Distillation concentration apparatus for insulin production

Abstract

This utility model relates to the field of insulin production technology and discloses a distillation and concentration device for insulin production. The device includes a heating tank, a vacuum pump fixedly connected to the outer wall of the heating tank, a discharge valve fixedly connected to the outer wall of the heating tank, a motor and a steam pipe at the top of the heating tank, a check valve fixedly connected to the middle of the steam pipe, and a condenser fixedly connected to the bottom. An auxiliary distillation component is located at the bottom of the motor. The auxiliary distillation component includes a rotating shaft, a fixing component, a spiral column, and a scraper. In this utility model, the motor drives the auxiliary distillation component to rotate. As the spiral column rotates, it increases the contact area between the surrounding liquid and the heating surface. The scraper on the spiral column scrapes away the evaporation residue accumulated on the inner wall of the heating tank, thereby increasing the heated surface area of ​​the drug solution. This solves the problem of insufficient heating and poor evaporation, and improves the efficiency of the distillation equipment.

Description

Technical Field

[0001] This utility model relates to the field of insulin production technology, and in particular to distillation and concentration equipment for insulin production. Background Technology

[0002] In the field of biopharmaceuticals, the large-scale production of insulin relies on the development of early chemical solution concentration technology. Through improvements tailored to the characteristics of bioactive substances, an equipment system has been formed that is adapted to the high-purity, high-concentration formulation requirements of insulin production and can efficiently separate solvents and target components.

[0003] Structurally, existing equipment typically includes core components such as a feeding unit, a heating and evaporation chamber, a gas-liquid separation device, and a discharge system. The feeding unit precisely controls the flow rate to smoothly deliver the insulin solution to be processed into the heating and evaporation chamber. The specially designed heat exchange components within the evaporation chamber enable rapid solvent vaporization at lower temperatures, reducing the impact of high temperatures on insulin activity. The separation device effectively intercepts tiny droplets escaping with the vapor, ensuring the purity of the subsequently recovered solvent. This design maintains the high efficiency of traditional distillation technology while also ensuring the stability of the bioproducts through optimizations in details such as temperature control.

[0004] However, in actual operation, the liquid flow state inside the equipment still has certain limitations. When the solution flows through a specific path in the evaporation chamber, some areas are prone to insufficient contact time between the liquid and the evaporation surface due to excessively high flow rates or uneven distribution. This results in some solvent failing to fully vaporize before being discharged with the main flow, affecting not only the single-pass concentration efficiency but also requiring subsequent recycling to compensate, thus increasing the complexity of the production process. Therefore, a distillation and concentration device for insulin production is proposed to address these issues. Utility Model Content

[0005] To overcome the above deficiencies, this utility model provides a distillation and concentration device for insulin production, which aims to improve the problem of insufficient contact between crude insulin and evaporation equipment in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a distillation and concentration device for insulin production, comprising a heating tank, a vacuum pump fixedly connected to the outer wall of the heating tank, a discharge valve fixedly connected to the outer wall of the heating tank, a motor installed at the top of the heating tank, an auxiliary distillation assembly installed at the bottom of the motor, a steam pipe fixedly connected to the top of the heating tank, a check valve fixedly connected to the middle of the steam pipe, and a condenser fixedly connected to the bottom of the steam pipe;

[0007] The auxiliary distillation assembly includes a rotating shaft, the top of which is located at the output end of the motor, and a fixing component is fixedly connected to the bottom of the rotating shaft. A spiral column is fixedly connected to the bottom of the fixing component, and multiple scrapers are fixedly connected to the outer wall of the spiral column.

[0008] As a further description of the above technical solution: the anti-reverse component includes an outer tube, both ends of which are fixedly connected to the outer wall of the steam pipe.

[0009] As a further description of the above technical solution: one end of the outer tube is provided with an inlet, and a spring-like device is provided inside the outer tube.

[0010] As a further description of the above technical solution: the spring-like device includes a positioning block, the outer wall of which is fixedly connected to the inner wall of the outer tube.

[0011] As a further description of the above technical solution: one end of the positioning block is fixedly connected to a limiting post, and a spring is sleeved on the outer wall of the limiting post.

[0012] As a further description of the above technical solution: the outer wall of the spring is disposed inside the outer tube, and one end of the spring is fixedly connected to one end of the positioning block.

