A polypeptide drug inducer stable addition device

Abstract

The utility model provides a kind of polypeptide drug inducer stable adding device, comprising: material box, discharging assembly, the material box includes box, the bottom of the box is provided with cooling cavity for polypeptide drug inducer on the bottom of box cooling, the discharging assembly includes conduit, the right end downside of the conduit is fixed with cooling pipe for cooling polypeptide drug inducer, compared with prior art, the utility model has the beneficial effects as follows: by setting cooling cavity in material box bottom, and setting multiple partitions with front and rear staggered distribution communication hole in its inside, it is ensured that polypeptide drug is not affected by temperature after adding polypeptide drug inducer, which also makes the addition of polypeptide drug inducer more stable, by setting cooling pipe on the conduit of discharging assembly, and by hose one, hose two, refrigerant is transported to cooling pipe, so that polypeptide drug inducer always maintains lower temperature when adding through conduit.

Description

Technical Field

[0001] This utility model belongs to the field of material addition technology, and specifically relates to a device for stabilizing the addition of polypeptide drug inducers. Background Technology

[0002] Existing peptide drug inducer stabilization and addition devices often suffer from temperature rises during the friction transport process due to the lack of an effective cooling structure. This temperature increase can lead to peptide backbone breakage or aggregation, resulting in drug inactivation and severely impacting its bioactivity and therapeutic efficacy. The main sources of temperature rise are mechanical friction between the material and the equipment's inner wall during transport, as well as heat conduction from the environment.

[0003] To mitigate this issue, conventional approaches include optimizing the delivery path to reduce friction, employing external cooling systems to cool the equipment, or adding heat stabilizers to the formulation. However, these methods have limitations: optimizing the delivery path cannot fundamentally solve the temperature rise problem; external cooling systems are energy-intensive and inefficient, easily causing localized temperature unevenness; and while heat stabilizers can delay the thermal degradation of peptide drugs to some extent, they may introduce new impurities or affect drug release characteristics, thus posing potential safety and efficacy risks and limiting their widespread application. Therefore, we aim to design a novel peptide drug inducer stabilization and addition device to address this problem. Utility Model Content

[0004] To address the shortcomings of existing technologies, the purpose of this invention is to provide a stable addition device for polypeptide drug inducers, thereby solving the problems mentioned in the background section.

[0005] This utility model is achieved through the following technical solution: a stable addition device for polypeptide drug inducers, comprising: a material box and a feeding assembly, wherein the material box includes a box body, a conveying screw is provided at the lower end of the box body, the left end of the conveying screw is connected to an external driving device through a spline shaft, and a cooling chamber is provided at the bottom of the box body for cooling down the polypeptide drug inducers at the bottom of the box body; The feeding assembly includes a conduit, and a cooling tube for cooling the peptide drug inducer is fixed to the lower right end of the conduit.

[0006] In a preferred embodiment, the cooling chamber is provided with multiple equally spaced partitions from left to right. Each adjacent partition has a connecting hole on its front and rear sides for supplying refrigerant. The left rear side of the cooling chamber is connected to an external refrigerant supply device. In actual use, liquid nitrogen can be used for cooling, which has a low temperature and good cooling effect. This ensures that when the peptide drug inducer is added to the peptide drug, it has a low temperature, avoiding the impact of high-temperature addition on the peptide drug.

[0007] In a preferred embodiment, a connector is provided on the lower right side of the housing, and a flexible claw is welded to the right surface of the housing at the position directly above the connector.

[0008] In a preferred embodiment, a second hose is provided on the front right side of the cooling chamber and a second hose is provided on the rear right side of the cooling chamber for conveying refrigerant. In actual use, the first hose and the second hose can be low-temperature resistant hoses, which can deliver the refrigerant to the cooling pipe and back to the cooling chamber without being affected.

[0009] In a preferred embodiment, the feeding assembly further includes a clamping plate, and an elastic clamping plate is provided on the upper left side of the guide tube for movably engaging and fixing the guide tube with the clamping claw. The upper left side of the guide tube is sealed and inserted into the insertion tube.

[0010] In a preferred embodiment, a switch tube is rotatably mounted on the upper end of the conduit, and a feed notch is provided on the right side of its lower end for adjusting the material feeding switch.

[0011] In a preferred embodiment, the lower end of the conduit is provided with an external thread, and a cooling pipe is movably installed thereon via a nut. The lower left side of the cooling pipe is movably inserted and fixed to the end of the second hose, and the upper side of the cooling pipe is movably inserted and fixed to the end of the first hose. The interior of the cooling pipe is provided with an inner cavity for storing refrigerant and cooling the conduit portion.

