A device for cleaning liquid chromatography tandem mass spectrometry

Abstract

The application relates to the technical field of cleaning equipment for liquid chromatography tandem mass spectrometers, in particular to a liquid chromatography tandem mass spectrometry cleaning device which comprises a cleaning device body, a liquid chromatography tandem mass spectrometer, a liquid outlet pipe and a liquid adding pipe, the cleaning device body is arranged on one side of the liquid chromatography tandem mass spectrometer, and one end of the liquid adding pipe is connected with the top of the liquid chromatography tandem mass spectrometer. The cleaning device body, the moving adjusting assembly, the liquid outlet pipe and the liquid adding pipe and other components are arranged, the movable connection of the fixing rod and the connecting ring, the sliding cooperation of the moving block on the fixing rod and the locking of the spring pushing plug-in block inserted into the plug-in groove of the fixing rod are achieved, the cleaning device body can be self-adaptively adjusted in the vertical direction through the moving adjusting assembly, the device can be flexibly adjusted according to the height deviation of different models of mass spectrometers or the installation positions of liquid adding openings, and the effect of accurate butt joint with the liquid adding openings is ensured.

Description

Technical Field

[0001] This application relates to the technical field of cleaning equipment for liquid chromatography-tandem mass spectrometry, and in particular to a cleaning apparatus for liquid chromatography-tandem mass spectrometry. Background Technology

[0002] Liquid chromatography-tandem mass spectrometry (LC-MS / MS) is a technique that combines the separation capabilities of liquid chromatography with the qualitative and quantitative capabilities of mass spectrometry. Liquid chromatography separates mixtures based on differences in substances such as polarity and molecular weight, while mass spectrometry identifies substances through ionization and mass analysis. Its impact lies in its ability to detect trace substances in complex samples with high sensitivity and specificity, and it is widely used in fields such as drug analysis and metabolomics, providing a key means for precise detection.

[0003] A search revealed Chinese Patent Publication No. CN219003899U, which discloses a cleaning device for liquid chromatography-tandem mass spectrometry (LC-MS / MS), comprising an LC-MS / MS spectrometer, a cleaning auxiliary device, a liquid inlet, and a positioning mechanism. The positioning mechanism includes a connecting sleeve movably connected to the outside of the cleaning auxiliary device and fitted onto the outside of the liquid inlet. An active groove is formed on the inner side of the connecting sleeve, and a limiting block is movably connected to the inner side of the active groove. A connecting rod is fixedly connected to one end face of the limiting block near the liquid inlet. A groove is formed on the outer side of the liquid inlet, and one end of the connecting rod is movably connected to the inner side of the groove. A reinforcing component is movably connected to the other end face of the limiting block. Through this positioning mechanism, a connection can be established between the cleaning auxiliary device and the liquid inlet when using the LC-MS / MS cleaning device, ensuring that the connection between the cleaning auxiliary device and the liquid inlet remains stable throughout the cleaning process.

[0004] Regarding the aforementioned technologies, the inventors have discovered the following defects: When the existing cleaning auxiliary device is connected to the liquid inlet of a liquid chromatography-tandem mass spectrometer, its fixing structure adopts a fixed positioning design and lacks an adjustable height compensation mechanism. When facing different models of mass spectrometers or when there are height deviations in the installation position of the liquid inlet, the fixing structure cannot make adaptive vertical adjustments according to the actual working conditions, resulting in the inability to fix it in a suitable position with the liquid inlet, causing inconvenience in use. Utility Model Content

[0005] To address the problems mentioned in the background art, this application provides a cleaning apparatus for liquid chromatography-tandem mass spectrometry.

[0006] This application provides a cleaning device for liquid chromatography-tandem mass spectrometry (LC-MS / MS), which adopts the following technical solution: A cleaning device for LC-MS / MS includes a cleaning device body, a liquid chromatography-tandem mass spectrometer (LC-MS / MS), an outlet tube, and a filling tube. The cleaning device body is disposed on one side of the LC-MS / MS. One end of the filling tube is connected to the top of the LC-MS / MS, and one end of the outlet tube is connected to the bottom of the cleaning device body near the LC-MS / MS. A movable adjustment component is fixedly connected to the bottom of the cleaning device body. The movable adjustment component includes a fixed rod, a connecting ring movably connected to the surface of the fixed rod, a movable block slidably connected to one side of the fixed rod, and the movable block is fixedly connected to the connecting ring. A plug-in block is fixedly connected inside the movable block by a spring. The connecting ring is located on the surface of the outlet tube, and a movable fixing component is disposed on the outside of the filling tube.

