Biological coating anastomosis staple

Abstract

The utility model discloses a kind of biological coating anastomosis nail, belong to medical instrument technical field.Biological coating anastomosis nail includes anastomosis nail metal matrix, rough structure and biological coating, anastomosis nail metal matrix includes first nail leg, anastomosis nail main body and second nail leg, the first nail leg and the second nail leg are respectively arranged at the both ends of the anastomosis nail main body;Rough structure is arranged on the outer wall of the anastomosis nail metal matrix;Biological coating is arranged on the outer wall of the anastomosis nail metal matrix and covers the rough structure, and the biological component of the biological coating includes one or more of protein, collagen, polysaccharide class.The utility model can better promote cell to climb, accelerate local tissue healing.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a bio-coated anastomotic staple. Background Technology

[0002] Surgical staples, also known as anastomotic staples or surgical staples, are medical devices used to replace traditional hand sutures. Using a specialized stapler, the staple is pushed out of its cartridge, penetrating the tissue and forming a reliable anastomosis on the opposite side. They are commonly used in gastrointestinal reconstruction after surgery, hemorrhoid surgery, and other surgeries requiring tissue suturing. The use of surgical staples can simplify the surgical procedure, reduce surgical time, and lower surgical risks.

[0003] However, with the continuous development of medical technology and the increasing diversification of surgical needs, staples with only a single suturing function are no longer sufficient to meet the actual clinical needs. When existing staples are used for intraoperative wound anastomosis, the wound healing speed and effectiveness are unsatisfactory.

[0004] This section provides background information related to this application, which is not necessarily prior art. Utility Model Content

[0005] The purpose of this invention is to provide a bio-coated anastomotic staple that can better promote cell adhesion and accelerate local tissue healing.

[0006] To achieve the above objectives, the following technical solution is provided:

[0007] Bio-coated staples, including:

[0008] The metal substrate of the staple includes a first stapling leg, a staple body, and a second stapling leg, wherein the first stapling leg and the second stapling leg are respectively disposed at both ends of the staple body;

[0009] A rough structure is provided on the outer wall of the metal substrate of the staples;

[0010] A bio-coating is disposed on the outer wall of the metal substrate of the anastomosis staple and covers the rough structure. The bio-components of the bio-coating include one or more of proteins, collagen, and polysaccharides.

[0011] As an alternative to bio-coated anastomotic staples, the roughened structure includes micropores, with a plurality of such micropores disposed on the outer wall of the first staple leg, and / or

[0012] The outer wall of the second nail leg is provided with a plurality of micropores.

[0013] As an alternative to bio-coated anastomotic staples, the micropore diameter is 10nm-100μm.

[0014] As an alternative to bio-coated staples, the roughened structure further includes strip-shaped grooves disposed on the outer wall of the staple metal substrate, the extension direction of the strip-shaped grooves conforming to the extension direction of the staple metal substrate.

[0015] As an alternative to bio-coated anastomotic staples, the outer wall of the staple metal substrate is provided with a plurality of strip-shaped grooves spaced apart in the circumferential direction.

[0016] As an alternative to bio-coated staples, the carrier component of the bio-coating includes one or more of lactic acid, glycolic acid, and polylactic-co-glycolic acid copolymer.

[0017] As an optional solution for bio-coated anastomotic staples, the overall width of the bio-coated anastomotic staples is 2-6 mm, and the overall height of the bio-coated anastomotic staples is 3-10 mm.

[0018] As an alternative to bio-coated anastomotic staples, the metal substrate of the staples is made of titanium alloy, nickel-titanium alloy, iron alloy, or magnesium alloy.

[0019] As an alternative to bio-coated anastomotic staples, the cross-sectional shape of the staple metal substrate is circular or polygonal.

[0020] As an alternative to the bio-coated anastomosis staple, the first staple leg has a first staple tip at the end furthest from the staple body; and / or

[0021] The second stud leg is provided with a second stud tip at the end away from the main body of the staple.

[0022] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0023] The bio-coated anastomosis staple provided by this invention has a first stapling leg and a second stapling leg connected to both ends of the staple body. The tissue is sutured by puncturing and bending through the first and second stapling legs. The bio-coating is placed on the outer wall of the metal substrate. Since the bio-components of the bio-coating include one or more of proteins, collagen, and polysaccharides, it helps to better promote cell adhesion and accelerate local tissue healing. Due to the rough structure of the outer wall of the bio-coating and the staple metal substrate, the contact stability between the bio-coating and the staple metal substrate is improved, ensuring that the bio-coating will not detach and improving the drug stability of the bio-coated anastomosis staple in promoting tissue healing. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments of this utility model will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the content of the embodiments of this utility model and these drawings without creative effort.