[0012] After adopting the above technical solution, the beneficial effects of this utility model are: 1. By setting a cooling chamber at the bottom of the material box, the peptide drug inducer and the conveying screw can be cooled at the same time, so that the peptide drug inducer will not have a significant temperature rise when it is conveyed by friction with the conveying screw, ensuring that the peptide drug is not affected by temperature after the peptide drug inducer is added, which also makes the addition of the peptide drug inducer more stable.

[0013] 2. By installing a cooling pipe on the conduit of the feeding assembly, and supplying refrigerant to the cooling pipe through hose one and hose two, the refrigerant lowers the overall temperature of the cooling pipe, thereby cooling the area where the conduit is located. This ensures that the peptide drug inducer is always kept at a low temperature when added through the conduit. The addition of the peptide drug inducer in conjunction with a heat stabilizer has been addressed, as it may introduce new impurities or affect the drug release characteristics. This ensures the stability of the peptide drug inducer addition. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0015] Figure 1 This is a schematic diagram of the overall structure of a polypeptide drug inducer stabilization addition device according to the present invention.

[0016] Figure 2 This is a schematic cross-sectional view of the device for stabilizing the addition of a polypeptide drug inducer according to the present invention.

[0017] Figure 3 This is a schematic diagram showing the connection between the conveying screw and the feeding assembly of a polypeptide drug inducer stabilization addition device according to this utility model.

[0018] Figure 4 This is a schematic diagram of the feeding component structure of a polypeptide drug inducer stabilization and addition device according to the present invention.

[0019] Figure 5 This is a schematic diagram of the switching tube structure of a polypeptide drug inducer stabilization addition device according to the present invention.

[0020] In the diagram, 100-material box, 110-conveying screw, 120-box body, 121-cooling chamber, 122-partition, 130-claw, 140-connector, 150-hose one, 160-hose two; 200-Feeding assembly, 210-Conduit, 220-Card, 230-Switch tube, 240-Cooling tube. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] As the first embodiment of this utility model: Please see Figures 1 to 5 A stable addition device for peptide drug inducers includes: a material box 100 and a feeding assembly 200. The material box 100 includes a box body 120. A conveying screw 110 is provided at the lower end of the box body 120. The left end of the conveying screw 110 is connected to an external driving device through a spline shaft. A cooling chamber 121 is provided at the bottom of the box body 120 for cooling the peptide drug inducer at the bottom of the box body 120. The feeding assembly 200 includes a conduit 210, and a cooling pipe 240 for cooling the peptide drug inducer is fixed to the lower right end of the conduit 210.

[0023] The interior of the cooling chamber 121 is provided with multiple equally spaced partitions 122 from left to right. Each adjacent partition 122 has a connecting hole on its front and rear sides for supplying refrigerant. The left rear side of the cooling chamber 121 is connected to an external refrigerant supply device. In actual use, liquid nitrogen can be used for cooling, which has a low temperature and good cooling effect. This ensures that when the peptide drug inducer is added to the peptide drug, it has a low temperature, avoiding the impact of high temperature addition on the peptide drug.

[0024] A connector 140 is provided on the lower right side of the housing 120, and a flexible claw 130 is welded on the right surface of the housing 120 at the position directly above the connector 140.

[0025] A second hose 160 is provided on the front right side of the cooling chamber 121, and a second hose 160 is provided on the rear right side of the cooling chamber 121 for conveying refrigerant. In actual use, the first hose 150 and the second hose 160 can be made of low-temperature resistant hoses, which can convey the refrigerant to the cooling pipe 240 and back to the cooling chamber 121 without being affected.

[0026] Specifically, by setting a cooling chamber 121 at the bottom of the material box 100, and setting multiple baffles 122 with staggered connecting holes inside the chamber, the refrigerant can move in a serpentine structure in the cooling chamber 121, thereby increasing the residence time of the refrigerant in the cooling chamber 121. The upper side of the cooling chamber 121 is the conveying screw 110 and the stored peptide drug inducer. The peptide drug inducer and the conveying screw 110 can be cooled at the same time, so that the peptide drug inducer will not have a significant temperature rise when it is conveyed by friction with the conveying screw 110. This ensures that the peptide drug is not affected by temperature after the peptide drug inducer is added, which also makes the addition of the peptide drug inducer more stable.

