A syringe and liquid embolization system

Abstract

The utility model provides a kind of syringe and liquid embolization system, syringe includes syringe barrel, piston and core rod;Piston is set to the head of core rod, and core rod is configured as piston is driven in the reciprocating motion in the inner chamber of syringe barrel;Syringe barrel includes syringe barrel main body, taper head and outer sleeve flange;The head of syringe barrel is shrunk to the direction close to its axis, forms taper head;The tail of syringe barrel is outwardly expanded along the direction away from its axis, forms outer sleeve flange;The part between taper head and outer sleeve flange is syringe barrel main body;Taper head is equipped with a luer connector on outer wall;Wherein, the inner diameter of taper head is 0.5-2.5mm, the wall thickness of taper head is 0.1-2mm, and the length of taper head away from the head of syringe barrel beyond luer connector is 1-3mm.The utility model provides a kind of syringe and liquid embolization system, can solve the problem that existing technology is not convenient for control in the field of nerve intervention vascular embolization for matching syringe, cannot effectively control the injection pressure when injection.

Description

Technical Field

[0001] This utility model relates to the field of medical equipment technology, and in particular to a syringe and a liquid embolization system. Background Technology

[0002] With the development of neurointerventional therapy, liquid embolic agents have become a core treatment method for diseases such as cerebral arteriovenous malformation (AVM) and dural arteriovenous fistula (DAVF) due to their ability to be delivered via microcatheters and adapt to complex vascular morphologies.

[0003] ONYX is a novel non-adhesive intravascular embolization agent composed of a suspension of vinylene glycol isomer (EVOH), DMSO (dimethyl sulfoxide), and tantalum powder particles in a specific ratio. EVOH is insoluble in water but soluble in DMSO. When it comes into contact with an aqueous solution (such as blood), the DMSO rapidly diffuses into the aqueous solution, while the EVOH precipitates as a solid, thus achieving an embolic effect.

[0004] Liquid embolic agents like ONYX, which solidify by relying on the escape of DMSO solvent, place stringent demands on the performance of their compatible syringes. On one hand, DMSO, the solvent in ONYX, has potential vascular toxicity, necessitating slow injection to ensure patient tolerance. Therefore, the syringe used with these liquid embolic agents must effectively control the injection pressure to achieve controlled, slow injection. On the other hand, solvents such as DMSO in ONYX liquid embolic agents are corrosive, requiring the syringe to possess good corrosion resistance. Utility Model Content

[0005] The purpose of this invention is to provide a syringe and a liquid embolization system to solve the problems of inconvenient operation and inability to effectively control the injection pressure of existing syringes used in the field of neurointerventional vascular embolization.

[0006] To solve the above-mentioned technical problems, this utility model provides a syringe for use in the field of neurointerventional vascular embolization, including a syringe barrel, a piston, and a core rod; the piston is disposed at the head of the core rod, the head of the core rod is inserted into the inner cavity of the syringe barrel, and the core rod is configured to drive the piston to reciprocate within the inner cavity of the syringe barrel; the syringe barrel includes a syringe barrel body, a cone head, and an outer rolled edge; the head of the syringe barrel contracts towards its axis to form the cone head; the tail of the syringe barrel extends outward in a direction away from its axis to form the outer rolled edge; the portion between the cone head and the outer rolled edge constitutes the syringe barrel body; a Luer connector is fitted on the outer wall of the cone head; wherein, the inner diameter of the cone head is 0.5-2.5mm, the wall thickness of the cone head is 0.1-2mm, the wall thickness of the cone head gradually thins away from the syringe barrel body, and the length of the head of the cone head extending beyond the Luer connector away from the syringe barrel body is 1-3mm.

[0007] Furthermore, the thickness of the outer sheath along the first direction is 1-5mm, the length of the outer sheath along the second direction is 25-60mm, and the two sides of the outer sheath along the second direction are semi-circular with a radius of 5-10mm. The first direction is the extension direction of the injection cylinder, and the second direction is the extension direction of the outer sheath.

[0008] Furthermore, the distance between the surface of the Luer connector away from the main body of the syringe and the bottom surface of the outer sleeve edge away from the main body of the syringe is 75-150mm; the distance between the surface of the cone head near the main body of the syringe and the bottom surface of the outer sleeve edge away from the main body of the syringe is 65-120mm.

[0009] Furthermore, the piston has at least two sealing rings, the outer diameter of which is 4.5-17mm and the height along the first direction is 0.3-0.8mm; the distance between the at least two sealing rings is 2-5mm.

