Chromatographic extraction and purification apparatus

Abstract

The utility model relates to chemical separation equipment technical field discloses a chromatography extraction and purification device, including upper head, cylinder, tetrafluoro area filter screen gasket, pressurizing mouth, fluid distribution device, lower head and flexible connecting pipe, the upper head top connects the cleaning shower nozzle, the upper head inside joint in place the cylinder, and the gasket support framework is inserted to the upper side in the cylinder inner chamber, tetrafluoro area filter screen gasket is laid on gasket support framework surface, and the filler support framework is inserted to the lower side in the cylinder inside, and the lower head is connected to the discharge gate in the lower head inside export, the flexible connecting pipe is connected in the discharge gate export place, the cylinder back upper side connects the pressurizing mouth, and the back pressurizing mouth lower side connects the feed inlet, and the fluid distribution device is connected in the cylinder inside and the feed inlet corresponding position, the device passes through the fluid distribution device and the feed inlet cooperation, makes sample fluid even dispersion, avoids the ditch flow or wall flow, and promotes separation effect and efficiency, and gasket support framework and tetrafluoro area filter screen gasket cooperation realizes the filtration.

Description

Technical Field

[0001] This utility model relates to the field of chemical separation equipment technology, specifically a chromatography extraction and purification device. Background Technology

[0002] In experiments and production processes in fields such as chemistry and biology, chromatography columns are widely used separation tools for separating and purifying different components in mixtures. However, existing chromatography column devices generally have some shortcomings, which seriously affect the separation effect and work efficiency.

[0003] Common chromatography columns lack a scientifically designed distribution structure for fluid handling. After the sample fluid enters the column through the inlet, uneven fluid impact can easily lead to local velocity differences, resulting in "channeling" or "wall flow" phenomena. This prevents the sample components from fully contacting and reacting uniformly with the packing material inside the column, significantly reducing the separation effect between different components and ultimately affecting the overall separation efficiency. Furthermore, traditional chromatography columns often use complex connection methods such as bolt fixing between the end cap and the column body. The disassembly and assembly process requires various tools, making the operation cumbersome. This not only consumes a lot of manpower and time but also easily damages the equipment due to improper disassembly and assembly, significantly reducing the efficiency and ease of maintenance of the equipment. It cannot meet the working requirements of chemical separation equipment. Therefore, a chromatography extraction and purification device is proposed. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a chromatographic extraction and purification device that solves the technical problems of uneven fluid impact leading to local flow rate differences, affecting overall separation efficiency, and complicated assembly and disassembly.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a chromatography extraction and purification apparatus, comprising:

[0006] The upper end cap has a cleaning port at its top, and a cleaning nozzle is connected to the outlet of the cleaning port. A column is snapped into the inside of the upper end cap, and a gasket support frame is inserted into the upper side of the inner cavity of the column.

[0007] A PTFE filter pad is laid on the surface of the pad support frame. A packing support frame is inserted into the lower side of the inside of the column. A lower end cap is snapped into the bottom of the column. A discharge port is connected to the internal outlet of the lower end cap.

[0008] A flexible connecting tube is connected to the outlet of the discharge port. A pressurization port is connected to the upper back side of the column. An inlet is connected to the back of the column below the pressurization port. A fluid distribution device is connected inside the column at a position corresponding to the inlet.

[0009] Preferably, the gasket support frame is provided with protrusions in the inner circumferential direction, and the number of protrusions is 3-6 sets. The edge of the PTFE tape filter gasket is provided with grooves at positions corresponding to the protrusions. The mesh size of the PTFE tape filter gasket is 100-300 mesh. The protrusions allow the PTFE tape filter gasket to be precisely aligned with the gasket support frame, effectively preventing the gasket from shifting or sliding during use and ensuring that the gasket is always in a stable working position.

[0010] Preferably, the front sidewall of the column is fitted with a sight glass, and the number of sight glasses is 3-5 sets. The column is made of engineering plastic. The sight glass inserted in the front sidewall of the column allows the staff to observe the separation status of the sample and the filling status inside the column at any time. The internal working process can be grasped without disassembling the device, abnormalities can be detected and adjusted in time, and errors caused by blind operation can be reduced.

