Portable sampler for biopharmaceuticals

Abstract

The utility model discloses a portable biological pharmacy is with sampler belongs to pharmaceutical sampler technical field, including pump cylinder, pump cylinder outside fixedly connected with antiskid cover about pump cylinder center symmetry distribution with in the pump cylinder sliding connection has piston rod, and piston rod upper end fixedly connected with handle simultaneously, handle lower surface with pump cylinder upper surface is pasted with, and pump cylinder lower end fixedly connected with fixed frame, and fixed frame inner wall slidingly connected with connector, and the connector front side upper end fixedly connected with exhaust hole simultaneously, the connector right side upper end fixedly connected with air inlet pipe. This portable biological pharmacy is with sampler, through setting up the stressed board and the sliding column, can dismantle the sampler, reduce the whole occupies space, make things convenient for staff to carry, and be convenient for staff to move between different sites, can effectively avoid the situation that the device is extruded and the collision occurs simultaneously, has improved the protection to the sampler.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical sampler technology, specifically a portable sampler for biopharmaceutical applications. Background Technology

[0002] Pharmaceutical samplers are crucial tools in the pharmaceutical, biotechnology, and food industries for accurately extracting representative samples from raw materials, intermediates, or finished products. They must strictly adhere to requirements for sterility, contamination-free operation, and precise sampling to ensure drug quality and compliance. Biopharmaceutical samplers are essential tools in biopharmaceutical production processes for accurately extracting representative samples from cell culture media, fermentation broths, intermediates, or finished products. Their design must strictly meet requirements for sterility, pyrogen-free operation, low residue, and high compatibility to ensure the quality and safety of biological products (such as antibodies, vaccines, and recombinant proteins). However, in biopharmaceutical sampling, inserting a steel tube into the powder, rotating it slightly until the groove is filled with powder, and then removing it and emptying the powder from the groove makes accurate positioning difficult, especially when sampling deep into powder samples. Furthermore, the inconvenience of emptying the tube reduces the device's efficiency.

[0003] To overcome the above-mentioned defects, the prior art (Chinese patent application number 202321182867.4, application date 2023-05-16) provides a pharmaceutical powder sampler capable of single-quantitative sampling, including an outer sleeve, an inner sleeve rod, and a replaceable sampling head structure. The outer sleeve has a movable groove inside, extending through the top of the outer sleeve. A first gripping plate is located at the top of the outer sleeve, with a through-hole matching the movable groove. A notch is located on one side of the outer sleeve near its bottom. A threaded groove is located at the bottom end of the inner sleeve rod, and the replaceable sampling head structure is installed in the threaded groove at the bottom end of the inner sleeve rod. This device can conveniently complete single-point quantitative sampling of powder, and the required sampling volume can be changed by replacing the sampling head, effectively avoiding secondary sampling and thus effectively improving the accuracy of sampling and subsequent test results, making it highly practical.

[0004] Biopharmaceutical workshops typically have multiple production stages, such as fermentation, purification, and formulation areas. Each area has different production conditions and sample characteristics, requiring real-time or periodic sampling and monitoring of each stage. Portable samplers allow staff to easily move between different areas, quickly obtain samples, and promptly understand parameter changes during the production process to ensure stable product quality. However, the aforementioned devices are not easy to carry, resulting in the samplers occupying a large amount of space and severely hindering staff from moving flexibly between different areas, thus affecting work efficiency and progress. Utility Model Content

[0005] The purpose of this invention is to provide a portable biopharmaceutical sampler to solve the problems mentioned in the background art, such as the inconvenience of carrying the sampler, the large space occupied by the sampler, and the serious obstruction of the flexible movement of staff between different locations, thereby affecting work efficiency and progress.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a portable biopharmaceutical sampler, comprising a pump cylinder, an anti-slip sleeve fixedly connected to the outer side of the pump cylinder, the anti-slip sleeve being symmetrically distributed about the center of the pump cylinder, and a piston rod slidably connected inside the pump cylinder, with a handle fixedly connected to the upper end of the piston rod; the lower surface of the handle is in contact with the upper surface of the pump cylinder, and a fixing frame is fixedly connected to the lower end of the pump cylinder, with a connector slidably connected to the inner wall of the fixing frame, and an exhaust hole fixedly connected to the upper front side of the connector; an air inlet pipe is fixedly connected to the upper right side of the connector, and a control valve is fixedly connected to the upper left side of the connector, with one-way valves fixedly connected to both the surface of the air inlet pipe and the surface of the exhaust hole, and an air outlet pipe is fixedly connected to the lower surface of the connector; a sliding groove is formed inside the connector through a snap-fit ​​structure.

