Sample injection device for high performance liquid chromatography tandem mass spectrometer

Abstract

The application relates to the technical field of sample injection devices of high-performance liquid chromatography tandem mass spectrometers, in particular to a sample injection device of a high-performance liquid chromatography tandem mass spectrometer, which comprises a box body, a side plate is fixedly connected to the middle part of the right end of the box body, a liquid suction pipe is fixedly connected to the middle part of the upper end of a liquid storage box, a first switch valve is arranged on the outer surface of the liquid suction pipe, a sleeve is fixedly connected to the other end of the liquid suction pipe, a supporting plate is fixedly connected to the middle part of the upper end of the box body, a first electric push rod is fixedly connected to the middle part of the upper end of the supporting plate, a driving motor is fixedly connected to the middle part of the lower box wall of the box body, and a control table is fixedly connected to the left part of the lower box wall of the box body. Through cooperation of the liquid storage box, the electric push rod and other components, large-capacity sample storage and accurate transmission, accurate control of sample injection quantity and position are realized, and problems such as frequent sample injection, transmission error and inaccurate sample injection of traditional devices are solved.

Description

Technical Field

[0001] This application relates to the field of sample introduction devices for high performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS), and particularly to sample introduction devices for HPLC-MS / MS. Background Technology

[0002] High performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) is widely used in compound detection and analysis due to its high selectivity and high sensitivity; however, the injection devices currently on the market have many problems. In terms of sample storage and addition, traditional sample introduction devices are unable to store large quantities of liquid samples to be tested, requiring operators to frequently add samples. This not only consumes time and effort but also easily introduces errors during operation, greatly affecting testing efficiency. Moreover, existing sample storage containers usually lack an effective way to visually check the remaining sample volume, making it difficult for operators to know the sample balance in a timely manner. This may lead to interruptions in the testing process due to insufficient samples, delaying the testing work. In the sample transfer and injection stages, some sample introduction devices have complex structures and unreasonable sample transfer channel designs, making it easy for samples to leak or backflow during transfer. This seriously affects the accuracy and stability of sample delivery, thereby reducing the reliability of test results. At the same time, the adjustment of the injection position is not flexible enough to adapt to different testing needs, making it impossible to achieve precise injection and limiting the diversity and accuracy of testing. Utility Model Content

[0003] To address the problems mentioned in the background section, this application provides an injection device for a high-performance liquid chromatography-tandem mass spectrometer.

[0004] The sample introduction device for a high-performance liquid chromatography-tandem mass spectrometer provided in this application adopts the following technical solution: it includes a housing, a side plate fixedly connected to the middle of the right end of the housing, a liquid storage box fixedly connected to the upper end of the side plate, a box cover provided at the front of the upper end of the liquid storage box, a first observation strip provided at the front of the right end of the liquid storage box, a liquid extraction tube fixedly connected to the middle of the upper end of the liquid storage box, a first switch valve provided on the outer surface of the liquid extraction tube, a sleeve fixedly connected to the other end of the liquid extraction tube, a support plate fixedly connected to the middle of the upper end of the housing, a first electric push rod fixedly connected to the middle of the upper end of the support plate, a drive motor fixedly connected to the middle of the lower wall of the housing, and a control panel fixedly connected to the left side of the lower wall of the housing.

[0005] Optionally, the output end of the first electric push rod passes through the support plate and is fixedly connected to a piston push block. A second observation strip cover is provided on the front of the outer surface of the sleeve. The sleeve is inserted and fixedly connected to the middle of the upper end of the box. A second electric push rod is fixedly connected to the lower left end of the sleeve.

[0006] Optionally, the output end of the second electric push rod is fixedly connected to a circular box, a movable collar is fixedly connected to the upper middle part of the circular box, a telescopic tube is sleeved on the upper middle part of the movable collar, a second switch valve is provided on the lower part of the outer surface of the telescopic tube, multiple connectors are fixedly connected to the lower end of the circular box, a brush plate is fixedly connected to the open end of the connectors, and the other end of the telescopic tube is fixedly connected to the lower middle part of the sleeve.

[0007] Optionally, the output end of the drive motor passes through the housing and is fixedly connected to a small gear. A large gear is meshed with the left side of the outer surface of the small gear. A rotating block is fixedly connected to the upper middle part of the large gear. A turntable is fixedly connected to the upper end of the rotating block. The bottom of the large gear is movably connected to the housing through a bearing.

[0008] Optionally, the rotating block is rotatably connected to the housing, and the bottom of the turntable does not contact the drive motor.

[0009] Preferably, the piston pusher is in close contact with the inner wall of the sleeve.