[0007] Optionally, the movable fixing assembly includes three sets of clamping blocks, with a movable spring fixedly connected to the outer side of each clamping block, an electromagnetic block fixedly connected to the other end of each movable spring, and a movable block fixedly connected to the outer side of each electromagnetic block.

[0008] Optionally, a movable ring is fixedly connected to the outer side of the connecting ring, and an anti-slip groove is provided on the outer side of the movable ring.

[0009] Optionally, a rubber plate is fixedly connected to the inner side of the clamping block, and a plurality of protrusions are fixedly connected to the inner side of the rubber plate.

[0010] Optionally, the bottom of the connecting ring is rotatably connected to a movable rod via a hinge, and the other end of the movable rod is fixedly connected to the top of the movable block.

[0011] Optionally, a limiting rod is fixedly connected to the surface of the liquid outlet pipe, and the limiting rod is slidably connected to the inside of the connecting ring.

[0012] Optionally, a number of insertion slots are provided on one side of the fixing rod, and the insertion block can be inserted into the insertion slot. A movable rod is fixedly connected to the other side of the insertion block.

[0013] Optionally, the movable blocks are fixedly connected by elastic strips, and several elastic strips are provided, with the elastic strips arranged at equal intervals.

[0014] In summary, this application includes the following beneficial technical effects:

[0015] This invention comprises a cleaning device body, a movable adjustment component, a liquid outlet pipe, and a liquid inlet pipe. Through the movable connection between the fixed rod and the connecting ring, the sliding engagement of the movable block on the fixed rod, and the locking mechanism achieved by the spring pushing the insertion block into the insertion slot of the fixed rod, the cleaning device body can be vertically height-adaptively adjusted via the movable adjustment component. This allows the device to be flexibly adjusted according to the height deviation of different mass spectrometer models or the liquid inlet installation position, ensuring precise alignment with the liquid inlet.

[0016] This invention utilizes a movable fixing component, a rubber plate, protrusions, and an elastic strip. An electromagnetic block, when energized, moves the movable block to control the opening and closing of the clamping block. This, combined with the elastic clamping force of a movable spring, and the inner protrusion of the rubber plate enhancing friction and sealing with the filling pipe, along with the elastic strip providing elastic tension to the movable block, allows the movable fixing component to securely connect the filling pipe through the dual action of electromagnetic control and elastic clamping. This enables the device to adapt to filling pipes of different diameters, achieving rapid fixation, preventing leakage, and improving cleaning stability. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure in an embodiment of this application;

[0018] Figure 2 This is a schematic diagram of the split structure in an embodiment of this application;

[0019] Figure 3 This is a schematic diagram of a partially split cross-sectional structure in an embodiment of this application;

[0020] Figure 4 This is an embodiment of the present application. Figure 3 Enlarged structural diagram at point A in the middle;

[0021] Figure 5 This is an embodiment of the present application. Figure 3 Enlarged structural diagram at point B.

[0022] Reference numerals in the attached diagram: 1. Cleaning device body; 2. Liquid chromatography-tandem mass spectrometry; 3. Discharge tube; 4. Addition tube; 5. Moving adjustment assembly; 51. Fixed rod; 52. Connecting ring; 53. Moving block; 54. Insertion block; 6. Movable fixing assembly; 61. Clamping block; 62. Movable spring; 63. Electromagnetic block; 64. Movable block; 7. Movable ring; 8. Anti-slip groove; 9. Rubber plate; 10. Protrusion; 11. Moving rod; 12. Limiting rod; 13. Insertion groove; 14. Movable rod; 15. Elastic strip. Detailed Implementation

[0023] The following is in conjunction with the appendix Figure 1-5 This application will be described in further detail.

[0024] This application discloses a cleaning apparatus for liquid chromatography-tandem mass spectrometry.