[0025] Figure 1 This is a first-view structural schematic diagram of the bio-coated anastomosis staple in Embodiment 1 of this utility model;

[0026] Figure 2 This is a schematic diagram of the bio-coated anastomosis staple from a second perspective in Embodiment 1 of this utility model;

[0027] Figure 3 This is a first-view structural schematic diagram of the bio-coated anastomosis staple in Embodiment 2 of this utility model;

[0028] Figure 4 This is a schematic diagram of the bio-coated anastomosis staple from a second perspective in Embodiment 2 of this utility model.

[0029] Figure label:

[0030] 1. Metal substrate of the staples; 2. Micropores; 3. Strip grooves;

[0031] 11. First nail leg; 111. First nail tip; 12. Matching nail body; 13. Second nail leg; 131. Second nail tip. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0033] In the description of this utility model, it should be noted that the terms "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this utility model is in use. They are used only for the convenience of describing this utility model and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first," "second," and "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0034] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0035] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0036] To better promote cell adhesion and accelerate local tissue healing, this embodiment provides a bio-coated anastomotic staple, which is described below. Figures 1 to 4 The specific content of this embodiment will be described in detail.

[0037] Example 1

[0038] like Figure 1 Combination Figure 2 As shown, the bio-coated anastomotic staple in this embodiment includes a staple metal substrate 1, a roughening structure, and a bio-coating. The staple metal substrate 1 includes a first staple leg 11, a staple body 12, and a second staple leg 13, with the first staple leg 11 and the second staple leg 13 respectively disposed at both ends of the staple body 12. The roughening structure is disposed on the outer wall of the staple metal substrate 1. The bio-coating is disposed on the outer wall of the staple metal substrate 1 and covers the roughening structure. The biological components of the bio-coating include one or more of proteins, collagen, and polysaccharides. The bio-coating can be applied to the staple metal substrate 1 using electrospinning, ultrasonic spraying, or physical dip coating.

[0039] In summary, the bio-coated anastomotic staple provided by this invention has a first staple leg 11 and a second staple leg 13 connected to both ends of the staple body 12. The tissue is sutured by puncturing and bending through the first staple leg 11 and the second staple leg 13. The bio-coating is placed on the outer wall of the metal substrate. Since the bio-components of the bio-coating include one or more of proteins, collagen, and polysaccharides, it helps to better promote cell adhesion and accelerate local tissue healing. Due to the contact between the bio-coating and the rough structure of the outer wall of the staple metal substrate 1, the contact stability between the bio-coating and the staple metal substrate 1 is improved, ensuring that the bio-coating will not detach and improving the drug stability of the bio-coated anastomotic staple in promoting tissue healing.

[0040] Furthermore, the roughened structure includes micropores 2. Multiple micropores 2 are provided on the outer wall of the first nail leg 11, and / or on the outer wall of the second nail leg 13. By providing multiple micropores 2 on the first nail leg 11 and the second nail leg 13, the adhesion and stability of the bio-coating on the first nail leg 11 and the second nail leg 13 are improved. For example, the diameter of the micropores 2 is 10 nm-100 μm, which allows for a tighter bonding of the bio-coating. Optionally, the micropores 2 in this embodiment can be fabricated by methods such as anodizing or electropolishing.

[0041] Furthermore, the carrier components of the bio-coating include one or more of lactic acid, glycolic acid, poly(lactic-co-glycolic acid) copolymer, and poly(D,L-lactide). Poly(lactic-co-glycolic acid) copolymer (PLGA) is an important biomedical polymer material, randomly polymerized from lactic acid and glycolic acid monomers. PDLLA, or poly(D,L-lactic acid) and also known as poly(D,L-lactide), is an important biomedical polymer material. PDLLA has good biocompatibility, can naturally degrade into lactic acid in vivo, and further metabolize into carbon dioxide and water, thus being non-toxic and harmless to the human body. PDLLA is biodegradable, but its degradation rate is relatively slow, which allows it to provide more lasting therapeutic effects in clinical applications.

[0042] Furthermore, the overall width of the bio-coated staple is 2-6 mm, and the overall height of the bio-coated staple is 3-10 mm. The staple metal substrate 1 is made of titanium alloy, nickel-titanium alloy, iron alloy, or magnesium alloy. The cross-sectional shape of the staple metal substrate 1 is circular or polygonal.

