A granulation device in the processing of oral dosage forms

Abstract

This utility model discloses a granulation device in the processing of oral dosage forms, relating to the field of wet granulation technology. It includes: a main body of a granulator for granulating moist raw materials; an auxiliary feeding mechanism for feeding moist raw materials into the main body of the granulator; a longitudinal cleaning mechanism for cleaning residual moist raw materials inside the auxiliary feeding mechanism; and a centrifugal anti-residue mechanism, which includes a rotating shaft fixedly mounted on the top of a piston scraper, with sliding protrusions fixedly mounted on the side of the rotating shaft. After the piston scraper completes the cleaning of the moist raw materials adhering to the inner wall of the auxiliary hopper and enters the storage chamber of the main body of the granulator, this utility model utilizes centrifugal force to clean the moist raw materials adhering to the bottom of the piston scraper, thereby reducing material residue and waste, resulting in a more ideal practical effect.

Description

Technical Field

[0001] This utility model relates to the field of wet granulation technology, and in particular to a granulation device in the processing of oral preparations. Background Technology

[0002] Quetiapine fumarate tablets are a novel atypical antipsychotic drug that exerts its pharmacological effects mainly by acting on multiple receptors in the central nervous system. Clinically, it is often used to treat mental illnesses such as schizophrenia and bipolar disorder. Currently, most quetiapine fumarate tablets are produced using wet granulation.

[0003] A search revealed that utility model patent CN220861366U discloses an oral solid dosage form wet granulation machine, including a wet granulation machine body. The top of the granulation cylinder of the wet granulation machine body is provided with a material inlet. It also includes an auxiliary hopper. By setting the auxiliary hopper at the material inlet and having an inner wall cleaning mechanism, the dosage of the dosage is avoided during the dosage process, the equipment is kept clean, and the subsequent maintenance is convenient.

[0004] Although the above-mentioned device can clean the inner wall of the auxiliary hopper through the inner wall cleaning mechanism, since the pharmaceutical raw materials are wet, the wet raw materials cleaned off during the process of the piston plug cleaning the inner wall of the auxiliary hopper are very easy to adhere to the bottom of the piston plug and cannot enter the body of the wet granulation machine. The actual use effect is still not ideal.

[0005] Therefore, it is necessary to invent a granulation device for oral dosage form processing to solve the above problems. Utility Model Content

[0006] The purpose of this invention is to provide a granulation device for oral preparation processing. After the piston scraper cleans the damp raw material adhering to the inner wall of the auxiliary hopper and it enters the storage chamber of the main body of the granulator, centrifugal force can be used to clean the damp raw material adhering to the bottom of the piston scraper, thereby reducing material residue and waste. The actual use effect is more ideal, thus solving the problem mentioned in the background art that, because the pharmaceutical raw material is damp, the damp raw material cleaned by the piston plug during the cleaning of the inner wall of the auxiliary hopper is very easy to adhere to the bottom of the piston plug and cannot enter the interior of the wet granulator body, so the actual use effect is still not ideal.

[0007] According to one aspect of this disclosure, a granulation apparatus for oral dosage form processing is provided, comprising:

[0008] The main body of the granulator is used to form wet raw materials into granules;

[0009] An auxiliary feeding mechanism is used to feed wet raw materials into the main body of the pellet mill.

[0010] A longitudinal cleaning mechanism is used to clean the residual damp raw materials inside the auxiliary feeding mechanism; and

[0011] The centrifugal residue prevention mechanism includes a rotating shaft fixedly mounted on the top of a piston scraper. A sliding protrusion is fixedly mounted on the side of the rotating shaft. A rotating sleeve is slidably sleeved on the outer side of the rotating shaft and the sliding protrusion along the vertical direction. A sliding groove adapted to the sliding protrusion is opened on the inner side of the rotating sleeve. The sliding protrusion is located inside the sliding groove. The centrifugal residue prevention mechanism also includes a drive motor fixedly mounted on the top of an auxiliary hopper. The drive motor is connected to the top of the rotating sleeve.

