Biochip analyzer

Abstract

This application relates to a biochip analyzer. The analyzer includes a chassis, a chip loading module, a sample introduction module, a reagent module, an incubation module, a cleaning and separation module, and a photoelectric signal acquisition module. The chip loading module is responsible for loading and transferring the biochip and reaction cups; the sample introduction module is used for automated sample loading; the reagent module provides the liquid required for the reaction; the incubation module is used for the biochip reaction process; the cleaning and separation module is responsible for cleaning and disposal of the chip; and the photoelectric signal acquisition module is used to detect the photoelectric signals on the biochip. This biochip analyzer, through its modular design, enables simultaneous detection of multiple samples, significantly improving detection efficiency. Its automated operation process, from sample loading to result output, requires no manual intervention, reducing human error and ensuring the accuracy of the test results. Furthermore, the analyzer is compatible with various testing items, meeting diverse clinical testing needs.

Description

Technical Field

[0001] This application relates to the field of bioanalytical technology, and in particular to biochip analyzers. Background Technology

[0002] With the continuous development of biomedical analytical detection technologies, chemiluminescence immunoassay (CIA) technology has emerged. With its high sensitivity, high specificity, and rapid detection capabilities, CIA technology can efficiently perform quantitative or qualitative analysis of multiple components in biological samples, providing strong support for early disease diagnosis, treatment monitoring, and health assessment. This technology detects the concentration of biomolecules through light signals generated by chemical reactions, offering advantages such as ease of operation, fast detection speed, and accurate results, and has therefore been widely used in the field of immunodiagnostics.

[0003] In related technologies, traditional chemiluminescence detection devices typically employ single-sample detection, resulting in low efficiency and difficulty in meeting the needs of large-scale clinical sample testing. Furthermore, some devices are bulky, lack automation, are complex to operate, require highly skilled personnel, and pose a risk of cross-contamination during testing, affecting the accuracy of results. Additionally, some existing detection devices struggle to balance speed and accuracy when handling different testing items, such as rapid tests (e.g., myocardial, cardiopulmonary, infection) and tests with longer reaction times (e.g., tumor marker detection), limiting their application in diverse testing scenarios.

[0004] However, the aforementioned traditional detection methods or related devices suffer from low detection efficiency, insufficient automation, inability to simultaneously detect multiple samples, and difficulty in adapting to the needs of different detection items. These problems, to some extent, restrict the further promotion and application of chemiluminescence detection technology in clinical diagnosis and urgently need to be addressed through innovative technological means. Utility Model Content

[0005] Therefore, it is necessary to provide a fully automated biochip analyzer capable of simultaneous detection of multiple samples, addressing the problems of low detection efficiency, insufficient automation, and inability to meet the needs of simultaneous detection of multiple samples and different detection items in existing chemiluminescence detection devices.

[0006] A biochip analyzer, the biochip analyzer comprising:

[0007] Chassis (100), wherein the chassis (100) is provided with:

[0008] A chip loading module, located on the left side of the chassis (100), is used to load and transfer biochips and reaction cups;

[0009] Sample loading modules are distributed within the chassis (100) and are used to load samples into the chip loading modules;

[0010] A reagent module, located on the lower right side of the chassis (100), is used to provide the liquid required for the reaction;

[0011] An incubation module is located above the center of the chassis (100) and is used for carrying out the reaction;

[0012] A cleaning and separation module is located on the left and right sides of the incubation module and is used for cleaning and waste disposal of the biochip.

[0013] The photoelectric signal acquisition module is located in the upper right corner of the chassis (100) and is used for signal detection.

[0014] In one embodiment, the chip loading module includes: a chip placement component (1), a chip loading arm (2), a chip temporary storage position (3), and a sampling temporary storage position (4), wherein:

[0015] The chip placement assembly (1) includes: a chip placement plate (101), a first drive motor (102) and a first transmission mechanism (103). The chip placement plate (101) is disposed above the first transmission mechanism (103), and the first transmission mechanism (103) is disposed on the first drive motor (102). The chip placement plate (101) is used to load the biochip and the reaction cup.

[0016] The chip loading arm (2) includes: a first X-axis drive motor (201), a first X-axis transmission mechanism (202), a first Y-axis drive motor (203), a first Y-axis transmission mechanism (204), a first Z-axis drive motor (205), a first Z-axis transmission mechanism (206), and a first electric gripper (207).

[0017] The chip storage position (3) and the sample loading position (4) are provided. The chip loading arm (2) is used to pick up the biochip and the reaction cup and transfer them to the chip storage position (3) and the sample loading position (4).

[0018] In one embodiment, the sample storage position (4) includes a sample storage base (401) and a DC solenoid (402).

[0019] In one embodiment, the sample injection module includes: a test tube rack placement assembly (5), a first gushing tube assembly (61), a processing liquid tank assembly (7), and a sample dispensing arm (8).

[0020] The test tube rack placement assembly (5) includes: a push-in drive motor (501), a push-in transmission mechanism (502), a transverse drive motor (503), a transverse transmission mechanism (504), an ejection drive motor (505), an ejection transmission mechanism (506), and a test tube rack placement cavity (507).

[0021] The first spring pipe assembly (61) includes: a first spring pipe (601), a first spring nozzle core (602), a first water inlet needle pipe (603), and a first spring cleaning position (604).

[0022] The processing liquid tank assembly (7) includes: a second drive motor (701), a second transmission mechanism (702) and a processing liquid placement rack (703). The processing liquid placement rack (703) is provided with a reagent placement position. The second drive motor (701), the second transmission mechanism (702) and the processing liquid placement rack (703) are stacked in sequence.

[0023] The sample feeding arm (8) includes: a first rotary drive motor (801), a first rotary transmission mechanism (802), a first lifting drive motor (803), a first lifting transmission mechanism (804), a first sample feeding needle (805), a first liquid level plate (806), a first two-way motor plate (807), and a first anti-collision mechanism (808). The first liquid level plate (806), the first anti-collision mechanism (808), and the first sample feeding needle (805) are disposed on the first rotary transmission mechanism (802), and the first two-way motor plate (807) is disposed between the first lifting drive motor (803) and the first rotary drive motor (801).

[0024] The first spring tube assembly (61) is used to clean the first sample dispensing needle (805).

[0025] In one embodiment, the reagent module includes: a reagent tray assembly (9), a reagent arm (10), a detection liquid arm (11), a second gushing tube assembly (62), and a third gushing tube assembly (63).

[0026] The reagent tray assembly (9) includes: a third drive motor (901), a third transmission mechanism (902), a reagent liquid holder (903), and a heat dissipation assembly (904). The third transmission mechanism (902) is located above the third drive motor (901), the reagent liquid holder (903) is located above the third transmission mechanism (902), and the heat dissipation assembly (904) is located on the side of the reagent liquid holder (903).

[0027] The reagent arm 10 includes: a second rotary drive motor, a second rotary transmission mechanism, a second lifting drive motor, a second lifting transmission mechanism, a second sample dispensing needle, a second liquid level plate, a second dual-motor plate, and a second anti-collision mechanism. The second liquid level plate, the second anti-collision mechanism, and the second sample dispensing needle are disposed on the second rotary transmission mechanism, and the second dual-motor plate is disposed between the second lifting drive motor and the second rotary drive motor.