[0011] Preferably, the upper and lower end caps are connected to the column body via a quick-release connection and are equipped with sealing gaskets. The packing support frame is internally filled with stainless steel wire mesh, with 3-6 layers of stainless steel wire mesh. The sealing gaskets at the connection points between the upper and lower end caps and the column body significantly enhance the sealing performance of the connection, effectively preventing fluid leakage from the column body through the connection gaps, preventing sample loss or affecting separation purity due to leakage, and ensuring the sealing performance of the device. The stainless steel wire mesh filling inside the packing support frame further enhances the support strength of the packing material inside the column, preventing the packing material from collapsing or shifting under fluid impact. At the same time, the stainless steel wire mesh also plays a certain role in filtration and diversion, allowing the fluid to pass through the packing layer more evenly.

[0012] Preferably, the feed inlet is connected to the interior of the fluid distribution device. Rubber plugs are inserted at the inlets of both the pressurization port and the feed inlet. The fluid distribution device consists of a conical distributing head and a diverter tube. The feed inlet is connected to the interior of the fluid distribution device to ensure that the sample can smoothly enter the fluid distribution device, avoiding feed blockage and ensuring the continuity of sample delivery. The rubber plugs inserted at the inlets of the pressurization port and the feed inlet can seal the inlets when the device is not in use, preventing external dust and impurities from entering the internal components and contaminating them, thus keeping the device clean.

[0013] Preferably, the inner wall of the feed inlet is provided with internal threads, and a metal reinforcing sleeve is fitted at the connection between the feed inlet and the fluid distribution device. The rubber stopper has a cross-shaped cut in the middle, and the inner wall of the cross-shaped cut is provided with an elastic rubber flap. The internal threads on the inner wall of the feed inlet facilitate connection between the feed inlet and external conveying pipes or components, resulting in stronger stability and less loosening, ensuring smooth feeding. The metal reinforcing sleeve at the connection between the feed inlet and the fluid distribution device enhances the structural strength of the connection, preventing damage due to wear or excessive stress after long-term use, thus extending the service life of the device. The cross-shaped cut and elastic rubber flap in the middle of the rubber stopper allow for easy insertion of external pipes or appliances when a pressurization port or feed inlet is needed. Simultaneously, the elastic rubber flap tightly fits the inserted component, providing a good seal and preventing fluid leakage.

[0014] Compared with the prior art, the present invention provides a chromatographic extraction and purification device, which has the following beneficial effects:

[0015] This chromatographic extraction and purification device, through its fluid distribution mechanism, works in conjunction with the inlet to uniformly disperse the sample fluid entering the column. This avoids localized flow rate differences caused by uneven fluid distribution in traditional chromatography columns, preventing channeling or wall flow. It ensures that all sample components can fully contact and react uniformly with the packing material, significantly improving the separation effect between different components and thus greatly enhancing overall separation efficiency. Simultaneously, the gasket support frame on the upper side of the column works in conjunction with the PTFE filter gasket to effectively filter the sample and prevent impurities from clogging the packing material and affecting the separation process, further ensuring the stability and efficiency of the separation process. The installed packing support frame also provides stable support for the packing material, preventing displacement under fluid impact and maintaining a consistent separation environment within the column. Furthermore, since the upper and lower end caps are connected to the column via snap-fit ​​connections, disassembly and assembly can be completed quickly without the need for complex tools, significantly reducing manpower and time investment during disassembly and avoiding the difficulties caused by complex connection methods such as bolt fixing in traditional equipment. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of this utility model;

[0017] Figure 2 This is a schematic diagram of the pressure port and feed port structure of this utility model;

[0018] Figure 3 This is a schematic diagram of the gasket support frame and the PTFE gasket with filter screen of this utility model;

[0019] Figure 4 This is a schematic diagram of the filler support skeleton structure of this utility model;

[0020] Figure 5 This is a schematic diagram of the combined connection structure of this utility model.

