Rapid amino acid fractionation device

Abstract

This utility model relates to the field of amino acid technology and provides a rapid amino acid fractionation and separation device, including a support, a chromatography column mounted on top of the support, and an adjustment structure fixed to the outside of the chromatography column. The adjustment structure includes a fixed disk fixed to the outside of the chromatography column, and rotating shafts fixed on both sides of the fixed disk. A housing is fixed to the outer wall of the support at one end of the rotating shaft, and an internal cavity is provided inside the housing. By incorporating the adjustment structure, when the worm gear operates inside the internal cavity, it drives the rotating shaft to rotate via a worm wheel. This causes the rotating shaft to rotate the chromatography column via the fixed disk, thereby changing the angle of the chromatography column. The worm gear prevents the worm wheel from rotating on its own without external force, thus enabling easy angle adjustment and improving the working efficiency of the rapid amino acid fractionation and separation device.

Description

Technical Field

[0001] This utility model relates to the field of amino acid technology, and in particular to a rapid amino acid fractionation and separation device. Background Technology

[0002] Nitrogenous substances such as proteins in animal carcasses are converted into a mixture of amino acids after pretreatment such as hydrolysis. The chromatography column utilizes the differences in the distribution coefficients and adsorption capacities of different amino acids between the stationary and mobile phases to make the amino acids move at different speeds in the chromatography column, thereby achieving separation. Therefore, a rapid amino acid fractionation separation device is used.

[0003] To address this, patent CN207708575U discloses a novel chromatography column, comprising an upper chromatography column, a lower chromatography column, a filter device, a flow guide, a column cap, a cone, a flow controller, and an inlet hose. The upper chromatography column has a flow guide sleeve at its top, a filter device between the upper and lower columns, and the inlet hose extends into the upper column through an opening at the center of the column cap, which is connected to the upper end of the column. The lower end of the lower chromatography column is connected to the cone, and a flow controller is located at the bottom of the cone via a long tube. This novel chromatography column offers excellent sealing, effectively preventing external contamination. It allows for easy disassembly and replacement of components, facilitating cleaning, storage, and transportation. During sample injection, the sample solution is guided by the outer wall of the flow guide and flows down the inner wall of the column, preventing splashing of the packing material inside the upper column and thus improving the protease chromatography effect.

[0004] Although the novel chromatography column mentioned above does not cause splashing of packing material inside the upper chromatography column to improve the protease chromatography effect, it is inconvenient to adjust the angle and make it difficult to distribute the mobile phase more evenly inside the column, thus making it difficult to improve the separation effect and resulting in low working efficiency during use. Utility Model Content

[0005] The purpose of this invention is to provide a rapid amino acid fractionation and separation device to solve the problem of inconvenient angle adjustment in existing rapid amino acid fractionation and separation devices.

[0006] To solve the above-mentioned technical problems, this utility model provides the following technical solution: a rapid amino acid fractionation and separation device, including a support;

[0007] A chromatography column is provided on the top of the support. An adjustment structure is fixed on the outside of the chromatography column. The adjustment structure includes a fixed plate fixed to the outside of the chromatography column. A rotating shaft is fixed on both sides of the fixed plate. A housing is fixed on the outer wall of the support at one end of the rotating shaft. An internal cavity is provided inside the housing. A worm gear is provided on the top of the internal cavity. A worm is meshed with the bottom end of the worm gear. One end of the worm extends to the outside of the housing and is fixed with a handwheel.

[0008] The top of the chromatography column is fixed with a top cover, and the top of the top cover is fixed with a quantitative structure.

[0009] A separation structure is installed at the bottom of the chromatography column.

[0010] When using this device, the adjustable structure allows for easy angle adjustment, thereby improving the working efficiency of the rapid amino acid fractionation and separation device; the quantitative structure facilitates quantitative feeding, thus improving the applicability of the rapid amino acid fractionation and separation device; and the separation structure facilitates separation, thus improving the convenience of use.

[0011] Preferably, a lower cover is fixed to the bottom end of the chromatography column, and a discharge port is fixed to the bottom end of the lower cover.

[0012] Preferably, one end of the rotating shaft extends to the outside of the support and forms a rotating structure with the support, while one end of the rotating shaft on one side of the fixed disk extends into the interior of the internal cavity and is fixedly connected to one side of the worm gear. The rotating shaft drives the chromatography column to rotate through the fixed disk, thereby changing the angle of the chromatography column. Under the action of the worm, the worm gear is prevented from rotating on its own without external force.