[0010] Furthermore, the head of the core rod protrudes outward in a direction away from its center to form a protruding layer, and the tail of the core rod extends outward in a direction away from its center to form a core rod handle; the outer diameter of the protruding layer is 4.5-17mm, the height of the protruding layer along the first direction is 0.5-1.5mm, and the distance between the protruding layer and the core rod handle is 80-100mm.

[0011] Furthermore, the inner wall of the syringe body near the rolled edge of the outer casing is provided with a circumferential protrusion. The protrusion is either a continuous ring or a discontinuous ring, and the distance between the protrusion and the rolled edge of the outer casing is 4-20mm.

[0012] Furthermore, the outer diameter of the core rod is 5-15mm, the core rod handle is a cylinder with a radius of 7-20mm and a height of 1-4mm along the first direction, and the distance between the surface of the piston away from the core rod and the bottom surface of the core rod handle away from the piston is 80-160mm.

[0013] Furthermore, the bottom surface of the core rod press away from the piston is provided with textured protrusions.

[0014] Furthermore, a lubricating coating is provided on the inner wall of the syringe.

[0015] This invention also provides a liquid embolization system, including the syringe described above.

[0016] In summary, compared with the prior art, the syringe and liquid embolization system provided by this utility model have the following advantages:

[0017] This invention optimizes the materials of the syringe barrel and piston, making the syringe more resistant to acids, alkalis, and corrosion, thus making it more suitable for the injection of liquid embolic agents in the field of neurointerventional vascular embolization.

[0018] This invention also optimizes the dimensions of the syringe components, making the syringe more ergonomically designed, resulting in a better, smoother, and less strenuous injection experience. It also allows the operator to effectively control the injection pressure during injection, enabling controlled and slow injection of the liquid embolic agent. Attached Figure Description

[0019] Figure 1 A schematic diagram of the structure of a syringe according to one embodiment of this utility model;

[0020] Figure 2 A schematic diagram of the syringe barrel structure of a syringe according to one embodiment of this utility model;

[0021] Figure 3 A cross-sectional view of the syringe barrel of a syringe according to one embodiment of the present invention;

[0022] Figure 4 A schematic diagram of the rolled edge of the outer casing of a syringe according to one embodiment of this utility model;

[0023] Figure 5 A schematic diagram of the core rod and piston structure of a syringe according to one embodiment of the present invention;

[0024] Figure 6 A cross-sectional view of the core rod and piston of a syringe according to one embodiment of the present invention;

[0025] Figure 7A schematic diagram of the core rod of a syringe according to one embodiment of this utility model.

[0026] The reference numerals in the attached figures are as follows:

[0027] 10-Injection cartridge; 20-Piston; 30-Core rod; 11-Conical head; 12-Injection cartridge body; 13-Outer jacket rolled edge; 14-Luer connector; 15-Protrusion; 21-Sealing ring; 31-Protruding layer; 32-Core rod handle. Detailed Implementation

[0028] The present invention provides a syringe and liquid embolization system in further detail below with reference to the accompanying drawings and specific embodiments. The advantages and features of the present invention will become clearer from the following description.

[0029] It should be noted that the accompanying drawings are in a very simplified form and use non-precise proportions, and are only used to facilitate and clearly illustrate the purpose of the embodiments of this utility model. Please refer to the accompanying drawings to make the purpose, features, and advantages of this utility model more apparent and understandable. It should be understood that the structures, proportions, sizes, etc., depicted in the accompanying drawings are only used to complement the content disclosed in the specification, for those skilled in the art to understand and read, and are not intended to limit the implementation conditions of this utility model. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to the size, without affecting the effects and purposes achieved by this utility model, should still fall within the scope of the technical content disclosed in this utility model.

[0030] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0031] In this document, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0032] The purpose of this invention is to provide a syringe and a liquid embolization system to solve the problems of inconvenient operation and inability to effectively control the injection pressure of existing syringes used in the field of neurointerventional vascular embolization.