[0007] Preferably, the engaging structure includes a sliding block slidably disposed on the surface of the sliding groove, and one end of a connecting spring is fixedly connected to the surface of the sliding groove.

[0008] Preferably, the other end of the connecting spring is fixedly connected to the sliding block, and the sliding blocks are symmetrically distributed about the center of the connector.

[0009] Preferably, the surface of the sliding block is inclined at the end near the pump cylinder, and the one-way valve is fixedly connected to the surface of the air outlet pipe.

[0010] Preferably, the fixing frame has a connecting groove inside, and the sliding block is slidably connected to the surface of the connecting groove.

[0011] Preferably, a baffle is fixedly connected to the upper outer side of the fixing frame, and a sliding column is slidably connected inside the baffle, and a push plate is fixedly connected to the surface of the sliding column near the end of the connecting groove.

[0012] Preferably, one end of a buffer spring is fixedly connected to the surface of the push plate, and the other end of the buffer spring is fixedly connected to the baffle. A force-bearing plate is fixedly connected to the surface of the sliding column, and the force-bearing plate is slidably disposed on the surface of the connecting groove.

[0013] Compared with the prior art, the beneficial effects of this utility model are: this portable biopharmaceutical sampler adopts a novel structural design, the specific details of which are as follows: This portable biopharmaceutical sampler, with its designed force plate and sliding column, allows for disassembly, reducing the overall space occupied and making it easier for staff to carry and move between different locations. It also effectively prevents the device from being squeezed or collided with, thus improving the protection of the sampler.

[0014] Furthermore, disassembling the sampler allows staff to easily clean it, removing residual biological liquids and attached microorganisms, ensuring no unsanitary corners, effectively avoiding cross-contamination caused by residual samples, and guaranteeing the accuracy of subsequent sampling.

[0015] This portable biopharmaceutical sampler, with its sliding block and sliding groove, allows for quick connection between the connector and the pump barrel, greatly shortening the sampler assembly time and enabling staff to quickly prepare the sampler for work, effectively improving work efficiency and making the entire sampling process smoother.

[0016] Furthermore, a sealing gasket is used at the connection between the sliding block and the sliding groove to prevent external impurities from entering the sampling system, ensuring that the quality of the collected samples is not contaminated and ensuring the accuracy of subsequent test results.

[0017] (3) The portable biopharmaceutical sampler improves the stability of the device during operation by setting a one-way valve and an exhaust port, ensuring that the gas can smoothly enter the sampler and guaranteeing the accuracy and purity of the sample, providing a reliable sample for subsequent biopharmaceutical analysis. At the same time, it can prevent excessive pressure from impacting the pump body and effectively extend the service life of the device. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the connection structure between the pump barrel and the fixing frame of this utility model.

[0019] Figure 2 This is a schematic diagram of the connection structure between the piston rod and the handle of this utility model.

[0020] Figure 3 This is a schematic diagram of the connection structure between the connector and the air outlet pipe of this utility model.

[0021] Figure 4 This is a schematic diagram of the connection structure between the connector and the vent hole of this utility model.

[0022] Figure 5 This utility model Figure 4 Enlarged structural diagram at point A in the middle.

[0023] Figure 6 This is a schematic diagram of the connection structure between the sliding column and the force-bearing plate of this utility model.

[0024] Figure 7 This is a schematic diagram of the connection structure between the push plate and the sliding column of this utility model.

[0025] In the diagram: 1. Pump cylinder; 2. Piston rod; 3. Handle; 4. Anti-slip sleeve; 5. Exhaust port; 6. Air outlet pipe; 7. Air inlet pipe; 8. Control valve; 9. Connector; 10. Sliding groove; 11. Connecting spring; 12. Sliding block; 13. Fixing frame; 14. Connecting groove; 15. Baffle; 16. Sliding column; 17. Push plate; 18. Buffer spring; 19. Force plate; 20. One-way valve. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] Example 1: By incorporating the anti-slip sleeve 4, one-way valve 20, and pump cylinder 1, the stability of the device during operation is improved, and excessive pressure impact on the pump body is prevented, effectively extending the service life of the device. Figures 1-3 As shown: It includes a pump cylinder 1, with an anti-slip sleeve 4 fixedly connected to the outside of the pump cylinder 1. The anti-slip sleeve 4 is symmetrically distributed about the center of the pump cylinder 1. A piston rod 2 is slidably connected inside the pump cylinder 1. A handle 3 is fixedly connected to the upper end of the piston rod 2. The lower surface of the handle 3 is in contact with the upper surface of the pump cylinder 1. A fixing frame 13 is fixedly connected to the lower end of the pump cylinder 1. A connector 9 is slidably connected to the inner wall of the fixing frame 13. An exhaust hole 5 is fixedly connected to the upper front side of the connector 9. An air inlet pipe 7 is fixedly connected to the upper right side of the connector 9. A control valve 8 is fixedly connected to the upper left side of the connector 9. One-way valves 20 are fixedly connected to both the surface of the air inlet pipe 7 and the surface of the exhaust hole 5. An air outlet pipe 6 is fixedly connected to the lower surface of the connector 9. A sliding groove 10 is opened inside the connector 9 through a snap-fit ​​structure.

