A protein chip mass spectrometry apparatus
By installing end cap electrodes and ring electrode blocks in the protein chip mass spectrometry analysis device, the problem of uneven ion displacement was solved, achieving uniform ion displacement and vibrational absorption, thus improving detection accuracy and analysis results.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- 洛兮医疗科技(河北)有限公司
- Filing Date
- 2025-06-09
- Publication Date
- 2026-08-04
AI Technical Summary
In existing protein chip mass spectrometry analysis equipment, the high-voltage electromagnetic field is formed by energizing four electric rods, which causes ions to not move uniformly, affecting the detection accuracy.
The device employs end cap electrodes installed at both ends of the chamber, and multiple sets of evenly distributed fixing rings fixed on the outer wall of the chamber. Annular electrode blocks are installed inside, and ion displacement is controlled by an electric or magnetic field. Baffles are placed between the electrode blocks to avoid interference, and shock-absorbing components are installed at the bottom of the device to absorb vibration impact.
It achieves uniform ion displacement and effective absorption of vibration, improving detection accuracy and preventing vibration from affecting the analysis results.
Smart Images
Figure CN224594562U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of bioanalytical technology, and in particular to a protein chip mass spectrometry analysis device. Background Technology
[0002] Protein chips, also known as protein microarrays or microarray protein chips, are a high-throughput protein analysis technology. With the continuous development of science and technology, protein chip technology is also constantly improving and perfecting. It has a wide range of applications in disease diagnosis, drug development, proteomics research, and other fields. Protein chips have advantages such as high throughput, high sensitivity, high efficiency, simplicity, and low cost. They can detect a large number of proteins in a short time, improving detection efficiency. At the same time, the use of solid-phase media as a carrier makes the operation simpler and the cost relatively low.
[0003] In existing protein chip mass spectrometry analysis equipment, the analyte is processed into a gaseous state by various ionization technologies. The ionized substances pass through a high-voltage electromagnetic field, and the content and proportion of substances in the analyte are determined based on the different speeds of movement. However, the existing high-voltage electromagnetic field is formed by energizing four electric rods. Because the distance of the four electric rods from the center point and their respective intervals are different, the ions cannot be uniformly displaced.
[0004] It should be noted that the above content falls within the inventor's technical knowledge and does not necessarily constitute prior art. Utility Model Content
[0005] To overcome the above shortcomings, this utility model provides a protein chip mass spectrometry analysis device, which aims to improve the problem in the prior art where the high-voltage electromagnetic field is formed by energizing four electric rods. Because the distance of the four electric rods from the center point and their respective intervals are different, the ions passing through cannot be uniformly displaced.
[0006] To achieve the above objectives, the present invention adopts the following technical solution: a protein chip mass spectrometry analysis device, including a protective shell, a chamber is formed in the middle of the protective shell, and ion shifting components are provided at the left and right ends of the chamber;
[0007] The ion displacement assembly includes two end cap electrodes, both of which are fixedly connected to the left and right ends of the chamber. Each end cap electrode has an electrode ring in its middle. The middle of the left end cap electrode is connected to an ion input tube, and the middle of the right end cap electrode is connected to an ion output tube. Multiple evenly distributed fixing rings are fixedly connected to the outer wall of the chamber. Multiple evenly distributed partitions are arranged inside the multiple fixing rings. Electrode blocks are arranged on adjacent sides of the multiple partitions. A shock-absorbing assembly is arranged at the bottom of the protective shell.
[0008] As a further description of the above technical solution:
[0009] The shock absorption assembly includes multiple grooves, each groove being formed at the bottom of the protective shell. A damper is fixedly connected to the middle of the inner top wall of each groove, a support leg is fixedly connected to the bottom of each damper, a shock-absorbing pad is fixedly connected to the bottom of each support leg, and a shock-absorbing spring is provided on the outer wall of each damper.
[0010] As a further description of the above technical solution:
[0011] The bottom ends of the plurality of shock-absorbing springs are fixedly connected to the top ends of the support legs, and the top ends of the plurality of shock-absorbing springs are fixedly connected to the inner top wall of the groove.
[0012] As a further description of the above technical solution:
[0013] The outer wall of the ion input tube is provided with a first outer protective layer.
