A pharmaceutical granule spray-drying granulation apparatus

Abstract

The utility model discloses a kind of medicine particle spray drying granulating equipment, it is related to spray drying granulating technical field, and the utility model includes bottom plate, the top of bottom plate is equipped with drying mechanism, for drying atomized medicine particle, drying mechanism includes: feeding assembly includes two drying towers arranged at the top of bottom plate, the top of two drying towers is equipped with Y type pipe, the lower part both ends of Y type pipe are respectively fixedly installed in the top middle part of two drying towers, the present application is differentiated by double drying tower roughness, when medicine particle needs high-strength drying, cylinder drives baffle deflection and is inserted into card slot, guide stock enters the drying tower of larger diameter, the effective reduction hot air flow rate of coarser drying tower, prolong the contact time of hot air and atomized medicine particle, ensure that moisture is fully evaporated;And for the case that drying degree requirement is lower, it can be switched to thinner drying tower, accelerate hot air flow rate, realize rapid drying.

Description

Technical Field

[0001] This utility model relates to the field of spray drying granulation technology, specifically to a spray drying granulation device for pharmaceutical particles. Background Technology

[0002] In the pharmaceutical manufacturing industry, spray drying granulation technology has become one of the key processes for preparing drug particles due to its high efficiency and continuous operation. This technology atomizes drug solutions into tiny droplets, allowing them to come into full contact with hot air and rapidly evaporate moisture to form particles. It is widely used in the production process of various solid dosage forms.

[0003] Referring to the patent document: Patent Publication No. CN213437173U, Patent Publication Date 2021-06-15, a user-friendly high-density metal powder spray drying granulation device is provided, comprising: a bottom plate; two support plates, the two support plates being fixedly connected to the top of the bottom plate; a pressing cylinder, the pressing cylinder being fixedly connected between the tops of the pressing cylinder; a drying chamber, the drying chamber being fixedly connected to the top of the pressing cylinder via two connecting plates; and a pressing granulation assembly, the pressing granulation assembly being disposed inside the pressing cylinder, the pressing granulation assembly including a receiving box, the bottom of the receiving box being fixedly connected to the right side of the top of the bottom plate. This user-friendly high-density metal powder spray drying granulation device eliminates the need for a pressure plate to compress and granulate the material during the granulation process. It utilizes the extrusion force generated by the pressing rod to transform the material into strips, which are then cut into granules by a scraper, greatly reducing the labor intensity of workers and increasing the granulation speed.

[0004] Based on the search of patent numbers and the shortcomings of existing technologies, the following was found:

[0005] In practical applications, most traditional spray drying granulation equipment is difficult to adjust flexibly to meet the drying requirements of different drug particles. It cannot effectively control the hot air flow rate and drying time, resulting in uneven drying of drug particles, which affects the quality and stability of the drug. On the other hand, the inner wall of the drying tower is prone to the adhesion of moist drug particles during use, which affects the drying effect. Usually, the inner wall is scraped and cleaned by rotating scrapers, but long-term use will wear down the inside of the drying tower, making its inner wall rough, which will further deteriorate and cause more drug particles to stick.

[0006] Therefore, this utility model provides a drug particle spray drying granulation equipment. Utility Model Content

[0007] To address the issues that spray drying granulation equipment cannot flexibly adjust to the drying requirements of drug particles, and that drug particles easily stick to the inner wall of the drying tower, which can be damaged by traditional scraper cleaning methods; the purpose of this invention is to provide a spray drying granulation equipment for drug particles.

[0008] To achieve the above objectives, this utility model provides the following technical solution: a drug particle spray drying granulation device, comprising a base plate, wherein a drying mechanism is provided at the top of the base plate for drying the atomized drug particles, the drying mechanism comprising:

[0009] The feeding assembly includes two drying towers set at the top of the base plate. The top of the two drying towers is equipped with a Y-shaped pipe. The lower two ends of the Y-shaped pipe are respectively fixedly installed at the middle of the top of the two drying towers. A rotating shaft is rotatably installed on the upper part of the Y-shaped pipe. A baffle is fixedly installed on the upper part of the rotating shaft. The two ends of the baffle are in contact with the inner wall of the Y-shaped pipe. A drive plate is fixedly installed on one end of the rotating shaft. A cylinder is provided on one side of the upper part of the Y-shaped pipe. The drive end of the cylinder is movably installed on the upper side of the drive plate.