[0028] The operator moves handle 3 up and down, causing piston rod 2 to slide back and forth inside pump cylinder 1. When handle 3 is pulled upwards, piston rod 2 moves upwards, increasing the volume inside pump cylinder 1 and decreasing the pressure. At this time, at the inlet pipe 7, one-way valve 20 opens because the external pressure is greater than the pressure inside pump cylinder 1. The gas sample enters connector 9 through inlet pipe 7 under the action of pressure difference and further flows into pump cylinder 1. Simultaneously, during the sampling process, when the pressure inside pump cylinder 1 is higher than a certain external value, one-way valve 20 opens, and some gas is discharged, thereby preventing excessive pressure from impacting the pump body and maintaining the stability of the device during operation. At the same time, control valve 8 can be used to adjust the gas or liquid flow rate of inlet pipe 7 to further ensure the smoothness of the sampling process. When the operator carries the sampler, they can press the sliding column 16 on the outside of the fixing frame 13 (e.g., Figure 6 As shown in the figure, the connector 9 is separated from the fixing frame 13, which not only makes it convenient for staff to carry, but also greatly reduces the overall size. At the same time, after the sampler is disassembled, staff can easily clean the sampler, remove residual biological liquid and attached microorganisms, ensure no unsanitary dead corners, effectively avoid cross-contamination caused by residual samples, and ensure the accuracy of subsequent sampling.

[0029] In Example 2, unlike Example 1, the sliding groove 10, connecting spring 11, and sliding block 12 enable the connector 9 to be quickly connected to the pump cylinder 1, greatly shortening the sampler assembly time. Figures 4-5 As shown: The engaging structure includes a sliding block 12 slidably disposed on the surface of the sliding groove 10, and one end of a connecting spring 11 is fixedly connected to the surface of the sliding groove 10. The other end of the connecting spring 11 is fixedly connected to the sliding block 12, and the sliding block 12 is symmetrically distributed about the center of the connector 9. The surface of the sliding block 12 is inclined at the end near the pump cylinder 1, and a one-way valve 20 is fixedly connected to the surface of the air outlet pipe 6.

[0030] When connecting connector 9 to the fixing frame 13 at the lower end of pump cylinder 1, the operator holds connector 9, keeping it parallel to the pump cylinder 1 at the lower end of fixing frame 13, and slowly pushes connector 9 to slide inside fixing frame 13 (e.g., Figure 3 and Figure 4 As shown), when the connector 9 contacts the fixing bracket 13, the fixing bracket 13 pushes the sliding block 12 on the outer side of the connector 9 to slide on the surface of the sliding groove 10, and the sliding block 12 pushes the connecting spring 11 on the surface to retract towards the inner wall of the connector 9 (as shown). Figure 5 As shown), when the upper surface of the connector 9 is in contact with the lower surface of the fixing bracket 13, the connecting spring 11 pushes the sliding block 12 to slide on the surface of the connecting groove 14, and makes the sliding block 12 fit tightly against the surface of the connecting groove 14 (as shown). Figure 7As shown in the figure, the connection between the connector 9 and the fixing frame 13 is realized, which greatly shortens the sampler assembly time and enables the staff to quickly prepare the sampler for work, effectively improving work efficiency. At the same time, it makes the whole sampling process smoother. In addition, the sealing gasket at the connection between the sliding block 12 and the sliding groove 10 can prevent external impurities from entering the sampling system, ensuring that the quality of the collected sample is not contaminated and ensuring the accuracy of subsequent test results.