[0010] Preferably, the sleeve is connected to the inside of the liquid storage box via a liquid extraction tube, and the sleeve is connected to the inside of the round box, the brush plate, and the brush plate via a telescopic tube.

[0011] In summary, this application includes the following beneficial technical effects: This invention incorporates components such as a storage box, a first observation strip, a suction tube, and a first switching valve. The storage box, fixed to the upper part of the side plate, can store a large number of samples to be tested. The first observation strip, combined with the transparent material of the storage box, forms a viewing window. The suction tube, controlled by the first switching valve, connects to the sleeve. When the sample is stored in the storage box, the large-capacity design reduces the need for frequent sample additions. The operator can monitor the remaining amount in real time through the first observation strip. When a sample needs to be extracted, the first switching valve is opened, and the sample is accurately delivered to the sleeve through the suction tube, avoiding interruptions in testing due to insufficient sample. This invention solves the problems of small storage capacity, frequent sample additions, and testing interruptions caused by insufficient sample in traditional devices, thus improving testing efficiency and continuity.

[0012] This invention comprises a first electric push rod, a piston push block, a second electric push rod, a sleeve, and a second observation strip cover. The output end of the first electric push rod is connected to the piston push block, which is in close contact with the inner wall of the sleeve. The output end of the second electric push rod is connected to the circular box and communicates with the sleeve through a telescopic tube. The second observation strip cover is used to monitor the sample volume. The precise extension and retraction of the first electric push rod drives the piston push block to move within the sleeve. Combined with the tight contact between the piston push block and the inner wall of the sleeve, precise control of the sample extraction volume is achieved. The second observation strip cover assists in dose calibration. The second electric push rod lifts and lowers the circular box and the brush plate, which, together with the drive motor, drives the turntable to rotate, enabling precise multi-position sample injection. This invention solves the problems of dose error caused by sample transmission leakage and backflow in traditional devices, as well as the fixed injection position, which cannot adapt to different detection needs, significantly improving detection accuracy and applicability. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the overall structure in an embodiment of this application; Figure 2 These are partial structural schematic diagrams of embodiments of this application; Figure 3 These are partial structural schematic diagrams of embodiments of this application; Figure 4 This is a magnified structural diagram of section A in the embodiments of this application.

[0014] Reference numerals: 1. Box body; 2. Support plate; 3. Side plate; 4. Liquid storage box; 5. Liquid extraction tube; 6. First observation strip cover; 7. Box cover; 8. First switch valve; 9. First electric push rod; 10. Sleeve; 11. Second observation strip cover; 12. Turntable; 13. Control panel; 14. Piston push block; 15. Second electric push rod; 16. Round box; 17. Telescopic tube; 18. Second switch valve; 19. Movable collar; 20. Connector; 21. Brush plate; 22. Drive motor; 23. Small gear; 24. Large gear; 25. Rotating block. Detailed Implementation

[0015] The following is in conjunction with the appendix Figure 1-4 This application will be described in further detail.

[0016] This application discloses an injection device for a high-performance liquid chromatography-tandem mass spectrometer. For example... Figure 1 and Figure 2As shown, the device includes a housing 1, with a side plate 3 fixedly connected to the middle of the right end of the housing 1. This makes the entire sample injection device structure more stable, facilitates the installation and fixation of other components, and ensures that the device will not easily shake during operation, providing a stable foundation for subsequent accurate sample injection. A liquid storage box 4 is fixedly connected to the upper end of the side plate 3, which can store a large amount of liquid sample to be tested, reducing the need for frequent sample addition and improving detection efficiency. A box cover 7 is provided at the front of the upper end of the liquid storage box 4, and a first observation strip 6 is provided at the front of the right end of the liquid storage box 4. The remaining amount of sample in the liquid storage box 4 can be directly viewed through the first observation strip 6 so as to replenish the sample in time and avoid affecting the detection process due to insufficient sample.