[0012] According to at least one embodiment of the granulation apparatus in the oral formulation processing of the present disclosure, the auxiliary feeding mechanism includes an auxiliary hopper fixedly connected to the top feed port of the main body of the granulator, a guide sleeve fixedly provided through the top left side of the auxiliary hopper and a pressure equalization hole opened on the top back side.

[0013] According to at least one embodiment of the granulation apparatus in the oral formulation processing of the present disclosure, a feed window is provided at the bottom front of the auxiliary hopper, and a guide hopper is fixedly provided inside the feed window.

[0014] According to at least one embodiment of the granulation apparatus in the oral formulation processing of the present disclosure, the longitudinal cleaning mechanism includes a piston scraper that slides vertically against the interior of an auxiliary hopper, and a movable ring is rotatably nested at the top of the piston scraper via a bearing.

[0015] According to at least one embodiment of the granulation apparatus in the oral formulation processing of the present disclosure, a guide optical shaft is fixedly provided on the top left side of the movable ring, the guide optical shaft is slidably provided in the vertical direction inside a matching guide sleeve, and a connecting rod is fixedly provided on the top right side of the movable ring.

[0016] According to at least one embodiment of the granulation apparatus in the oral formulation processing of the present disclosure, the longitudinal cleaning mechanism further includes an electric push rod fixedly disposed on the right side of the top of the auxiliary hopper, the output shaft of the electric push rod being fixedly connected to a connecting rod.

[0017] The technical effects and advantages of this utility model are as follows:

[0018] After the piston scraper cleans the damp raw material adhering to the inner wall of the auxiliary hopper and enters the storage chamber of the main body of the granulator, the present invention can use centrifugal force to clean the damp raw material adhering to the bottom of the piston scraper, thereby reducing material residue and waste, and the actual use effect is more ideal. Attached Figure Description

[0019] The accompanying drawings illustrate exemplary embodiments of the present disclosure and, together with the description thereof, serve to explain the principles of the present disclosure. These drawings are included to provide a further understanding of the present disclosure and are incorporated in and constitute a part of this specification.

[0020] Figure 1 This is a schematic diagram of the overall structure of a granulation apparatus in an oral formulation processing according to one embodiment of the present disclosure.

[0021] Figure 2 This is a schematic diagram of the auxiliary feeding mechanism of a granulation device in an oral formulation processing according to one embodiment of the present disclosure.

[0022] Figure 3 This is a schematic diagram of the longitudinal cleaning mechanism and the centrifugal residue prevention mechanism of a granulation device in the oral dosage form processing according to one embodiment of the present disclosure.

[0023] The specific labels in the attached figures are as follows:

[0024] 1. Main body of the pellet mill;

[0025] 2. Auxiliary feeding mechanism; 21. Auxiliary hopper; 22. Guide sleeve; 23. Feed window; 24. Guide hopper;

[0026] 3. Longitudinal cleaning mechanism; 31. Piston scraper; 32. Moving ring; 33. Guide shaft; 34. Connecting rod; 35. Electric push rod;

[0027] 4. Centrifugal anti-residue mechanism; 41. Rotating shaft; 42. Sliding protrusion; 43. Rotating sleeve; 44. Sliding groove; 45. Drive motor. Detailed Implementation

[0028] For descriptive purposes, this disclosure may use spatial relative terms such as “below,” “under,” “below,” “down,” “above,” “above,” “higher,” and “side (e.g., in a “sidewall”)” to describe the relationship between one component and another component as shown in the accompanying drawings. In addition to the orientations depicted in the drawings, the spatial relative terms are also intended to encompass different orientations of the device during use, operation, and / or manufacture. For example, if the device in the drawings is flipped, a component described as “below” or “under” other components or features would subsequently be positioned “above” said other components or features. Thus, the exemplary term “below” can encompass both “above” and “below” orientations. Furthermore, the device may be otherwise positioned (e.g., rotated 90 degrees or in other orientations), thus interpreting the spatial relative descriptive terms used herein accordingly.

[0029] Figure 1 This is a schematic diagram of the overall structure of a granulation apparatus in an oral formulation processing according to one embodiment of the present disclosure.

[0030] Figure 2 This is a schematic diagram of the auxiliary feeding mechanism 2 of the granulation device in the oral formulation processing according to one embodiment of the present disclosure.