[0031] In embodiment three, unlike embodiment two, the sampler can be disassembled using the connecting slot 14, baffle 15, and buffer spring 18, reducing the overall space occupied and making it easier for staff to carry. Figures 6-7 As shown: The fixed frame 13 has a connecting groove 14 inside, and a sliding block 12 is slidably connected to the surface of the connecting groove 14. A baffle 15 is fixedly connected to the upper outer side of the fixed frame 13, and a sliding column 16 is slidably connected inside the baffle 15. A push plate 17 is fixedly connected to one end of the sliding column 16 near the connecting groove 14. One end of a buffer spring 18 is fixedly connected to the surface of the push plate 17, and the other end of the buffer spring 18 is fixedly connected to the baffle 15. A force plate 19 is fixedly connected to the surface of the sliding column 16, and the force plate 19 is slidably disposed on the surface of the connecting groove 14.

[0032] When the staff carries the sampler, they press the sliding post 16 on the outside of the fixing frame 13 (as shown). Figure 6 As shown), at this time, the force plate 19 at the end of the sliding column 16 slides on the surface of the connecting groove 14 inside the fixed frame 13, and drives the buffer spring 18 on the surface of the push plate 17 to retract towards the surface of the baffle 15 on the outside of the fixed frame 13, thereby causing the force plate 19 to push the sliding block 12 to slide towards the inner wall of the connector 9 (as shown). Figure 5 and Figure 7 As shown, when the sliding block 12 is fully inserted into the connector 9, the connector 9 is pulled to separate it from the fixing frame 13. This not only makes it convenient for staff to carry, but also greatly reduces the overall size. In practical applications, the disassembled sampler components can be compactly stored, taking up less space and making it easy to put into various small tool bags or lab coat pockets.

[0033] The above is the entire working process of the device, and all contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0034] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A portable biopharmaceutical sampler, comprising a pump cylinder (1), an anti-slip sleeve (4) fixedly connected to the outside of the pump cylinder (1), the anti-slip sleeve (4) being symmetrically distributed about the center of the pump cylinder (1), and a piston rod (2) being slidably connected inside the pump cylinder (1), while a handle (3) is fixedly connected to the upper end of the piston rod (2). Its features are: The lower surface of the handle (3) is in contact with the upper surface of the pump cylinder (1), and a fixed frame (13) is fixedly connected to the lower end of the pump cylinder (1), and a connector (9) is slidably connected to the inner wall of the fixed frame (13), while an exhaust hole (5) is fixedly connected to the upper front side of the connector (9). An air inlet pipe (7) is fixedly connected to the upper right side of the connector (9), and a control valve (8) is fixedly connected to the upper left side of the connector (9). A one-way valve (20) is fixedly connected to both the surface of the air inlet pipe (7) and the surface of the exhaust hole (5). At the same time, an air outlet pipe (6) is fixedly connected to the lower surface of the connector (9). The connector (9) has a sliding groove (10) inside through a snap-fit ​​structure.

2. The portable biopharmaceutical sampler according to claim 1, characterized in that: The engaging structure includes a sliding block (12) slidably disposed on the surface of the sliding groove (10), and one end of a connecting spring (11) is fixedly connected to the surface of the sliding groove (10).

3. A portable biopharmaceutical sampler according to claim 2, characterized in that: The other end of the connecting spring (11) is fixedly connected to the sliding block (12), and the sliding block (12) is symmetrically distributed about the center of the connector (9).

4. A portable biopharmaceutical sampler according to claim 3, characterized in that: The surface of the sliding block (12) is inclined at the end near the pump cylinder (1), and the one-way valve (20) is fixedly connected to the surface of the air outlet pipe (6).

5. A portable biopharmaceutical sampler according to claim 4, characterized in that: The fixing frame (13) has a connecting groove (14) inside, and the sliding block (12) is slidably connected to the surface of the connecting groove (14).

6. A portable biopharmaceutical sampler according to claim 5, characterized in that: A baffle (15) is fixedly connected to the upper outer side of the fixed frame (13), and a sliding column (16) is slidably connected inside the baffle (15), and a push plate (17) is fixedly connected to one end of the sliding column (16) near the connecting groove (14).

7. A portable biopharmaceutical sampler according to claim 6, characterized in that: The push plate (17) has one end of a buffer spring (18) fixedly connected to its surface, and the other end of the buffer spring (18) is fixedly connected to the baffle (15). The sliding column (16) has a force plate (19) fixedly connected to its surface, and the force plate (19) is slidably disposed on the surface of the connecting groove (14).

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