[0013] Preferably, the metering structure includes a feed hopper, a metering cylinder, a cover plate, a drive shaft, a metering plate, and a drive motor. The metering cylinder is fixed to the top of the cover, a cover plate is fixed to one side of the metering cylinder, a feed hopper is fixed to the top of the metering cylinder, a drive shaft is disposed inside the metering cylinder, metering plates are uniformly fixed to the outer wall of the drive shaft, and a drive motor is installed on the outer wall of the cover plate at one end of the drive shaft. When the drive shaft operates inside the metering cylinder, it drives the metering plate to rotate.

[0014] Preferably, one end of the drive shaft extends to the outside of the cover plate and is fixedly connected to the output end of the drive motor, and the quantitative plates are evenly distributed outside the drive shaft. The evenly spaced quantitative plates ensure that the sample amount can quantitatively enter the interior of the chromatography column, avoiding poor separation due to differences in sample amount.

[0015] Preferably, the separation structure includes a fixing ring, a snap-fit ​​groove, a snap-fit ​​block, a reserved groove, a holding frame, a filter screen, a handle, and a support ring. The fixing ring is fixed to the bottom of the chromatography column. Snap-fit ​​grooves are provided on both sides of the bottom end of the fixing ring. Snap-fit ​​blocks are provided inside each snap-fit ​​groove. Reserved grooves are provided inside each snap-fit ​​block. The bottom end of each snap-fit ​​block extends to the outside of the fixing ring and is fixed to a holding frame. A filter screen is fixed to the bottom of the holding frame. Handles are fixed on both sides of the bottom end of the holding frame. A support ring is provided at the bottom end of each handle. The snap-fit ​​blocks and snap-fit ​​grooves work together to fix or separate the holding frame and the fixing ring. When the holding frame is separated from the fixing ring, the filter screen can be cleaned. The bottom end of the handle abuts against the top end of the support ring, providing support for the holding frame.

[0016] Preferably, the snap-fit ​​block and the fixing ring form an engaging structure through snap-fit ​​grooves, and the outer side of the support ring is fixedly connected to the inner side of the lower cover. Separation is achieved by utilizing the molecular sieve effect of the gel, based on molecular size, and by utilizing the differences in adsorption capacity of the adsorbent for different substances. The filter screen prevents adsorbent leakage.

[0017] The advantages of the rapid amino acid fractionation and separation device provided by this utility model are as follows:

[0018] With the adjustment structure, when the worm gear works inside the built-in cavity, the worm gear will drive the rotating shaft to rotate through the worm wheel, and the rotating shaft will drive the chromatography column to rotate through the fixed disk, thereby changing the angle of the chromatography column. Under the action of the worm gear, the worm wheel is prevented from rotating on its own without external force, realizing the function of easy angle adjustment of the device, thereby improving the working efficiency of the rapid amino acid fractionation and separation device during use.

[0019] By incorporating a quantitative structure, when the drive shaft operates inside the quantitative cylinder, it drives the quantitative plate to rotate. Under the action of the equally spaced quantitative plates, the sample amount can be quantitatively introduced into the interior of the chromatography column, avoiding poor separation effect due to differences in sample amount. This realizes the function of easy quantitative feeding of the device, thereby improving the applicability of the rapid amino acid fractionation separation device in use.

[0020] By incorporating a separation structure, the holding frame and the fixing ring are fixed or separated through the cooperation of the locking block and locking groove. When the holding frame is separated from the fixing ring, the filter screen can be cleaned. The bottom of the handle abuts against the top of the support ring, providing support for the holding frame. Separation is achieved by utilizing the molecular sieve effect of the gel, based on molecular size, and by utilizing the differences in adsorption capacity of the adsorbent for different substances. The filter screen prevents adsorbent leakage, thus enabling the device to facilitate separation and improving the ease of use of this rapid amino acid fractionation separation device. Attached Figure Description

[0021] Figure 1 This is a three-dimensional structural schematic diagram of the present invention;

[0022] Figure 2 This is a schematic diagram of the front cross-sectional structure of this utility model;

[0023] Figure 3 For the present utility model Figure 2 Enlarged structural diagram at point A in the middle;

[0024] Figure 4 This is a three-dimensional structural schematic diagram of the quantitative structure cross-section of this utility model;

[0025] Figure 5 This is a partial side view cross-sectional diagram of the adjustment structure of this utility model;

[0026] Figure 6 This is a three-dimensional exploded structural diagram of the separation structure of this utility model.