[0043] Furthermore, the first stapling leg 11 has a first stapling tip 111 at the end away from the staple body 12; and / or the second stapling leg 13 has a second stapling tip 131 at the end away from the staple body 12. By adding the first stapling tip 111 and the second stapling tip 131, it is easier for the first stapling leg 11 and the second stapling leg 13 to successfully puncture the tissue in one go, thereby improving the anastomosis success rate of the stapler.

[0044] Example 2

[0045] This embodiment provides a bio-coated anastomosis staple. Compared with Embodiment 1, the basic structure of the bio-coated anastomosis staple provided in this embodiment is the same as that in Embodiment 1, except that the roughness structure is different. This embodiment will not describe the structure that is the same as that in Embodiment 1 again.

[0046] Furthermore, such as Figure 3 Combination Figure 4 As shown, the rough structure also includes a strip groove 3, which is disposed on the outer wall of the anastomosis staple metal substrate 1. The extension direction of the strip groove 3 follows the extension direction of the anastomosis staple metal substrate 1, and the bio-coating can be embedded in the strip groove 3.

[0047] Furthermore, the outer wall of the staple metal substrate 1 is provided with a plurality of strip-shaped grooves 3 spaced apart circumferentially. By providing a plurality of strip-shaped grooves 3 on the outer wall of the staple metal substrate 1, it helps to improve the adhesion of the bio-coating to the staple metal substrate 1.

[0048] The bio-coated anastomotic staple processing method in this embodiment includes the following steps: 1. Selecting a suitable metal wire and feeding it into a cutting and forming device to directly cut it into anastomotic staples with staple tips; 2. After the anastomotic staples are cut and formed, some oxidation is observed, so they are cleaned in an ultrasonic water bath with an acid pickling solution for a period of time; 3. Micropores are created on the surface of the anastomotic staples by anodizing or electrolytic polishing; 4. A polymer carrier containing one or more mixtures of proteins, collagen, and polysaccharides is introduced into a syringe, catheter, or beaker, and any one of electrospinning, ultrasonic spraying, or physical dip coating is performed to prepare the coating on the anastomotic staples mounted on the fixture, while the fixture is rotated. After completion, the anastomotic staples are removed and dried.

[0049] Note that the above description is merely a preferred embodiment of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments. Many other equivalent embodiments may be included without departing from the concept of the present invention, and the scope of the present invention is determined by the scope of the appended claims.

Claims

1. A bio-coated anastomotic staple, characterized in that, include: The metal substrate (1) of the staple includes a first stapling leg (11), a staple body (12) and a second stapling leg (13), wherein the first stapling leg (11) and the second stapling leg (13) are respectively disposed at both ends of the staple body (12); A rough structure is provided on the outer wall of the metal substrate (1) of the staples; A bio-coating is disposed on the outer wall of the metal substrate (1) of the anastomosis staple and covers the rough structure. The bio-components of the bio-coating include one or more of proteins, collagen, and polysaccharides.

2. The bio-coated anastomotic staple according to claim 1, characterized in that, The rough structure includes micropores (2), and a plurality of micropores (2) are provided on the outer wall of the first nail leg (11), and / or The outer wall of the second nail leg (13) is provided with a plurality of microholes (2).

3. The bio-coated anastomotic staple according to claim 2, characterized in that, The diameter of the micropore (2) is 10nm-100μm.

4. The bio-coated anastomotic staple according to claim 1, characterized in that, The rough structure also includes a strip groove (3), which is disposed on the outer wall of the staple metal substrate (1), and the extension direction of the strip groove (3) follows the extension direction of the staple metal substrate (1).

5. The bio-coated anastomotic staple according to claim 4, characterized in that, The outer wall of the metal substrate (1) of the staple is provided with a plurality of strip grooves (3) spaced apart in the circumferential direction.

6. The bio-coated anastomotic staple according to claim 1, characterized in that, The carrier component of the bio-coating includes one or more of lactic acid, glycolic acid, and polylactic acid-glycolic acid copolymer.

7. The bio-coated anastomotic staple according to any one of claims 1-6, characterized in that, The overall width of the bio-coated staple is 2-6 mm, and the overall height of the bio-coated staple is 3-10 mm.

8. The bio-coated anastomosis staple according to claim 7, characterized in that, The metal matrix (1) of the staples is made of titanium alloy, nickel-titanium alloy, iron alloy or magnesium alloy.

9. The bio-coated anastomosis staple according to claim 7, characterized in that, The cross-sectional shape of the metal substrate (1) of the staple is circular or polygonal.

10. The bio-coated anastomotic staple according to claim 7, characterized in that, The first stud leg (11) has a first stud tip (111) at the end away from the staple body (12); and / or The second nail leg (13) is provided with a second nail tip (131) at the end away from the staple body (12).

Images