[0017] Please see Figure 1 and Figure 2 A suction tube 5 is fixedly connected to the upper middle part of the liquid storage box 4, which is used to transport the sample in the liquid storage box 4 to subsequent components. It is an important channel for sample transfer. A first switch valve 8 is provided on the outer surface of the suction tube 5, which can control the flow of the sample in the suction tube 5. When the sample does not need to be extracted, the first switch valve 8 is closed to prevent sample leakage and unnecessary waste. A sleeve 10 is fixedly connected to the other end of the suction tube 5 to realize the transfer of the sample from the suction tube 5 to the sleeve 10, ensuring the continuity of sample transfer. A support plate 2 is fixedly connected to the upper middle part of the box 1, and a first electric push rod 9 is fixedly connected to the upper middle part of the support plate 2. Through the extension and retraction of the first electric push rod 9, the movement of the piston push block 14 can be precisely controlled, thereby realizing precise control of the sample extraction volume. An electric push rod 9 has its output end passing through a support plate 2 and is fixedly connected to a piston push block 14. The piston push block 14 is tightly attached to the inner wall of the sleeve 10 to prevent the sample from leaking or flowing back inside the sleeve 10, ensuring the accuracy and stability of sample delivery. A second observation strip cover 11 is provided on the front of the outer surface of the sleeve 10. The sleeve 10 is inserted and fixedly connected to the upper middle part of the box 1. The sleeve 10 communicates with the inside of the liquid storage box 4 through the liquid extraction tube 5, realizing the smooth transfer of the sample from the liquid storage box 4 to the sleeve 10. The sleeve 10 communicates with the round box 16, the brush plate 21 and the inside of the brush plate 21 through the telescopic tube 17. A second electric push rod 15 is fixedly connected to the lower left part of the sleeve 10 to control the lifting and lowering of the round box 16 and other components, so as to facilitate the adjustment of the sample injection position and adapt to different detection needs.

[0018] Please see Figure 1 and Figure 3A drive motor 22 is fixedly connected to the middle of the lower wall of the housing 1, providing power to the rotating parts of the entire device and driving the relevant parts to rotate, so as to achieve uniform distribution of samples and sample injection operations at different positions. A control panel 13 is fixedly connected to the left side of the lower wall of the housing 1, which facilitates the operator to control and operate the entire sample injection device, set operating parameters, and monitor the operating status of the device. The output end of the drive motor 22 passes through the housing 1 and is fixedly connected to a small gear 23. A large gear 24 is meshed with the left side of the outer surface of the small gear 23. The upper end of the large gear 24... A rotating block 25 is fixedly connected in the middle, which transmits the rotation of the large gear 24 to the rotating block 25, thereby driving the turntable 12 to rotate. The rotating block 25 is rotatably connected to the housing 1, ensuring that the rotating block 25 can rotate flexibly and that the turntable 12 runs smoothly. The upper end of the rotating block 25 is fixedly connected to the turntable 12. The bottom of the turntable 12 does not contact the drive motor 22, so as to avoid friction and collision between the turntable 12 and the drive motor 22, and ensure the safety and stability of the device operation. The bottom of the large gear 24 is movably connected to the housing 1 through a bearing.

[0019] Please see Figure 1 , Figure 2 and Figure 4 The output end of the second electric push rod 15 is fixedly connected to a circular box 16. The second electric push rod 15 controls the lifting and lowering of the circular box 16, adjusting the relative position of the circular box 16 with components such as the turntable 12 to achieve precise sample injection. A movable collar 19 is fixedly connected to the upper middle part of the circular box 16. The movable collar 19 allows the telescopic tube 17 to move within a certain range, preventing the telescopic tube 17 from being pulled by the movement of the circular box 16 and ensuring the stability of sample transmission. The movable collar 19 is fixedly connected to the upper middle part of the circular box 16, and the telescopic tube 17 is sleeved on the upper middle part of the movable collar 19, allowing the sample to be fed from the sleeve... The sample is transferred from the sleeve 10 to the round box 16, and the telescopic tube 17 can extend and retract according to the position change of the round box 16 to ensure the flexibility of the transfer. A second switch valve 18 is provided on the lower part of the outer surface of the telescopic tube 17. Multiple connectors 20 are fixedly connected to the lower end of the round box 16. The multiple connectors 20 can evenly distribute the sample to the brush plate 21 to achieve uniform sample distribution. The open ends of the connectors 20 are all fixedly connected to the brush plate 21. The other end of the telescopic tube 17 is fixedly connected to the middle of the lower end of the sleeve 10 to achieve stable transfer of the sample from the sleeve 10 to the round box 16 and ensure the continuity of sample delivery.