[0027] The following are the annotations in the figure: 1. Support; 2. Chromatography column; 3. Adjustment structure; 301. Fixed plate; 302. Rotating shaft; 303. Shell; 304. Internal cavity; 305. Worm gear; 306. Worm; 307. Handwheel; 4. Top cover; 5. Quantitative structure; 501. Feed hopper; 502. Quantitative cylinder; 503. Cover plate; 504. Drive shaft; 505. Quantitative plate; 506. Drive motor; 6. Bottom cover; 7. Discharge port; 8. Separation structure; 801. Fixing ring; 802. Snap-fit ​​groove; 803. Snap-fit ​​block; 804. Reserved groove; 805. Container frame; 806. Filter screen; 807. Handle; 808. Support ring. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0029] Please see Figures 1-6The rapid amino acid fractionation device provided by this utility model includes a support 1, a chromatography column 2 is provided on the top of the support 1, an adjustment structure 3 is fixed on the outside of the chromatography column 2, the adjustment structure 3 includes a fixed disk 301 fixed on the outside of the chromatography column 2, a rotating shaft 302 is fixed on both sides of the fixed disk 301, a housing 303 is fixed on the outer wall of the support 1 at one end of the rotating shaft 302, an internal cavity 304 is provided inside the housing 303, a worm gear 305 is provided on the top of the internal cavity 304, a worm 306 is meshed with the bottom end of the worm gear 305, one end of the worm 306 extends to the outside of the housing 303 and is fixed with a handwheel 307, one end of the rotating shaft 302 extends to the outside of the support 1 and forms a rotating structure with the support 1, and one end of the rotating shaft 302 on one side of the fixed disk 301 extends into the inside of the internal cavity 304 and is fixedly connected to one side of the worm gear 305.

[0030] Reference Figure 2 and Figure 5 As shown, rotating the handwheel 307 causes the worm gear 306 to rotate inside the internal cavity 304. The worm gear 306 then drives the rotating shaft 302 to rotate via the worm wheel 305. This causes the rotating shaft 302 to rotate via the fixed disk 301, thereby changing the angle of the chromatography column 2. Under the action of the worm gear 306, the worm wheel 305 is prevented from rotating on its own without external force.

[0031] A top cover 4 is fixed to the top of the chromatography column 2. A quantitative structure 5 is fixed to the top of the top cover 4. The quantitative structure 5 includes a feed hopper 501, a quantitative cylinder 502, a cover plate 503, a drive shaft 504, quantitative plates 505, and a drive motor 506. The quantitative cylinder 502 is fixed to the top of the top cover 4. A cover plate 503 is fixed to one side of the quantitative cylinder 502. A feed hopper 501 is fixed to the top of the quantitative cylinder 502. A drive shaft 504 is arranged inside the quantitative cylinder 502. Quantitative plates 505 are evenly fixed on the outer wall of the drive shaft 504. A drive motor 506 is installed on the outer wall of the cover plate 503 at one end of the drive shaft 504. One end of the drive shaft 504 extends to the outside of the cover plate 503 and is fixedly connected to the output end of the drive motor 506. The quantitative plates 505 are evenly distributed outside the drive shaft 504.

[0032] Reference Figure 2 and Figure 4 As shown, the sample amount is fed into the quantitative cylinder 502 through the feed hopper 501. The drive motor 506 is started, and the drive motor 506 drives the drive shaft 504 to rotate inside the quantitative cylinder 502. The drive shaft 504 will drive the quantitative plate 505 to rotate. Under the action of the equally spaced quantitative plates 505, the sample amount can be quantitatively entered into the interior of the chromatography column 2, avoiding poor separation effect due to the difference in sample amount.

[0033] A separation structure 8 is installed at the bottom of the chromatography column 2. The separation structure 8 includes a fixing ring 801, a snap-fit ​​groove 802, a snap-fit ​​block 803, a reserved groove 804, a holding frame 805, a filter screen 806, a handle 807, and a support ring 808. The fixing ring 801 is fixed to the bottom of the chromatography column 2. Snap-fit ​​grooves 802 are provided on both sides of the bottom end of the fixing ring 801. A snap-fit ​​block 803 is provided inside each snap-fit ​​groove 802. A reserved groove 804 is provided inside each snap-fit ​​block 803. The bottom ends of the column 2 extend to the outside of the fixing ring 801 and are fixed with a holding frame 805. A filter screen 806 is fixed to the bottom of the holding frame 805. Handles 807 are fixed to both sides of the bottom end of the holding frame 805. A support ring 808 is provided at the bottom end of each handle 807. The snap-fit ​​block 803 and the fixing ring 801 form a snap-fit ​​structure through the snap-fit ​​groove 802. The outer side of the support ring 808 is fixedly connected to the inner side of the lower cover 6. The bottom end of the chromatography column 2 is fixed with the lower cover 6. The bottom end of the lower cover 6 is fixed with a discharge port 7.