[0013] As a further description of the above technical solution: a ball plug is provided at the other end of the spring, and one side of the ball plug is slidably connected to the inside of the inlet.

[0014] This utility model has the following beneficial effects:

[0015] 1. In this utility model, when the equipment is running, the vacuum pump first evacuates the air, then the heating tank starts heating. The motor drives the rotating shaft at the bottom, which in turn drives the fixed component and the spiral column to rotate. When the spiral column rotates, it causes the liquid inside the heating tank to rise and rotate. The scraper fixed on the spiral column also scrapes away any evaporation residue that may accumulate on the inner wall of the heating tank, thereby increasing the contact area between the liquid and the heating tank. This solves the problem of insufficient contact leading to low evaporation efficiency and improves the effectiveness of the distillation and concentration equipment.

[0016] 2. In this utility model, the steam generated by heating is discharged from the steam pipe to the condenser. The steam pushes the ball plug from the inlet and enters the outer tube of the check valve assembly. The check valve assembly is in the open state. After the steam stops flowing in the pipe, the spring of the check valve assembly will push its ball plug back into the inlet, and the check valve assembly will close, achieving the effect of steam only going out and not going in. This solves the problem of backflow after the steam stops flowing and improves the stability and efficiency of the evaporation process. Attached Figure Description

[0017] Figure 1This is a three-dimensional schematic diagram of the distillation and concentration equipment for insulin production proposed in this utility model.

[0018] Figure 2 This is a schematic diagram of the spiral column structure of the distillation and concentration equipment for insulin production proposed in this utility model.

[0019] Figure 3 This is a cross-sectional structural diagram of the heating tank of the distillation and concentration equipment for insulin production proposed in this utility model;

[0020] Figure 4 This is a schematic diagram of the anti-reverse flow component of the distillation and concentration equipment for insulin production proposed in this utility model;

[0021] Figure 5 This is a cross-sectional structural diagram of the anti-reverse flow component of the distillation and concentration equipment for insulin production proposed in this utility model.

[0022] Legend:

[0023] 1. Heating tank; 10. Discharge valve; 2. Motor; 21. Rotary shaft; 22. Fixing assembly; 23. Scraper; 24. Spiral column; 3. Vacuum pump; 4. Steam pipe; 5. Check valve assembly; 50. Outer pipe; 500. Inlet; 51. Ball plug; 52. Positioning block; 521. Spring; 53. Limiting post; 6. Condensate tank. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Reference Figures 1-3 The present invention provides an embodiment of a distillation and concentration device for insulin production, comprising a heating tank 1, a vacuum pump 3 fixedly connected to the outer wall of the heating tank 1, the function of which is to extract part of the air inside the heating tank 1, thereby reducing the internal air pressure of the heating tank 1, and heating the liquid to boiling point at a low temperature to begin evaporation, thus preventing insulin from being deactivated due to high temperature. A discharge valve 10 is fixedly connected to the outer wall of the heating tank 1. A motor 2 is installed at the top of the heating tank 1, the function of which is to drive the auxiliary distillation components such as the spiral column 24 to start rotating. An auxiliary distillation component is installed at the bottom of the motor 2. A steam pipe 4 is fixedly connected to the top of the heating tank 1. A check valve component 5 is fixedly connected to the middle of the steam pipe 4, the function of which is to prevent steam backflow. A condenser 6 is fixedly connected to the bottom of the steam pipe 4.

[0026] The auxiliary distillation assembly includes a rotating shaft 21, with the top of the rotating shaft 21 located at the output end of the motor 2. A fixing component 22 is fixedly connected to the bottom of the rotating shaft 21, which secures the connection between the rotating shaft 21 and the spiral column 24. The spiral column 24 is fixedly connected to the bottom of the fixing component 22, which stirs the liquid inside the heating tank 1 and increases the contact area with the heating surface to promote evaporation. Multiple scrapers 23 are fixedly connected to the outer wall of the spiral column 24, which scrape away any evaporation residue that may accumulate on the inner wall of the heating tank 1 during the heating process.