[0020] The implementation principle of the sample introduction device of the high-performance liquid chromatography-tandem mass spectrometer in this application embodiment is as follows: When the sample introduction device of the high-performance liquid chromatography-tandem mass spectrometer is working, firstly, the liquid sample to be detected is stored in the liquid storage box 4 fixedly connected to the upper end of the side plate 3, reducing the operation of frequently adding samples and improving detection efficiency. The remaining amount of sample can be directly viewed through the first observation strip 6 at the front right end of the liquid storage box 4, so that the sample can be replenished in time. When it is necessary to extract the sample, the first switch valve 8 on the outer surface of the extraction tube 5 is opened, and the sample in the liquid storage box 4 is transported to the sleeve 10 through the extraction tube 5. The extraction tube 5 is an important channel for sample transmission, realizing the smooth transmission of the sample from the liquid storage box 4 to the sleeve 10. At this time, the first electric push rod 9 fixedly connected to the middle of the upper end of the support plate 2 is activated, and its output end extends and retracts, driving the piston push block 14 fixedly connected to it to move inside the sleeve 10. Because the piston push block 14 is in close contact with the inner wall of the sleeve 10, it can prevent sample leakage or backflow, thereby accurately controlling the sample extraction volume. The operator can observe the sample status and remaining amount in real time through the second observation strip 11 on the front of the outer surface of the sleeve 10. Then, the sample enters the round box 16 from the sleeve 10 through the telescopic tube 17. The second switch valve 18 on the lower surface of the telescopic tube 17 can control the sample flow and avoid unnecessary leakage. Multiple connectors 20 at the lower end of the round box 16 evenly distribute the sample to the brush plate 21 to achieve uniform sample distribution. At the same time, the drive motor 22 fixedly connected to the middle of the lower wall of the box 1 starts, and its output end drives the small gear 23 to rotate. The small gear 23 meshes with the large gear 24 to achieve power deceleration transmission. The large gear 24 drives the rotating block 25 to rotate, which in turn makes the turntable 12 rotate. During the rotation of the turntable 12, the sample can be injected at different positions to achieve uniform sample distribution and multi-position detection. In addition, the second electric push rod 15 fixedly connected to the lower left of the sleeve 10 can control the lifting and lowering of the round box 16 and other components to adjust the injection position to adapt to different detection needs and ultimately achieve accurate injection.

[0021] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. An injection device for a high-performance liquid chromatography-tandem mass spectrometer, comprising a housing (1), characterized in that: A side plate (3) is fixedly connected to the middle of the right end of the box (1). A liquid storage box (4) is fixedly connected to the upper end of the side plate (3). A box cover (7) is provided at the front of the upper end of the liquid storage box (4). A first observation strip cover (6) is provided at the front of the right end of the liquid storage box (4). A liquid extraction tube (5) is fixedly connected to the middle of the upper end of the liquid storage box (4). A first switch valve (8) is provided on the outer surface of the liquid extraction tube (5). A sleeve (10) is fixedly connected to the other end of the liquid extraction tube (5). A support plate (2) is fixedly connected to the middle of the upper end of the box (1). A first electric push rod (9) is fixedly connected to the middle of the upper end of the support plate (2). A drive motor (22) is fixedly connected to the middle of the lower box wall of the box (1). A control panel (13) is fixedly connected to the left side of the lower box wall of the box (1).

2. The sample introduction device for a high-performance liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that: The output end of the first electric push rod (9) passes through the support plate (2) and is fixedly connected to the piston push block (14). The front of the outer surface of the sleeve (10) is provided with a second observation strip cover (11). The sleeve (10) is inserted and fixedly connected to the middle of the upper end of the box (1). The lower left end of the sleeve (10) is fixedly connected to the second electric push rod (15).

3. The sample introduction device for a high-performance liquid chromatography-tandem mass spectrometer according to claim 2, characterized in that: The output end of the second electric push rod (15) is fixedly connected to a round box (16). A movable collar (19) is fixedly connected to the middle of the upper end of the round box (16). A telescopic tube (17) is sleeved on the middle of the upper end of the movable collar (19). A second switch valve (18) is provided on the lower part of the outer surface of the telescopic tube (17). Multiple connectors (20) are fixedly connected to the lower end of the round box (16). A brush plate (21) is fixedly connected to the open end of the connectors (20). The other end of the telescopic tube (17) is fixedly connected to the middle of the lower end of the sleeve (10).

4. The sample introduction device for a high-performance liquid chromatography-tandem mass spectrometer according to claim 1, characterized in that: The output end of the drive motor (22) passes through the housing (1) and is fixedly connected to a small gear (23). A large gear (24) is meshed with the left side of the outer surface of the small gear (23). A rotating block (25) is fixedly connected to the middle of the upper end of the large gear (24). A turntable (12) is fixedly connected to the upper end of the rotating block (25). The bottom of the large gear (24) is movably connected to the housing (1) through a bearing.

5. The sample introduction device for a high-performance liquid chromatography-tandem mass spectrometer according to claim 4, characterized in that: The rotating block (25) is rotatably connected to the housing (1), and the bottom of the turntable (12) does not contact the drive motor (22).

6. The sample introduction device for a high-performance liquid chromatography-tandem mass spectrometer according to claim 2, characterized in that: The piston pusher (14) is in close contact with the inner wall of the sleeve (10).

7. The sample introduction device for a high-performance liquid chromatography-tandem mass spectrometer according to claim 2, characterized in that: The sleeve (10) is connected to the inside of the liquid storage box (4) through the liquid extraction tube (5), and the sleeve (10) is connected to the inside of the round box (16), the brush plate (21) and the brush plate (21) through the telescopic tube (17).

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