[0010] The cleaning component, located at the top of the drying tower, is used to clean the inner wall of the drying tower.

[0011] Preferably, the cleaning assembly includes a driven gear rotatably mounted on the upper part of the drying tower, a driving gear on one side of the driven gear, the driving gear and the driven gear meshing with each other, a driving assembly at the bottom of the driving gear, and multiple nozzles arranged in a ring array fixedly mounted on the inner walls of both driven gears.

[0012] Preferably, a heating device is fixedly installed on one side of the top of the base plate, and an air supply duct is fixedly installed at the output end of the heating device. One side of the air supply duct is fixedly installed on the top of the two drying towers respectively.

[0013] Preferably, an mounting block is fixedly installed on one side of the upper part of the Y-shaped pipe, and one end of the cylinder is slidably installed on the middle of one side of the mounting block.

[0014] Preferably, a groove is provided on the upper side of the Y-shaped pipe, and the lower side of the baffle is slidably engaged inside the groove.

[0015] Preferably, two fixing frames are fixedly installed at the top of the base plate, and both drying towers are fixedly installed in the middle of the fixing frames.

[0016] Preferably, the drive assembly includes a mounting base fixedly installed on one side of the mounting frame, a servo motor fixedly installed on the top of the mounting base, and the bottom ends of the two drive gears fixedly installed on the drive end of the servo motor.

[0017] Beneficial effects

[0018] This invention provides a spray drying granulation device for pharmaceutical particles. Compared with the prior art, it has the following advantages:

[0019] 1. This application adopts a dual-drying tower design with different coarse and fine diameters. When the drug particles need high-intensity drying, the cylinder drives the baffle to deflect and engage with the slot, guiding the raw liquid into the larger diameter drying tower. The coarser drying tower effectively reduces the hot air flow rate and prolongs the contact time between the hot air and the atomized drug particles, ensuring that the moisture evaporates fully. For situations where the degree of drying is less required, the application can switch to a finer drying tower to accelerate the hot air flow rate and achieve rapid drying.

[0020] 2. This application uses a servo motor to drive the active and driven gears to rotate, causing the nozzles distributed in a ring array to rotate and spray inert gas, which comprehensively covers and cleans the inner wall of the drying tower, effectively preventing drug particles from sticking to the inner wall of the drying tower and affecting the drying effect and equipment operation. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the structure of this utility model.

[0022] Figure 2 This is a cross-sectional structural diagram of the present invention.

[0023] Figure 3 This is a schematic diagram of the cross-sectional structure of the Y-shaped pipe of this utility model.

[0024] Figure 4 This is a schematic diagram of the feeding component structure of this utility model.

[0025] Figure 5 This is a schematic diagram of the cleaning component structure of this utility model.

[0026] Figure 6 This is a schematic diagram of the card slot structure of this utility model.

[0027] In the diagram: 1. Base plate; 2. Drying mechanism; 21. Feeding assembly; 211. Y-shaped pipe; 212. Drying tower; 213. Fixing frame; 214. Cylinder; 2141. Mounting block; 215. Drive plate; 216. Rotating shaft; 217. Baffle; 2171. Slot; 22. Cleaning assembly; 221. Servo motor; 222. Mounting base; 223. Drive gear; 224. Driven gear; 225. Nozzle; 3. Heating equipment; 31. Air supply duct. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0029] Please see Figure 1-6 This utility model provides a technical solution: a drug particle spray drying granulation device, including a base plate 1, and a drying mechanism 2 at the top of the base plate 1 for drying the atomized drug particles. The drying mechanism 2 includes:

[0030] The feeding assembly 21 includes two drying towers 212 disposed at the top of the base plate 1. The two drying towers 212 differ in structural design; one drying tower 212 has a larger diameter, while the other is relatively thinner. This differentiated design addresses different drying requirements. By changing the diameter of the drying tower 212, the flow rate of the hot air entering the drying tower 212 can be controlled, allowing it to flow out quickly (for the thinner drying tower) or reducing the flow rate to ensure thorough mixing and drying with the atomized drug particles (for the coarser drying tower). The bottom of the drying tower 212 is connected to a collection device to collect coarse particles. The finer air, along with the hot air, is drawn together by a fan to a gas-solid separation system for dust removal and recovery of the finer particles. The tops of the two drying towers 212 are equipped with… Y-shaped pipe 211, with its lower ends fixedly installed at the top center of two drying towers 212 respectively. A rotating shaft 216 is rotatably installed on the upper part of the Y-shaped pipe 211, and a baffle 217 is fixedly installed on the upper part of the rotating shaft 216. The two ends of the baffle 217 are in contact with the inner wall of the Y-shaped pipe 211. A drive plate 215 is fixedly installed on one end of the rotating shaft 216. A cylinder 214 is provided on one side of the upper part of the Y-shaped pipe 211. The cylinder 214 is a compact cylinder of the SMCCJ2 series, model CJ2B63-50, with a cylinder diameter of 63mm, a stroke of 50mm, and a maximum pressure resistance of 1.0MPa. It is suitable for precision control scenarios with frequent start and stop. The drive end of the cylinder 214 is movably installed on the upper side of the drive plate 215.

[0031] The cleaning component 22 is located at the top of the drying tower 212 and is used to clean the inner wall of the drying tower 212.

[0032] The cleaning component 22 includes a driven gear 224 rotatably mounted on the upper part of the drying tower 212. A driving gear 223 is provided on one side of the driven gear 224. The driving gear 223 and the driven gear 224 are meshed with each other. A drive component is provided at the bottom of the driving gear 223. Multiple nozzles 225 arranged in a ring array are fixedly installed on the inner wall of both driven gears 224. The nozzles 225 adopt wide-angle spray nozzles, which can achieve full coverage cleaning of the inner wall of the drying tower 212.

[0033] A heating device 3 is fixedly installed on one side of the top of the base plate 1. The heating device 3 includes a blower and a heating element. An air supply duct 31 is fixedly installed at the output end of the heating device 3. One side of the air supply duct 31 is fixedly installed at the top of the two drying towers 212 respectively.

[0034] An installation block 2141 is fixedly installed on one side of the upper part of the Y-shaped pipe 211. One end of the cylinder 214 is slidably installed on the middle of one side of the installation block 2141, so that the cylinder 214 can drive the drive plate 215 to swing.

[0035] A slot 2171 is provided on the upper side of the Y-shaped pipe 211. The lower side of the baffle 217 is slidably locked inside the slot 2171. The size of the slot 2171 is precisely matched with the baffle 217. When the baffle 217 is locked into the slot 2171, it can completely block the channel on one side of the Y-shaped pipe 211.

[0036] Two fixing frames 213 are fixedly installed on the top of the base plate 1. The fixing frames 213 are welded from high-strength steel. Both drying towers 212 are fixedly installed in the middle of the fixing frames 213. The fixing method is to fasten them with bolts and to equip them with anti-loosening gaskets to ensure that the drying towers 212 remain stable during equipment operation.

[0037] The drive assembly includes a mounting base 222 fixedly installed on one side of the mounting bracket 213. A servo motor 221 is fixedly installed on the top of the mounting base 222. The servo motor 221 is a Mitsubishi servo motor model MR-J4-100A+HG-SR102J. The motor has a built-in 20-bit encoder to support full closed-loop control. The driver can exchange data with the PLC in real time. The control mode adopts position mode. The PLC sends pulse commands to control the start, stop and speed of the motor. The bottom ends of the two drive gears 223 are fixedly installed on the drive end of the servo motor 221. The servo motor 221 drives the drive gears 223 to rotate, which drives the meshed driven gear 224 to rotate. This allows multiple nozzles 225 to spray high-pressure air evenly to clean the inner wall of the drying tower 212.