[0028] The detection liquid arm 11 includes: a third rotary drive motor, a third rotary transmission mechanism, a third lifting drive motor, a third lifting transmission mechanism, a third sampling needle, a third liquid level plate, a third dual-motor plate, and a third anti-collision mechanism. The third liquid level plate, the third anti-collision mechanism, and the third sampling needle are disposed on the third rotary transmission mechanism, and the third dual-motor plate is disposed between the third lifting drive motor and the third rotary drive motor.

[0029] The second spring tube assembly (62) includes: a second spring tube, a second spring nozzle core, a second water inlet needle tube and a second spring cleaning position. The second spring tube assembly (62) is used to clean the second sample dispensing needle.

[0030] The third spring tube assembly (63) includes: a third spring tube, a third spring nozzle core, a third water inlet needle tube, and a third spring cleaning position. The third spring tube assembly (63) is used to clean the third sample dispensing needle.

[0031] In one embodiment, the incubation module includes a serum reaction disk assembly (12), wherein:

[0032] The serum reaction plate assembly (12) includes: a temperature control component (1201), a serum reaction plate (1202), a fourth drive motor (1203), and a fourth transmission mechanism (1204). The temperature control component (1201) and the serum reaction plate (1202) are sequentially arranged above the fourth drive motor (1203) and the fourth transmission mechanism (1204).

[0033] In one embodiment, the incubation temperature control component (1201) includes a heating element, an over-temperature protector, and a temperature sensor; the serum reaction plate (1202) includes a reaction plate and a serum plate.

[0034] In one embodiment, the cleaning and separation module includes: a first cleaning box assembly (13), a second cleaning box assembly (14), and a cup removal assembly (19).

[0035] The first cleaning box assembly (13) includes: a first drying assembly (1301), a first rinsing and drying assembly (1302), a first rinsing tank (1303), and a first rinsing tank cover (1304).

[0036] The second cleaning box assembly (14) includes: a second drying assembly (1401), a second rinsing and drying assembly (1402), a second rinsing tank (1403), and a second rinsing tank cover (1404).

[0037] The cup removal assembly (19) includes: an electric gripper assembly (1901), an electric gripper fixing assembly (1902), and a discharge tube (1903). The electric gripper fixing assembly (1902) is disposed above the discharge tube (1903), and the electric gripper assembly (1901) is disposed on the side of the discharge tube (1903).

[0038] In one embodiment, the photoelectric signal acquisition module includes: a CMOS camera assembly (20), an exposure mechanism assembly (21), and an exposure loading arm (22).

[0039] The CMOS camera assembly 20 includes a CMOS camera (2001) and a camera adjustment assembly (2002), wherein the CMOS camera (2001) is disposed above the camera adjustment assembly (2002);

[0040] The exposure mechanism assembly (21) includes: a fifth drive motor (2101), a fifth transmission mechanism (2102), and an exposure turntable assembly (2103). The exposure turntable assembly (2103) is disposed above the fifth transmission mechanism (2102), and the fifth transmission mechanism (2102) is disposed above the fifth drive motor (2101).

[0041] The exposure loading arm (22) includes: a second X-axis drive motor (2201), a second X-axis transmission mechanism (2202), a second Y-axis drive motor (2203), a second Y-axis transmission mechanism (2204), a second Z-axis drive motor (2205), a second Z-axis transmission mechanism (2206), and a second electric gripper (2207). The CMOS camera assembly (20) is located below the exposure loading arm (22).

[0042] In one embodiment, the cleaning and separation module further includes: a peristaltic pump assembly (15), a diaphragm pump assembly (16), an air pump assembly (17), and a pressure transmitter assembly (18), wherein:

[0043] The peristaltic pump assembly (15) includes: a peristaltic pump (1501), a pressure regulating valve (1502), and a pure water solenoid valve (1503).

[0044] The diaphragm pump assembly (16) includes: a diaphragm pump (1601) and a first shock absorber (1602), wherein the diaphragm pump (1601) is disposed above the first shock absorber (1602);

[0045] The air pump assembly (17) includes an air pump (1701) and a second shock absorber (1702), wherein the air pump (1701) is disposed above the second shock absorber (1702);

[0046] The pressure transmitter assembly (18) includes a pressure transmitter (1801) and a pressure transmitter mounting base (1802), wherein the pressure transmitter (1801) is disposed on the pressure transmitter mounting base (1802).

[0047] The aforementioned biochip analyzer, through its modular design, can efficiently perform simultaneous testing of multiple samples, significantly improving testing efficiency and solving the problem of low testing efficiency in existing technologies. Its automated operation process, from sample loading to result output, requires no manual intervention, not only improving operational convenience but also reducing human error and ensuring the accuracy of test results. Furthermore, through optimized module design and operating procedures, the analyzer is compatible with various testing items, thereby meeting diverse clinical testing needs. Attached Figure Description

[0048] Figure 1 This is a schematic diagram of the overall appearance of a biochip analyzer provided in one embodiment of this application.

[0049] Figure 2 This is a schematic diagram of the overall structure of a biochip analyzer provided in one embodiment of this application.

[0050] Figure 3 This is a schematic diagram of the structure of a chip placement assembly provided in an embodiment of this application.

[0051] Figure 4 This is a schematic diagram of the structure of a chip loading arm provided in an embodiment of this application.

[0052] Figure 5 This is a schematic diagram of the sample storage location provided in one embodiment of this application.

[0053] Figure 6a This is a schematic diagram of the structure of a test tube rack placement assembly provided in an embodiment of this application.

[0054] Figure 6b This is a structural schematic diagram of a test tube rack placement assembly provided in one embodiment of this application from another perspective.

[0055] Figure 7a A schematic diagram of the structure of a first spring pipe assembly provided in an embodiment of this application.

[0056] Figure 7b A cross-sectional view of a first spring pipe assembly provided in an embodiment of this application.

[0057] Figure 7c A top view of a first spring pipe assembly provided in an embodiment of this application.

[0058] Figure 8a This is a schematic diagram of the processing liquid tank assembly provided in one embodiment of this application.

[0059] Figure 8b This is a cross-sectional view of a processing liquid tank assembly provided in one embodiment of this application.

[0060] Figure 9 This is a schematic diagram of the sample loading arm provided in one embodiment of this application.

[0061] Figure 10a This is a schematic diagram of the structure of a reagent tray assembly provided in an embodiment of this application.

[0062] Figure 10b This is a cross-sectional view of a reagent tray assembly provided in an embodiment of this application.

[0063] Figure 11a This is a schematic diagram of the structure of a serum reaction disk assembly provided in an embodiment of this application.

[0064] Figure 11b A cross-sectional view of a serum reaction disk assembly provided in an embodiment of this application.

[0065] Figure 11c This is a top view of a serum reaction disk assembly provided in one embodiment of this application.

[0066] Figure 12 This is a schematic diagram of the structure of a first cleaning box assembly provided in an embodiment of this application.

[0067] Figure 13 This is a schematic diagram of the structure of a second cleaning box assembly provided in an embodiment of this application.

[0068] Figure 14 This is a schematic diagram of the peristaltic pump assembly provided in one embodiment of this application.

[0069] Figure 15 This is a schematic diagram of the structure of a diaphragm pump assembly provided in an embodiment of this application.

[0070] Figure 16 This is a schematic diagram of the structure of an air pump assembly provided in an embodiment of this application.

[0071] Figure 17 This is a schematic diagram of the structure of a pressure transmitter assembly provided in an embodiment of this application.

[0072] Figure 18 This is a schematic diagram of the structure of a cup removal assembly provided in an embodiment of this application.