[0021] In the diagram: 1. Upper head; 2. Cleaning port; 3. Cleaning nozzle; 4. Fluid distribution device; 5. Gasket support frame; 6. PTFE gasket with filter screen; 7. Sight glass; 8. Column; 9. Packing support frame; 10. Lower head; 11. Discharge port; 12. Flexible connecting pipe; 13. Pressurization port; 14. Feed port. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] This utility model provides a technical solution: a chromatography extraction and purification device, comprising an upper end cap 1, a cleaning port 2, a cleaning nozzle 3, a fluid distribution device 4, a gasket support frame 5, a PTFE gasket with filter screen 6, a sight glass 7, a column 8, a packing support frame 9, a lower end cap 10, a discharge port 11, a flexible connecting pipe 12, a pressurization port 13, and a feed port 14.

[0024] Please see Figure 1 The top of the upper end cap 1 is provided with a cleaning port 2, and a cleaning nozzle 3 is connected to the outlet of the cleaning port 2. A column 8 is snapped into the inside of the upper end cap 1, and a gasket support frame 5 is inserted into the upper side of the inner cavity of the column 8.

[0025] The PTFE filter pad 6 is laid on the surface of the pad support frame 5. Please refer to [link / reference]. Figure 1 and Figure 4 A packing support frame 9 is inserted into the lower side of the interior of the column 8. A lower end cap 10 is snapped into the bottom of the column 8. A discharge port 11 is connected to the internal outlet of the lower end cap 10. Please refer to [link / reference]. Figure 3 The inner circumferential of the gasket support frame 5 is provided with protrusions, and the number of protrusions is 3-6 sets. The edge of the PTFE belt filter gasket 6 is provided with grooves at the positions corresponding to the protrusions. The mesh size of the PTFE belt filter gasket 6 is 100-300 mesh.

[0026] Please see Figure 1 Flexible connecting pipe 12 is connected to the outlet of discharge port 11. Please refer to [link / reference]. Figure 2 A pressurization port 13 is connected to the upper back of column 8, and a feed port 14 is connected to the back of column 8 below the pressurization port 13. Please refer to [link / reference]. Figure 1A fluid distribution device 4 is connected inside the column 8 at a position corresponding to the feed inlet 14. A sight glass 7 is inserted into the front side wall of the column 8. The number of sight glasses 7 is 3-5 sets. The column 8 is made of engineering plastic.

[0027] Please see Figure 5 The fluid distribution device 4, in conjunction with the feed inlet 14, uniformly disperses the sample fluid entering the column 8 into the interior of the column 8. This avoids localized flow rate differences caused by uneven fluid distribution in traditional chromatography columns, preventing channeling or wall flow. It ensures that all sample components can fully contact and react uniformly with the column packing material, significantly improving the separation effect between different components and thus significantly enhancing the overall separation efficiency. Simultaneously, the gasket support frame 5 on the upper side of the column 8 works in conjunction with the PTFE filter pad 6, effectively filtering the sample while preventing... The separation process is prevented from being blocked by impurities, thus ensuring its stability and efficiency. The packing support frame 9 provides stable support for the packing, preventing displacement under fluid impact and maintaining a consistent separation environment within the column. Furthermore, since the upper end cap 1 and the column body 8, as well as the lower end cap 10 and the column body 8, are connected by snap-fit, disassembly and assembly can be completed quickly without the need for complex tools, significantly reducing manpower and time investment during disassembly and avoiding the disassembly and assembly difficulties caused by complex connection methods such as bolt fixing in traditional equipment.

[0028] The upper end cap 1 and lower end cap 10 are connected to the column 8 by a quick-release connection and are equipped with sealing gaskets. The inside of the packing support skeleton 9 is filled with stainless steel wire mesh, and the number of stainless steel wire mesh layers is 3-6. The feed port 14 is connected to the inside of the fluid distribution device 4. Rubber plugs are inserted at the inlets of the pressurization port 13 and the feed port 14. The fluid distribution device 4 is composed of a conical distribution head and a diverter tube. The inner wall of the feed port 14 is provided with internal threads, and a metal reinforcing sleeve is fitted at the connection between the feed port 14 and the fluid distribution device 4. A cross-shaped cut is opened in the middle of the rubber plug, and an elastic rubber flap is provided on the inner wall of the cross-shaped cut.