[0038] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0039] During operation, the input end of the Y-shaped pipe 211 is connected to the conveying end of the feed pump of the feeding system, so that the mixed drug liquid is conveyed to the drying tower 212 through the feed pump via the Y-shaped pipe 211. During conveying, depending on the required degree of drying of the drug particles, the drive plate 215 is deflected by the cylinder 214, which drives the rotating shaft 216 to rotate, thereby causing the baffle 217 to deflect to one side. When the required degree of drying of the drug particles is greater, the baffle 217 can be deflected to one side. The deflection causes it to be inserted into the slot 2171. At this time, the raw liquid to be dried enters the coarser drying tower 212 through one end of the Y-shaped pipe 211. The raw liquid is atomized and sprayed out by the centrifugal atomizing device. At this time, the heating device 3 is started, and the blower blows air into the heating device to heat it. The hot air enters the drying tower 212 through the air supply pipe 31. Since the drying tower 212 is coarser, the air velocity is reduced, which allows the hot air to fully and for a long time contact the atomized drug particles to dry them.

[0040] At the same time, by intermittently controlling the start and stop of the servo motor 221, the drive gear 223 is driven to rotate, which in turn drives the driven gear 224 to rotate, that is, drives multiple nozzles 225 to rotate. By connecting the nozzles 225 to the output end of an external air pump, inert gas is blown out to remove the drug particles attached to the inner wall of the drying tower 212.

[0041] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0042] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A spray drying granulation device for pharmaceutical particles, comprising a base plate (1), characterized in that: The top of the base plate (1) is provided with a drying mechanism (2) for drying the atomized drug particles. The drying mechanism (2) includes: The feeding assembly (21) includes two drying towers (212) set at the top of the base plate (1). The top of the two drying towers (212) is provided with a Y-shaped pipe (211). The lower ends of the Y-shaped pipe (211) are respectively fixedly installed at the middle of the top of the two drying towers (212). A rotating shaft (216) is rotatably installed on the upper part of the Y-shaped pipe (211). A baffle (217) is fixedly installed on the upper part of the rotating shaft (216). The two ends of the baffle (217) are in contact with the inner wall of the Y-shaped pipe (211). A drive plate (215) is fixedly installed on one end of the rotating shaft (216). A cylinder (214) is provided on one side of the upper part of the Y-shaped pipe (211). The drive end of the cylinder (214) is movably installed on the upper side of the drive plate (215). A cleaning component (22) is provided at the top of the drying tower (212) for cleaning the inner wall of the drying tower (212).

2. The drug particle spray drying granulation equipment according to claim 1, characterized in that: The cleaning assembly (22) includes a driven gear (224) rotatably mounted on the upper part of the drying tower (212). A driving gear (223) is provided on one side of the driven gear (224). The driving gear (223) and the driven gear (224) are meshed and connected to each other. A driving assembly is provided at the bottom end of the driving gear (223). Multiple nozzles (225) arranged in a ring array are fixedly installed on the inner walls of the two driven gears (224).

3. The drug particle spray drying granulation equipment according to claim 1, characterized in that: A heating device (3) is fixedly installed on one side of the top of the base plate (1), and an air supply pipe (31) is fixedly installed at the output end of the heating device (3). One side of the air supply pipe (31) is fixedly installed on the top of the two drying towers (212).

4. The drug particle spray drying granulation equipment according to claim 1, characterized in that: An installation block (2141) is fixedly installed on one side of the upper part of the Y-shaped pipe (211), and one end of the cylinder (214) is slidably installed on the middle of one side of the installation block (2141).

5. The drug particle spray drying granulation equipment according to claim 1, characterized in that: The upper side of the Y-shaped pipe (211) is provided with a slot (2171), and the lower side of the baffle (217) is slidably locked inside the slot (2171).

6. The drug particle spray drying granulation equipment according to claim 1, characterized in that: Two fixing frames (213) are fixedly installed on the top of the base plate (1), and the two drying towers (212) are fixedly installed in the middle of the fixing frames (213).

7. The drug particle spray drying granulation equipment according to claim 2, characterized in that: The drive assembly includes a mounting base (222) fixedly mounted on one side of the mounting bracket (213). A servo motor (221) is fixedly mounted on the top of the mounting base (222), and the bottom ends of the two drive gears (223) are fixedly mounted on the drive end of the servo motor (221).

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