An experimental biosafety negative pressure pig isolator

Abstract

This utility model discloses a biosafety negative pressure pig isolator for laboratory use, comprising: an isolator body, a ventilation mechanism, and a retrieval mechanism. Through the retrieval mechanism, this utility model's experimental pig isolator achieves independent isolation within the retrieval chamber, ensuring no material interaction between the inside and outside of the isolator. When moving experimental equipment or other items into or out of the isolator, simultaneous and automatic item movement and disinfection of the retrieval chamber are achieved, further preventing cross-contamination between the inside and outside of the isolator during the use of experimental equipment, ensuring biosafety and experimental operational safety, while also improving the ease of use of the isolator.

Description

Technical Field

[0001] This utility model relates to the field of laboratory animal isolators, specifically a laboratory biosafety negative pressure pig isolator. Background Technology

[0002] Laboratory animals, such as pigs, are typically cared for and subjected to experimental procedures within sterile isolators. Sterile isolators are crucial devices used in laboratory animal husbandry and research. They create a suitable growth environment for laboratory animals by physically isolating them from the complex external environment, preventing interference from pathogens and bacteria. During use, all items entering and exiting the isolator from the outside, as well as any contaminated air inside and outside the isolator, must be thoroughly disinfected. For example, when placing materials into the isolator, existing laboratory animal isolators require manual separation of the retrieval mechanism from the isolator and manual connection to the docking device or external environment. Then, the items are placed into the retrieval mechanism and disinfected with contaminated air. This is achieved by manually or via a spray system spraying disinfectant into the cavity. After disinfection, the retrieval mechanism is isolated from the docking device or external environment and connected to the isolator before the materials are transferred into the isolator. The above process is complex and the isolator is inconvenient to use. If the experimental staff does not operate it in a standardized manner, it is very easy to cause incomplete disinfection of items or cross-contamination of the environment on both sides of the retrieval mechanism, which will affect biosafety and experimental safety. Utility Model Content

[0003] The purpose of this invention is to provide a biosafety negative pressure pig isolator for experiments, in order to solve the problems of inconvenient operation of existing experimental pig isolators, which affect biosafety and experimental safety.

[0004] To achieve the above objectives, this utility model adopts the following technical solution: a biosafety negative pressure pig isolator for laboratory use, comprising:

[0005] The isolator body has several windows with operating gloves, and a first mesh plate is installed inside each window.

[0006] A ventilation mechanism, comprising an air inlet box and an air outlet box equipped with a fan, wherein the air inlet box and the air outlet box are mounted on the isolator body and communicate with the inner cavity of the isolator body;

[0007] The object retrieval mechanism includes a housing, a door, a roller, and an air impeller. At least two openings are provided on the side of the housing, connecting to an object retrieval chamber. One of the openings connects to the inner cavity of the isolator body. The door is positioned on the opening. The roller is driven to rotate within the object retrieval chamber. Several sealing plates are spaced circumferentially on its side. The roller and sealing plates airtightly divide the object retrieval chamber into two independent chambers. Each independent chamber has a mounting groove extending from its side. The mounting groove connects to a first connector on the housing via a flow channel. The air impeller is rotatably connected to an impeller frame within the mounting groove. A second connector connecting to the object retrieval chamber is also provided on the housing.

[0008] As a further description of the above technical solution:

[0009] The inner cavity of the isolator body has partition plates between the first mesh plates.

[0010] As a further description of the above technical solution:

[0011] The inner cavity of the isolator body has a second mesh plate at the bottom of the first mesh plate, and the bottom of the isolator body has a conical drain bottom shell, which is connected to the conveying pipeline of the waste recycling equipment through a drain port.

[0012] As a further description of the above technical solution:

[0013] Both the air inlet box and the air outlet box are connected to the isolator body through filter boxes with built-in filter components.

[0014] As a further description of the above technical solution:

[0015] Guide rails are provided on both sides of the inner cavity of the isolator body, and the guide rails extend toward the object retrieval mechanism, with a receiving tray slidably mounted on them.

[0016] As a further description of the above technical solution:

[0017] The door is an inward-opening door hinged to the opening on one side, with a limiting plate extending from its side to abut against the inner wall of the box.

[0018] As a further description of the above technical solution:

[0019] A sealing gasket is provided on the outer side of the sealing plate to tightly abut against the inner wall of the box.

