed plate, the transparent detection tube is located inside the light shield, and the light source emitter and the light source receiver are respectively fixed to the two opposite inner walls of the light shield.

[0016] Furthermore, the fixing plate is provided with a clearance hole for avoiding the waste discharge pipe.

[0017] Furthermore, an electromagnetic valve is installed on the discharge pipe, and the sampling pipe is connected to the discharge pipe at a position above the electromagnetic valve installed on the discharge pipe.

[0018] Furthermore, one-way valves are installed on the inlet pipe and the sampling pipe, and solenoid valves are installed on the waste discharge pipe and the drain pipe.

[0019] This utility model has the following beneficial effects:

[0020] This invention collects the reaction liquid in the discharge pipe through the first pump pipe and collects the reagent in the reagent box through the second pump pipe. The dual-channel peristaltic pump can synchronously and accurately pump the reagent and reaction liquid into the four-way connector for convergence.

[0021] This invention allows reagents and reaction solutions to enter the four-way connector, then through the second connecting tube into the static mixer. After thorough shearing and mixing by its internal structure, the mixture is then fed into the transparent detection tube, ensuring uniform mixing of the reaction solution and reagents, avoiding localized component differences, and improving the consistency of the test samples.

[0022] Of course, any product implementing this utility model does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0023] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is a schematic diagram of the overall appearance structure of this utility model;

[0025] Figure 2 This is a cross-sectional view of the light shield of this utility model;

[0026] Figure 3 This is a partial structural schematic diagram of the present invention;

[0027] Figure 4 This is a cross-sectional view of the static mixer of this utility model;

[0028] The attached diagram lists the components represented by each number as follows:

[0029] In the diagram: 1. Reaction vessel; 101. Discharge pipe; 2. Dual-channel peristaltic pump; 201. First pump pipe; 202. Second pump pipe; 203. Connecting pipe one; 3. Reagent box; 301. Liquid inlet pipe; 4. Sampling pipe; 5. Four-way connector; 6. Static mixer; 601. Connecting pipe two; 7. Transparent detection tube; 701. Waste discharge pipe; 8. Waste liquid tank; 9. Water pump; 901. Drain pipe; 10. Fixing frame; 1001. Fixing plate; 1002. Clearance hole; 11. Light shield; 12. Detection module; 1201. Light source emitter; 1202. Light source receiver. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0031] In the description of this utility model, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "around" and other terms indicating orientation or positional relationship are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0032] Please see Figure 1 - Figure 4 As shown, this utility model is an online detection instrument for heparin sodium production, including a reaction tank 1 and a discharge pipe 101 connected to its bottom end, and also includes: a dual-channel peristaltic pump 2, the inlet end of the first pump pipe 201 of the dual-channel peristaltic pump 2 is connected to the discharge pipe 101 through a sampling pipe 4, and the inlet end of the second pump pipe 202 of the dual-channel peristaltic pump 2 is connected to the reagent tank 3 through an inlet pipe 301; a four-way connector 5, the two interfaces of the four-way connector 5 are respectively connected to the outlet ends of the first pump pipe 201 and the second pump pipe 202 through two connecting pipes 1 203; a static mixer 6, which is set below the four-way connector 5, the top end of the static mixer 6 is connected to one interface of the four-way connector 5 through a connecting pipe 2 601, and the bottom end of the static mixer 6 is connected to a transparent detection tube 7, the transparent detection tube 7 is provided with a detection module 12; and a water pump 9, the outlet end of which is connected to one interface of the four-way connector 5 through a drain pipe 901.

[0033] This embodiment provides an online detection instrument for heparin sodium production. The dual-channel peristaltic pump 2 can simultaneously extract and transport the reaction solution and reagents. The flow rate of the sampling tube 4 and the inlet tube 301 is controlled by the dual-channel peristaltic pump 2. The reaction solution and reagents enter the four-way connector 5 and then enter the static mixer 6 through the connecting tube 601. The static mixer 6 mixes the reaction solution and reagents and then injects them into the transparent detection tube 7. The solution in the transparent detection tube 7 is detected by the detection module 12. The water inlet of the water pump 9 is connected to a container containing cleaning solution through a pipe (not shown in the figure). After the detection is completed, the water pump 9 injects cleaning water into the four-way connector 5 to rinse the static mixer 6 and the transparent detection tube 7, so as to avoid the residual waste liquid in the static mixer 6 and the transparent detection tube 7 from affecting the subsequent detection results.