[0025] Please see Figure 1-5 A cleaning device for liquid chromatography-tandem mass spectrometry (LC-MS / MS) includes a cleaning device body 1, an LC-MS / MS spectrometer 2, an outlet tube 3, and an inlet tube 4. The cleaning device body 1 is disposed on one side of the LC-MS / MS spectrometer 2. One end of the inlet tube 4 is connected to the top of the LC-MS / MS spectrometer 2, and one end of the outlet tube 3 is connected to the bottom of the cleaning device body 1 near the LC-MS / MS spectrometer 2. A movable adjustment assembly 5 is fixedly connected to the bottom of the cleaning device body 1. The movable adjustment assembly 5 includes a fixed rod 51, a connecting ring 52 movably connected to the surface of the fixed rod 51, a movable block 53 slidably connected to one side of the fixed rod 51, and the movable block 53 is fixedly connected to the connecting ring 52. A plug-in block 54 is fixedly connected to the inside of the movable block 53 by a spring. The connecting ring 52 is located on the surface of the outlet tube 3, and a movable... The fixed component 6 and the cleaning device body 1 can be adjusted in position by means of the movable adjustment component 5. The fixed rod 51 is movably connected to the connecting ring 52, and the sliding block 53 slides on the fixed rod 51. With the spring and the locking of the plug block 54 in the plug slot 13, the height and position of the cleaning device body 1 can be adjusted according to actual needs. The liquid addition pipe 4 and the liquid outlet pipe 3 are respectively connected to the liquid chromatography-tandem mass spectrometer 2 and the cleaning device body 1, providing a channel for the delivery of cleaning liquid. The movable fixed component 6 is used for the stable connection of the liquid addition pipe 4. The outer side of the connecting ring 52 is fixedly connected to the movable ring 7. The outer side of the movable ring 7 is provided with an anti-slip groove 8. The movable ring 7 on the outer side of the connecting ring 52 and the anti-slip groove 8 on its surface can increase the stability of the connecting ring 52 during movement, avoid slippage during movement, and enhance the ease of movement during use.

[0026] Please see Figure 1-5 The movable fixing component 6 includes three sets of clamping blocks 61. A movable spring 62 is fixedly connected to the outer side of the clamping block 61. An electromagnetic block 63 is fixedly connected to the other end of the movable spring 62. A movable block 64 is fixedly connected to the outer side of the electromagnetic block 63. Under the elastic action of the movable spring 62, the three sets of clamping blocks 61 in the movable fixing component 6 can form a clamping force on the liquid filling tube 4. When the electromagnetic block 63 is energized, it can drive the movable block 64 to move, thereby controlling the opening and closing of the clamping block 61 and realizing the flexible fixing and disassembly of the liquid filling tube 4. A rubber plate 9 is fixedly connected to the inner side of the clamping block 61. Several protrusions 10 are fixedly connected to the inner side of the rubber plate 9. The rubber plate 9 and the protrusions 10 on the inner side of the clamping block 61 can enhance the sealing and friction when clamping the liquid filling tube 4, making the fixing more secure and preventing leakage.

[0027] Please see Figure 1-5The bottom of the connecting ring 52 is rotatably connected to a moving rod 11 via a hinge. The other end of the moving rod 11 is fixedly connected to the top of the movable block 64. The moving rod 11 at the bottom of the connecting ring 52 is connected to the movable block 64 via a hinge. When the connecting ring 52 moves, it can drive the movable block 64 to move, which is convenient for adjustment and use according to different equipment. A limiting rod 12 is fixedly connected to the surface of the liquid outlet pipe 3. The limiting rod 12 is slidably connected to the inside of the connecting ring 52. The limiting rod 12 on the surface of the liquid outlet pipe 3 is slidably connected to the inside of the connecting ring 52, which can limit the movement direction of the connecting ring 52 and prevent the connecting ring 52 from tilting to one side during movement, thereby enhancing the movement stability during use.

[0028] Please see Figure 1-5 The fixed rod 51 has several sets of insertion slots 13 on one side, and the insertion block 54 can be inserted into the insertion slot 13. The other side of the insertion block 54 is fixedly connected to a movable rod 14. The insertion slot 13 on the fixed rod 51 cooperates with the insertion block 54. The spring pushes the insertion block 54 into the insertion slot 13, which can lock the position of the movable block 53 on the fixed rod 51, so that the adjustment position of the cleaning device body 1 remains stable. The movable rod 14 can facilitate the user to move the insertion block 54. There are several elastic strips 15 fixedly connected between the movable blocks 64. The elastic strips 15 are arranged at equal intervals. The elastic strips 15 between the movable blocks 64 can provide elastic tension, which can facilitate the movement of the movable blocks 64 to the surface of pipes of different sizes, thus enhancing the fixing effect during use.

[0029] The implementation principle of the liquid chromatography-tandem mass spectrometry cleaning device in this application embodiment is as follows: In use, the height of the cleaning device body 1 is first adaptively adjusted by the moving adjustment component 5. Specifically, the operator can first pull the plug block 54 to compress the spring and disengage it from the plug slot 13 of the fixed rod 51. At this time, the connecting ring 52 and the moving block 53 can slide freely along the fixed rod 51. At the same time, the limiting rod 12 limits the inner position of the connecting ring 52 to ensure the stability of the moving direction. When the cleaning device body 1 is adjusted to the height corresponding to the liquid inlet of the target mass spectrometer, the plug block 54 is released, and the spring pushes it to insert into the corresponding plug slot 13 to lock it. At this time, the anti-slip groove 8 on the outside of the movable ring 7 can help the operator to hold the connecting ring 52 stably and avoid slippage during the adjustment process.