[0073] Figure 19 This is a schematic diagram of the structure of a CMOS camera assembly provided in an embodiment of this application.

[0074] Figure 20a This is a schematic diagram of the structure of an exposure mechanism component provided in an embodiment of this application.

[0075] Figure 20b This is a cross-sectional view of an exposure mechanism component provided in an embodiment of this application.

[0076] Figure 21 This is a schematic diagram of the structure of an exposure loading arm provided in an embodiment of this application.

[0077] The reference numerals in the detailed embodiments are as follows:

[0078] 100. Chassis;

[0079] 1. Chip placement assembly; 2. Chip loading arm; 3. Chip temporary storage area; 4. Sampling temporary storage area;

[0080] 101. Chip placement board; 102. First drive motor; 103. First transmission mechanism;

[0081] 201. First X-axis drive motor; 202. First X-axis transmission mechanism; 203. First Y-axis drive motor; 204. First Y-axis transmission mechanism; 205. First Z-axis drive motor; 206. First Z-axis transmission mechanism; 207. First electric gripper;

[0082] 401. Sample storage holder; 402. DC solenoid;

[0083] 5. Test tube rack placement assembly; 61. First spring tube assembly; 7. Processing liquid tank assembly; 8. Sample dispensing arm;

[0084] 501. Push-in drive motor; 502. Push-in transmission mechanism; 503. Horizontal movement drive motor; 504. Horizontal movement transmission mechanism; 505. Push-out drive motor; 506. Push-out transmission mechanism; 507. Test tube rack placement cavity;

[0085] 601. First spring pipe; 602. First spring nozzle core; 603. First inlet needle pipe; 604. First spring cleaning position;

[0086] 701, Second drive motor; 702, Second transmission mechanism; 703, Processing liquid placement rack;

[0087] 801. First rotary drive motor; 802. First rotary transmission mechanism; 803. First lifting drive motor; 804. First lifting transmission mechanism; 805. First sampling needle; 806. First liquid level plate; 807. First dual-motor plate; 808. First anti-collision mechanism;

[0088] 9. Reagent tray assembly; 10. Reagent arm; 11. Detection liquid arm; 62. Second gushing tube assembly; 63. Third gushing tube assembly;

[0089] 901. Third drive motor; 902. Third transmission mechanism; 903. Reagent solution rack; 904. Heat dissipation assembly;

[0090] 12. Serum reaction disk assembly;

[0091] 1201. Temperature control and incubation components; 1202. Serum reaction plate; 1203. Fourth drive motor; 1204. Fourth transmission mechanism;

[0092] 13. First cleaning box assembly; 14. Second cleaning box assembly;

[0093] 1301, First drying assembly; 1302, First rinsing and drying assembly; 1303, First rinsing tank; 1304, First rinsing tank cover;

[0094] 1401. Second drying assembly; 1402. Second rinsing and drying assembly; 1403. Second rinsing tank; 1404. Second rinsing tank cover;

[0095] 15. Peristaltic pump assembly; 16. Diaphragm pump assembly; 17. Air pump assembly; 18. Pressure transmitter assembly;

[0096] 1501. Peristaltic pump; 1502. Pressure regulating valve; 1503. Pure water solenoid valve;

[0097] 1601. Diaphragm pump; 1602. First shock absorber;

[0098] 1701. Air pump; 1702. Second shock absorber;

[0099] 1801, Pressure transmitter; 1802, Pressure transmitter mounting base;

[0100] 19. Cup release assembly;

[0101] 1901. Electric gripper assembly; 1902. Electric gripper fixing assembly; 1903. Feed tube;

[0102] 20. CMOS camera assembly; 21. Exposure mechanism assembly; 22. Exposure loading arm;

[0103] 2001, CMOS camera; 2002, Camera adjustment components;

[0104] 2101. Fifth drive motor; 2102. Fifth transmission mechanism; 2103. Exposure turntable assembly;

[0105] 2201. Second X-axis drive motor; 2202. Second X-axis transmission mechanism; 2203. Second Y-axis drive motor; 2204. Second Y-axis transmission mechanism; 2205. Second Z-axis drive motor; 2206. Second Z-axis transmission mechanism; 2207. Second electric gripper. Detailed Implementation

[0106] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0107] In the description of this application, it should be understood that if terms such as "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" appear, these terms indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0108] Furthermore, where the terms "first" and "second" appear, these terms are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined with "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, where the term "multiple" appears, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0109] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0110] In this application, unless otherwise expressly specified and limited, the use of descriptions such as "above" or "below" the second feature indicates that the first and second features are in direct contact or indirect contact via an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. Similarly, "below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0111] It should be noted that if an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. If an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. If so, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this application are for illustrative purposes only and do not represent the only possible implementation.

[0112] See Figure 1 , Figure 1 A schematic diagram of the overall shape of a biochip analyzer according to one embodiment of this application is shown. The biochip analyzer provided in this embodiment includes a chassis 100. The chassis 100, as the supporting frame of the overall structure, not only provides stable installation space for the various internal functional modules, but also ensures efficient collaborative operation between the modules through optimized layout. Its compact design effectively reduces the footprint of the device while ensuring functional integrity, making it suitable for deployment in space-constrained laboratory environments.

[0113] Combination Figure 2 As shown, Figure 2The diagram illustrates the overall structure of a biochip analyzer according to one embodiment of this application. In some embodiments, the biochip analyzer includes: a chassis 100, which houses: a chip loading module (1, 2, 3, 4), a sample injection module (5, 61, 7, 8), a reagent module (9, 10, 11, 62, 63), an incubation module (12), a cleaning and separation module (13, 14, 19), and a photoelectric signal acquisition module (20, 21, 22). The chip loading module (1, 2, 3, 4) is located on the left side of the chassis 100 and is used to load and transfer the biochip and reaction cup; the sample injection module... (5, 61, 7, 8), dispersed within the chassis 100, are used to load samples onto the chip loading modules (1, 2, 3, 4); reagent modules (9, 10, 11, 62, 63), located on the lower right side of the chassis 100, are used to provide the liquid required for the reaction; incubation module (12), located in the upper middle part of the chassis 100, is used for the reaction; cleaning and separation modules (13, 14, 19), located on the left and right sides of the incubation module (12), are used for cleaning and disposal of the biochip; photoelectric signal acquisition modules (20, 21, 22), located in the upper right corner of the chassis 100, are used for signal detection.

[0114] The chassis 100 adopts a partitioned design, with the chip loading modules (1, 2, 3, 4) centrally arranged on the left side, facilitating quick replacement of biochips and reaction cups by operators. The layout of the reagent modules (9, 10, 11, 62, 63) on the lower right side and the incubation module (12) in the upper center shortens the reagent transmission path, thereby improving reaction efficiency. The photoelectric signal acquisition modules (20, 21, 22) in the upper right corner are designed with independent space to avoid interference from the mechanical vibration of other modules on signal detection.

[0115] According to some embodiments of this application, the material selection of the chassis 100 balances structural strength and electromagnetic shielding performance, and an internal heat dissipation duct is designed to ensure temperature control stability during long-term operation. Its exterior features a user-friendly sloping control panel design, conforming to ergonomic principles and facilitating routine maintenance and emergency intervention by operators. Furthermore, the chassis 100 has openable maintenance doors on both the front and rear sides, with the front door made of transparent tempered glass, allowing for easy observation of the internal operating status while also providing safety protection.