[0034] The four-way connector 5 has its interfaces located in the four directions: up, down, left, and right. The two connecting pipes 203 are connected to the interfaces on the left and right sides respectively. The connecting pipe 601 is connected to the lower interface of the four-way connector 5. The drain pipe 901 is connected to the upper interface of the four-way connector 5.

[0035] The bottom end of the transparent detection tube 7 is connected to the waste discharge pipe 701, and a waste liquid tank 8 is set below the waste discharge pipe 701. After the test is completed, the waste liquid in the transparent detection tube 7 and the subsequent cleaning solution are discharged from the waste discharge pipe 701 into the waste liquid tank 8 for unified collection and unified treatment.

[0036] The dual-channel peristaltic pump 2 and reagent box 3 are mounted on the top surface of the fixed frame 10, and a fixed plate 1001 is fixed on the side of the fixed frame 10. The transparent detection tube 7 is fixed above the fixed plate 1001 and is made of a material with good light transmission properties, such as glass or quartz.

[0037] The detection module 12 includes a light source emitter 1201 and a light source receiver 1202 arranged opposite to each other. A light shield 11 is fixed on the top surface of the fixing plate 1001. The transparent detection tube 7 is located inside the light shield 11. The light source emitter 1201 and the light source receiver 1202 are respectively fixed to the two opposite inner walls of the light shield 11. The detection module uses spectrophotometry for detection. The light source emitter 1201 and the light source receiver 1202 are respectively facing the two side walls of the transparent detection tube 7. The light source emitter 1201 emits a light beam of a specific wavelength (e.g., around 540nm, suitable for the heparin sodium-azuron A reaction system). After the light beam passes through the transparent detection tube 7 and the mixture inside the tube, it is received by the light source receiver 1202. The light source receiver 1202 converts the light signal into an electrical signal and transmits it to an external controller (not shown in the figure). The controller processes the data and calculates the absorbance value. Through a pre-calibrated concentration-absorbance standard curve, the concentration of heparin sodium in the reaction solution is calculated, and the processing result is transmitted to an external display device to complete the online detection.

[0038] Preferably, an inspection port can be opened on the outer wall of the sunshade 11, and a door can be hinged at the inspection port to facilitate the inspection and maintenance of the parts inside the sunshade 11.

[0039] The fixing plate 1001 has a clearance hole 1002 for avoiding the waste discharge pipe 701, so as to prevent the waste discharge pipe 701 from interfering with the fixing plate 1001.

[0040] The discharge pipe 101 is equipped with a solenoid valve. The sampling pipe 4 is connected to the discharge pipe 101 above the solenoid valve installed on the discharge pipe 101. When the discharge pipe 101 does not discharge the reaction liquid, the reaction liquid can be extracted by the sampling pipe 4.

[0041] One-way valves are installed on the liquid inlet pipe 301 and the sampling pipe 4, and solenoid valves are installed on the waste discharge pipe 701 and the drain pipe 901.

[0042] It is understood that this invention can extract and test the reaction solution during the production of heparin sodium, and secondly, when the reaction solution and reagent pass through the static mixer 6, the reagent and reaction solution are uniformly mixed.

[0043] A specific application of the operation process of this embodiment is as follows: When it is necessary to test the reaction liquid in the reaction tank 1, the dual-channel peristaltic pump 2 is started to simultaneously draw the reaction liquid in the reaction tank 1 and the reagent in the reagent box 3 through the sampling pipe 4 and the liquid inlet pipe 301 respectively. The reaction liquid enters the four-way connector 5 through the first pump pipe 201 and the first connecting pipe 203, and the reagent enters the four-way connector 5 through the second pump pipe 202 and the first connecting pipe 203. After the reagent and the reaction liquid are combined in the four-way connector 5, they enter the static mixer 6 through the second connecting pipe 601. The spiral blades inside the static mixer 6 generate a shearing action on the mixture, so that it is fully mixed and uniform.