[0030] Next, the liquid filling tube 4 is quickly fixed by the movable fixing component 6. After the position of the cleaning device body 1 is determined, the moving rod 11 at the bottom of the connecting ring 52 drives the movable block 64 to move through the hinge, so that the three sets of clamping blocks 61 are aligned with the outer wall of the liquid filling tube 4. At this time, the electromagnetic block 63 is energized and generates magnetism, attracting the movable block 64 to move outward. The movable spring 62 is compressed and stores force. When it moves to the appropriate position, the movable spring 62 pushes the clamping block 61 to reset and move when the electromagnetic block 63 is closed. When the rubber plate 9 on its inner side contacts the liquid filling tube 4, the protrusion 10 on the rubber plate 9 is embedded in the pipe surface to enhance friction and sealing. At the same time, the elastic strip 15 between the movable blocks 64 provides elastic tension, which can adapt to liquid filling tubes 4 of different diameters. If disassembly is required, the power of the electromagnetic block 63 is turned on, the clamping block 61 moves and compresses the movable spring 62 to push, and the fixation can be released.

[0031] Subsequently, the cleaning solution is injected into the liquid chromatography-tandem mass spectrometer 2 through the liquid addition tube 4 to complete the cleaning operation and ensure the stability of the device structure throughout the cleaning process. When facing different models of mass spectrometers or deviations in the liquid addition port position, the above adjustment and fixing steps can be repeated. Through the synergistic effect of the movable adjustment component 5 and the movable fixing component 6, the device can be quickly adapted and accurately docked, avoiding leakage or docking failure caused by the non-adjustable fixed structure.

[0032] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A cleaning apparatus for liquid chromatography-tandem mass spectrometry, comprising a cleaning apparatus body (1), a liquid chromatography-tandem mass spectrometer (2), an outlet tube (3), and a filling tube (4), characterized in that: The cleaning device body (1) is located on one side of the liquid chromatography-tandem mass spectrometer (2). One end of the liquid addition tube (4) is connected to the top of the liquid chromatography-tandem mass spectrometer (2). One end of the liquid outlet tube (3) is connected to the bottom of the cleaning device body (1) near the liquid chromatography-tandem mass spectrometer (2). A movable adjustment component (5) is fixedly connected to the bottom of the cleaning device body (1). The movable adjustment component (5) includes a fixed rod (51). A connecting ring (52) is movably connected to the surface of the fixed rod (51). A movable block (53) is slidably connected to one side of the fixed rod (51). The movable block (53) is fixedly connected to the connecting ring (52). A plug block (54) is fixedly connected inside the movable block (53) by a spring. The connecting ring (52) is located on the surface of the liquid outlet tube (3). A movable fixing component (6) is provided on the outside of the liquid addition tube (4).

2. The apparatus for cleaning liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that: The movable fixing component (6) includes three sets of clamping blocks (61). A movable spring (62) is fixedly connected to the outside of the clamping block (61). An electromagnetic block (63) is fixedly connected to the other end of the movable spring (62). A movable block (64) is fixedly connected to the outside of the electromagnetic block (63).

3. The apparatus for cleaning liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that: A movable ring (7) is fixedly connected to the outside of the connecting ring (52), and an anti-slip groove (8) is provided on the outside of the movable ring (7).

4. The apparatus for cleaning liquid chromatography-tandem mass spectrometry according to claim 2, characterized in that: A rubber plate (9) is fixedly connected to the inner side of the clamping block (61), and a number of protrusions (10) are fixedly connected to the inner side of the rubber plate (9).

5. The apparatus for cleaning liquid chromatography-tandem mass spectrometry according to claim 2, characterized in that: The bottom of the connecting ring (52) is rotatably connected to a movable rod (11) via a hinge, and the other end of the movable rod (11) is fixedly connected to the top of the movable block (64).

6. The apparatus for cleaning liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that: The surface of the liquid outlet pipe (3) is fixedly connected to a limiting rod (12), and the limiting rod (12) is slidably connected to the inside of the connecting ring (52).

7. The apparatus for cleaning liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that: The fixed rod (51) has several sets of insertion slots (13) on one side, and the insertion block (54) can be inserted into the insertion slot (13). The other side of the insertion block (54) is fixedly connected to a movable rod (14).

8. The apparatus for cleaning liquid chromatography-tandem mass spectrometry according to claim 2, characterized in that: Elastic strips (15) are fixedly connected between the movable blocks (64), and there are several elastic strips (15) arranged at equal intervals.

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