[0116] Combination Figure 3-5 As shown, Figure 3 This illustration shows a schematic diagram of the chip placement assembly in one embodiment of the present application. Figure 4 A schematic diagram of the chip loading arm in one embodiment of this application is shown. Figure 5A schematic diagram of the sampling temporary storage position is shown in one embodiment of this application. In some embodiments, the chip loading module (1, 2, 3, 4) includes: a chip placement component 1, a chip loading arm 2, a chip temporary storage position 3, and a sampling temporary storage position 4.

[0117] In some embodiments of this application, the chip placement assembly 1 includes a chip placement plate 101, a first drive motor 102, and a first transmission mechanism 103. The chip placement plate 101 is disposed above the first transmission mechanism 103, which is mounted on the first drive motor 102. The first drive motor 102 drives the first transmission mechanism 103. The chip placement plate 101 is used to load biochips and reaction cups. The chip placement plate 101 can load eight chip clips at a time, each chip clip containing ten chips and ten reaction cups. The design of the chip placement assembly 1 fully considers the needs of high-throughput detection. The surface of the chip placement plate 101 has precise positioning grooves to ensure accurate positioning of each chip clip. Furthermore, the chip placement plate 101 is made of multi-layer composite material with a specially treated surface, ensuring stable support of the biochips and reaction cups while effectively preventing electrostatic interference. Through the precise cooperation between the first drive motor 102 and the first transmission mechanism 103, the chip placement plate 101 can achieve smooth linear movement, ensuring that the chip clip remains horizontal during loading and transfer, and avoiding chip displacement caused by vibration.

[0118] In some embodiments of this application, the chip loading arm 2 includes: a first X-axis drive motor 201, a first X-axis transmission mechanism 202, a first Y-axis drive motor 203, a first Y-axis transmission mechanism 204, a first Z-axis drive motor 205, a first Z-axis transmission mechanism 206, and a first electric gripper 207. The chip loading arm 2 achieves fully automated and precise transfer of the biochip and reaction cup through a three-axis linkage design. The first X-axis drive motor 201 and the first X-axis transmission mechanism 202 constitute a horizontal lateral motion system, the first Y-axis drive motor 203 and the first Y-axis transmission mechanism 204 are responsible for longitudinal motion control, and the first Z-axis drive motor 205 and the first Z-axis transmission mechanism 206 achieve precise vertical positioning. The first electric gripper 207 ensures stable gripping of the biochip and reaction cup. The gripper surface is specially treated to have anti-slip and anti-static properties, ensuring that the biochip and reaction cup will not accidentally fall off or be affected by electrostatic interference during the transfer process.

[0119] In some embodiments of this application, the chip temporary storage position 3 includes 21 chip temporary storage slots, and the chip temporary storage position 3 is used for the temporary storage of biochips.

[0120] In some embodiments of this application, the sample storage position 4 includes a sample storage base 401 and a DC solenoid 402. The sample storage position 4 is used for temporary storage of reaction cups. As a temporary transfer station for reaction cups, the sample storage position 4's sample storage base 401 adopts a split magnetic suction structure design, achieving rapid locking and releasing functions through precise control of the DC solenoid 402. When a reaction cup is transferred to the storage base, the solenoid is energized to generate a magnetic field, causing the cup base to generate an adsorption force to fix the reaction cup, ensuring stability even under vibration during equipment operation. The chip loading arm 2 is used to grip the biochip and reaction cup and transfer them to the chip storage position 3 and the sample storage position 4.

[0121] See Figure 6- Figure 9 Figure 6 shows a schematic diagram of the test tube rack placement assembly in one embodiment of this application; Figure 7 shows a schematic diagram of the first fountain pipe assembly in one embodiment of this application; and Figure 8 shows a schematic diagram of the processing liquid tank assembly in one embodiment of this application. Figure 9 A schematic diagram of the sample dispensing arm in one embodiment of this application is shown. In some embodiments, the sample injection module (5, 61, 7, 8) includes: a test tube rack placement assembly 5, a first fountain tube assembly 61, a processing liquid tank assembly 7, and a sample dispensing arm 8.

[0122] In some embodiments of this application, the test tube rack placement assembly 5 includes: a push-in drive motor 501, a push-in transmission mechanism 502, a lateral drive motor 503, a lateral transmission mechanism 504, an ejection drive motor 505, an ejection transmission mechanism 506, and a test tube rack placement cavity 507. The test tube rack placement assembly 5 is responsible for pushing, lateralizing, and ejecting the test tube racks. The test tube rack placement cavity 507 can simultaneously hold five test tube racks, each rack holding five samples. The test tube rack placement assembly 5 achieves automated sample processing through a multi-axis collaborative drive system. The push-in drive motor 501 and the push-in transmission mechanism 502 use belt drive to ensure that the test tube racks can enter the test tube rack placement cavity 507 smoothly and accurately. The lateral drive motor 503 and the lateral transmission mechanism 504 constitute a horizontal transfer system. The ejection drive motor 505 and the ejection transmission mechanism 506 use dual closed-loop control, continuously monitoring the running resistance during ejection. When an abnormality is detected, a protection program is immediately activated to prevent the test tube racks from jamming or tipping over.

[0123] In some embodiments of this application, the first spring pipe assembly 61 includes: a first spring pipe 601, a first spring nozzle core 602, a first water inlet needle pipe 603, and a first spring cleaning position 604.

[0124] In some embodiments of this application, the processing liquid tank assembly 7 includes a second drive motor 701, a second transmission mechanism 702, and a processing liquid placement rack 703. The processing liquid placement rack 703 has reagent placement positions, and the second drive motor 701, the second transmission mechanism 702, and the processing liquid placement rack 703 are stacked sequentially. The processing liquid tank assembly 7 is mainly used to store reagents such as processing liquids, diluents, syringe washes, and reaction solutions. The processing liquid placement rack 703 has a total of 8 reagent positions. This highly integrated design allows 8 reagents to be placed in a compact space, significantly improving the automation and reliability of the detection system.

[0125] In some embodiments of this application, the sample dispensing arm 8 includes: a first rotary drive motor 801, a first rotary transmission mechanism 802, a first lifting drive motor 803, a first lifting transmission mechanism 804, a first dispensing needle 805, a first liquid level plate 806, a first dual-path motor plate 807, and a first anti-collision mechanism 808. The first liquid level plate 806, the first anti-collision mechanism 808, and the first dispensing needle 805 are disposed on the first rotary transmission mechanism 802, and the first dual-path motor plate 807 is disposed between the first lifting drive motor 803 and the first rotary drive motor 801. The sample dispensing arm 8 is mainly used for the aspiration, dispensing, and transfer of reagents such as samples, processing solutions, diluents, and needle washing solutions. As the core liquid handling unit of the biochip analyzer, the sample dispensing arm 8 achieves high-precision liquid handling functions through multi-axis coordinated motion. The coordinated operation of the first rotary drive motor 801 and the first lifting drive motor 803 enables the sample dispensing arm 8 to move flexibly in three-dimensional space, ensuring that the dispensing needle can accurately reach the sample positions in each test tube rack placement cavity 507 and the reagent positions in the processing liquid tank assembly 7. This design not only improves the sample dispensing efficiency but also reduces errors caused by human operation, ensuring the accuracy of the test results.

[0126] Furthermore, the inclusion of the first liquid level plate 806 and the first anti-collision mechanism 808 further enhances the safety and reliability of the sample dispensing arm 8. The first liquid level plate 806 can monitor the liquid level of the dispensing needle 805 in real time, preventing liquid overflow or insufficient aspiration and ensuring accurate volume dispensing each time. The first anti-collision mechanism 808 can immediately stop its operation when an abnormal collision is detected during the movement of the sample dispensing arm 8, protecting the sample dispensing arm 8 and its surrounding equipment from damage.