[0027] As a second embodiment of this utility model: Please see Figures 1 to 5 The unloading assembly 200 also includes a clamping plate 220. The upper left side of the conduit 210 is provided with an elastic clamping plate 220 for movably engaging with the claw 130 to fix the conduit 210. The upper left side of the conduit 210 is sealed and inserted into the insertion tube 140.

[0028] A switch tube 230 is rotatably mounted on the upper end of the conduit 210, and a feed notch is provided on the lower right side of the conduit for adjusting the material discharge switch.

[0029] The lower end of the conduit 210 is provided with an external thread, and a cooling pipe 240 is movably installed by a nut. The lower left side of the cooling pipe 240 is movably inserted and fixed to the end of the second hose 160, and the upper side of the cooling pipe 240 is movably inserted and fixed to the end of the first hose 150. The interior of the cooling pipe 240 is provided with an inner cavity for storing refrigerant and cooling part of the conduit 210.

[0030] Based on the first embodiment described above, further, by providing a cooling pipe 240 on the conduit 210 of the feeding assembly 200, and by delivering refrigerant to the cooling pipe 240 through hose one 150 and hose two 160, the refrigerant lowers the overall temperature of the cooling pipe 240, thereby cooling the location of the conduit 210. This ensures that the peptide drug inducer is always kept at a low temperature when added through the conduit 210. The addition of the peptide drug inducer in conjunction with a heat stabilizer has been addressed, which may introduce new impurities or affect the drug release characteristics. This ensures the stability of the peptide drug inducer addition.

[0031] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A polypeptide drug inducer stable addition device, comprising: Material box (100) and unloading assembly (200), characterized in that the material box (100) includes a box body (120), a conveying screw (110) is provided at the lower end of the box body (120), the left end of the conveying screw (110) is connected to an external driving device through a spline shaft, and a cooling chamber (121) is provided at the bottom of the box body (120) for cooling the polypeptide drug inducer at the bottom of the box body (120); The feeding assembly (200) includes a conduit (210), and a cooling tube (240) for cooling the peptide drug inducer is fixed to the lower right end of the conduit (210).

2. The polypeptide drug inducer stabilizing additive device of claim 1, wherein: The cooling chamber (121) has multiple equally spaced partitions (122) arranged inside from left to right. The two adjacent partitions (122) have connecting holes on the front and rear sides respectively for conveying refrigerant. The left rear side of the cooling chamber (121) is connected to an external refrigerant supply device.

3. The polypeptide drug inducer stabilizing additive device of claim 1, wherein: the polypeptide drug inducer stabilizing additive device is a polypeptide drug inducer stabilizing additive device for a drug delivery device. A connector (140) is provided on the lower right side of the housing (120), and an elastic claw (130) is welded on the right surface of the housing (120) at the position directly above the connector (140).

4. The polypeptide drug inducer stabilizing additive device of claim 1, wherein: the polypeptide drug inducer stabilizing additive device is a polypeptide drug inducer stabilizing additive device for a drug delivery device. A second hose (160) is provided on the front right side of the cooling chamber (121), and a second hose (160) is provided on the rear right side of the cooling chamber (121) for conveying refrigerant.

5. The polypeptide drug inducer stabilizing additive device of claim 1, wherein: the polypeptide drug inducer stabilizing additive device is a polypeptide drug inducer stabilizing additive device for a drug delivery device. The feeding assembly (200) also includes a clamping plate (220). The upper left side of the conduit (210) is provided with an elastic clamping plate (220) for movably clamping and fixing the conduit (210) with the clamping claw (130). The upper left side of the conduit (210) is sealed and inserted into the insertion tube (140).

6. The polypeptide drug inducer stabilizing additive device of claim 5, wherein: The upper end of the conduit (210) is rotatably equipped with a switch tube (230), and the lower right end is provided with a feed notch for adjusting the material feeding switch.

7. The polypeptide drug inducer stabilizing additive device of claim 4, wherein: the polypeptide drug inducer stabilizing additive device is a polypeptide drug inducer stabilizing additive device for a drug delivery device. The lower end of the conduit (210) is provided with an external thread, and a cooling pipe (240) is movably installed by a nut. The lower left side of the cooling pipe (240) is movably inserted and fixed to the end of the second hose (160), and the upper side of the cooling pipe (240) is movably inserted and fixed to the end of the first hose (150). The interior of the cooling pipe (240) is provided with an inner cavity for storing refrigerant and cooling the conduit (210).

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