A compound separation and purification column fixing mechanism

Abstract

The utility model relates to compound separation technical field especially, it relates to a compound separation and purification with chromatographic column fixing mechanism, including support base, two groups of clamping mechanism, interval adjusting assembly and drive assembly, two groups clamping mechanism all are located the top of support base and are located same straight line, are used for to chromatographic column formation coaxial vertical clamping fixed, interval adjusting assembly is located support base and with two groups clamping mechanism all transmission connection, are used for adjusting two groups clamping mechanism along linear direction synchronous movement, with adjusting the interval between two groups clamping mechanism, drive assembly with two groups clamping mechanism all transmission connection, the utility model discloses through interval adjusting assembly adjustment two groups of clamping assembly synchronous movement, adjust the interval between both, to nimble adaptation chromatographic column of different length use, drive assembly drive two groups of clamping mechanism synchronous clamping and release simultaneously, only needs one operation to complete chromatographic column's fixed or disassembly, improve the convenience of operation.

Description

Technical Field

[0001] This utility model relates to the field of compound separation technology, and in particular to a chromatographic column fixation mechanism for compound separation and purification. Background Technology

[0002] In the process of compound separation and purification, the chromatographic column is the core device. By fixing the chromatographic column vertically, the separation and purification of each component can be achieved by utilizing the difference in the interaction forces between different components in the mixture and the stationary and mobile phases.

[0003] However, a fixing mechanism is required when vertically fixing the chromatographic column. Currently, the fixing mechanism is generally a butterfly-shaped clamp set on the support frame. The column is fixed by the clamping action of the butterfly-shaped clamp, which is convenient and quick. However, the spacing between the clamping points is fixed and can only be used for chromatographic columns of a specific length. It has poor versatility for chromatographic columns of different lengths. Therefore, in order to improve the flexibility of use, some adjustable spacing separate clamping mechanisms have also emerged. Although this improves the adaptability to chromatographic columns of different lengths, it requires operating two clamping points separately. The operation process is cumbersome and it is easy for the two clamping points to become misaligned due to improper operation, causing the chromatographic column to tilt.

[0004] Therefore, based on the above situation, it is necessary to design a chromatographic column fixation mechanism for compound separation and purification to solve the above problems. Utility Model Content

[0005] This invention provides a column fixation mechanism for the separation and purification of compounds, thereby solving the problems in the prior art.

[0006] The technical problem solved by this utility model is achieved by the following technical solution: A chromatographic column fixing mechanism for compound separation and purification includes a support base, two sets of clamping mechanisms, a spacing adjustment component, and a drive component. The two sets of clamping mechanisms are both located above the support base and on the same straight line, for coaxial vertical clamping and fixing of the chromatographic column. The spacing adjustment component is located on the support base and is drive-connected to both sets of clamping mechanisms, for adjusting the synchronous movement of the two sets of clamping mechanisms along a straight line to adjust the spacing between the two sets of clamping mechanisms. The drive component is drive-connected to both sets of clamping mechanisms, for driving the two sets of clamping mechanisms to synchronously clamp and release.

[0007] Preferably, the spacing adjustment assembly includes a bidirectional screw rotatably connected to the support base and a guide frame disposed on the support base. The two sets of clamping mechanisms are respectively threadedly connected to the threaded sections of the bidirectional screw with different helix directions, and both sets of clamping mechanisms are slidably connected inside the guide frame.

[0008] Preferably, the clamping mechanism includes a threaded seat threadedly connected to a bidirectional screw, a first clamping plate fixedly connected to the threaded seat, and a second clamping plate slidably connected to the threaded seat. The first clamping plate and the second clamping plate are arranged opposite to each other and form a clamping space for vertically clamping the chromatographic column.

[0009] Preferably, the driving assembly includes a movable plate located on one side of the guide frame and a connecting rod slidably connected along the length extension direction of the movable plate. The end of the connecting rod away from the movable plate is connected to a second clamping plate and slidably connected to the guide frame. An adjusting screw is rotatably connected to the guide frame, and the adjusting screw passes through the movable plate and is threadedly connected to the movable plate.

[0010] Preferably, both ends of the movable plate are connected to a balance bar, and the balance bar is slidably connected to the guide frame.

[0011] Preferably, both the first clamping plate and the second clamping plate have elastic pads on their clamping surfaces, and the elastic pads have multiple anti-slip grooves.