[0014] As a further description of the above technical solution:
[0015] The outer wall of the ion output tube is provided with a second outer protective layer.
[0016] As a further description of the above technical solution:
[0017] The front end of the protective shell is fixedly connected to an adjustment panel.
[0018] The advantages of this utility model are:
[0019] 1. In this utility model, by installing end cap electrodes at both ends of the chamber and fixing multiple sets of uniformly distributed fixing rings on the outer wall of the chamber, and installing multiple arc-shaped electrode blocks inside the fixing rings, the gas phase ions can be controlled by electric or magnetic fields to make the ions move uniformly. By using partitions to separate the multiple electrode blocks, it can be ensured that the multiple electrode blocks will not interfere with each other.
[0020] 2. In this utility model, a groove is opened at the bottom of the protective shell and a damper is fixed inside it. A support leg is fixed at the bottom of the damper, and a shock-absorbing pad is fixedly connected at the bottom of the support leg. A shock-absorbing spring is set on the outside of the damper. Thus, when the equipment is subjected to external impact, the shock-absorbing pad, the shock-absorbing spring and the damper work together to gradually reduce and absorb the impact force, preventing the vibration from affecting the mass spectrometry analysis. Attached Figure Description
[0021] Figure 1 A three-dimensional view of a protein chip mass spectrometry analysis device proposed in this utility model;
[0022] Figure 2 This is a cross-sectional view of the chamber of a protein chip mass spectrometry analysis device proposed in this utility model;
[0023] Figure 3 Figure A is an enlarged view of a protein chip mass spectrometry analysis device proposed in this utility model;
[0024] Figure 4 This is a schematic diagram of a damper for a protein chip mass spectrometry analysis device proposed in this utility model.
[0025] Legend:
[0026] 1. Protective shell; 2. Chamber; 3. End cap electrode; 4. Electrode ring; 5. Ion input tube; 6. Ion output tube; 7. Fixing ring; 8. Partition plate; 9. Electrode block; 10. Groove; 11. Damper; 12. Support leg; 13. Shock-absorbing pad; 14. Shock-absorbing spring; 15. First outer protective layer; 16. Second outer protective layer; 17. Control panel. Detailed Implementation
[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0028] Reference Figure 1 , Figure 2 and Figure 3 One embodiment of this utility model is a protein chip mass spectrometry analysis device, including a protective shell 1, a chamber 2 opened in the middle of the protective shell 1, and ion displacement components arranged at the left and right ends of the chamber 2.
[0029] The ion displacement assembly includes two end cap electrodes 3, which are fixedly connected to the left and right ends of the chamber 2. Each end cap electrode 3 has an electrode ring 4 in the middle. The middle of the left end cap electrode 3 is connected to an ion input tube 5, and the middle of the right end cap electrode 3 is connected to an ion output tube 6. Multiple evenly distributed fixing rings 7 are fixedly connected to the outer wall of the chamber 2. Multiple evenly distributed partitions 8 are arranged inside the multiple fixing rings 7. Electrode blocks 9 are arranged on the adjacent side of the multiple partitions 8. A shock-absorbing assembly is arranged at the bottom of the protective shell 1. A control panel 17 is fixedly connected to the front end of the protective shell 1.
[0030] Specifically, by installing annularly distributed electrode blocks 9 inside the fixed ring 7 and keeping the spacing between multiple electrode blocks 9 consistent with the center point, ions can be uniformly displaced with the cooperation of the end cap electrode 3.
[0031] Reference Figure 1 and Figure 4 The shock absorption assembly includes multiple grooves 10, all of which are formed at the bottom of the protective shell 1. A damper 11 is fixedly connected to the middle of the inner top wall of each groove 10. A support leg 12 is fixedly connected to the bottom of each damper 11. A shock-absorbing pad 13 is fixedly connected to the bottom of each support leg 12. A shock-absorbing spring 14 is provided on the outer side wall of each damper 11. The bottom of each shock-absorbing spring 14 is fixedly connected to the top of each support leg 12, and the top of each shock-absorbing spring 14 is fixedly connected to the inner top wall of the groove 10.