[0127] In addition, the first fountain tube assembly 61 is used to clean the first sampling needle 805. The cooperation between the first fountain tube assembly 61 and the sampling arm 8 provides an efficient cleaning function for the sampling needle 805. After each aspiration of different reagents or samples, the sampling needle 805 is guided to the cleaning position of the first fountain tube assembly 61 for cleaning, ensuring that the sampling needle 805 remains clean every time it is used and avoiding cross-contamination between reagents.

[0128] Referring to Figure 10, Figure 10 shows a schematic diagram of the structure of a reagent tray assembly in one embodiment of this application. In some embodiments, the reagent module (9, 10, 11, 62, 63) includes: a reagent tray assembly 9, a reagent arm 10, a detection liquid arm 11, a second gushing tube assembly 62, and a third gushing tube assembly 63.

[0129] In some embodiments of this application, the reagent tray assembly 9 includes: a third drive motor 901, a third transmission mechanism 902, a reagent liquid placement rack 903, and a heat dissipation assembly 904. The third transmission mechanism 902 is positioned above the third drive motor 901, the reagent liquid placement rack 903 is positioned above the third transmission mechanism 902, and the heat dissipation assembly 904 is positioned on the side of the reagent liquid placement rack 903. The combination of the third drive motor 901 and the third transmission mechanism 902 enables the reagent liquid placement rack 903 to achieve precise rotational movement, thereby facilitating the storage and use of reagents. The reagent tray assembly 9 is mainly used to store reagents such as test solutions and reaction solutions, and the reagent liquid placement rack 903 has 10 reagent positions. In addition, the reagent tray assembly 9 adopts a specific constant temperature mode. This setting further optimizes the storage conditions of reagents. Through precise temperature control, the reagent tray assembly 9 can provide a stable environment for reagents such as test solutions and reaction solutions, ensuring that the reagents remain in optimal condition during the detection process. It can be seen that the design of the reagent tray assembly 9 fully considers the storage requirements and usage efficiency of reagents.

[0130] In some embodiments of this application, the reagent arm 10 includes: a second rotary drive motor, a second rotary transmission mechanism, a second lifting drive motor, a second lifting transmission mechanism, a second sampling needle, a second liquid level plate, a second dual-motor plate, and a second anti-collision mechanism. The second liquid level plate, the second anti-collision mechanism, and the second sampling needle are disposed on the second rotary transmission mechanism, and the second dual-motor plate is disposed between the second lifting drive motor and the second rotary drive motor. The detection liquid arm 11 includes: a third rotary drive motor, a third rotary transmission mechanism, a third lifting drive motor, a third lifting transmission mechanism, a third sampling needle, a third liquid level plate, a third dual-motor plate, and a third anti-collision mechanism. The third liquid level plate, the third anti-collision mechanism, and the third sampling needle are disposed on the third rotary transmission mechanism, and the third dual-motor plate is disposed between the third lifting drive motor and the third rotary drive motor. The reagent arm 10 is mainly used for the aspiration, dissipation, and transfer of reagents such as reaction solutions, and the detection liquid arm 11 is mainly used for the aspiration, dissipation, and transfer of reagents such as detection solutions. It should be noted that the structures of the reagent arm 10 and the detection liquid arm 11 are consistent with those of the sampling arm 8.

[0131] Similarly, both reagent arm 10 and detection liquid arm 11 are equipped with a rotary drive motor, a rotary transmission mechanism, a lifting drive motor, and a lifting transmission mechanism. This multi-axis coordinated motion design enables them to flexibly perform precise reagent transfer operations between the reagent tray assembly 9 and the reaction area. The second and third sampling needles are respectively mounted on the rotary transmission mechanisms of reagent arm 10 and detection liquid arm 11, ensuring accurate positioning of the reagent and reaction sites during rotation, thereby achieving efficient reagent dispensing.

[0132] In some embodiments of this application, the second fountain tube assembly 62 includes: a second fountain tube, a second fountain nozzle, a second inlet needle, and a second fountain cleaning position, and is used to clean the second sample dispensing needle; the third fountain tube assembly 63 includes: a third fountain tube, a third fountain nozzle, a third inlet needle, and a third fountain cleaning position, and is used to clean the third sample dispensing needle. It should be noted that the structures of the second fountain tube assembly 62 and the third fountain tube assembly 63 are consistent with those of the first fountain tube assembly 61.

[0133] The second and third fountain tube assemblies 62 and 63 are used to clean the second and third sample dispensing needles, respectively, ensuring that the needles remain clean after each reagent aspiration and transfer, preventing cross-contamination. The second fountain tube, second fountain nozzle, and second inlet syringe in the second fountain tube assembly 62 work together to form a highly efficient cleaning system. After the second sample dispensing needle completes its reagent transfer task, it is guided to the second fountain cleaning station for cleaning. During this process, cleaning liquid is introduced through the second fountain tube and the second inlet syringe, and the water flow generated by the second fountain nozzle rinses the second sample dispensing needle. This design effectively removes residual reagent from the surface of the needle, ensuring accurate reagent aspiration during subsequent uses without interference from previous operations. Similarly, the third fountain tube, third fountain nozzle, and third inlet syringe in the third fountain tube assembly 63 play a similar role. The third fountain tube assembly 63 provides a cleaning function for the third sample dispensing needle, ensuring that the needle remains clean during the transfer of reagents such as detection solutions. This cleaning mechanism is designed with full consideration of the strict requirements for reagent purity during the testing process. By precisely controlling the intensity and direction of the water flow, it achieves efficient cleaning of the sample needle, thereby ensuring the accuracy and reliability of the test results.

[0134] Furthermore, the structural consistency between the second gushing pipe assembly 62 and the third gushing pipe assembly 63 means they can share the same maintenance and upkeep procedures. This design not only reduces equipment maintenance costs but also improves operational efficiency. In practice, technicians can use the same tools and methods to inspect and maintain these components, reducing maintenance complexity caused by component differences. Simultaneously, this consistency allows for a higher degree of standardization in the design and manufacturing process, further improving the overall quality and performance of the equipment.

[0135] Referring to Figure 11, Figure 11 shows a schematic diagram of the structure of a serum reaction disk assembly according to one embodiment of this application. In some embodiments, the incubation module includes a serum reaction disk assembly 12.

[0136] In some embodiments of this application, the serum reaction plate assembly 12 includes: a temperature control component 1201, a serum reaction plate 1202, a fourth drive motor 1203, and a fourth transmission mechanism 1204. The temperature control component 1201 and the serum reaction plate 1202 are sequentially disposed above the fourth drive motor 1203 and the fourth transmission mechanism 1204.

[0137] In some embodiments of this application, the temperature control component 1201 includes a heating element, an over-temperature protector, and a temperature sensor. Its main function is to control the temperature of the serum reaction pan 1202 within the range of 30℃±1.0℃. In the event of a temperature control system failure, i.e., when the temperature reaches 50℃±5℃, it will shut off the heating function to prevent excessive temperature from harming the human body or causing incorrect test results. Furthermore, the temperature control component 1201 can collect the temperature of the serum reaction pan 1202 in real time.