[0044] After the reaction solution and reagent are uniformly mixed, they enter the transparent detection tube 7. A light beam emitted by the light source emitter 1201 passes through the transparent detection tube 7 and the mixture inside the tube and is received by the light source receiver 1202.

[0045] After the test is completed, open the solenoid valve of the waste discharge pipe 701, and the waste liquid flows into the waste liquid tank 8 through the waste discharge pipe 701;

[0046] Start the water pump 9 to draw up the cleaning fluid and inject it into the four-way connector 5 through the drain pipe 901. The cleaning fluid rinses the static mixer 6 and the transparent detection tube 7. Finally, the waste liquid is discharged to the waste liquid tank 8 through the waste discharge pipe 701.

[0047] In the description of this specification, references to terms such as "an embodiment," "example," and "specific example" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0048] The preferred embodiments of this utility model disclosed above are merely illustrative of the present utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to the specific implementations described. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of this utility model, thereby enabling those skilled in the art to better understand and utilize it. This utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A kind of heparin sodium production online detector, including reaction tank (1) and the discharge pipe (101) of the bottom end communication thereof, it is characterized in that, Also includes: A dual-channel peristaltic pump (2) has its first pump tube (201) inlet end connected to the discharge tube (101) via a sampling tube (4), and its second pump tube (202) inlet end connected to the reagent box (3) via an inlet tube (301). Four-way connector (5), the two ports of the four-way connector (5) are respectively connected to the liquid outlet of the first pump pipe (201) and the second pump pipe (202) through two connecting pipes (203); A static mixer (6) is located below the four-way connector (5). The top of the static mixer (6) is connected to one interface of the four-way connector (5) through a connecting pipe (601), and the bottom of the static mixer (6) is connected to a transparent detection tube (7). A detection module (12) is provided outside the transparent detection tube (7). The water pump (9) has its outlet end connected to one interface of the four-way connector (5) via a drain pipe (901).

2. The on-line detector for heparin sodium production according to claim 1, characterized in that: The interfaces of the four-way connector (5) are respectively located in the four directions of up, down, left and right. The two connecting pipes (203) are respectively connected to the interfaces on the left and right sides. The connecting pipe (601) is connected to the lower interface of the four-way connector (5). The drain pipe (901) is connected to the upper interface of the four-way connector (5).

3. The on-line detector for heparin sodium production according to claim 1, characterized in that: The bottom end of the transparent detection tube (7) is connected to a waste discharge pipe (701), and a waste liquid tank (8) is provided below the waste discharge pipe (701).

4. The on-line detector for heparin sodium production according to claim 3, characterized in that: The dual-channel peristaltic pump (2) and reagent box (3) are set on the top surface of the fixed frame (10), and a fixed plate (1001) is fixed on the side of the fixed frame (10), and the transparent detection tube (7) is fixed above the fixed plate (1001).

5. The on-line detector for heparin production according to claim 4, characterized in that: The detection module (12) includes a light source emitter (1201) and a light source receiver (1202) arranged opposite to each other. A light shield (11) is fixed on the top surface of the fixing plate (1001). The transparent detection tube (7) is located inside the light shield (11). The light source emitter (1201) and the light source receiver (1202) are respectively fixed to the two opposite inner walls of the light shield (11).

6. The on-line detector for heparin production according to claim 4, characterized in that: The fixing plate (1001) has a clearance hole (1002) for avoiding the waste discharge pipe (701).

7. The on-line detector for heparin production according to claim 1, characterized in that: An electromagnetic valve is installed on the discharge pipe (101), and the sampling pipe (4) is connected to the discharge pipe (101) above the electromagnetic valve installed on the discharge pipe (101).

8. The on-line detector for heparin production according to claim 3, characterized in that: One-way valves are installed on the inlet pipe (301) and the sampling pipe (4), and solenoid valves are installed on the waste discharge pipe (701) and the drain pipe (901).

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