[0032] Specifically, by providing a damping spring 14 on the outer wall of the damper 11, the spring's deformation effect gradually absorbs the impact force when the equipment is subjected to vibration and shock. At the same time, with the cooperation of the damper 11, the impact of vibration and shock on the equipment can be effectively eliminated.
[0033] Reference Figure 1 , Figure 2 and Figure 3 The outer wall of the ion input tube 5 is provided with a first outer protective layer 15; the outer wall of the ion output tube 6 is provided with a second outer protective layer 16.
[0034] Specifically, by providing a first outer protective layer 15 on the outer wall of the ion input tube 5 and a second outer protective layer 16 on the outer wall of the ion output tube 6, the ion input tube 5 and the ion output tube 6 can be protected by the first outer protective layer 15 and the second outer protective layer 16 respectively.
[0035] It should be noted that (end cover electrode 3, electrode ring 4, damper 11, control panel 17) are all well-known or known to those skilled in the art, and therefore will not be described here.
[0036] Working principle: The device has end cap electrodes 3 installed at both ends of the chamber 2, and multiple sets of uniformly distributed fixing rings 7 fixed on the outer wall of the chamber 2. At the same time, multiple arc-shaped electrode blocks 9 are installed inside the fixing rings 7. Thus, gas phase ions can be controlled by electric field or magnetic field to make the ions move uniformly. By using partitions 8 to separate the multiple electrode blocks 9, it can be ensured that the multiple electrode blocks 9 will not interfere with each other.
[0037] Furthermore, by creating a groove 10 at the bottom of the protective shell 1 and fixing a damper 11 inside, and fixing a support leg 12 at the bottom of the damper 11, while fixing a shock-absorbing pad 13 at the bottom of the support leg 12, and setting a shock-absorbing spring 14 on the outside of the damper 11, when the equipment is subjected to external impact, the shock-absorbing pad 13, the shock-absorbing spring 14 and the damper 11 work together to gradually reduce and absorb the impact force, preventing vibration from affecting mass spectrometry analysis.
[0038] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A protein chip mass spectrometry analysis device, comprising a protective shell (1), characterized in that: The protective shell (1) has a chamber (2) in the middle, and ion displacement components are provided at the left and right ends of the chamber (2); The ion displacement assembly includes two end cap electrodes (3), both of which are fixedly connected to the left and right ends of the chamber (2). An electrode ring (4) is provided in the middle of each of the two end cap electrodes (3). An ion input tube (5) is connected to the middle of the left end cap electrode (3), and an ion output tube (6) is connected to the middle of the right end cap electrode (3). Multiple uniformly distributed fixing rings (7) are fixedly connected to the outer wall of the chamber (2). Multiple uniformly distributed partitions (8) are provided inside the multiple fixing rings (7). An electrode block (9) is provided on the adjacent side of the multiple partitions (8). A shock-absorbing assembly is provided at the bottom of the protective shell (1).
2. The protein chip mass spectrometry analysis device according to claim 1, characterized in that: The shock-absorbing assembly includes multiple grooves (10), each groove (10) being formed at the bottom of the protective shell (1). A damper (11) is fixedly connected to the middle of the inner top wall of each groove (10). A support leg (12) is fixedly connected to the bottom of each damper (11). A shock-absorbing pad (13) is fixedly connected to the bottom of each support leg (12). A shock-absorbing spring (14) is provided on the outer side wall of each damper (11).
3. The protein chip mass spectrometry analysis device according to claim 2, characterized in that: The bottom ends of the plurality of shock-absorbing springs (14) are fixedly connected to the top end of the support leg (12), and the top ends of the plurality of shock-absorbing springs (14) are fixedly connected to the inner top wall of the groove (10).
4. The protein chip mass spectrometry analysis device according to claim 1, characterized in that: The outer wall of the ion input tube (5) is provided with a first outer protective layer (15).
5. The protein chip mass spectrometry analysis device according to claim 1, characterized in that: The outer wall of the ion output tube (6) is provided with a second outer protective layer (16).
6. The protein chip mass spectrometry analysis device according to claim 1, characterized in that: The front end of the protective shell (1) is fixedly connected to the control panel (17).