[0020] As a further description of the above technical solution:

[0021] The side of the picking chamber extends into a gear groove, and the gears at both ends of the roller shaft are rotatably disposed in the gear groove, with the teeth on the gears abutting against the blades on the air supply impeller.

[0022] As a further description of the above technical solution:

[0023] A sealing kit is provided on the tooth of the gear, and the sealing kit abuts tightly against the inner wall of the gear groove. The sealing plate is parallel to the axis of one tooth of the gear and its end is tightly spliced ​​or fixed.

[0024] As a further description of the above technical solution:

[0025] A first magnet is provided on the roller and / or sealing plate, and the first magnet is magnetically connected to a second magnet on the housing.

[0026] In summary, by adopting the above technical solution, this utility model has the following beneficial effects compared with the prior art:

[0027] This utility model's experimental pig isolator, through the design of its retrieval mechanism, can achieve independent isolation within the retrieval chamber, ensuring no material interaction between the inside and outside of the isolator. When moving experimental equipment or other items into or out of the isolator, it can simultaneously and automatically push the items and disinfect the inside of the retrieval chamber, further avoiding cross-contamination between the inside and outside of the isolator during the use of experimental equipment, ensuring biosafety and experimental operation safety, while also improving the ease of use of the isolator. Attached Figure Description

[0028] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0029] Figure 1 This is a schematic diagram of a biosafety negative pressure pig isolator for experimental use.

[0030] Figure 2 This is a cross-sectional view of an experimental biosafety negative pressure pig isolator.

[0031] Figure 3 This describes the operational status of the retrieval mechanism in a biosafety negative pressure pig isolator used in experiments. Figure 1 .

[0032] Figure 4 This describes the operational status of the retrieval mechanism in a biosafety negative pressure pig isolator used in experiments. Figure 2 .

[0033] Figure 5 This is a schematic diagram of the structure of rollers, gears, and air impeller in an experimental biosafety negative pressure pig isolator.

[0034] Legend:

[0035] 1. Isolator body; 2. Window; 3. First mesh plate; 4. Air inlet box; 5. Air outlet box; 6. Retrieval mechanism; 7. Box body; 8. Opening; 9. Door; 10. Retrieval chamber; 11. Roller; 12. Sealing plate; 13. Mounting groove; 14. Flow channel; 15. First connector; 16. Impeller frame; 17. Air supply impeller; 18. Second connector; 19. Divider plate; 20. Second mesh plate; 21. Drainage bottom shell; 22. Drainage port; 23. Waste recovery equipment; 24. Conveying pipeline; 25. Filter box; 26. Guide rail; 27. Receiving tray; 28. Limiting plate; 29. ​​Sealing gasket; 30. Gear groove; 31. Gear; 32. Sealing kit; 33. First magnet; 34. Second magnet. Detailed Implementation

[0036] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0037] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0038] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0039] In the description of the embodiments of this utility model, it should be noted that the terms "upper" and "inner" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the utility model product is usually placed when in use. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0040] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection, an indirect connection through an intermediate medium, or a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0041] Please see Figure 1-5 This utility model provides a technical solution: a biosafety negative pressure pig isolator for laboratory use, comprising:

[0042] The isolator body 1 has several windows 2 with operating gloves on it, and a first mesh plate 3 is installed inside each window.

[0043] The ventilation mechanism includes an air inlet box 4 and an air outlet box 5 with a fan. The air inlet box 4 and the air outlet box 5 are mounted on the isolator body 1 and communicate with the inner cavity of the isolator body 1.

[0044] The retrieval mechanism 6 includes a housing 7, a door 9, a roller 11, and an air impeller 17. The side of the housing 7 is provided with at least two openings 8 that connect to the retrieval chamber 10 inside it. One of the openings 8 connects to the inner cavity of the isolator body 1. The door 9 is arranged on the opening 8. The roller 11 is driven to rotate and is arranged in the retrieval chamber 10. Several sealing plates 12 are arranged circumferentially on its side. The roller 11 and the sealing plates 12 airtightly divide the retrieval chamber 10 into two independent chambers. The side of each independent chamber extends with a mounting groove 13. The mounting groove 13 is connected to a first connector 15 on the housing 7 through a flow channel 14. The air impeller 17 is rotatably connected to an impeller frame 16 in the mounting groove 13. The housing 7 is also provided with a second connector 18 that connects to the retrieval chamber 10. The first connector 15 and the second connector 18 are connected to the external air circulation pipeline. The fan in the air circulation pipeline can operate in both directions (the bidirectional operation of the fan is existing technology and will not be described in detail here). The air circulation pipeline is also connected to the disinfectant liquid nozzle, which atomizes the disinfectant liquid. The atomized disinfectant liquid enters the retrieval chamber 10 with the airflow in the air circulation pipeline, thereby disinfecting the internal air, experimental objects, etc., and ensuring the biosafety of use.