[0138] In some embodiments of this application, the serum reaction disk 1202 includes a reaction disk and a serum disk. The serum reaction disk 1202 is the main site for the biochip reaction. Its structural design consists of three rings: an outer ring with 32 sample positions serving as the reaction disk for secondary antibody reaction; and two inner rings with a total of 48 sample positions serving as the serum disk for serum reaction. Driven by a fourth drive motor 1203 and a fourth transmission mechanism 1204, the serum reaction disk achieves precise rotational movement, thereby ensuring that the biochip receives uniform incubation and reaction solution treatment during the reaction process.

[0139] refer to Figure 12 , Figure 13 and Figure 18 , Figure 12 A schematic diagram of the structure of the first cleaning box assembly in one embodiment of this application is shown. Figure 13 A schematic diagram of the structure of the second cleaning box assembly in one embodiment of this application is shown. Figure 18A schematic diagram of the decupling assembly in one embodiment of this application is shown. In some embodiments, the cleaning and separation module includes a first cleaning box assembly 13, a second cleaning box assembly 14, and a decupling assembly 19. The coordinated operation of the first cleaning box assembly 13, the second cleaning box assembly 14, and the decupling assembly 19 provides efficient support for the cleaning and waste disposal processes of the biochip analyzer.

[0140] In some embodiments of this application, the first cleaning box assembly 13 includes: a first drying assembly 1301, a first rinsing and drying assembly 1302, a first rinsing tank 1303, and a first rinsing tank cover 1304. The first cleaning box assembly 13 is mainly used for cleaning and drying the chips inside the serum reaction tray 1202. These components work together to ensure that the chips inside the serum reaction tray 1202 can be thoroughly cleaned after the reaction and quickly dried by the drying assembly.

[0141] In some embodiments of this application, the second cleaning box assembly 14 includes: a second drying assembly 1401, a second rinsing and drying assembly 1402, a second rinsing tank 1403, and a second rinsing tank cover 1404. The second cleaning box assembly 14 is mainly used for cleaning and drying the chips within the serum reaction tray 1202. Similar to the first cleaning box assembly 13, the second cleaning box assembly 14 ensures that the chips within the serum reaction tray 1202 can be thoroughly cleaned after undergoing complex chemical reactions through precise rinsing and drying operations. This zoned cleaning design fully considers the characteristics of chips at different reaction stages, improving the targeting and effectiveness of the cleaning.

[0142] In some embodiments of this application, the cup removal assembly 19 includes: an electric gripper assembly 1901, an electric gripper fixing assembly 1902, and a discharge tube 1903. The electric gripper fixing assembly 1902 is disposed above the discharge tube 1903, and the electric gripper assembly 1901 is disposed on the side of the discharge tube 1903. The cup removal assembly 19 is mainly used to discard used reaction cups and chips. The primary function of the cup removal assembly 19 is to discard used reaction cups and chips. Through precise control of the electric grippers, the reaction cups and chips can be safely removed and discarded into the designated discharge tube 1903, thereby avoiding interference from waste materials in subsequent testing processes.

[0143] refer to Figures 19-21 , Figure 19 Figure 20 shows a schematic diagram of the structure of a CMOS camera assembly according to an embodiment of this application, and Figure 21 shows a schematic diagram of the structure of an exposure mechanism assembly according to an embodiment of this application. Figure 21 A schematic diagram of the exposure loading arm in one embodiment of this application is shown. In some embodiments, the photoelectric signal acquisition module includes: a CMOS camera assembly 20, an exposure mechanism assembly 21, and an exposure loading arm 22.

[0144] In some embodiments of this application, the CMOS camera assembly 20 includes a CMOS camera 2001 and a camera adjustment assembly 2002, with the CMOS camera 2001 positioned above the camera adjustment assembly 2002. The CMOS camera assembly 20 is primarily used to acquire photoelectric signals from a biochip.

[0145] The CMOS camera 2001 is the core component for acquiring photoelectric signals from the biochip. Through a highly sensitive image sensor, it can quickly and accurately capture the weak light signals generated by the biochip during the chemiluminescence reaction. The high resolution and high dynamic range of the CMOS camera 2001 enable it to precisely distinguish signal intensity differences at different locations on the biochip, which is crucial for subsequent quantitative analysis and qualitative judgment. The camera adjustment assembly 2002 provides flexible adjustment functions for the CMOS camera 2001. This adjustment capability ensures that the camera is always aligned with the optimal detection area of ​​the biochip, thereby improving the accuracy and reliability of signal acquisition.

[0146] In some embodiments of this application, the exposure mechanism assembly 21 includes a fifth drive motor 2101, a fifth transmission mechanism 2102, and an exposure turntable assembly 2103. The exposure turntable assembly 2103 is disposed above the fifth transmission mechanism 2102, which is disposed above the fifth drive motor 2101. The exposure mechanism assembly 21 is mainly used to load the biochip to be exposed. The fifth drive motor 2101 serves as the power source for the exposure mechanism assembly, transmitting power to the exposure turntable assembly 2103 via the fifth transmission mechanism 2102, enabling it to achieve precise rotation and positioning. This design ensures that the biochip can accurately reach the preset exposure position during the exposure process, thereby guaranteeing the uniformity and consistency of the exposure.

[0147] In some embodiments of this application, an illuminating cup is provided inside the exposure turntable assembly 2103 for placing the chip to be exposed.

[0148] In some embodiments of this application, the exposure loading arm 22 includes: a second X-axis drive motor 2201, a second X-axis transmission mechanism 2202, a second Y-axis drive motor 2203, a second Y-axis transmission mechanism 2204, a second Z-axis drive motor 2205, a second Z-axis transmission mechanism 2206, and a second electric gripper 2207. The CMOS camera assembly 20 is disposed below the exposure loading arm 22. The exposure loading arm 22 is mainly used to grip and transfer the biochip to be exposed. The second X-axis drive motor 2201, the second Y-axis drive motor 2203, and the second Z-axis drive motor 2205 drive the corresponding transmission mechanisms, enabling the loading arm to be precisely positioned and moved in the horizontal and vertical directions. This multi-axis linkage design ensures the accurate placement and stable transfer of the biochip during the exposure process. In addition, the second electric gripper 2207 can precisely open and close according to preset programs and parameters, thereby safely gripping and releasing the biochip. The gripper design takes into account the size and shape of the biochip, ensuring that no damage is caused to the chip during gripping.

[0149] refer to Figures 14-17 , Figure 14 A schematic diagram of the peristaltic pump assembly according to one embodiment of this application is shown. Figure 15 A schematic diagram of the diaphragm pump assembly according to one embodiment of this application is shown. Figure 16 A schematic diagram of the air pump assembly in one embodiment of this application is shown. Figure 17 A schematic diagram of the pressure transmitter assembly in one embodiment of this application is shown. In some embodiments, the cleaning and separation module further includes: a peristaltic pump assembly 15, a diaphragm pump assembly 16, an air pump assembly 17, and a pressure transmitter assembly 18. It should be noted that the peristaltic pump assembly 15, the diaphragm pump assembly 16, the air pump assembly 17, and the pressure transmitter assembly 18 are components of the cleaning and separation module in the biochip analyzer. These four components are integrated inside the analyzer and therefore are not shown in the diagram. Figure 2 As shown.

[0150] In some embodiments of this application, the peristaltic pump assembly 15 includes: a peristaltic pump 1501, a pressure regulating valve 1502, and a pure water solenoid valve 1503. The peristaltic pump assembly 15 is mainly responsible for stabilizing the pressure of the water and air circuits, ensuring stable water and air pressure.