[0027] Reference Figures 4-5 The check valve assembly 5 includes an outer tube 50, both ends of which are fixedly connected to the outer wall of the steam pipe 4. One end of the outer tube 50 has an inlet 500, which facilitates steam flow and restricts its backflow. The outer tube 50 is equipped with a spring mechanism, which controls the movement of the ball plug 51. The spring mechanism includes a positioning block 52, the outer wall of which is fixedly connected to the inner wall of the outer tube 50. One end of the positioning block 52 is fixedly connected to a limiting post 53, which prevents excessive positional displacement between the spring 52 and the ball plug 51. A spring 521 is sleeved on the outer wall of the limiting post 53. The outer wall of the spring 521 is located inside the outer tube 50. One end of the spring 521 is fixedly connected to one end of the positioning block 52. The other end of the spring 521 is equipped with a ball plug 51. One side of the ball plug 51 is slidably connected to the inside of the inlet 500, which cooperates with the inlet 500 to control the flow and closure of the check valve by moving away from or touching it.

[0028] Working principle: When the distillation and concentration equipment is running, the vacuum pump 3 first starts to pump air, which lowers the air pressure in the heating tank. Then, the motor 2 drives the bottom rotating shaft 21 to start rotating. The fixed component 22, which is fixedly connected to the rotating shaft 2, drives the fixed spiral column 24 to start rotating as well. When the spiral column 24 rotates, it will drive the liquid inside the heating tank 1 to flow upward. The scraper 23, which is fixedly connected to the outer wall of the spiral column 24, comes into contact with the inner wall of the heating tank 1. As the scraper 23 rotates with the spiral column 24, it also scrapes away any possible evaporation residue buildup that may be stuck to the wall.

[0029] The steam generated by evaporation will enter the condenser 6 through the steam pipe 4. When the steam passes through the steam pipe 4, the ball plug 51 inside the check valve assembly 5 will drive the spring 521 to be pushed. The limiting post 53 fixed in the outer pipe 50 by the positioning block 52 will protect the spring 521 and the ball plug 51 from deviating too much from their positions. When the steam stops flowing in the pipe, the ball plug 51 will be pushed back to its original position by the spring 521, blocking the inlet 500 and preventing the steam from flowing back.

[0030] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A distillation and concentration apparatus for insulin production, comprising a heating tank (1), characterized in that: A vacuum pump (3) is fixedly connected to the outer wall of the heating tank (1), a discharge valve (10) is fixedly connected to the outer wall of the heating tank (1), a motor (2) is installed at the top of the heating tank (1), an auxiliary distillation assembly is installed at the bottom of the motor (2), a steam pipe (4) is fixedly connected to the top of the heating tank (1), a check valve assembly (5) is fixedly connected to the middle of the steam pipe (4), and a condenser (6) is fixedly connected to the bottom of the steam pipe (4). The auxiliary distillation assembly includes a rotating shaft (21), the top of which is located at the output end of the motor (2), and a fixing assembly (22) is fixedly connected to the bottom of the rotating shaft (21). A spiral column (24) is fixedly connected to the bottom of the fixing assembly (22), and multiple scrapers (23) are fixedly connected to the outer wall of the spiral column (24).

2. The distillation and concentration equipment for insulin production according to claim 1, characterized in that: The anti-reverse component (5) includes an outer tube (50), both ends of which are fixedly connected to the outer wall of the steam pipe (4).

3. The distillation and concentration apparatus for insulin production according to claim 2, characterized in that: The outer tube (50) has an inlet (500) at one end, and an elastic device is provided inside the outer tube (50).

4. The distillation and concentration apparatus for insulin production according to claim 3, characterized in that: The spring-loaded device includes a positioning block (52), the outer wall of which is fixedly connected to the inner wall of the outer tube (50).

5. The distillation and concentration apparatus for insulin production according to claim 4, characterized in that: One end of the positioning block (52) is fixedly connected to a limiting post (53), and a spring (521) is sleeved on the outer wall of the limiting post (53).

6. The distillation and concentration apparatus for insulin production according to claim 5, characterized in that: The outer wall of the spring (521) is disposed inside the outer tube (50), and one end of the spring (521) is fixedly connected to one end of the positioning block (52).

7. The distillation and concentration apparatus for insulin production according to claim 5, characterized in that: The other end of the spring (521) is provided with a ball plug (51), and one side of the ball plug (51) is slidably connected to the inside of the inlet (500).

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