[0012] The beneficial effects of this utility model are: by adjusting the spacing of the two sets of clamping components to move synchronously, the spacing between them can be adjusted to flexibly adapt to the use of chromatographic columns of different lengths. At the same time, the drive component drives the two sets of clamping mechanisms to clamp and release synchronously, so that the fixing or disassembly of the chromatographic column can be completed in one operation, thus improving the convenience of operation. Attached Figure Description

[0013] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0014] Figure 1 Schematic diagram of the three-dimensional structure provided by this utility model Figure 1 ; Figure 2 Schematic diagram of the three-dimensional structure provided by this utility model Figure 2 ; Figure 3 Schematic diagram of the cross-sectional structure provided by this utility model Figure 1 ; Figure 4 Schematic diagram of the cross-sectional structure provided by this utility model Figure 2 .

[0015] In the figure, 1 is the support base; 2 is the clamping mechanism; 21 is the threaded seat; 22 is the first clamping plate; 23 is the second clamping plate; 3 is the spacing adjustment assembly; 31 is the bidirectional screw; 32 is the guide frame; 4 is the drive assembly; 41 is the movable plate; 42 is the connecting rod; 5 is the adjusting screw; 6 is the balance bar; and 7 is the elastic pad. Detailed Implementation

[0016] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below with reference to specific illustrations.

[0017] Reference Figures 1-4 As shown, a chromatographic column fixing mechanism for compound separation and purification includes a support base 1. Two sets of clamping mechanisms 2 are provided above the support base 1 to clamp the chromatographic column. To ensure the column is held vertically, the two sets of clamping mechanisms 2 are positioned above the support base 1 and on the same straight line, forming a coaxial vertical clamping and fixing of the column, achieving a vertical and straight state for the column. Since different chromatographic columns have different lengths, to facilitate adaptation to different columns and change the clamping point, a spacing adjustment assembly 3 is provided on the support base 1. The component 3 is connected to both clamping mechanisms 2. Before clamping the chromatographic column, the two clamping mechanisms 2 can be adjusted to move synchronously in a straight line, and the distance between the two clamping mechanisms 2 can be adjusted to adapt to chromatographic columns of different lengths, ensuring that the chromatographic column is clamped vertically and avoiding tilting. In order to facilitate the use of the two clamping mechanisms 2, a drive component 4 is also provided, which is connected to the two clamping mechanisms 2. The drive component 4 drives the two clamping mechanisms 2 to clamp and release synchronously. The column can be fixed or disassembled in one operation, which improves the convenience of operation.

[0018] Reference Figure 1 , Figure 2 As shown, the spacing adjustment assembly 3 further includes a bidirectional screw 31 rotatably connected to the support base 1 and a guide seat provided on the support base 1. The two sets of clamping mechanisms 2 are respectively threadedly connected to the threaded sections of the bidirectional screw 31 with different directions of rotation. By rotating the bidirectional screw 31, the bidirectional screw 31 drives the two sets of clamping mechanisms 2 to move closer to each other or move away from each other in the opposite direction. In order to prevent the bidirectional screw 31 from driving the two sets of clamping mechanisms 2 to rotate, the two sets of clamping mechanisms 2 are slidably connected to the inside of the guide frame 32, thereby maintaining the stability of the two sets of clamping mechanisms 2.

[0019] Reference Figure 4As shown, the clamping mechanism 2 further includes a threaded seat 21 threadedly connected to the bidirectional screw 31, a first clamping plate 22 fixedly connected to the threaded seat 21, and a second clamping plate 23 slidably connected to the threaded seat 21. In use, the two second clamping plates 23 are synchronously driven to move closer to the first clamping plate 22 by the drive mechanism. At this time, a clamping space for clamping the chromatographic column is formed between the first clamping plate 22 and the second clamping plate 23, thereby fixing the chromatographic column. When the second clamping plate 23 moves away from the first clamping plate 22, the chromatographic column is synchronously released, eliminating the need to operate the clamping points separately in the traditional process and improving convenience.

[0020] Both the first clamping plate 22 and the second clamping plate 23 are provided with elastic pads 7 on their clamping surfaces. The elastic pads 7 can be made of materials such as rubber or silicone. At the same time, multiple anti-slip grooves are opened inside the elastic pads. When the chromatographic column is clamped and fixed, the elastic pads 7 protect the chromatographic column and reduce the damage caused by the hard contact between the first clamping plate 22, the second clamping plate 23 and the chromatographic column. At the same time, the elastic pads 7 can further increase the friction with the surface of the chromatographic column and improve the stability of the chromatographic column.