[0151] In some embodiments of this application, the diaphragm pump assembly 16 includes a diaphragm pump 1601 and a first damping pad 1602. The diaphragm pump 1601 is disposed above the first damping pad 1602. The diaphragm pump assembly 16 is mainly used to provide fluid flow to the first cleaning box assembly 13, the second cleaning box assembly 14, the first spring pipe assembly 61, the second spring pipe assembly 62, and the third spring pipe assembly 63. The first damping pad 1602 enhances the operational stability of the diaphragm pump assembly 16. The first damping pad 1602 can effectively absorb the mechanical vibration generated by the diaphragm pump 1601 during operation, reduce the impact on surrounding equipment, and also help extend the service life of the diaphragm pump 1601 itself.

[0152] In some embodiments of this application, the air pump assembly 17 includes an air pump 1701 and a second shock-absorbing pad 1702, with the air pump 1701 positioned above the second shock-absorbing pad 1702. As the core provider of airflow, the air pump 1701 precisely controls the intake and exhaust of gas through its internal mechanical movement. This pump operates by changing the pressure within a cylinder to compress and deliver the gas. In the biochip analyzer, the air pump 1701 provides a stable airflow to the first cleaning box assembly 13 and the second cleaning box assembly 14, ensuring a stable gas supply during the cleaning process. Furthermore, the second shock-absorbing pad 1702 further enhances the operational stability of the air pump assembly 17. The second shock-absorbing pad 1702 effectively absorbs the mechanical vibrations generated by the air pump 1701 during operation, reducing the impact on surrounding equipment and also helping to extend the service life of the air pump itself.

[0153] In some embodiments of this application, the pressure transmitter assembly 18 includes a pressure transmitter 1801 and a pressure transmitter mounting base 1802, with the pressure transmitter 1801 mounted on the pressure transmitter mounting base 1802. The pressure transmitter assembly 18 is primarily used to monitor the water circuit system related to cleaning and reaction in the biochip analyzer. Specifically, it monitors the water circuit pressure output from the diaphragm pump assembly 16. The diaphragm pump assembly 16 provides fluid flow to cleaning box assemblies (such as the first cleaning box assembly 13 and the second cleaning box assembly 14) and fountain assemblies (such as the first fountain assembly 61, the second fountain assembly 62, and the third fountain assembly 63). By monitoring the pressure values ​​of these water circuits, the pressure transmitter assembly 18 ensures a stable and uniform supply of liquid during cleaning and reaction processes.

[0154] The biochip analyzer in this application achieves simultaneous detection of multiple samples through a modular design, and its specific operation is as follows:

[0155] 1. Chip loading

[0156] like Figure 3As shown, firstly, the chip holder containing the biochip and reaction cup is placed onto the chip placement plate 101 of the chip placement assembly 1. The chip loading arm 2, through the coordinated control of the first X / Y / Z axis drive motors (201 / 203 / 205) and the transmission mechanism (202 / 204 / 206), picks up the chip and reaction cup and places them at the sample loading temporary storage position 4. Subsequently, the chip loading arm 2 transfers the chip to the chip temporary storage position 3 for temporary storage.

[0157] 2. Sample injection and reagent distribution

[0158] like Figures 6a-6b As shown, the sample tube rack is automatically positioned by the push-in / lateral drive motors (501 / 503) of the tube rack placement assembly 5. The sample dispensing arm 8 is moved from the processing liquid tank assembly 7 by the cooperation of the first rotary drive motor 801 and the first lifting drive motor 803. Figures 8a-8b The treatment solution was drawn from the 8 reagent positions and added to the reaction cup at sample storage position 4. Then, the sample was drawn from the test tube rack in test tube rack placement cavity 507 and added to the same reaction cup. First spring tube assembly 61 ( Figures 7a-7c After each sample addition, the first sample injection needle 805 should be cleaned to avoid cross-contamination.

[0159] 3. Incubation and reaction control

[0160] like Figures 11a-11c As shown, chip loading arm 2 transfers the reaction cup to the serum tray of serum reaction tray 1202 in the incubation module. The temperature control assembly 1201 precisely controls the temperature at 30℃±1.0℃ via a heating element and a temperature sensor. After the initial 30-minute incubation, chip loading arm 2 transfers the chip temporarily stored in chip storage position 3 to the serum tray of serum reaction tray 1202 for further incubation for 40 minutes. Subsequently, reagent arm 10 retrieves the chip from reagent tray assembly 9 (… Figures 10a-10b Take the reaction solution from the 10 reagent positions and add it to the reaction plate of serum reaction plate 1202.

[0161] 4. Cleaning and signal detection

[0162] During the reaction process, the peristaltic pump assembly 15, diaphragm pump assembly 16 and air pump assembly 17 of the cleaning and separation module provide stable pressure and flow to the water circuit and air circuit respectively, while the pressure transmitter assembly 18 monitors the water circuit pressure in real time to ensure the smooth progress of the cleaning and reaction process.

[0163] After incubation, chip loading arm 2 transfers the reaction cup and chip from the serum tray of serum reaction tray 1202 to the decanter assembly 19, discards the reaction cup, and transfers the chip to the cleaning box assembly 13 for cleaning and drying. Subsequently, chip loading arm 2 transfers the cleaned chip to the reaction tray of serum reaction tray 1202 (which has already been filled with the reaction solution from reagent tray assembly 9) and reacts for 40 minutes.

[0164] Subsequently, the detection liquid is drawn from the reagent tray assembly 9 by the detection liquid arm 11 and added to the light-emitting cup in the exposure mechanism assembly 21. Next, the exposure loading arm 22 transfers the chip from the reaction tray of the serum reaction tray 1202 after the reaction is complete to the second cleaning box assembly 14 for cleaning and drying, and then transfers it to the light-emitting cup in the exposure mechanism assembly 21 for light emission detection. Figures 20a-20b Finally, the CMOS camera assembly 20 ( Figure 19 After collecting photoelectric signals and analyzing the results using the host computer software, the chip is transferred to the cup removal assembly 19 via the exposure loading arm 22 to complete the waste disposal process.

[0165] The entire process, through the cooperation of various modules, achieves fully automated detection from sample loading to result output, improving detection efficiency and accuracy.

[0166] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0167] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this patent application should be determined by the appended claims.

Claims

1. A biochip analyzer characterized by comprising: The biochip analyzer includes: Chassis (100), wherein the chassis (100) is provided with: A chip loading module, located on the left side of the chassis (100), is used to load and transfer biochips and reaction cups; Sample loading modules are distributed within the chassis (100) and are used to load samples into the chip loading modules; A reagent module, located on the lower right side of the chassis (100), is used to provide the liquid required for the reaction; An incubation module is located above the center of the chassis (100) and is used for carrying out the reaction; A cleaning and separation module is located on the left and right sides of the incubation module and is used for cleaning and waste disposal of the biochip. The photoelectric signal acquisition module is located in the upper right corner of the chassis (100) and is used for signal detection.

2. The biochip analyzer according to claim 1, wherein The chip loading module includes: a chip placement component (1), a chip loading arm (2), a chip temporary storage position (3), and a sampling temporary storage position (4), wherein: The chip placement assembly (1) includes: a chip placement plate (101), a first drive motor (102) and a first transmission mechanism (103). The chip placement plate (101) is disposed above the first transmission mechanism (103), and the first transmission mechanism (103) is disposed on the first drive motor (102). The chip placement plate (101) is used to load the biochip and the reaction cup. The chip loading arm (2) includes: a first X-axis drive motor (201), a first X-axis transmission mechanism (202), a first Y-axis drive motor (203), a first Y-axis transmission mechanism (204), a first Z-axis drive motor (205), a first Z-axis transmission mechanism (206), and a first electric gripper (207). The chip storage position (3) and the sample loading position (4) are provided. The chip loading arm (2) is used to pick up the biochip and the reaction cup and transfer them to the chip storage position (3) and the sample loading position (4).