[0045] The inner cavity of the isolator body 1 is provided with partition plates 19 between the first mesh plates 3 to separate the space inside the isolator body 1, ensuring that the growth and experimentation of experimental animals do not interfere with each other.

[0046] The inner cavity of the isolator body 1 has a second mesh plate 20 at the bottom of the first mesh plate 3. The bottom of the isolator body 1 has a conical drainage bottom shell 21. The drainage bottom shell 21 is connected to the conveying pipeline 24 of the waste recycling device 23 through the drainage port 22. This improves the cleanliness of the internal environment by removing pollutants such as excrement from experimental animals (pigs) inside the isolator body 1, ensuring a suitable growth environment for experimental animals and the experimental environment.

[0047] Both the inlet air box 4 and the outlet air box 5 are connected to the isolator body 1 through a filter box 25 with built-in filter components. The negative pressure condition inside the isolator is maintained by adjusting the control valves (electric valves or manual valves) on the inlet air box 4 and the outlet air box 5.

[0048] Guide rails 26 are provided on both sides of the inner cavity of the isolator body 1. The guide rails 26 extend toward the object retrieval mechanism 6, and a receiving tray 27 is slidably mounted on them. In use, experimental equipment can be placed on the receiving tray 27, and the receiving tray 27 can be slid along the guide rails 26 to the corresponding position to facilitate experimental operations and the movement of the equipment into or out of the isolator, thus improving ease of use.

[0049] The door 9 is an inward-opening door hinged to the opening 8 on one side, with a limiting plate 28 extending from its side to abut against the inner wall of the housing 7. This prevents the door 9 from accidentally opening during tasks such as disinfection of the retrieval mechanism 6, which could lead to cross-contamination of the internal and external environments of the isolator, affecting biosafety and the safety of experimental operations.

[0050] The side of the picking chamber 10 extends into a gear groove 30, and the gears 31 at both ends of the roller shaft 11 are rotatably disposed in the gear groove 30. The teeth on the gears 31 abut against the blades on the air supply impeller 17.

[0051] A sealing gasket 29 is provided on the outer side of the sealing plate 12, which is in close contact with the inner wall of the housing 7. A sealing kit 32 is provided on the teeth of the gear 31, which is in close contact with the inner wall of the gear groove 30. The sealing plate 12 is parallel to the axis of one tooth of the gear 31 and the ends are tightly spliced ​​or fixed. This ensures that when the sterilization airflow into the retrieval chamber 10 is not performed, the roller 11 and the two sides of the sealing plate 12 are isolated from the inner cavity of the isolator body 1 and the external environment of the isolator, respectively, without material interaction, improving the airtightness of the structure and further ensuring biosafety and experimental operation safety.

[0052] A first magnet 33 is provided on the roller 11 and / or the sealing plate 12, and the first magnet 33 is magnetically connected to a second magnet 34 on the housing 7. This allows the roller 11 and the sealing plate 12 to automatically rotate to a designated position under magnetic force when no disinfection airflow is introduced into the retrieval cavity 10, that is, the sealing plate 12 is in airtight contact with the inner wall of the retrieval cavity 10, and the two independent cavities are isolated.