[0031] Figure 3 This is a schematic diagram of the longitudinal cleaning mechanism 3 and the centrifugal residue prevention mechanism 4 of a granulation device in the oral dosage form processing according to one embodiment of the present disclosure.

[0032] like Figures 1-3 As shown, the granulation device in the oral dosage form processing of this disclosure may include components such as: granulator main body 1, auxiliary feeding mechanism 2, longitudinal cleaning mechanism 3, and centrifugal anti-residue mechanism 4.

[0033] It should be noted that the main body 1 of the granulator described above is existing technology, so it will not be described in detail here.

[0034] like Figure 2 As shown in this disclosure, the auxiliary feeding mechanism 2 includes an auxiliary hopper 21 fixedly connected to the top feed port of the main body 1 of the pellet mill. A guide sleeve 22 is fixedly provided through the top left side of the auxiliary hopper 21 and a pressure equalization hole is opened on the top back side. A feed window 23 is opened at the bottom front side of the auxiliary hopper 21, and a guide hopper 24 is fixedly provided inside the feed window 23.

[0035] This allows the damp raw material to be added into the feed hopper 24. Guided by the feed hopper 24, the damp raw material slides along the inside of the feed hopper 24 and passes through the feed window 23 into the auxiliary feed hopper 21. Finally, under the action of gravity, it falls into the storage chamber of the main body 1 of the pellet mill and is made into pellets by the main body 1 of the pellet mill. For the damp raw material adhering to the inside of the feed hopper 24, the operator can manually use tools to clean it and add the cleaned damp raw material into the auxiliary feed hopper 21 through the feed window 23.

[0036] The verticality of the pressure equalization hole allows outside air to enter the upper part of the inner cavity of the auxiliary hopper 21 through the pressure equalization hole when the piston scraper 31 moves downward inside the auxiliary hopper 21. This avoids negative pressure from affecting the normal fit between the outer wall of the piston scraper 31 and the inner wall of the auxiliary hopper 21, thus ensuring the sealing between the outer wall of the piston scraper 31 and the inner wall of the auxiliary hopper 21.

[0037] like Figure 2 As shown, in a preferred embodiment, the longitudinal cleaning mechanism 3 includes a piston scraper 31 that slides vertically and fits against the inside of the auxiliary hopper 21. A movable ring 32 is rotatably nested on the top of the piston scraper 31 via a bearing. A guide shaft 33 is fixedly disposed on the left side of the top of the movable ring 32. The guide shaft 33 slides vertically inside a matching guide sleeve 22. A connecting rod 34 is fixedly disposed on the right side of the top of the movable ring 32. The longitudinal cleaning mechanism 3 also includes an electric push rod 35 fixedly disposed on the right side of the top of the auxiliary hopper 21. The output shaft of the electric push rod 35 is fixedly connected to the connecting rod 34.

[0038] Therefore, after feeding is completed, the electric push rod 35 drives the connecting rod 34 to move continuously downward. When the connecting rod 34 moves downward, it drives the piston scraper 31 to move continuously downward along the inner wall of the auxiliary hopper 21 through the movable ring 32. During this process, the guide shaft 33 slides vertically downward inside the guide sleeve 22 to guide. As the piston scraper 31 moves downward continuously, the wet raw material adhering to the inner wall of the auxiliary hopper 21 is pushed into the storage chamber of the main body 1 of the pellet mill. At the same time, some wet raw material adheres to the bottom of the piston scraper 31 and waits to be cleaned.

[0039] like Figure 3 As shown in this disclosure, the centrifugal anti-residue mechanism 4 includes a rotating shaft 41 fixedly mounted on the top of the piston scraper 31. A sliding protrusion 42 is fixedly mounted on the side of the rotating shaft 41. A rotating sleeve 43 is slidably sleeved on the outer side of the rotating shaft 41 and the sliding protrusion 42 along the vertical direction. A sliding groove 44 adapted to the sliding protrusion 42 is opened on the inner side of the rotating sleeve 43. The sliding protrusion 42 is located inside the sliding groove 44. The centrifugal anti-residue mechanism 4 also includes a drive motor 45 fixedly mounted on the top of the auxiliary hopper 21. The drive motor 45 is connected to the top of the rotating sleeve 43 in a transmission connection.