[0033] To achieve the above idea, such as Figure 1 As shown, this utility model provides a syringe for use in the field of neurointerventional vascular embolization, including a syringe barrel 10, a piston 20, and a plunger 30; the piston 20 is disposed at the head of the plunger 30, the head of the plunger 30 is inserted into the inner cavity of the syringe barrel 10, and the plunger 30 is configured to drive the piston 20 to reciprocate within the inner cavity of the syringe barrel 10; the syringe barrel 10 is made of an α-olefin (terminal olefin) polymer, the monomer of which may have one or more alkyl branches, the branches may be located in the middle or near the middle of the carbon chain or other positions, and the length is mostly methyl (-CH3), but may also be ethyl (-CH2CH3), for example, it may be 3-methyl-1-butene, 4,4- Dimethyl-1-pentene, 5-methyl-1-hexene, 3,4-dimethyl-1-pentene, 3-methyl-1-pentene, 4-methyl-1-pentene, vinylcyclohexane, etc., or modified materials or commercial granules based on them; the piston 20 is made of one or more of silicone rubber, fluororubber and fluorosilicone rubber, or a composite rubber composed of several of them, including commercially available materials based on them, or the piston 20 is made of coated halogenated butyl rubber or coated ethylene propylene rubber, wherein the coating includes, but is not limited to, fluorinated olefin polymers or fluorinated olefin copolymers, such as polytetrafluoroethylene or fluorinated polyethylene such as FEP (fluorinated ethylene propylene copolymer) or ETFE (ethylene-tetrafluoroethylene copolymer), etc.

[0034] In existing technologies, syringes are generally made of polycarbonate (PC), which has good transparency but is sensitive to chemical solvents and easily dissolved and damaged. When applied in the field of neurointerventional vascular embolization, this can lead to dissolution reactions between the liquid embolic agent and the syringe, affecting the safety and effectiveness of the medication. Syringes made of polypropylene (PP) are also available on the market. Although these syringes have significantly improved solvent resistance, the poor transparency of polypropylene results in a hazy, frosted appearance on the syringe casing, affecting the user experience. In the solution of this invention, the syringe barrel 10 is made of α-olefin polymer, which has better corrosion resistance and acid and alkali resistance. It maintains good transparency while effectively resisting chemical solvent erosion, improving the reliability and service life of the syringe in complex environments. Furthermore, the piston 20 is also made of a solvent- and acid / alkali-resistant material. Therefore, when the syringe draws in liquid embolic agents such as ONYX, it will not corrode the syringe, thus ensuring the normal injection of the liquid embolic agent.

[0035] Furthermore, the material of the core rod 30 can be selected from ABS plastic (i.e., a terpolymer of three monomers: acrylonitrile (A), butadiene (B), and styrene (S)) or nylon material. In the present invention, the core rod 30 is made of a rigid material, which makes it easier to transmit force during injection.

[0036] Specifically, such as Figures 2 to 4 As shown, the syringe 10 may include a syringe body 12, a cone 11, and an outer rolled edge 13; the head of the syringe 10 tapers towards its axis to form the cone 11; the tail of the syringe 10 extends outwards away from its axis to form the outer rolled edge 13; the portion between the cone 11 and the outer rolled edge 13 constitutes the syringe body 12; a Luer connector 14 is fitted onto the outer wall of the cone 11, for example, a matching external thread may be provided on the outer wall of the cone 11, and the Luer connector 14 is threaded onto the cone 11; wherein, the inner diameter D1 of the cone 11 is 0.5-2.5mm, the wall thickness D2 of the cone 11 is 0.1-2mm, the wall thickness of the cone may gradually decrease along the direction away from the syringe, and the length L1 of the cone 11 extending beyond the Luer connector 14 away from the syringe body 12 is 1-3mm. By limiting the size of the cone 11, when the syringe injects the liquid embolizing agent from the inner cavity, the flow rate of the liquid embolizing agent flowing out of the cone 11 can be better controlled. This can prevent excessive flow from causing damage to blood vessels by toxic solvents in the liquid embolizing agent, and also prevent insufficient flow from causing the drug dosage to be insufficient to play a therapeutic role.

[0037] Furthermore, the inner diameter D3 of the syringe body 12 is 4-16 mm, and the wall thickness D4 of the syringe body 12 is 0.5-4 mm. Limiting the dimensions of the syringe body 12 allows for minimizing the overall weight of the syringe while ensuring structural strength.

[0038] Preferably, the thickness L3 of the outer sheath 13 along the first direction is 1-5mm, the length L4 of the outer sheath 13 along the second direction is 25-60mm, and the two sides of the outer sheath 13 along the second direction are semi-circular with a radius R1 of 5-10mm. In this embodiment, the cross-sectional shape of the outer sheath 13 is generally waist-shaped, wherein the first direction is the extension direction of the syringe 10, and the second direction is the extension direction of the outer sheath 13. As an important component of the liquid embolization system, if the outer sheath 13 cannot be smoothly inserted into the sheath groove of the injection pump for automatic injection, it will result in no drug output or a large dose output due to siphoning, causing harm to the patient. In the solution of this utility model, the size of the outer sheath 13 has been optimized to make it easier to adapt to the injection pump.