3. The biochip analyzer according to claim 2, wherein The sample storage position (4) includes a sample storage base (401) and a DC solenoid (402).

4. The biochip analyzer according to claim 1, wherein The sample injection module includes: a test tube rack placement assembly (5), a first gushing tube assembly (61), a processing liquid tank assembly (7), and a sample dispensing arm (8). The test tube rack placement assembly (5) includes: a push-in drive motor (501), a push-in transmission mechanism (502), a transverse drive motor (503), a transverse transmission mechanism (504), an ejection drive motor (505), an ejection transmission mechanism (506), and a test tube rack placement cavity (507). The first spring pipe assembly (61) includes: a first spring pipe (601), a first spring nozzle core (602), a first water inlet needle pipe (603), and a first spring cleaning position (604). The processing liquid tank assembly (7) includes: a second drive motor (701), a second transmission mechanism (702) and a processing liquid placement rack (703). The processing liquid placement rack (703) is provided with a reagent placement position. The second drive motor (701), the second transmission mechanism (702) and the processing liquid placement rack (703) are stacked in sequence. The sample feeding arm (8) includes: a first rotary drive motor (801), a first rotary transmission mechanism (802), a first lifting drive motor (803), a first lifting transmission mechanism (804), a first sample feeding needle (805), a first liquid level plate (806), a first two-way motor plate (807), and a first anti-collision mechanism (808). The first liquid level plate (806), the first anti-collision mechanism (808), and the first sample feeding needle (805) are disposed on the first rotary transmission mechanism (802), and the first two-way motor plate (807) is disposed between the first lifting drive motor (803) and the first rotary drive motor (801). The first spring tube assembly (61) is used to clean the first sample dispensing needle (805).

5. The biochip analyzer according to claim 1, wherein The reagent module includes: a reagent tray assembly (9), a reagent arm (10), a detection liquid arm (11), a second gushing tube assembly (62), and a third gushing tube assembly (63). The reagent tray assembly (9) includes: a third drive motor (901), a third transmission mechanism (902), a reagent liquid holder (903), and a heat dissipation assembly (904). The third transmission mechanism (902) is located above the third drive motor (901), the reagent liquid holder (903) is located above the third transmission mechanism (902), and the heat dissipation assembly (904) is located on the side of the reagent liquid holder (903). The reagent arm (10) includes: a second rotary drive motor, a second rotary transmission mechanism, a second lifting drive motor, a second lifting transmission mechanism, a second sample dispensing needle, a second liquid level plate, a second two-way motor plate, and a second anti-collision mechanism. The second liquid level plate, the second anti-collision mechanism, and the second sample dispensing needle are disposed on the second rotary transmission mechanism, and the second two-way motor plate is disposed between the second lifting drive motor and the second rotary drive motor. The detection liquid arm (11) includes: a third rotary drive motor, a third rotary transmission mechanism, a third lifting drive motor, a third lifting transmission mechanism, a third sampling needle, a third liquid level plate, a third two-way motor plate, and a third anti-collision mechanism. The third liquid level plate, the third anti-collision mechanism, and the third sampling needle are disposed on the third rotary transmission mechanism, and the third two-way motor plate is disposed between the third lifting drive motor and the third rotary drive motor. The second spring tube assembly (62) includes: a second spring tube, a second spring nozzle core, a second water inlet needle tube and a second spring cleaning position. The second spring tube assembly (62) is used to clean the second sample dispensing needle. The third spring tube assembly (63) includes: a third spring tube, a third spring nozzle core, a third water inlet needle tube, and a third spring cleaning position. The third spring tube assembly (63) is used to clean the third sample dispensing needle.

6. The biochip analyzer according to claim 1, wherein The incubation module includes a serum reaction disk assembly (12), wherein: The serum reaction plate assembly (12) includes: a temperature control component (1201), a serum reaction plate (1202), a fourth drive motor (1203), and a fourth transmission mechanism (1204). The temperature control component (1201) and the serum reaction plate (1202) are sequentially arranged above the fourth drive motor (1203) and the fourth transmission mechanism (1204).

7. The biochip analyzer according to claim 6, wherein The temperature control component (1201) includes a heating element, an over-temperature protector, and a temperature sensor; the serum reaction plate (1202) includes a reaction plate and a serum plate.

8. The biochip analyzer according to claim 1, wherein The cleaning and separation module includes: a first cleaning box assembly (13), a second cleaning box assembly (14), and a cup removal assembly (19). The first cleaning box assembly (13) includes: a first drying assembly (1301), a first rinsing and drying assembly (1302), a first rinsing tank (1303), and a first rinsing tank cover (1304). The second cleaning box assembly (14) includes: a second drying assembly (1401), a second rinsing and drying assembly (1402), a second rinsing tank (1403), and a second rinsing tank cover (1404). The cup removal assembly (19) includes: an electric gripper assembly (1901), an electric gripper fixing assembly (1902), and a discharge tube (1903). The electric gripper fixing assembly (1902) is disposed above the discharge tube (1903), and the electric gripper assembly (1901) is disposed on the side of the discharge tube (1903).

9. The biochip analyzer according to claim 1, wherein The photoelectric signal acquisition module includes: a CMOS camera assembly (20), an exposure mechanism assembly (21), and an exposure loading arm (22). The CMOS camera assembly (20) includes: a CMOS camera (2001) and a camera adjustment assembly (2002), wherein the CMOS camera (2001) is disposed above the camera adjustment assembly (2002); The exposure mechanism assembly (21) includes: a fifth drive motor (2101), a fifth transmission mechanism (2102), and an exposure turntable assembly (2103). The exposure turntable assembly (2103) is disposed above the fifth transmission mechanism (2102), and the fifth transmission mechanism (2102) is disposed above the fifth drive motor (2101). The exposure loading arm (22) includes: a second X-axis drive motor (2201), a second X-axis transmission mechanism (2202), a second Y-axis drive motor (2203), a second Y-axis transmission mechanism (2204), a second Z-axis drive motor (2205), a second Z-axis transmission mechanism (2206), and a second electric gripper (2207). The CMOS camera assembly (20) is located below the exposure loading arm (22).

10. The biochip analyzer according to claim 8, wherein The cleaning and separation module further includes: a peristaltic pump assembly (15), a diaphragm pump assembly (16), an air pump assembly (17), and a pressure transmitter assembly (18), wherein: The peristaltic pump assembly (15) includes: a peristaltic pump (1501), a pressure regulating valve (1502), and a pure water solenoid valve (1503). The diaphragm pump assembly (16) includes: a diaphragm pump (1601) and a first shock absorber (1602), wherein the diaphragm pump (1601) is disposed above the first shock absorber (1602); The air pump assembly (17) includes an air pump (1701) and a second shock absorber (1702), wherein the air pump (1701) is disposed above the second shock absorber (1702); The pressure transmitter assembly (18) includes a pressure transmitter (1801) and a pressure transmitter mounting base (1802), wherein the pressure transmitter (1801) is disposed on the pressure transmitter mounting base (1802).

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