[0053] The working principle of a biosafety negative pressure pig isolator for experiments in this embodiment includes: when experimental equipment is moved into the isolator, such as... Figure 3 The roller 11 and sealing plate 12 automatically rotate to a vertical position under magnetic force, separating the independent cavities on both sides. At this time, push the door 9 on the side facing the external environment inward and place the item into the independent cavity on that side. Then, release the door 9, which automatically closes at the opening 8. The disinfection and transfer of items begins. Specifically, the fan in the air circulation pipeline runs, causing high-pressure, high-velocity disinfection airflow to enter the retrieval chamber 10 and drive the air impeller 17 to rotate. The gear 31 is driven by the blades of the air impeller 17 (overcoming the magnetic force) and rotates synchronously. It rotates together with the roller 11 (both are lightweight structures), connecting the independent cavities on both sides. The disinfection airflow disinfects the air in the retrieval chamber 10 (external contaminated air entering the retrieval chamber 10 when the doors 9 on both sides are open, and contaminated air in the isolator) and the items. The sealing plate 12 pushes the experimental equipment, etc., to move them to the independent cavity on the other side. Figure 4 As shown (where the solid arrow indicates the direction of the disinfection airflow, and the dashed arrow indicates the direction of rotation of the air supply impeller 17); after disinfection, the disinfection airflow stops, and the thrust acting on the air supply impeller 17 is removed. The roller 11 and the sealing plate 12 automatically rotate to a vertical position under magnetic force, thus separating the two independent cavities again. Then, the door 9 on one side of the isolator can be opened to move the disinfected experimental equipment into the isolator. The process of removing items from the isolator is the same as the above process, except that the fan in the air circulation pipe rotates in the opposite direction, which realizes the reverse rotation of the gear 31, roller 11, and sealing plate 12, so as to push the items outward. Then, the experimental staff can take out the disinfected items through the door 9 on the side of the external environment.

[0054] In summary, due to the adoption of the above technical solution, the experimental biosafety negative pressure pig isolator of this embodiment has the following beneficial effects compared with the prior art:

[0055] This utility model's experimental pig isolator, through the design of its retrieval mechanism, can achieve independent isolation within the retrieval chamber, ensuring no material interaction between the inside and outside of the isolator. When moving experimental equipment or other items into or out of the isolator, it can simultaneously and automatically push the items and disinfect the inside of the retrieval chamber, further avoiding cross-contamination between the inside and outside of the isolator during the use of experimental equipment, ensuring biosafety and experimental operation safety, while also improving the ease of use of the isolator.

[0056] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A biosafety negative pressure pig isolator for laboratory use, characterized in that, include: The isolator body has several windows with operating gloves, and a first mesh plate is installed inside each window. A ventilation mechanism, comprising an air inlet box and an air outlet box equipped with a fan, wherein the air inlet box and the air outlet box are mounted on the isolator body and communicate with the inner cavity of the isolator body; The object retrieval mechanism includes a housing, a door, a roller, and an air impeller. At least two openings are provided on the side of the housing, connecting to an object retrieval chamber. One of the openings connects to the inner cavity of the isolator body. The door is positioned on the opening. The roller is driven to rotate within the object retrieval chamber. Several sealing plates are spaced circumferentially on its side. The roller and sealing plates airtightly divide the object retrieval chamber into two independent chambers. Each independent chamber has a mounting groove extending from its side. The mounting groove connects to a first connector on the housing via a flow channel. The air impeller is rotatably connected to an impeller frame within the mounting groove. A second connector connecting to the object retrieval chamber is also provided on the housing.

2. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, The inner cavity of the isolator body has partition plates between the first mesh plates.

3. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, The inner cavity of the isolator body has a second mesh plate at the bottom of the first mesh plate, and the bottom of the isolator body has a conical drain bottom shell, which is connected to the conveying pipeline of the waste recycling equipment through a drain port.

4. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, Both the air inlet box and the air outlet box are connected to the isolator body through filter boxes with built-in filter components.

5. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, Guide rails are provided on both sides of the inner cavity of the isolator body, and the guide rails extend toward the object retrieval mechanism, with a receiving tray slidably mounted on them.

6. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, The door is an inward-opening door hinged to the opening on one side, with a limiting plate extending from its side to abut against the inner wall of the box.

7. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, A sealing gasket is provided on the outer side of the sealing plate to tightly abut against the inner wall of the box.

8. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, The side of the picking chamber extends into a gear groove, and the gears at both ends of the roller shaft are rotatably disposed in the gear groove, with the teeth on the gears abutting against the blades on the air supply impeller.

9. A biosafety negative pressure pig isolator for laboratory use according to claim 8, characterized in that, A sealing kit is provided on the tooth of the gear, and the sealing kit abuts tightly against the inner wall of the gear groove. The sealing plate is parallel to the axis of one tooth of the gear and its end is tightly spliced ​​or fixed.

10. The experimental biosafety negative pressure pig isolator according to claim 1, characterized in that, A first magnet is provided on the roller and / or sealing plate, and the first magnet is magnetically connected to a second magnet on the housing.

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