[0039] In one implementation of this utility model, the distance L2 between the surface of the Luer connector 14 away from the syringe body 12 and the bottom surface of the outer sleeve edging 13 away from the syringe body 12 is 70-150mm; the distance L5 between the surface of the cone 11 near the syringe body 12 and the bottom surface of the outer sleeve edging 13 away from the syringe body 12 is 65-120mm. By limiting the relevant dimensions of the syringe body 12, the overall length of the syringe can be made more ergonomic and easier for the operator to use.

[0040] Further preferred, such as Figures 5 to 7 As shown, the piston 20 has at least two sealing rings 21. The sealing rings 21 are interference-fitted with the syringe body 12. By reasonably designing the size of the sealing rings 21, an interference-fit connection is formed between them and the syringe body 12 and the core rod 30, which can ensure the isolation and sealing of various liquids and gases.

[0041] The sealing ring 21 can be made of silicone with a hardness in the range of 50-70. The outer diameter D6 of the sealing ring 21 is 4.5-17 mm, and the height L6 along the first direction is 0.3-0.8 mm. The outer diameters of the two sealing rings 21 can be equal or unequal, and similarly, the heights of the two sealing rings can be equal or unequal. The distance L7 between the at least two sealing rings 21 is 2-5 mm. The design of two sealing rings improves the sealing effect of the piston 20, preventing liquid from seeping between the piston 20 and the inner wall of the syringe body 12.

[0042] Preferably, the head of the core rod 30 protrudes outward in a direction away from its center to form a protruding layer 31, and the tail of the core rod 30 extends outward in a direction away from its center to form a core rod handle 32; the outer diameter D7 of the protruding layer 31 is 4.5-17mm, the height L8 of the protruding layer 31 along the first direction is 0.5-1.5mm, and the distance L9 between the protruding layer 31 and the core rod handle 32 is 70-150mm.

[0043] Preferably, the outer wall of the syringe body 12 is provided with multiple graduation lines for quantitative control of the liquid drawn by the syringe. For example, taking a 1ml syringe as an example, the outer wall of the syringe body 12 of this invention can be provided with 10 graduation lines in units of 0.1ml, with the graduation lines near the cone tip 11 having smaller values ​​and the graduation lines near the outer rolled edge 13 having larger values.

[0044] Since the main body 12 of the injection cylinder is made of α-olefin polymer, which is a special material, conventional ink spraying cannot guarantee a firm adhesion, making it difficult to make scale lines. Therefore, the outer wall of the main body 12 of the injection cylinder can be plasma treated first to enhance its surface activity so that scale lines or other markings can be made by ink printing later.

[0045] In another embodiment of this utility model, a circumferential protrusion is provided on the inner wall of the syringe body 12 near the rolled edge of the outer casing. The protrusion can be continuous or discontinuous. For example, the protrusion 15 is continuous and located between the maximum scale line of the syringe body 12 and the rolled edge 13 of the outer casing. This annular protrusion 15 can block the protruding layer 31 of the core rod 30. When the syringe is used, it is necessary to draw liquid or gas by pulling the core rod 30. At this time, due to the blocking of the protruding layer 31 by the protrusion 15, the core rod 30 can be prevented from being pulled out of the syringe body 12 when pulling it, thus preventing difficulty in drawing or contamination of the preparation.

[0046] Preferably, the distance L12 between the protrusion 15 and the outer sleeve hem 13 is 4-20 mm. The radial dimension of the protrusion 15 is set so as not to affect the smoothness of the core rod's back and forth pushing and pulling.

[0047] Furthermore, the outer diameter D5 of the core rod 30 is 5-15mm, the core rod handle 32 is a cylinder with a radius R2 of 7-20mm, a height L10 along the first direction of 1-4mm, and a distance L11 between the surface of the piston 20 away from the core rod 30 and the bottom surface of the core rod handle 32 away from the piston 20 is 80-160mm. By optimizing the relevant dimensional parameters of the core rod 30, it is easier for the operator to apply force during use, making the entire injection process smoother and less strenuous, and allowing the operator to effectively control the injection pressure to achieve controllable slow injection.

[0048] Furthermore, the bottom surface of the core rod handle 32, away from the piston 20, is provided with textured protrusions, such as striped protrusions, corrugated protrusions, checkered protrusions, or combinations thereof. This allows the bottom surface of the core rod handle 32 to obtain greater friction than a flat surface, providing a better experience for the operator when using the syringe and preventing slippage that could lead to errors when pressing the core rod 30.