[0021] Reference Figures 2-4 As shown, the drive assembly 4 further includes a movable plate 41 located on one side of the guide frame 32 and a connecting rod 42 slidably connected along the length extension direction of the movable plate 41. The end of the connecting rod 42 away from the movable plate 41 is connected to the second clamping plate 23. At this time, the connecting rod 42 passes through one side of the guide frame 32 and can be slidably connected to the sliding frame. When the distance between the two sets of clamping mechanisms 2 is adjusted, the two sets of clamping assemblies move up and down along the guide frame 32, and at the same time drive the connecting rod 42 to slide up and down in the guide frame 32 and the movable plate 41. When it is necessary to start the movement of the second connecting plate to clamp or release the chromatographic column, the guide frame 32 is rotatably connected to the adjusting screw 5. By turning the adjusting screw 5, the movable plate 41 threadedly connected to the adjusting screw 5 will drive the connecting rod 42 and the second clamping plate 23 to slide left and right on the adjusting screw 5, thereby driving the two sets of clamping mechanisms 2 to clamp or release synchronously.

[0022] The movable plate 41 is connected to two ends of a balance bar 6. The balance bar 6 is slidably connected to the guide frame 32. The balance bar 6 is distributed at both ends of the movable plate 41 and forms a rigid connection frame with the movable plate 41 and the guide frame 32. It can resist the reaction force transmitted by the chromatographic column during the clamping process, ensure that the movable plate 41 moves in a straight line along the guide frame 32, and improve the smooth operation of the drive component 4.

[0023] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A chromatographic column fixing mechanism for compound separation and purification, comprising a support base (1), characterized in that, Also includes; Two sets of clamping mechanisms (2) are provided above the support base (1) and are located on the same straight line, for forming a coaxial vertical clamping and fixing of the chromatographic column; The spacing adjustment component (3) is mounted on the support base (1) and is connected to both clamping mechanisms (2) for adjusting the two clamping mechanisms (2) to move synchronously in a straight line, so as to adjust the spacing between the two clamping mechanisms (2). The drive component (4) is connected to both clamping mechanisms (2) and is used to drive the two clamping mechanisms (2) to clamp and release synchronously.

2. The chromatographic column fixation mechanism for compound separation and purification according to claim 1, characterized in that, The spacing adjustment assembly (3) includes a bidirectional screw (31) rotatably connected to the support base (1) and a guide frame (32) provided on the support base (1). The two sets of clamping mechanisms (2) are respectively threaded to the threaded sections of the bidirectional screw (31) with different directions of rotation. The two sets of clamping mechanisms (2) are slidably connected inside the guide frame (32).

3. The chromatographic column fixation mechanism for compound separation and purification according to claim 2, characterized in that, The clamping mechanism (2) includes a threaded seat (21) threadedly connected to a bidirectional screw (31), a first clamping plate (22) fixedly connected to the threaded seat (21), and a second clamping plate (23) slidably connected to the threaded seat (21). The first clamping plate (22) and the second clamping plate (23) are arranged opposite to each other and form a clamping space for vertically clamping the chromatographic column.

4. The chromatographic column fixation mechanism for compound separation and purification according to claim 1, characterized in that, The drive assembly (4) includes a movable plate (41) located on one side of the guide frame (32) and a connecting rod (42) slidably connected along the length extension direction of the movable plate (41). The end of the connecting rod (42) away from the movable plate (41) is connected to the second clamping plate (23) and slidably connected to the guide frame (32). An adjusting screw (5) is rotatably connected to the guide frame (32). The adjusting screw (5) passes through the movable plate (41) and is threadedly connected to the movable plate (41).

5. The chromatographic column fixation mechanism for compound separation and purification according to claim 4, characterized in that, Both ends of the movable plate (41) are connected to balance bars (6), which are slidably connected to the guide frame (32).

6. The chromatographic column fixation mechanism for compound separation and purification according to claim 3, characterized in that, Both the first clamping plate (22) and the second clamping plate (23) are provided with elastic pads (7), and the elastic pads (7) have multiple anti-slip patterns.

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