[0029] This design, through the fluid distribution device 4, works in conjunction with the feed inlet 14 to uniformly disperse the sample fluid entering the column 8 inside the column 8. This avoids localized flow rate differences caused by uneven fluid distribution in traditional chromatography columns, preventing channeling or wall flow phenomena. It ensures that all sample components can fully contact and react uniformly with the column packing material, significantly improving the separation effect between different components and thus significantly enhancing the overall separation efficiency. Simultaneously, the gasket support frame 5 on the upper side of the column 8 works in conjunction with the PTFE filter gasket 6 to effectively filter the sample. To prevent impurities from clogging the packing and affecting the separation process, the stability and efficiency of the separation process are further guaranteed. The installed packing support frame 9 can provide stable support for the packing, preventing it from shifting under fluid impact and maintaining the consistency of the separation environment inside the column. At the same time, since the upper end cap 1 and the column body 8, as well as the lower end cap 10 and the column body 8, are connected by snap-fit, disassembly and assembly operations can be completed quickly without the need for complicated tools, greatly reducing the manpower and time investment in the disassembly process and avoiding the disassembly and assembly difficulties caused by the complicated connection methods such as bolt fixing in traditional equipment.

[0030] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0031] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A chromatographic extraction and purification apparatus, characterized in that, include: The upper end cap (1) has a cleaning port (2) at its top. A cleaning nozzle (3) is connected to the outlet of the cleaning port (2). A column (8) is snapped into the interior of the upper end cap (1). A gasket support frame (5) is inserted into the upper side of the inner cavity of the column (8). PTFE filter pad (6) is laid on the surface of the pad support frame (5). A filler support frame (9) is inserted into the lower side of the inside of the column (8). A lower end cap (10) is snapped into the bottom of the column (8). A discharge port (11) is connected to the internal outlet of the lower end cap (10). A flexible connecting pipe (12) is connected to the outlet of the discharge port (11). A pressurizing port (13) is connected to the upper back side of the column (8). A feed inlet (14) is connected to the back of the column (8) below the pressurizing port (13). A fluid distribution device (4) is connected to the inside of the column (8) at a position corresponding to the feed inlet (14).

2. The chromatographic extraction and purification apparatus according to claim 1, characterized in that: The inner circumferential of the gasket support frame (5) is provided with protrusions, and the number of protrusions is 3-6 sets. The edge of the PTFE belt filter gasket (6) is provided with grooves at positions corresponding to the protrusions. The mesh size of the PTFE belt filter gasket (6) is 100-300 mesh.

3. The chromatographic extraction and purification apparatus according to claim 1, characterized in that: The front side wall of the column (8) is provided with a sight glass (7), and the number of sight glasses (7) is 3-5 sets. The column (8) is made of engineering plastic.

4. The chromatographic extraction and purification apparatus according to claim 1, characterized in that: The upper end cap (1) and lower end cap (10) are connected to the column (8) by a quick-release connection and are provided with sealing gaskets. The interior of the filler support skeleton (9) is filled with stainless steel wire mesh, and the number of stainless steel wire mesh layers is 3-6.

5. The chromatographic extraction and purification apparatus according to claim 1, characterized in that: The feed inlet (14) is connected to the inside of the fluid distribution device (4). Rubber plugs are inserted at the inlets of both the pressurization port (13) and the feed inlet (14). The fluid distribution device (4) consists of a conical distribution head and a diversion pipe.

6. The chromatographic extraction and purification apparatus according to claim 5, characterized in that: The inner wall of the feed inlet (14) is provided with an internal thread, and a metal reinforcing sleeve is fitted at the connection between the feed inlet (14) and the fluid distribution device (4). A cross-shaped cut is provided in the middle of the rubber plug, and an elastic rubber flap is provided on the inner wall of the cross-shaped cut.

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