[0049] In addition, in order to maintain good lubrication between the piston 20 and the inner wall of the syringe 10 and improve the smoothness of extraction and injection, a lubricating coating is provided on the inner wall of the syringe 10. This lubricating coating can be formed by lubricating oil adhering to the inner wall of the syringe 10. The lubricating oil can reduce the friction between the two. The lubricating oil does not react with the inner wall of the syringe 10 or the piston 20, does not dissolve or adsorb, and has stable properties. For example, the lubricating oil can be a PTFE lubricating coating, medical-grade dimethyl silicone oil (high viscosity), or a strictly controlled silicone oil emulsion made from it.

[0050] This invention also provides a liquid embolization system, including the syringe described above.

[0051] In summary, compared with the prior art, the syringe and liquid embolization system provided by this utility model have the following advantages:

[0052] This invention optimizes the materials of the syringe barrel and piston, making the syringe more resistant to acids, alkalis, and corrosion, thus making it more suitable for the injection of liquid embolic agents in the field of neurointerventional vascular embolization.

[0053] This invention also optimizes the dimensions of the syringe components, making the syringe more ergonomically designed, resulting in a better, smoother, and less strenuous injection experience. It also allows the operator to effectively control the injection pressure during injection, enabling controlled and slow injection of the liquid embolic agent.

[0054] The above description is merely a description of the preferred embodiment of this utility model and is not intended to limit the scope of this utility model in any way. Any changes or modifications made by those skilled in the art based on the above disclosure shall fall within the protection scope of the claims. Obviously, those skilled in the art can make various modifications and variations to the utility model without departing from its spirit and scope. Therefore, if these modifications and variations of this utility model fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A syringe for use in the field of neurointerventional vascular embolization, characterized in that, Includes the syringe, piston, and core rod; The piston is disposed at the head of the core rod, the head of the core rod is inserted into the inner cavity of the injection cylinder, and the core rod is configured to drive the piston to reciprocate within the inner cavity of the injection cylinder; The injection barrel includes an injection barrel body, a cone head, and a rolled outer edge; The head of the syringe tapers towards its axis to form the cone. The tail of the injection cylinder extends outward in a direction away from its axis to form the outer sheath; The portion between the cone and the rolled edge of the outer casing constitutes the main body of the injection cylinder; A Luer connector is fitted onto the outer wall of the cone. The inner diameter of the cone is 0.5-2.5 mm, the wall thickness of the cone is 0.1-2 mm, the wall thickness of the cone gradually decreases in the direction away from the main body of the syringe, and the length of the head of the cone that extends away from the main body of the syringe beyond the Luer connector is 1-3 mm.

2. A syringe according to claim 1, wherein The thickness of the outer sheath along the first direction is 1-5mm, the length of the outer sheath along the second direction is 25-60mm, and the two sides of the outer sheath along the second direction are semi-circular with a radius of 5-10mm. The first direction is the extension direction of the injection cylinder, and the second direction is the extension direction of the outer sheath.

3. The syringe of claim 1, wherein The distance between the surface of the Luer connector away from the main body of the syringe and the bottom surface of the outer sleeve roll away from the main body of the syringe is 70-150mm; The distance between the surface of the cone tip near the main body of the injection barrel and the bottom surface of the outer sleeve away from the main body of the injection barrel is 65-120mm.

4. The syringe of claim 1, wherein The piston has at least two sealing rings, the outer diameter of which is 4.5-17mm and the height along the first direction is 0.3-0.8mm; the distance between the at least two sealing rings is 2-5mm.

5. The syringe of claim 1, wherein The head of the core rod protrudes outward in a direction away from its center to form a ring of protrusions, and the tail of the core rod extends outward in a direction away from its center to form a core rod handle. The outer diameter of the protruding layer is 4.5-17mm, and the height of the protruding layer along the first direction is 0.5-1.5mm; the distance between the protruding layer and the core rod handle is 70-150mm.

6. A syringe according to claim 5, wherein The inner wall of the syringe body is provided with a circumferential protrusion near the rolled edge of the outer casing. The protrusion can be a continuous ring or a discontinuous ring, and the distance between the protrusion and the rolled edge of the outer casing is 4-20mm.

7. A syringe according to claim 5, wherein The outer diameter of the core rod is 5-15mm, the core rod handle is a cylinder with a radius of 7-20mm and a height of 1-4mm along the first direction, and the distance between the surface of the piston away from the core rod and the bottom surface of the core rod handle away from the piston is 80-160mm.

8. A syringe according to claim 7, wherein The bottom surface of the core rod, away from the piston, is provided with textured protrusions.

9. The syringe of claim 1, wherein The inner wall of the syringe is provided with a lubricating coating.

10. A liquid embolization system, comprising: Including the syringe as described in any one of claims 1-9.

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