[0034] Reference Figure 3 and Figure 6 As shown, by moving the holding frame 805 with the handle 807, the top of the snap-fit ​​block 803 abuts against the bottom of the snap-fit ​​groove 802, pushing the holding frame 805, and under the action of the reserved groove 804, the snap-fit ​​block 803 will move into the inside of the snap-fit ​​groove 802, thereby fixing the holding frame 805 and the fixing ring 801 together. At this time, the bottom of the handle 807 abuts against the top of the support ring 808, and under the action of the support ring 808, it plays a supporting role for the holding frame 805. By pulling the holding frame 805 with the handle 807, the holding frame 805 and the fixing ring 801 are separated from each other, so as to clean the filter screen 806. By placing the adsorbent and gel in sequence inside the holding frame 805 at the top of the filter screen 806, the molecular sieve effect of the gel is used to separate them according to the molecular size, and the adsorbent is used to separate them according to the difference in adsorption capacity of different substances. Under the action of the filter screen 806, the adsorbent leakage is prevented.

[0035] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A rapid amino acid fractionation and separation device, including a support (1); Its features are: A chromatography column (2) is provided on the top of the support (1). An adjustment structure (3) is fixed on the outside of the chromatography column (2). The adjustment structure (3) includes a fixed disk (301) fixed on the outside of the chromatography column (2). A rotating shaft (302) is fixed on both sides of the fixed disk (301). A housing (303) is fixed on the outer wall of the support (1) at one end of the rotating shaft (302). An internal cavity (304) is provided inside the housing (303). A worm gear (305) is provided on the top of the internal cavity (304). A worm (306) is meshed with the bottom end of the worm gear (305). One end of the worm (306) extends to the outside of the housing (303) and is fixed with a handwheel (307). The top of the chromatography column (2) is fixed with a top cover (4), and the top of the top cover (4) is fixed with a quantitative structure (5); The bottom of the chromatography column (2) is equipped with a separation structure (8).

2. The rapid amino acid fractionation and separation device according to claim 1, characterized in that: The bottom end of the chromatography column (2) is fixed with a lower cover (6), and the bottom end of the lower cover (6) is fixed with a discharge port (7).

3. The rapid amino acid fractionation and separation device according to claim 1, characterized in that: One end of the rotating shaft (302) extends to the outside of the support (1) and forms a rotating structure with the support (1). One end of the rotating shaft (302) on one side of the fixed disk (301) extends into the inside of the built-in cavity (304) and is fixedly connected to one side of the worm gear (305).

4. The rapid amino acid fractionation and separation device according to claim 1, characterized in that: The quantitative structure (5) includes a feed hopper (501), a metering cylinder (502), a cover plate (503), a drive shaft (504), a metering plate (505), and a drive motor (506). The metering cylinder (502) is fixed to the top of the upper cover (4). A cover plate (503) is fixed to one side of the metering cylinder (502). The feed hopper (501) is fixed to the top of the metering cylinder (502). A drive shaft (504) is provided inside the metering cylinder (502). Metering plates (505) are evenly fixed on the outer wall of the drive shaft (504). A drive motor (506) is installed on the outer wall of the cover plate (503) at one end of the drive shaft (504).

5. The rapid amino acid fractionation and separation device according to claim 4, characterized in that: One end of the drive shaft (504) extends to the outside of the cover plate (503) and is fixedly connected to the output end of the drive motor (506). The metering plates (505) are evenly distributed outside the drive shaft (504).

6. The rapid amino acid fractionation and separation device according to claim 2, characterized in that: The separation structure (8) includes a fixing ring (801), a snap-fit ​​groove (802), a snap-fit ​​block (803), a reserved groove (804), a holding frame (805), a filter screen (806), a handle (807), and a support ring (808). The fixing ring (801) is fixed to the bottom of the chromatography column (2). Snap-fit ​​grooves (802) are provided on both sides of the bottom end of the fixing ring (801), and snap-fit ​​blocks (802) are provided inside each snap-fit ​​groove (802). The connecting block (803) has a reserved groove (804) inside. The bottom end of the connecting block (803) extends to the outside of the fixing ring (801) and is fixed with a holding frame (805). A filter screen (806) is fixed at the bottom of the holding frame (805). A handle (807) is fixed on both sides of the bottom end of the holding frame (805). A support ring (808) is provided at the bottom end of the handle (807).

7. The rapid amino acid fractionation and separation device according to claim 6, characterized in that: The snap-fit ​​block (803) and the fixing ring (801) form a snap-fit ​​structure through the snap-fit ​​groove (802), and the outer side of the support ring (808) is fixedly connected to the inner side of the lower cover (6).

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