[0040] Therefore, when the piston scraper 31 moves downward to push and clean the wet raw material adhering to the inner wall of the auxiliary hopper 21, the rotating shaft 41 moves continuously downward along the inner wall of the rotating sleeve 43 under the drive of the piston scraper 31, and the sliding protrusion 42 moves continuously downward along the sliding groove 44. After the piston scraper 31 moves from the inside of the auxiliary hopper 21 to the storage cavity of the main body 1 of the granulator, there is no longer any obstruction on the outside of the piston scraper 31. At this time, the drive motor 45 is energized. After the drive motor 45 is energized, it drives the rotating sleeve 43 to rotate continuously. The rotating sleeve 43 drives the piston through the sliding protrusion 42 and the sliding groove 44. The scraper 31 rotates continuously at the bottom of the movable ring 32. At this time, the wet raw material adhering to the bottom of the piston scraper 31 is thrown into the storage chamber of the main body 1 of the pellet mill under the centrifugal force. Then, the drive motor 45 is stopped and the electric push rod 35 drives the piston scraper 31 to move upward and reset. Compared with the prior art, after the piston scraper 31 has finished cleaning the wet raw material adhering to the inner wall of the auxiliary hopper 21 and entered the storage chamber of the main body 1 of the pellet mill, the wet raw material adhering to the bottom of the piston scraper 31 can be cleaned by centrifugal force, thereby reducing material residue and waste. The actual use effect is more ideal.

[0041] It should also be noted that any content not described in detail in this specification is prior art known to those skilled in the art.

[0042] Those skilled in the art should understand that the above embodiments are merely for illustrating the present disclosure and are not intended to limit the scope of the disclosure. Those skilled in the art can make other changes or modifications based on the above disclosure, and these changes or modifications still fall within the scope of the present disclosure.

Claims

1. A granulation device for oral dosage form processing, characterized in that, include: The main body of the granulator is used to form wet raw materials into granules; An auxiliary feeding mechanism is used to feed wet raw materials into the main body of the pellet mill. A longitudinal cleaning mechanism is used to clean the residual damp raw materials inside the auxiliary feeding mechanism; and The centrifugal residue prevention mechanism includes a rotating shaft fixedly mounted on the top of a piston scraper. A sliding protrusion is fixedly mounted on the side of the rotating shaft. A rotating sleeve is slidably sleeved on the outer side of the rotating shaft and the sliding protrusion along the vertical direction. A sliding groove adapted to the sliding protrusion is opened on the inner side of the rotating sleeve. The sliding protrusion is located inside the sliding groove. The centrifugal residue prevention mechanism also includes a drive motor fixedly mounted on the top of an auxiliary hopper. The drive motor is connected to the top of the rotating sleeve.

2. The granulation apparatus in the oral dosage form processing according to claim 1, characterized in that: The auxiliary feeding mechanism includes an auxiliary hopper fixedly connected to the top feed inlet of the main body of the pellet mill. A guide sleeve is fixedly installed through the top left side of the auxiliary hopper, and a pressure equalization hole is opened on the top back side.

3. The granulation apparatus in the oral dosage form processing according to claim 2, characterized in that: The auxiliary hopper has a feeding window at the bottom front, and a guide hopper is fixedly installed inside the feeding window.

4. The granulation apparatus in the oral dosage form processing according to claim 3, characterized in that: The longitudinal cleaning mechanism includes a piston scraper that slides vertically into the interior of the auxiliary hopper, and a movable ring is nested at the top of the piston scraper via a bearing.

5. The granulation apparatus in the oral dosage form processing according to claim 4, characterized in that: A guide optical shaft is fixedly installed on the top left side of the movable ring. The guide optical shaft is slidably installed in the vertical direction inside the matching guide sleeve. A connecting rod is fixedly installed on the top right side of the movable ring.

6. The granulation apparatus for oral dosage form processing according to claim 5, characterized in that: The longitudinal cleaning mechanism also includes an electric push rod fixedly installed on the right side of the top of the auxiliary hopper, and the output shaft of the electric push rod is fixedly connected to the connecting rod.

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